(Q57810292)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29997861%20AND%20SRC:MED&resulttype=core&format=json

6 April 2020

title

Analysis of transition state mimicry by tight binding aminothiazoline inhibitors provides insight into catalysis by human O-GlcNAcase (English)

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6 April 2020

3

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6 April 2020

Gideon Davies

8

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6 April 2020

Christian Roth

9

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6 April 2020

author name string

N Cekic

1

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6 April 2020

J E Heinonen

2

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6 April 2020

Y He

5

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6 April 2020

A J Bennet

6

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6 April 2020

E J McEachern

7

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6 April 2020

C Roth

4

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6 April 2020

language of work or name

English

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publication date

15 February 2016

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6 April 2020

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6 April 2020

volume

7

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6 April 2020

issue

6

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6 April 2020

page(s)

3742-3750

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Exploring the O-GlcNAc proteome: direct identification of O-GlcNAc-modified proteins from the brain

6 April 2020

cites work

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Proteomic approaches to analyze the dynamic relationships between nucleocytoplasmic protein glycosylation and phosphorylation

21 January 2018

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Global identification and characterization of both O-GlcNAcylation and phosphorylation at the murine synapse

21 January 2018

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Three Decades of Research on O-GlcNAcylation - A Major Nutrient Sensor That Regulates Signaling, Transcription and Cellular Metabolism

21 January 2018

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Cross-talk between GlcNAcylation and phosphorylation: site-specific phosphorylation dynamics in response to globally elevated O-GlcNAc

21 January 2018

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Regulation of protein degradation by O-GlcNAcylation: crosstalk with ubiquitination

21 January 2018

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Post-translational O-GlcNAcylation is essential for nuclear pore integrity and maintenance of the pore selectivity filter

21 January 2018

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O-GlcNAcylation regulates cancer metabolism and survival stress signaling via regulation of the HIF-1 pathway.

21 January 2018

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Modulation of transcription factor function by O-GlcNAc modification

21 January 2018

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Evidence of the involvement of O-GlcNAc-modified human RNA polymerase II CTD in transcription in vitro and in vivo

21 January 2018

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Reduced O-GlcNAcylation links lower brain glucose metabolism and tau pathology in Alzheimer's disease

21 January 2018

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O-GlcNAcylation regulates phosphorylation of tau: a mechanism involved in Alzheimer's disease

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Increasing O-GlcNAc slows neurodegeneration and stabilizes tau against aggregation.

21 January 2018

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O-GlcNAc and neurodegeneration: biochemical mechanisms and potential roles in Alzheimer's disease and beyond.

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O-GlcNAc in cancer biology

21 January 2018

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Phosphofructokinase 1 glycosylation regulates cell growth and metabolism

21 January 2018

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A small molecule that inhibits OGT activity in cells

21 January 2018

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A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo

21 January 2018

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Cell-Penetrant, Nanomolar O-GlcNAcase Inhibitors Selective against Lysosomal Hexosaminidases

21 January 2018

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Functional expression of O-linked GlcNAc transferase. Domain structure and substrate specificity

21 January 2018

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Dynamic glycosylation of nuclear and cytosolic proteins. Cloning and characterization of a unique O-GlcNAc transferase with multiple tetratricopeptide repeats

21 January 2018

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Dynamic O-glycosylation of nuclear and cytosolic proteins: cloning and characterization of a neutral, cytosolic beta-N-acetylglucosaminidase from human brain

21 January 2018

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The carbohydrate-active enzymes database (CAZy) in 2013

21 January 2018

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Modulation of O-linked N-acetylglucosamine levels on nuclear and cytoplasmic proteins in vivo using the peptide O-GlcNAc-beta-N-acetylglucosaminidase inhibitor O-(2-acetamido-2-deoxy-D-glucopyranosylidene)amino-N-phenylcarbamate

21 January 2018

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O-GlcNAcase uses substrate-assisted catalysis: kinetic analysis and development of highly selective mechanism-inspired inhibitors.

