(Q36960954)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17916994%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

review article

1 reference

title

RET signaling in endocrine tumors: delving deeper into molecular mechanisms (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17916994%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

2

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8 January 2020

author name string

Andrea Z Lai

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17916994%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

Lois M Mulligan

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17916994%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

publication date

1 January 2007

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17916994%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17916994%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

volume

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17916994%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

page(s)

57-67

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17916994%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

issue

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17916994%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1007/s12022-007-0009-5

8 January 2020

exact match

0 references

cites work

ret transforming gene encodes a fusion protein homologous to tyrosine kinases

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS12022-007-0009-5

Mechanism of activation of the ret proto-oncogene by multiple endocrine neoplasia 2A mutations

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS12022-007-0009-5

The oncogenic activity of RET point mutants for follicular thyroid cells may account for the occurrence of papillary thyroid carcinoma in patients affected by familial medullary thyroid carcinoma

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS12022-007-0009-5

Identification of a novel point mutation in the RET gene (Ala883Thr), which is associated with medullary thyroid carcinoma phenotype only in homozygous condition

21 January 2018

1 reference

12 December 2020

Risk and penetrance of primary hyperparathyroidism in multiple endocrine neoplasia type 2A families with mutations at codon 634 of the RET proto-oncogene. Groupe D'etude des Tumeurs à Calcitonine.

1 reference

12 December 2020

Structure and chemical inhibition of the RET tyrosine kinase domain

1 reference

12 December 2020

Oncogenic activation of RET by two distinct FMTC mutations affecting the tyrosine kinase domain.

1 reference

12 December 2020

Molecular genetics of multiple endocrine neoplasia types 1 and 2.

1 reference

12 December 2020

Germline mutation of RET codon 883 in two cases of de novo MEN 2B.

1 reference

12 December 2020

The GDNF/RET signaling pathway and human diseases

1 reference

12 December 2020

Absence of RET proto-oncogene point mutations in sporadic hyperplastic and neoplastic lesions of the parathyroid gland

1 reference

12 December 2020

Role of MEN2A-derived RET in maintenance and proliferation of medullary thyroid carcinoma.

1 reference

12 December 2020

Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret

1 reference

12 December 2020

Review: Should patients with apparently sporadic pheochromocytomas or paragangliomas be screened for hereditary syndromes?

1 reference

12 December 2020

Proximity of chromosomal loci that participate in radiation-induced rearrangements in human cells

1 reference

12 December 2020

Genotype-phenotype correlation in multiple endocrine neoplasia type 2: report of the International RET Mutation Consortium

1 reference

12 December 2020

Human glial cell line-derived neurotrophic factor receptor alpha 4 is the receptor for persephin and is predominantly expressed in normal and malignant thyroid medullary cells

1 reference

12 December 2020

Disease associated mutations at valine 804 in the RET receptor tyrosine kinase confer resistance to selective kinase inhibitors

1 reference

12 December 2020

Molecular mechanisms of RET receptor-mediated oncogenesis in multiple endocrine neoplasia 2B.

1 reference

12 December 2020

Germ-line mutations of the RET proto-oncogene in multiple endocrine neoplasia type 2A.

1 reference

12 December 2020

Identification of tyrosine residues that are essential for transforming activity of the ret proto-oncogene with MEN2A or MEN2B mutation

1 reference

12 December 2020

MEN2A-RET-induced cellular transformation by activation of STAT3

1 reference

12 December 2020

Expression of the RET proto-oncogene in normal human tissues, pheochromocytomas, and other tumors of neural crest origin

1 reference

12 December 2020

Mutations of the BRAF gene in human cancer

1 reference

12 December 2020

RET/PTC activation in papillary thyroid carcinoma: European Journal of Endocrinology Prize Lecture.

1 reference

12 December 2020

Sporadic endocrine tumours and their relationship to the hereditary endocrine neoplasia syndromes

1 reference

12 December 2020

Central role of the threonine residue within the p+1 loop of receptor tyrosine kinase in STAT3 constitutive phosphorylation in metastatic cancer cells

1 reference

12 December 2020

The GDNF family: signalling, biological functions and therapeutic value

1 reference

12 December 2020

RET tyrosine kinase signaling in development and cancer

1 reference

12 December 2020

RET/PTC rearrangements and BRAF mutations in thyroid tumorigenesis

1 reference

12 December 2020

Mutations of the RET proto-oncogene in the multiple endocrine neoplasia type 2 syndromes, related sporadic tumours, and hirschsprung disease

1 reference

12 December 2020

RET proto-oncogene point mutations in sporadic neuroendocrine tumors

1 reference

12 December 2020

Identification of RET autophosphorylation sites by mass spectrometry

1 reference

12 December 2020

Catalytic specificity of protein-tyrosine kinases is critical for selective signalling

