(Q57184141)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22825244%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

title

Dual-function triazole-pyridine derivatives as inhibitors of metal-induced amyloid-β aggregation (English)

1 reference

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8 February 2020

author

Ayyalusamy Ramamoorthy

7

1 reference

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8 February 2020

Tim Storr

9

1 reference

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8 February 2020

author name string

Michael R Jones

1

1 reference

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8 February 2020

Erin L Service

2

1 reference

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8 February 2020

John R Thompson

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22825244%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

Michael C P Wang

4

1 reference

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8 February 2020

Isaac J Kimsey

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22825244%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

Alaina S DeToma

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22825244%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

Mi Hee Lim

8

1 reference

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8 February 2020

language of work or name

English

0 references

publication date

1 August 2012

1 reference

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8 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22825244%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

volume

4

1 reference

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8 February 2020

issue

9

1 reference

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8 February 2020

page(s)

910-920

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22825244%20AND%20SRC:MED&resulttype=core&format=json

Alzheimer's disease: a general introduction and pathomechanism

8 February 2020

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Copper homeostasis and neurodegenerative disorders (Alzheimer's, prion, and Parkinson's diseases and amyotrophic lateral sclerosis).

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Misfolded proteins in Alzheimer's disease and type II diabetes.

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100 years and counting: prospects for defeating Alzheimer's disease

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Alzheimer's disease: strategies for disease modification

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Structural studies of the Alzheimer's amyloid precursor protein copper-binding domain reveal how it binds copper ions

21 January 2018

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Iron-export ferroxidase activity of β-amyloid precursor protein is inhibited by zinc in Alzheimer's disease

21 January 2018

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Alzheimer's disease: molecular understanding predicts amyloid-based therapeutics

21 January 2018

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Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease

21 January 2018

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The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

21 January 2018

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A specific amyloid-beta protein assembly in the brain impairs memory

21 January 2018

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Clusters of hyperactive neurons near amyloid plaques in a mouse model of Alzheimer's disease.

21 January 2018

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ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models

21 January 2018

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Correlation of early-phase 18F-florbetapir (AV-45/Amyvid) PET images to FDG images: preliminary studies.

21 January 2018

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Oxidative damage is the earliest event in Alzheimer disease

21 January 2018

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S-nitrosylation of Drp1 mediates beta-amyloid-related mitochondrial fission and neuronal injury

21 January 2018

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Reactive oxygen species and protein oxidation in aging: a look back, a look ahead

21 January 2018

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The metallobiology of Alzheimer's disease

21 January 2018

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Biological metals and Alzheimer's disease: implications for therapeutics and diagnostics

21 January 2018

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Metal-associated amyloid-β species in Alzheimer's disease

21 January 2018

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Undetectable intracellular free copper: the requirement of a copper chaperone for superoxide dismutase

21 January 2018

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Metals in Alzheimer's and Parkinson's diseases

21 January 2018

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The heterogeneous nature of Cu2+ interactions with Alzheimer's amyloid-β peptide.

21 January 2018

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The role of metallobiology and amyloid-β peptides in Alzheimer's disease

21 January 2018

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Medicinal inorganic chemistry approaches to passivation and removal of aberrant metal ions in disease

21 January 2018

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Copper, iron and zinc in Alzheimer's disease senile plaques.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT20113E

Synchrotron-based infrared and X-ray imaging shows focalized accumulation of Cu and Zn co-localized with beta-amyloid deposits in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT20113E

Metals in Alzheimer's disease: a systemic perspective

21 January 2018

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Rapid induction of Alzheimer A beta amyloid formation by zinc.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT20113E

Concentration dependent Cu2+ induced aggregation and dityrosine formation of the Alzheimer's disease amyloid-beta peptide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT20113E

Trace metal contamination initiates the apparent auto-aggregation, amyloidosis, and oligomerization of Alzheimer's Abeta peptides.

21 January 2018

1 reference

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Stabilization of neurotoxic soluble beta-sheet-rich conformations of the Alzheimer's disease amyloid-beta peptide

21 January 2018

1 reference

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Cu(II) potentiation of alzheimer abeta neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction.

