(Q57082634)

Targeting proteases: successes, failures and future prospects

31 March 2020

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Human and mouse proteases: a comparative genomic approach

31 March 2020

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A genomic analysis of rat proteases and protease inhibitors

31 March 2020

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Mechanism of the Proteolytic Activity of Malignant Tissue Cells

31 March 2020

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New functions for the matrix metalloproteinases in cancer progression

31 March 2020

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Cysteine cathepsins: multifunctional enzymes in cancer

31 March 2020

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The emerging roles of human tissue kallikreins in cancer

31 March 2020

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Caspase 8 is deleted or silenced preferentially in childhood neuroblastomas with amplification of MYCN

31 March 2020

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Human autophagins, a family of cysteine proteinases potentially implicated in cell degradation by autophagy

31 March 2020

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Ubiquitin and ubiquitin-like proteins in cancer pathogenesis

31 March 2020

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Matrix Metalloproteinase Inhibitors and Cancer--Trials and Tribulations

31 March 2020

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Strategies for MMP inhibition in cancer: innovations for the post-trial era.

31 March 2020

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Loss of collagenase-2 confers increased skin tumor susceptibility to male mice.

31 March 2020

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A protective role for matrix metalloproteinase-3 in squamous cell carcinoma

31 March 2020

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Tumour microenvironment - opinion: validating matrix metalloproteinases as drug targets and anti-targets for cancer therapy.

31 March 2020

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A CASP-8 mutation recognized by cytolytic T lymphocytes on a human head and neck carcinoma.

31 March 2020

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Potentiation of neuroblastoma metastasis by loss of caspase-8.

31 March 2020

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Inactivating mutations of CASP10 gene in non-Hodgkin lymphomas.

31 March 2020

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Inactivating mutations of the caspase-10 gene in gastric cancer

31 March 2020

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Somatic mutations of CASP3 gene in human cancers

31 March 2020

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Repeated sequences in CASPASE-5 and FANCD2 but not NF1 are targets for mutation in microsatellite-unstable acute leukemia/myelodysplastic syndrome.

31 March 2020

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Mutational analysis of the CASP6 gene in colorectal and gastric carcinomas

31 March 2020

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Inactivating mutations of CASPASE-7 gene in human cancers

31 March 2020

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Identification of the familial cylindromatosis tumour-suppressor gene

31 March 2020

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Reduced expression of CYLD in human colon and hepatocellular carcinomas

31 March 2020

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Cyld inhibits tumor cell proliferation by blocking Bcl-3-dependent NF-kappaB signaling

31 March 2020

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Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization

31 March 2020

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The HAUSP gene plays an important role in non-small cell lung carcinogenesis through p53-dependent pathways

31 March 2020

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Roles of sumoylation of a reptin chromatin-remodelling complex in cancer metastasis

31 March 2020

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31 March 2020

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Tissue-specific Autophagy Alterations and Increased Tumorigenesis in Mice Deficient in Atg4C/Autophagin-3

31 March 2020

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Altered metastatic behavior of human breast cancer cells after experimental manipulation of matrix metalloproteinase 8 gene expression

31 March 2020

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Analysis of host- and tumor-derived proteinases using a custom dual species microarray reveals a protective role for stromal matrix metalloproteinase-12 in non-small cell lung cancer

31 March 2020

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Macrophage elastase (matrix metalloproteinase-12) suppresses growth of lung metastases

31 March 2020

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Implications of human macrophage metalloelastase and vascular endothelial growth factor gene expression in angiogenesis of hepatocellular carcinoma

31 March 2020

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Human macrophage metalloelastase gene expression in colorectal carcinoma and its clinicopathologic significance

31 March 2020

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Metalloelastase (MMP-12) expression by tumour cells in squamous cell carcinoma of the vulva correlates with invasiveness, while that by macrophages predicts better outcome

31 March 2020

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Macrophage-derived metalloelastase is responsible for the generation of angiostatin in Lewis lung carcinoma

31 March 2020

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Matrix metalloproteinase 26 proteolysis of the NH2-terminal domain of the estrogen receptor beta correlates with the survival of breast cancer patients

31 March 2020

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The stromal proteinase MMP3/stromelysin-1 promotes mammary carcinogenesis

31 March 2020

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MMP-9 supplied by bone marrow-derived cells contributes to skin carcinogenesis

31 March 2020

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Overexpression of matrix-metalloproteinase-9 in human breast cancer: a potential favourable indicator in node-negative patients

31 March 2020

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Stromal expression of MMP-9 and urokinase receptor is inversely associated with liver metastasis and with infiltrating growth in human colorectal cancer: a novel approach from immune/inflammatory aspect.

31 March 2020

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Low plasma levels of matrix metalloproteinase 9 permit increased tumor angiogenesis.

