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How do cytotoxic lymphocytes kill their targets?
scientific article published on 01 October 1998
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scholarly article
1 reference
stated in
Europe PubMed Central
PubMed publication ID
9794837
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9794837%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 December 2019
review article
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Europe PubMed Central
title
How do cytotoxic lymphocytes kill their targets?
(English)
1 reference
stated in
Europe PubMed Central
PubMed publication ID
9794837
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9794837%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 December 2019
main subject
cytotoxicity
0 references
author
Timothy A. Graubert
series ordinal
4
1 reference
stated in
Europe PubMed Central
PubMed publication ID
9794837
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9794837%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 December 2019
author name string
S Shresta
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed publication ID
9794837
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9794837%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 December 2019
C T Pham
series ordinal
2
1 reference
stated in
Europe PubMed Central
PubMed publication ID
9794837
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9794837%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 December 2019
D A Thomas
series ordinal
3
1 reference
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Europe PubMed Central
PubMed publication ID
9794837
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9794837%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 December 2019
T J Ley
series ordinal
5
1 reference
stated in
Europe PubMed Central
PubMed publication ID
9794837
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9794837%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 December 2019
publication date
1 October 1998
1 reference
stated in
Europe PubMed Central
PubMed publication ID
9794837
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9794837%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 December 2019
published in
Current Opinion in Immunology
1 reference
stated in
Europe PubMed Central
PubMed publication ID
9794837
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9794837%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 December 2019
volume
10
1 reference
stated in
Europe PubMed Central
PubMed publication ID
9794837
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9794837%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 December 2019
issue
5
1 reference
stated in
Europe PubMed Central
PubMed publication ID
9794837
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9794837%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 December 2019
page(s)
581-587
1 reference
stated in
Europe PubMed Central
PubMed publication ID
9794837
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9794837%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 December 2019
cites work
Mechanism of lymphocyte-mediated cytotoxicity
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980227-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Fas involvement in Ca(2+)-independent T cell-mediated cytotoxicity
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980227-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Protein sorting and secretion during CTL killing
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980227-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Lymphocyte granule-mediated apoptosis: matters of viral mimicry and deadly proteases
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980227-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A novel protein that interacts with the death domain of Fas/APO1 contains a sequence motif related to the death domain
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980227-6
retrieved
7 January 2021
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inferred from DOI database lookup
FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980227-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980227-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980227-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
FLICE Induced Apoptosis in a Cell-free System
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980227-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980227-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
CPP32/apopain is a key interleukin 1 beta converting enzyme-like protease involved in Fas-mediated apoptosis
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980227-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980227-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980227-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Human and murine cytotoxic T lymphocyte serine proteases: subsite mapping with peptide thioester substrates and inhibition of enzyme activity and cytolysis by isocoumarins
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980227-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980227-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980227-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A null mutation in the perforin gene impairs cytolytic T lymphocyte- and natural killer cell-mediated cytotoxicity
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980227-6
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7 January 2021
based on heuristic
inferred from DOI database lookup
Immune function in mice lacking the perforin gene
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980227-6
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7 January 2021
based on heuristic
inferred from DOI database lookup
Two distinct pathways of specific killing revealed by perforin mutant cytotoxic T lymphocytes
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980227-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980227-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Natural killer and lymphokine-activated killer cells require granzyme B for the rapid induction of apoptosis in susceptible target cells.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980227-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Granzyme A-deficient mice retain potent cell-mediated cytotoxicity.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980227-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Residual cytotoxicity and granzyme K expression in granzyme A-deficient cytotoxic lymphocytes
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980227-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980227-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980227-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Perforin/granzyme-dependent and independent mechanisms are both important for the development of graft-versus-host disease after murine bone marrow transplantation
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980227-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cytotoxic T cells deficient in both functional fas ligand and perforin show residual cytolytic activity yet lose their capacity to induce lethal acute graft-versus-host disease
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980227-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Fas and perforin pathways as major mechanisms of T cell-mediated cytotoxicity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980227-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980227-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Purification of three cytotoxic lymphocyte granule serine proteases that induce apoptosis through distinct substrate and target cell interactions
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980227-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Synergistic roles of granzymes A and B in mediating target cell death by rat basophilic leukemia mast cell tumors also expressing cytolysin/perforin
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980227-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Granzyme A is critical for recovery of mice from infection with the natural cytopathic viral pathogen, ectromelia
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980227-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
In vitro- and ex vivo-derived cytolytic leukocytes from granzyme A x B double knockout mice are defective in granule-mediated apoptosis but not lysis of target cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980227-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Long-range disruption of gene expression by a selectable marker cassette
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980227-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Recombinant human granzyme A binds to two putative HLA-associated proteins and cleaves one of them
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980227-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Production of fully active recombinant murine granzyme B in yeast
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980227-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Expression and purification of enzymatically active recombinant granzyme B in a baculovirus system
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980227-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Granzyme B (GraB) autonomously crosses the cell membrane and perforin initiates apoptosis and GraB nuclear localization.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980227-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
New Paradigm for Lymphocyte Granule-mediated Cytotoxicity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980227-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Nuclear transport of granzyme B (fragmentin-2). Dependence of perforin in vivo and cytosolic factors in vitro.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980227-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Activation of the apoptotic protease CPP32 by cytotoxic T-cell-derived granzyme B.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980227-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Proteolytic activation of the cell death protease Yama/CPP32 by granzyme B.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980227-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Processing and activation of CMH-1 by granzyme B.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980227-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
ICE-LAP6, a novel member of the ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980227-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cytotoxic T-cell-derived granzyme B activates the apoptotic protease ICE-LAP3
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980227-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The cytotoxic cell protease granzyme B initiates apoptosis in a cell-free system by proteolytic processing and activation of the ICE/CED-3 family protease, CPP32, via a novel two-step mechanism.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980227-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Granule-mediated killing: pathways for granzyme B-initiated apoptosis.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980227-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Granzyme B directly and efficiently cleaves several downstream caspase substrates: implications for CTL-induced apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980227-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cleavage of CPP32 by granzyme B represents a critical role for granzyme B in the induction of target cell DNA fragmentation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980227-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Target cell lysis by CTL granule exocytosis is independent of ICE/Ced-3 family proteases
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980227-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1016/S0952-7915(98)80227-6
1 reference
stated in
Europe PubMed Central
PubMed publication ID
9794837
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9794837%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 December 2019
PubMed publication ID
9794837
1 reference
stated in
Europe PubMed Central
PubMed publication ID
9794837
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9794837%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 December 2019
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