(Q33510934)

27 July 2017

title

Sequence and structure signatures of cancer mutation hotspots in protein kinases (English)

1 reference

27 July 2017

0 references

Gennady M Verkhivker

6

0 references

author name string

Anshuman Dixit

1

1 reference

27 July 2017

Lin Yi

2

1 reference

27 July 2017

Ragul Gowthaman

3

1 reference

27 July 2017

Ali Torkamani

4

1 reference

27 July 2017

Nicholas J Schork

5

1 reference

27 July 2017

language of work or name

English

0 references

publication date

16 October 2009

1 reference

27 July 2017

1 reference

27 July 2017

volume

4

1 reference

27 July 2017

issue

10

1 reference

27 July 2017

page(s)

e7485

1 reference

Creative Commons Attribution 4.0 International

27 July 2017

copyright license

start time

16 October 2009

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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High-throughput sequence analysis of the tyrosine kinome in acute myeloid leukemia

21 June 2018

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The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP

21 June 2018

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Allosteric cooperativity in protein kinase A.

21 June 2018

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Oncogene addiction: setting the stage for molecularly targeted cancer therapy

21 June 2018

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21 June 2018

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21 June 2018

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Large-scale allosteric conformational transitions of adenylate kinase appear to involve a population-shift mechanism

21 June 2018

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21 June 2018

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21 June 2018

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RET signaling in endocrine tumors: delving deeper into molecular mechanisms.

21 June 2018

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Crystal structure of the T315I Abl mutant in complex with the aurora kinases inhibitor PHA-739358

21 June 2018

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Crystal structure of the T315I mutant of AbI kinase

21 June 2018

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Computational modeling of protein mutant stability: analysis and optimization of statistical potentials and structural features reveal insights into prediction model development

21 June 2018

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21 June 2018

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21 June 2018

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Structural and functional diversity of the microbial kinome

21 June 2018

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Structures of Lung Cancer-Derived EGFR Mutants and Inhibitor Complexes: Mechanism of Activation and Insights into Differential Inhibitor Sensitivity

21 June 2018

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Patterns of somatic mutation in human cancer genomes

21 June 2018

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Distinguishing cancer-associated missense mutations from common polymorphisms

21 June 2018

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Surface comparison of active and inactive protein kinases identifies a conserved activation mechanism

21 June 2018

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Protein-protein interactions in the allosteric regulation of protein kinases

21 June 2018

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21 June 2018

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21 June 2018

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The consensus coding sequences of human breast and colorectal cancers

21 June 2018

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Structure and chemical inhibition of the RET tyrosine kinase domain

21 June 2018

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21 June 2018

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An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2759519

Src kinase activation: A switched electrostatic network

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2759519

Structural characterization of autoinhibited c-Met kinase produced by coexpression in bacteria with phosphatase

21 June 2018

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Mutually exclusive NRASQ61R and BRAFV600E mutations at the single-cell level in the same human melanoma

21 June 2018

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21 June 2018

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A haplotype map of the human genome

21 June 2018

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Structural evolution of the protein kinase-like superfamily

21 June 2018

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Scalable molecular dynamics with NAMD

21 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2759519

Somatic mutations of the protein kinase gene family in human lung cancer

21 June 2018

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21 June 2018

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Features of selective kinase inhibitors

21 June 2018

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TM-align: a protein structure alignment algorithm based on the TM-score

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2759519

Novel protein kinases and molecular mechanisms of autoinhibition

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2759519

Gapped alignment of protein sequence motifs through Monte Carlo optimization of a hidden Markov model

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2759519

Coding single-nucleotide polymorphisms associated with complex vs. Mendelian disease: evolutionary evidence for differences in molecular effects.

21 June 2018

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21 June 2018

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Regulation of protein kinases; controlling activity through activation segment conformation

21 June 2018

1 reference

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EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib

21 June 2018

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Tyrosine kinase inhibitors in cancer therapy

21 June 2018

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21 June 2018

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21 June 2018

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EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy

21 June 2018

1 reference

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Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib

21 June 2018

1 reference

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The Met kinase inhibitor SU11274 exhibits a selective inhibition pattern toward different receptor mutated variants

21 June 2018

1 reference

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Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF

21 June 2018

1 reference

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Recent kinase and kinase inhibitor X-ray structures: mechanisms of inhibition and selectivity insights

21 June 2018

1 reference

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Protein kinase inhibitors: insights into drug design from structure.

21 June 2018

1 reference

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The structural basis for autoinhibition of FLT3 by the juxtamembrane domain

21 June 2018

1 reference

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Automatic extraction of mutations from Medline and cross-validation with OMIM.