31 March 2020

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Physiological levels of tumstatin, a fragment of collagen IV alpha3 chain, are generated by MMP-9 proteolysis and suppress angiogenesis via alphaV beta3 integrin

31 March 2020

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Diet-induced obesity and reduced skin cancer susceptibility in matrix metalloproteinase 19-deficient mice

31 March 2020

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Earlier Onset of Tumoral Angiogenesis in Matrix Metalloproteinase-19–Deficient Mice

31 March 2020

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The ADAMTS metalloproteinases

31 March 2020

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ADAMTS1: a matrix metalloprotease with angioinhibitory properties

31 March 2020

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The carboxyl-terminal half region of ADAMTS-1 suppresses both tumorigenicity and experimental tumor metastatic potential

31 March 2020

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Full-length ADAMTS-1 and the ADAMTS-1 fragments display pro- and antimetastatic activity, respectively

31 March 2020

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ADAMTS1/METH1 Inhibits Endothelial Cell Proliferation by Direct Binding and Sequestration of VEGF165

31 March 2020

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ADAMTS1 mediates the release of antiangiogenic polypeptides from TSP1 and 2

31 March 2020

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Dysregulated expression of adamalysin-thrombospondin genes in human breast carcinoma

31 March 2020

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Expression of a disintegrin and metalloprotease (ADAM and ADAMTS) enzymes in human non-small-cell lung carcinomas (NSCLC).

31 March 2020

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METH-2 silencing and promoter hypermethylation in NSCLC

31 March 2020

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Expression of ADAMTS-8, a secreted protease with antiangiogenic properties, is downregulated in brain tumours

31 March 2020

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Identification of a tumor suppressive critical region mapping to 3p14.2 in esophageal squamous cell carcinoma and studies of a candidate tumor suppressor gene, ADAMTS9

31 March 2020

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The consensus coding sequences of human breast and colorectal cancers

31 March 2020

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Involvement of neutral endopeptidase in neoplastic progression

31 March 2020

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Neprilysin inhibits angiogenesis via proteolysis of fibroblast growth factor-2.

31 March 2020

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Synergy in tumor suppression by direct interaction of Neutral Endopeptidase with PTEN

31 March 2020

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Loss of neutral endopeptidase and activation of protein kinase B (Akt) is associated with prostate cancer progression

31 March 2020

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Decreased replication ability of E1-deleted adenoviruses correlates with increased brain tumor malignancy

31 March 2020

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Identification of carboxypeptidase of glutamate like-B as a candidate suppressor in cell growth and metastasis in human hepatocellular carcinoma

31 March 2020

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ADAM23, a possible tumor suppressor gene, is frequently silenced in gastric cancers by homozygous deletion or aberrant promoter hypermethylation

31 March 2020

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Rce1 deficiency accelerates the development of K-RAS-induced myeloproliferative disease

31 March 2020

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The lysosomal cysteine protease cathepsin L regulates keratinocyte proliferation by control of growth factor recycling.

31 March 2020

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Mitogenic response of osteoblast cells to prostate-specific antigen suggests an activation of latent TGF-beta and a proteolytic modulation of cell adhesion receptors

31 March 2020

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Prostate-specific antigen in breast cyst fluid: possible role of prostate-specific antigen in hormone-dependent breast cancer

31 March 2020

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Recombinant prostate specific antigen inhibits angiogenesis in vitro and in vivo

31 March 2020

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Human kallikrein 8 protease confers a favorable clinical outcome in non-small cell lung cancer by suppressing tumor cell invasiveness

31 March 2020

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The normal epithelial cell-specific 1 (NES1) gene, a candidate tumor suppressor gene on chromosome 19q13.3-4, is downregulated by hypermethylation in acute lymphoblastic leukemia

31 March 2020

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Expression and functional characterization of the cancer-related serine protease, human tissue kallikrein 14

31 March 2020

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Down-regulation of prostasin serine protease: a potential invasion suppressor in prostate cancer

31 March 2020

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Prostasin serine protease inhibits breast cancer invasiveness and is transcriptionally regulated by promoter DNA methylation

31 March 2020

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Hypermethylation of the 5' CpG island of the gene encoding the serine protease Testisin promotes its loss in testicular tumorigenesis.

31 March 2020

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Androgen regulation of prostasin gene expression is mediated by sterol-regulatory element-binding proteins and SLUG

31 March 2020

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A role for dipeptidyl peptidase IV in suppressing the malignant phenotype of melanocytic cells

31 March 2020

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Dipeptidyl peptidase inhibits malignant phenotype of prostate cancer cells by blocking basic fibroblast growth factor signaling pathway

31 March 2020

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Epigenetic silencing of the PRSS3 putative tumor suppressor gene in non-small cell lung cancer

31 March 2020

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Carcinogen exposure and gene promoter hypermethylation in bladder cancer

31 March 2020

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FAPalpha, a surface peptidase expressed during wound healing, is a tumor suppressor

31 March 2020

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Hepsin promotes prostate cancer progression and metastasis

31 March 2020

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Protease activity of urokinase and tumor progression in a syngeneic mammary cancer model.

31 March 2020

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Protease degradomics: mass spectrometry discovery of protease substrates and the CLIP-CHIP, a dedicated DNA microarray of all human proteases and inhibitors

31 March 2020

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Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation.

31 March 2020

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Enzyme replacement and enhancement therapies: lessons from lysosomal disorders

31 March 2020

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Targeting the apoptotic machinery in pancreatic cancers using small-molecule antagonists of the X-linked inhibitor of apoptosis protein

31 March 2020

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Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB

31 March 2020

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Characterization of a novel prostate-specific antigen-activated peptide-doxorubicin conjugate in patients with prostate cancer

31 March 2020

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Molecular imaging of proteolytic activity in cancer

31 March 2020

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Functional imaging of tumor proteolysis

31 March 2020

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Matrix metalloproteinases and tumor progression

31 March 2020

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