(Q57951136)

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18 February 2020

title

Nociceptin/orphanin FQ receptor agonists attenuate L-DOPA-induced dyskinesias (English)

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18 February 2020

0 references

1 reference

1

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18 February 2020

Remo Guerrini

4

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18 February 2020

Stefania Fasano

5

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18 February 2020

Ilaria Morella

6

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18 February 2020

Alessandro Tozzi

7

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18 February 2020

Riccardo Brambilla

8

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18 February 2020

Michele Simonato

10

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18 February 2020

Erwan Bezard

11

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18 February 2020

author name string

Donata Rodi

2

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18 February 2020

Qin Li

3

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18 February 2020

Paolo Calabresi

9

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18 February 2020

Michele Morari

12

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18 February 2020

language of work or name

English

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publication date

1 November 2012

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18 February 2020

published in

Journal of Neuroscience

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18 February 2020

volume

32

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18 February 2020

issue

46

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18 February 2020

page(s)

16106-16119

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describes a project that uses

18 February 2020

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC6794016/fullTextXML

inferred from PubMed Central ID database lookup

cites work

Levodopa-induced dyskinesia in MPTP-treated macaques is not dependent on the extent and pattern of nigrostrial lesioning.

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12 December 2020

MPTP treatment increases expression of pre-pro-nociceptin/orphanin FQ mRNA in a subset of substantia nigra reticulata neurons

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12 December 2020

Opioid receptor-like (ORL1) receptor distribution in the rat central nervous system: comparison of ORL1 receptor mRNA expression with (125)I-[(14)Tyr]-orphanin FQ binding

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12 December 2020

Increased slow oscillatory activity in substantia nigra pars reticulata triggers abnormal involuntary movements in the 6-OHDA-lesioned rat in the presence of excessive extracellular striatal dopamine

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12 December 2020

Dopamine released from 5-HT terminals is the cause of L-DOPA-induced dyskinesia in parkinsonian rats

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12 December 2020

Inhibition of Ras-guanine nucleotide-releasing factor 1 (Ras-GRF1) signaling in the striatum reverts motor symptoms associated with L-dopa-induced dyskinesia

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12 December 2020

[Nphe1,Arg14,Lys15]nociceptin-NH2, a novel potent and selective antagonist of the nociceptin/orphanin FQ receptor.

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12 December 2020

Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor

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12 December 2020

Brain interstitial nociceptin/orphanin FQ levels are elevated in Parkinson's disease

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12 December 2020

Unrestrained nociceptive response and disregulation of hearing ability in mice lacking the nociceptin/orphaninFQ receptor

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12 December 2020

Ratings of L-DOPA-induced dyskinesia in the unilateral 6-OHDA lesion model of Parkinson's disease in rats and mice

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12 December 2020

L-DOPA-induced dyskinesia in the rat is associated with striatal overexpression of prodynorphin- and glutamic acid decarboxylase mRNA.

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12 December 2020

Pharmacology of nociceptin and its receptor: a novel therapeutic target

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12 December 2020

The novel nociceptin/orphanin FQ receptor antagonist Trap-101 alleviates experimental parkinsonism through inhibition of the nigro-thalamic pathway: positive interaction with L-DOPA.

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12 December 2020

The nociceptin/orphanin FQ (NOP) receptor antagonist J-113397 enhances the effects of levodopa in the MPTP-lesioned nonhuman primate model of Parkinson's disease

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12 December 2020

Levodopa-induced dyskinesias in patients with Parkinson's disease: filling the bench-to-bedside gap.

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12 December 2020

Activation of nociceptin/orphanin FQ-NOP receptor system inhibits tyrosine hydroxylase phosphorylation, dopamine synthesis, and dopamine D(1) receptor signaling in rat nucleus accumbens and dorsal striatum.

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12 December 2020

Dopamine transporter binding is unaffected by L-DOPA administration in normal and MPTP-treated monkeys

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12 December 2020

Striatal dopamine-NMDA receptor interactions in the modulation of glutamate release in the substantia nigra pars reticulata in vivo: opposite role for D1 and D2 receptors

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12 December 2020

Combined 5-HT1A and 5-HT1B receptor agonists for the treatment of L-DOPA-induced dyskinesia

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12 December 2020

Nociceptin/orphanin FQ modulates motor behavior and primary motor cortex output through receptors located in substantia nigra reticulata

1 reference

12 December 2020

The molecular and behavioral pharmacology of the orphanin FQ/nociceptin peptide and receptor family

1 reference

12 December 2020

Blockade of nociceptin/orphanin FQ transmission attenuates symptoms and neurodegeneration associated with Parkinson's disease.

1 reference

12 December 2020

Behavioral effects of a synthetic agonist selective for nociceptin/orphanin FQ peptide receptors in monkeys

1 reference

12 December 2020

The Nociceptin/Orphanin FQ Receptor (NOP) as a Target for Drug Abuse Medications

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12 December 2020

The novel neuropeptide orphanin FQ fails to produce conditioned place preference or aversion

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12 December 2020

Orphanin FQ acts as an anxiolytic to attenuate behavioral responses to stress

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12 December 2020

Increased D1 dopamine receptor signaling in levodopa-induced dyskinesia.

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12 December 2020

Loss of bidirectional striatal synaptic plasticity in L-DOPA-induced dyskinesia

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12 December 2020

Amantadine as treatment for dyskinesias and motor fluctuations in Parkinson's disease

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12 December 2020

Parkinson's disease: clinical features and diagnosis

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12 December 2020

Endogenous nociceptin/orphanin FQ (N/OFQ) contributes to haloperidol-induced changes of nigral amino acid transmission and parkinsonism: a combined microdialysis and behavioral study in naïve and nociceptin/orphanin FQ receptor knockout mice.