21 June 2018

1 reference

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Opportunities and challenges in the development of kinase inhibitor therapy for cancer

21 June 2018

1 reference

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Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-Met and its complex with the microbial alkaloid K-252a

21 June 2018

1 reference

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PANTHER: a library of protein families and subfamilies indexed by function

21 June 2018

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A graph-theory algorithm for rapid protein side-chain prediction

21 June 2018

1 reference

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Mutations in the met oncogene unveil a "dual switch" mechanism controlling tyrosine kinase activity

21 June 2018

1 reference

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Several Bcr-Abl kinase domain mutants associated with imatinib mesylate resistance remain sensitive to imatinib

21 June 2018

1 reference

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The SWISS-PROT protein knowledgebase and its supplement TrEMBL in 2003

21 June 2018

1 reference

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The protein kinase complement of the human genome

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2759519

Evolution of protein kinase signaling from yeast to man

21 June 2018

1 reference

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K252a inhibits the oncogenic properties of Met, the HGF receptor

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2759519

Cancer. Addiction to oncogenes--the Achilles heal of cancer

21 June 2018

1 reference

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Predicting changes in the stability of proteins and protein complexes: a study of more than 1000 mutations

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2759519

The conformational plasticity of protein kinases

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2759519

Development and current status of the CHARMM force field for nucleic acids.

21 June 2018

1 reference

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Structural basis of oncogenic activation caused by point mutations in the kinase domain of the MET proto-oncogene: modeling studies

21 June 2018

1 reference

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Dynamic coupling between the SH2 and SH3 domains of c-Src and Hck underlies their inactivation by C-terminal tyrosine phosphorylation

21 June 2018

1 reference

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Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies

21 June 2018

1 reference

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Protein kinases as therapeutic targets

21 June 2018

1 reference

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Modeling of loops in protein structures

21 June 2018

1 reference

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Comparative protein structure modeling of genes and genomes

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2759519

Genomics: journey to the center of biology

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2759519

Two mutations affecting conserved residues in the Met receptor operate via different mechanisms

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2759519

Signaling--2000 and beyond

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2759519

21 June 2018

The Hallmarks of Cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2759519

KinMutBase, a database of human disease-causing protein kinase mutations

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2759519

dbSNP-database for single nucleotide polymorphisms and other classes of minor genetic variation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2759519

Uncoupling signal transducers from oncogenic MET mutants abrogates cell transformation and inhibits invasive growth

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2759519

Activating mutations for the met tyrosine kinase receptor in human cancer

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2759519

The protein kinases of budding yeast: six score and more

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2759519

Gibbs motif sampling: detection of bacterial outer membrane protein repeats

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2759519

Detecting subtle sequence signals: a Gibbs sampling strategy for multiple alignment

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2759519

Protein kinases 6. The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2759519

Identification of mutations in the coding sequence of the proto-oncogene c-kit in a human mast cell leukemia cell line causing ligand-independent activation of c-kit product

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2759519

Conformational dynamics of the EGFR kinase domain reveals structural features involved in activation.

21 June 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0007485

Identification of driver and passenger mutations of FLT3 by high-throughput DNA sequence analysis and functional assessment of candidate alleles

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0007485

Accurate prediction of deleterious protein kinase polymorphisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0007485

KinMutBase: a registry of disease-causing mutations in protein kinase domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0007485

Protein kinase resource: an integrated environment for phosphorylation research

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0007485

Did protein kinase regulatory mechanisms evolve through elaboration of a simple structural component?

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0007485

Identification of novel FLT-3 Asp835 mutations in adult acute myeloid leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0007485

Constitutively active mutant D816VKit induces megakayocyte and mast cell differentiation of early haemopoietic cells from murine foetal liver.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0007485

EGFR mutants found in non-small cell lung cancer show different levels of sensitivity to suppression of Src: implications in targeting therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0007485

Molecular mechanisms of RET receptor-mediated oncogenesis in multiple endocrine neoplasia 2B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0007485

RET is constitutively activated by novel tandem mutations that alter the active site resulting in multiple endocrine neoplasia type 2B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0007485

Tumorigenesis mediated by MET mutant M1268T is inhibited by dominant-negative Src.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0007485

Structural basis for the autoinhibition and STI-571 inhibition of c-Kit tyrosine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0007485

Molecular basis of the constitutive activity and STI571 resistance of Asp816Val mutant KIT receptor tyrosine kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0007485

Analysis of the activating mutations within the activation loop of leukemia targets Flt-3 and c-Kit based on protein homology modeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0007485

Molecular modeling of wild-type and D816V c-Kit inhibition based on ATP-competitive binding of ellipticine derivatives to tyrosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0007485

Comparison of simple potential functions for simulating liquid water

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0007485

Anatomy of a structural pathway for activation of the catalytic domain of Src kinase Hck

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0007485

Cancer-associated mutations are preferentially distributed in protein kinase functional sites

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2759519

Mapping the cancer genome. Pinpointing the genes involved in cancer will help chart a new course across the complex landscape of human malignancies.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2759519

A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2759519

Human Gene Mutation Database (HGMD): 2003 update

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2759519

Novel somatic mutations of the MET oncogene in human carcinoma metastases activating cell motility and invasion.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2759519

High-throughput oncogene mutation profiling in human cancer

31 October 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0007485

High-throughput mutational screen of the tyrosine kinome in chronic myelomonocytic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0007485

Protein Conformational Transitions: The Closure Mechanism of a Kinase Explored by Atomistic Simulations

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0007485

Human Gene Mutation Database?A biomedical information and research resource

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19834613

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Detailed conformational dynamics of juxtamembrane region and activation loop in c-Kit kinase activation process

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19834613

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Molecular implications of RET mutations for pheochromocytoma risk in multiple endocrine neoplasia 2

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19834613

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PONE.0007485

1 reference

27 July 2017

0 references

1 reference

27 July 2017

1 reference