1 reference

12 December 2020

Ret protein expression in adrenal medullary hyperplasia and pheochromocytoma

1 reference

12 December 2020

Self-association of the transmembrane domain of RET underlies oncogenic activation by MEN2A mutations

1 reference

12 December 2020

GFRalpha-mediated localization of RET to lipid rafts is required for effective downstream signaling, differentiation, and neuronal survival

1 reference

12 December 2020

Multiple endocrine neoplasia 2B syndrome due to codon 918 mutation: clinical manifestation and course in early and late onset disease

1 reference

12 December 2020

BRAF mutation in thyroid cancer

1 reference

12 December 2020

Mechanisms of Disease: cancer targeting and the impact of oncogenic RET for medullary thyroid carcinoma therapy.

1 reference

12 December 2020

Biological and biochemical properties of Ret with kinase domain mutations identified in multiple endocrine neoplasia type 2B and familial medullary thyroid carcinoma

1 reference

12 December 2020

Codon-specific development of pheochromocytoma in multiple endocrine neoplasia type 2.

1 reference

12 December 2020

Activation of RET as a dominant transforming gene by germline mutations of MEN2A and MEN2B

1 reference

12 December 2020

Multiple endocrine neoplasia type 2: evaluation of the genotype-phenotype relationship.

1 reference

12 December 2020

RET is constitutively activated by novel tandem mutations that alter the active site resulting in multiple endocrine neoplasia type 2B.

1 reference

12 December 2020

RET receptor expression in thyroid follicular epithelial cell-derived tumors.

1 reference

12 December 2020

The RET proto-oncogene in sporadic pheochromocytomas

1 reference

12 December 2020

Oncogenic RET receptors display different autophosphorylation sites and substrate binding specificities

1 reference

12 December 2020

Germline Homozygous Mutations at Codon 804 in theRETProtooncogene in Medullary Thyroid Carcinoma/Multiple Endocrine Neoplasia Type 2A Patients

1 reference

12 December 2020

Germline dinucleotide mutation in codon 883 of the RET proto-oncogene in multiple endocrine neoplasia type 2B without codon 918 mutation

1 reference

12 December 2020

The mouse soluble GFRalpha4 receptor activates RET independently of its ligand persephin

1 reference

12 December 2020

Timing and extent of surgery in patients with familial medullary thyroid carcinoma/multiple endocrine neoplasia 2A-related RET mutations not affecting codon 634.

1 reference

12 December 2020

How thyroid tumors start and why it matters: kinase mutants as targets for solid cancer pharmacotherapy

1 reference

12 December 2020

Cloning and expression of the ret proto-oncogene encoding a tyrosine kinase with two potential transmembrane domains

1 reference

12 December 2020

Familial medullary thyroid carcinoma without associated endocrinopathies: a distinct clinical entity

1 reference

12 December 2020

The RET proto-oncogene: a molecular therapeutic target in thyroid cancer

1 reference

12 December 2020

Heterogeneous mutation of the RET proto-oncogene in subpopulations of medullary thyroid carcinoma

1 reference

12 December 2020

Evaluation of potential mechanisms underlying genotype-phenotype correlations in multiple endocrine neoplasia type 2.

1 reference

12 December 2020

Expression and alternative splicing of mouse Gfra4 suggest roles in endocrine cell development

1 reference

12 December 2020

The RET/PTC3 oncogene: metastatic solid-type papillary carcinomas in murine thyroids

1 reference

12 December 2020

The relationship between specific RET proto-oncogene mutations and disease phenotype in multiple endocrine neoplasia type 2. International RET mutation consortium analysis

1 reference

12 December 2020

Prognostic value of RET proto-oncogene point mutations in malignant and benign, sporadic phaeochromocytomas

1 reference

12 December 2020

Mutation of the RET proto-oncogene is correlated with RET immunostaining in subpopulations of cells in sporadic medullary thyroid carcinoma

1 reference

12 December 2020

Ras/ERK1/2-mediated STAT3 Ser727 phosphorylation by familial medullary thyroid carcinoma-associated RET mutants induces full activation of STAT3 and is required for c-fos promoter activation, cell mitogenicity, and transformation.

1 reference

12 December 2020

Spatial and temporal expression of the ret proto-oncogene product in embryonic, infant and adult rat tissues.

