(Q57304549)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24323975%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

title

Activating mutations cluster in the "molecular brake" regions of protein kinases and do not associate with conserved or catalytic residues (English)

1 reference

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2 March 2020

2

1 reference

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2 March 2020

Cristian Tornador

3

1 reference

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2 March 2020

Amit J. Sabnis

4

1 reference

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Xavier Estivill i Pallejà

2 March 2020

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24323975%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

Cristina Marino-Buslje

8

1 reference

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2 March 2020

7

Trever G Bivona

1 reference

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2 March 2020

author name string

Miguel A Molina-Vila

1

1 reference

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2 March 2020

Rafael Rosell

5

1 reference

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2 March 2020

publication date

8 January 2014

1 reference

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2 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24323975%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

volume

35

1 reference

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2 March 2020

issue

3

1 reference

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2 March 2020

page(s)

318-328

1 reference

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Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma

2 March 2020

cites work

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Autoinhibition of the kit receptor tyrosine kinase by the cytosolic juxtamembrane region.

21 January 2018

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A Molecular Brake in the Kinase Hinge Region Regulates the Activity of Receptor Tyrosine Kinases

21 January 2018

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Cracking the Molecular Origin of Intrinsic Tyrosine Kinase Activity through Analysis of Pathogenic Gain-of-Function Mutations

21 January 2018

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Reorganizing the protein space at the Universal Protein Resource (UniProt)

21 January 2018

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21 January 2018

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Sequence and structure signatures of cancer mutation hotspots in protein kinases

21 January 2018

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A genetic model for colorectal tumorigenesis

21 January 2018

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COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer

21 January 2018

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Identification of driver and passenger mutations of FLT3 by high-throughput DNA sequence analysis and functional assessment of candidate alleles

21 January 2018

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A census of human cancer genes

21 January 2018

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Improving the prediction of the functional impact of cancer mutations by baseline tolerance transformation

21 January 2018

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Patterns of somatic mutation in human cancer genomes

21 January 2018

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The structural basis for autoinhibition of FLT3 by the juxtamembrane domain

21 January 2018

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Oncogenic potential is related to activating effect of cancer single and double somatic mutations in receptor tyrosine kinases

21 January 2018

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Dabrafenib in BRAF-mutated metastatic melanoma: a multicentre, open-label, phase 3 randomised controlled trial

21 January 2018

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Regulation of repulsion versus adhesion by different splice forms of an Eph receptor

21 January 2018

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Diverse somatic mutation patterns and pathway alterations in human cancers

21 January 2018

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Missense mutations interfere with VEGFR-3 signalling in primary lymphoedema

21 January 2018

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Bi-directional SIFT predicts a subset of activating mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22493

Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22493

The active conformation of the PAK1 kinase domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22493

High-throughput sequence analysis of the tyrosine kinome in acute myeloid leukemia

21 January 2018

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The protein kinase complement of the human genome

21 January 2018

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Networks of high mutual information define the structural proximity of catalytic sites: implications for catalytic residue identification.

21 January 2018

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The Eph-receptor A7 is a soluble tumor suppressor for follicular lymphoma

21 January 2018

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EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib

21 January 2018

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Eph receptors and ephrins in cancer: bidirectional signalling and beyond

21 January 2018

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UCSF Chimera--a visualization system for exploratory research and analysis

21 January 2018

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https://api.crossref.org/works/10.1002%2FHUMU.22493

Frequent activating FGFR2 mutations in endometrial carcinomas parallel germline mutations associated with craniosynostosis and skeletal dysplasia syndromes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22493

The Catalytic Site Atlas: a resource of catalytic sites and residues identified in enzymes using structural data

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22493

Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia

21 January 2018

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The Pfam protein families database

21 January 2018

1 reference

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Predicting the functional impact of protein mutations: application to cancer genomics

21 January 2018

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Screening for epidermal growth factor receptor mutations in lung cancer

21 January 2018

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Oncogenic mutations counteract intrinsic disorder in the EGFR kinase and promote receptor dimerization

21 January 2018

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Structural and functional impact of cancer-related missense somatic mutations

21 January 2018

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Imatinib: a review of its use in the management of gastrointestinal stromal tumours

21 January 2018

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Predicting the functional, molecular, and phenotypic consequences of amino acid substitutions using hidden Markov models

21 January 2018

1 reference

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Using the T-Coffee package to build multiple sequence alignments of protein, RNA, DNA sequences and 3D structures

21 January 2018

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Prediction of cancer driver mutations in protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22493

Congenital disease SNPs target lineage specific structural elements in protein kinases

21 January 2018

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https://api.crossref.org/works/10.1002%2FHUMU.22493

The genomic landscapes of human breast and colorectal cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22493

An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor

21 January 2018

1 reference

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The genetic basis of early T-cell precursor acute lymphoblastic leukaemia

21 January 2018

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The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification 1

21 January 2018

1 reference

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inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1002/HUMU.22493

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24323975%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

1 reference