21 January 2018

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GlcNAcstatin: a picomolar, selective O-GlcNAcase inhibitor that modulates intracellular O-glcNAcylation levels

21 January 2018

1 reference

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Inhibition of O-GlcNAcase Using a Potent and Cell-Permeable Inhibitor Does Not Induce Insulin Resistance in 3T3-L1 Adipocytes

21 January 2018

1 reference

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PUGNAc treatment leads to an unusual accumulation of free oligosaccharides in CHO cells

21 January 2018

1 reference

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Elevation of Global O-GlcNAc in rodents using a selective O-GlcNAcase inhibitor does not cause insulin resistance or perturb glucohomeostasis

21 January 2018

1 reference

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Elevation of Global O-GlcNAc Levels in 3T3-L1 Adipocytes by Selective Inhibition of O-GlcNAcase Does Not Induce Insulin Resistance

21 January 2018

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Identification of Asp174 and Asp175 as the key catalytic residues of human O-GlcNAcase by functional analysis of site-directed mutants

21 January 2018

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Structure and mechanism of a bacterial beta-glucosaminidase having O-GlcNAcase activity

21 January 2018

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Structural insights into the mechanism and inhibition of eukaryotic O-GlcNAc hydrolysis

21 January 2018

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GlcNAcstatins are nanomolar inhibitors of human O -GlcNAcase inducing cellular hyper- O -GlcNAcylation

21 January 2018

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Increasing brain protein O-GlcNAc-ylation mitigates breathing defects and mortality of Tau.P301L mice

21 January 2018

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Increased O-GlcNAcylation reduces pathological tau without affecting its normal phosphorylation in a mouse model of tauopathy.

21 January 2018

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Pharmacological inhibition of O-GlcNAcase (OGA) prevents cognitive decline and amyloid plaque formation in bigenic tau/APP mutant mice.

21 January 2018

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O-linked β-N-acetylglucosaminidase inhibitor attenuates β-amyloid plaque and rescues memory impairment

21 January 2018

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A divergent synthesis of 2-acyl derivatives of PUGNAc yields selective inhibitors of O-GlcNAcase.

21 January 2018

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Crystal structure of human beta-hexosaminidase B: understanding the molecular basis of Sandhoff and Tay-Sachs disease

21 January 2018

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Kinetics of the reversible inhibition of enzyme-catalysed reactions by tight-binding inhibitors

21 January 2018

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Determination of accurate KI values for tight-binding enzyme inhibitors: an in silico study of experimental error and assay design

21 January 2018

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Multicomponent NMR titration for simultaneous measurement of relative pKaS.

21 January 2018

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The maximal affinity of ligands

21 January 2018

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Analysis of PUGNAc and NAG-thiazoline as transition state analogues for human O-GlcNAcase: mechanistic and structural insights into inhibitor selectivity and transition state poise

21 January 2018

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Phosphonamidates as transition-state analogue inhibitors of thermolysin.

21 January 2018

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Binding Energy and Catalysis: The Implications for Transition-State Analogs and Catalytic Antibodies.

21 January 2018

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O-GlcNAcase catalyzes cleavage of thioglycosides without general acid catalysis

21 January 2018

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Reassessment of acarbose as a transition state analogue inhibitor of cyclodextrin glycosyltransferase

21 January 2018

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Elucidating the nature of the Streptomyces plicatus beta-hexosaminidase-bound intermediate using ab initio molecular dynamics simulations

21 January 2018

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Topography and polypeptide distribution of terminal N-acetylglucosamine residues on the surfaces of intact lymphocytes. Evidence for O-linked GlcNAc

21 January 2018

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12 December 2020

Role of sugar hydroxyl groups in glycoside hydrolysis. Cleavage mechanism of deoxyglucosides and related substrates by beta-glucosidase A3 from Aspergillus wentii

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12 December 2020

High-throughput screening of enzyme inhibitors: simultaneous determination of tight-binding inhibition constants and enzyme concentration

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12 December 2020

Evaluation of enzyme inhibitors in drug discovery. A guide for medicinal chemists and pharmacologists

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12 December 2020

An O-GlcNAcase-specific inhibitor and substrate engineered by the extension of the N-acetyl moiety

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12 December 2020

Identifiers

DOI

10.1039/C6SC00370B

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29997861%20AND%20SRC:MED&resulttype=core&format=json

6 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29997861%20AND%20SRC:MED&resulttype=core&format=json

6 April 2020

PubMed publication ID

29997861

1 reference