1 reference

12 December 2020

The multiple endocrine neoplasia type 2B point mutation switches the specificity of the Ret tyrosine kinase towards cellular substrates that are susceptible to interact with Crk and Nck

1 reference

12 December 2020

BAY 43-9006 inhibition of oncogenic RET mutants

1 reference

12 December 2020

Full activation of MEN2B mutant RET by an additional MEN2A mutation or by ligand GDNF stimulation

1 reference

12 December 2020

Expression of RET and its ligand complexes, GDNF/GFRalpha-1 and NTN/GFRalpha-2, in medullary thyroid carcinomas

1 reference

12 December 2020

RET oncogene amplification in thyroid cancer: correlations with radiation-associated and high-grade malignancy.

1 reference

12 December 2020

Molecular characterization of RET/PTC3; a novel rearranged version of the RETproto-oncogene in a human thyroid papillary carcinoma

1 reference

12 December 2020

Released GFRalpha1 potentiates downstream signaling, neuronal survival, and differentiation via a novel mechanism of recruitment of c-Ret to lipid rafts.

1 reference

12 December 2020

High prevalence of BRAF mutations in thyroid cancer: genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma

1 reference

12 December 2020

A Drosophila model of multiple endocrine neoplasia type 2.

1 reference

12 December 2020

Interphase chromosome folding determines spatial proximity of genes participating in carcinogenic RET/PTC rearrangements

1 reference

12 December 2020

The TRK and RET tyrosine kinase oncogenes cooperate with ras in the neoplastic transformation of a rat thyroid epithelial cell line.

1 reference

12 December 2020

Co-segregation of MEN2 and Hirschsprung's disease: the same mutation of RET with both gain and loss-of-function?

1 reference

12 December 2020

Development of thyroid papillary carcinomas secondary to tissue-specific expression of the RET/PTC1 oncogene in transgenic mice

1 reference

12 December 2020

Relative expression of the RET9 and RET51 isoforms in human pheochromocytomas

1 reference

12 December 2020

Inducible dimerization of RET reveals a specific AKT deregulation in oncogenic signaling

1 reference

12 December 2020

RET ligand-induced internalization and its consequences for downstream signaling.

1 reference

12 December 2020

Pathogenetic mechanisms in thyroid follicular-cell neoplasia

1 reference

12 December 2020

Targeted expression of the ret/PTC1 oncogene induces papillary thyroid carcinomas

1 reference

12 December 2020

RET-familial medullary thyroid carcinoma mutants Y791F and S891A activate a Src/JAK/STAT3 pathway, independent of glial cell line-derived neurotrophic factor.

1 reference

12 December 2020

Chromaffin cell mitogenesis by neurturin and glial cell line-derived neurotrophic factor

1 reference

12 December 2020

A model for GFR alpha 4 function and a potential modifying role in multiple endocrine neoplasia 2.

1 reference

12 December 2020

The RET/PTC-RAS-BRAF linear signaling cascade mediates the motile and mitogenic phenotype of thyroid cancer cells

1 reference

12 December 2020

Over-representation of a germline variant in the gene encoding RET co-receptor GFRalpha-1 but not GFRalpha-2 or GFRalpha-3 in cases with sporadic medullary thyroid carcinoma.

1 reference

12 December 2020

Glial cell line-derived neurotrophic factor-dependent recruitment of Ret into lipid rafts enhances signaling by partitioning Ret from proteasome-dependent degradation

1 reference

12 December 2020

RET/PTC-induced dedifferentiation of thyroid cells is mediated through Y1062 signaling through SHC-RAS-MAP kinase

1 reference

12 December 2020

Developmental expression of the RET protooncogene.

1 reference

12 December 2020

Multiple endocrine neoplasia type 2B (mucosal neuroma syndrome, Wagenmann-Froboese syndrome)

1 reference

12 December 2020

Biological properties of Ret with cysteine mutations correlate with multiple endocrine neoplasia type 2A, familial medullary thyroid carcinoma, and Hirschsprung's disease phenotype.

1 reference

12 December 2020

Specific mutations of the RET proto-oncogene are related to disease phenotype in MEN 2A and FMTC

1 reference

12 December 2020

Mutations in the RET protooncogene in sporadic pheochromocytomas

1 reference

12 December 2020

RET/PTC oncogene activation is an early event in thyroid carcinogenesis.

1 reference

12 December 2020

PTC is a novel rearranged form of the ret proto-oncogene and is frequently detected in vivo in human thyroid papillary carcinomas

1 reference

12 December 2020

Distinct frequency of ret rearrangements in papillary thyroid carcinomas of children and adults from Belarus

1 reference

12 December 2020

Mutations of the ret protooncogene in German multiple endocrine neoplasia families: relation between genotype and phenotype. German Medullary Thyroid Carcinoma Study Group

1 reference

12 December 2020

The RET proto-oncogene in human cancers

1 reference

12 December 2020