21 January 2018

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https://api.crossref.org/works/10.1039%2FC2MT20113E

Aqueous dissolution of Alzheimer's disease Abeta amyloid deposits by biometal depletion

21 January 2018

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Synthesis, characterization, and metal coordinating ability of multifunctional carbohydrate-containing compounds for Alzheimer's therapy

21 January 2018

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Intramuscular desferrioxamine in patients with Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT20113E

Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT20113E

Safety, efficacy, and biomarker findings of PBT2 in targeting Abeta as a modifying therapy for Alzheimer's disease: a phase IIa, double-blind, randomised, placebo-controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT20113E

The Alzheimer's therapeutic PBT2 promotes amyloid-β degradation and GSK3 phosphorylation via a metal chaperone activity

21 January 2018

1 reference

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Alzheimer's disease & metals: therapeutic opportunities

21 January 2018

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Multifunctional ligands in medicinal inorganic chemistry--current trends and future directions

21 January 2018

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Progress in Alzheimer's disease

21 January 2018

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PBT2 rapidly improves cognition in Alzheimer's Disease: additional phase II analyses

21 January 2018

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A prochelator activated by beta-secretase inhibits Abeta aggregation and suppresses copper-induced reactive oxygen species formation

21 January 2018

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Modifications of boronic ester pro-chelators triggered by hydrogen peroxide tune reactivity to inhibit metal-promoted oxidative stress

21 January 2018

1 reference

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Peptidotriazoles on solid phase: [1,2,3]-triazoles by regiospecific copper(i)-catalyzed 1,3-dipolar cycloadditions of terminal alkynes to azides

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT20113E

A stepwise huisgen cycloaddition process: copper(I)-catalyzed regioselective "ligation" of azides and terminal alkynes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT20113E

Metal-coordinated water-soluble cavitands act as C-H oxidation catalysts

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT20113E

An intramolecular [2 + 3] cycloaddition route to fused 5-heterosubstituted tetrazoles.

21 January 2018

1 reference

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Analysis and optimization of copper-catalyzed azide-alkyne cycloaddition for bioconjugation

21 January 2018

1 reference

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Effects of a flexible alkyl chain on a ligand for CuAAC reaction

21 January 2018

1 reference

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Hyperquad simulation and speciation (HySS): a utility program for the investigation of equilibria involving soluble and partially soluble species

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT20113E

Small molecule modulators of copper-induced Abeta aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT20113E

Exploring the reactivity of flavonoid compounds with metal-associated amyloid-β species

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT20113E

Design of small molecules that target metal-A{beta} species and regulate metal-induced A{beta} aggregation and neurotoxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT20113E

Synthesis and characterization of IMPY derivatives that regulate metal-induced amyloid-β aggregation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT20113E

Development of bifunctional stilbene derivatives for targeting and modulating metal-amyloid-β species.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT20113E

Positioning of the Alzheimer Abeta(1-40) peptide in SDS micelles using NMR and paramagnetic probes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT20113E

The solution structure of HIV-1 Nef reveals an unexpected fold and permits delineation of the binding surface for the SH3 domain of Hck tyrosine protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT20113E

Identification by NMR of the binding surface for the histidine-containing phosphocarrier protein HPr on the N-terminal domain of enzyme I of the Escherichia coli phosphotransferase system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT20113E

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT20113E

Solution structure of amyloid beta-peptide(1-40) in a water-micelle environment. Is the membrane-spanning domain where we think it is?

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT20113E

Discovery of selective bioactive small molecules by targeting an RNA dynamic ensemble

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT20113E

Effects of clioquinol on metal-triggered amyloid-beta aggregation revisited

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT20113E

Correlation of the Base Strengths of Amines 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT20113E

Cholesterol is an important factor affecting the membrane insertion of beta-amyloid peptide (A beta 1-40), which may potentially inhibit the fibril formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT20113E

Protein-ligand docking: current status and future challenges

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT20113E

Ligand-protein docking and rational drug design.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT20113E

Why is the amyloid beta peptide of Alzheimer's disease neurotoxic?

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT20113E

Bifunctional compounds for controlling metal-mediated aggregation of the aβ42 peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT20113E

Dramatic aggregation of Alzheimer abeta by Cu(II) is induced by conditions representing physiological acidosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT20113E

Degradation of the Alzheimer disease amyloid beta-peptide by metal-dependent up-regulation of metalloprotease activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT20113E

Increasing Cu bioavailability inhibits Abeta oligomers and tau phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT20113E

EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT20113E

EGCG remodels mature alpha-synuclein and amyloid-beta fibrils and reduces cellular toxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT20113E

Aromatic small molecules remodel toxic soluble oligomers of amyloid beta through three independent pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT20113E

The Aβ Peptide of Alzheimer's Disease Directly Produces Hydrogen Peroxide through Metal Ion Reduction†

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MT20113E

21 January 2018

Identifiers

DOI

10.1039/C2MT20113E

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22825244%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

1 reference