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12 December 2020

Nociceptin/orphanin FQ and opioid receptor-like receptor mRNA expression in dopamine systems

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12 December 2020

Striatal fosB expression is causally linked with l-DOPA-induced abnormal involuntary movements and the associated upregulation of striatal prodynorphin mRNA in a rat model of Parkinson's disease

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12 December 2020

In vivo evidence for a differential contribution of striatal and nigral D1 and D2 receptors to L-DOPA induced dyskinesia and the accompanying surge of nigral amino acid levels

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12 December 2020

The nociceptin/orphanin FQ receptor antagonist J-113397 and L-DOPA additively attenuate experimental parkinsonism through overinhibition of the nigrothalamic pathway.

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12 December 2020

Orphanin FQ: a neuropeptide that activates an opioidlike G protein-coupled receptor.

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12 December 2020

Parkinson's disease dyskinesias

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12 December 2020

L-DOPA-induced dopamine efflux in the striatum and the substantia nigra in a rat model of Parkinson's disease: temporal and quantitative relationship to the expression of dyskinesia

1 reference

12 December 2020

Further evidence for an involvement of nociceptin/orphanin FQ in the pathophysiology of Parkinson’s disease: a behavioral and neurochemical study in reserpinized mice

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12 December 2020

Modulation of 5-hydroxytryptamine efflux from rat cortical synaptosomes by opioids and nociceptin

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12 December 2020

Autoradiographic localization of (125)i[Tyr(14)] nociceptin/orphanin FQ binding sites in macaque primate CNS.

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12 December 2020

Localization of orphanin FQ (nociceptin) peptide and messenger RNA in the central nervous system of the rat.

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12 December 2020

The nociceptin/orphanin FQ receptor: a target with broad therapeutic potential

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12 December 2020

Long-term Potentiation in the Striatum is Unmasked by Removing the Voltage-dependent Magnesium Block of NMDA Receptor Channels.

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12 December 2020

Nociceptin/orphanin FQ receptor blockade attenuates MPTP-induced parkinsonism.

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12 December 2020

Striatal spiny neurons and cholinergic interneurons express differential ionotropic glutamatergic responses and vulnerability: implications for ischemia and Huntington's disease

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12 December 2020

Discovery of the first potent and selective small molecule opioid receptor-like (ORL1) antagonist: 1-[(3R,4R)-1-cyclooctylmethyl-3- hydroxymethyl-4-piperidyl]-3-ethyl-1, 3-dihydro-2H-benzimidazol-2-one (J-113397)

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12 December 2020

Pharmacological validation of behavioural measures of akinesia and dyskinesia in a rat model of Parkinson's disease.

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12 December 2020

Inhibition of serotonin outflow by nociceptin/orphaninFQ in dorsal raphe nucleus slices from normal and stressed rats: Role of corticotropin releasing factor.

1 reference

12 December 2020

Nociceptin/orphanin FQ decreases serotonin efflux in the rat brain but in contrast to a kappa-opioid has no antagonistic effect on mu-opioid-induced increases in serotonin efflux

1 reference

12 December 2020

Preparation of Iodine-131 Labelled Human Growth Hormone of High Specific Activity

1 reference

12 December 2020

Endothelial proliferation and increased blood-brain barrier permeability in the basal ganglia in a rat model of 3,4-dihydroxyphenyl-L-alanine-induced dyskinesia.

1 reference

12 December 2020

Attenuation of levodopa-induced dyskinesia by normalizing dopamine D3 receptor function

1 reference

12 December 2020

Inhibition of striatal and retinal dopamine release via nociceptin/orphanin FQ receptors

1 reference

12 December 2020

High-affinity, non-peptide agonists for the ORL1 (orphanin FQ/nociceptin) receptor

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12 December 2020

[3H]-nociceptin ligand-binding and nociceptin opioid receptor mrna expression in the human brain.

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12 December 2020

Nociceptin/orphanin FQ receptors modulate glutamate extracellular levels in the substantia nigra pars reticulata. A microdialysis study in the awake freely moving rat.

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12 December 2020

Dual motor response to l-dopa and nociceptin/orphanin FQ receptor antagonists in 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP) treated mice: Paradoxical inhibition is relieved by D(2)/D(3) receptor blockade

1 reference

12 December 2020

Pathophysiology of levodopa-induced dyskinesia: potential for new therapies

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12 December 2020

Pharmacological analysis demonstrates dramatic alteration of D1 dopamine receptor neuronal distribution in the rat analog of L-DOPA-induced dyskinesia

1 reference

12 December 2020

Dopamine–nociceptin/orphanin FQ interactions in the substantia nigra reticulata of hemiparkinsonian rats: Involvement of D2/D3 receptors and impact on nigro-thalamic neurons and motor activity

1 reference

12 December 2020

The selective D(3) receptor antagonist, S33084, improves parkinsonian-like motor dysfunction but does not affect L-DOPA-induced dyskinesia in 6-hydroxydopamine hemi-lesioned rats

1 reference

12 December 2020

L-DOPA-Induced Dyskinesia and Abnormal Signaling in Striatal Medium Spiny Neurons: Focus on Dopamine D1 Receptor-Mediated Transmission

1 reference

12 December 2020

Serotonergic neurons mediate ectopic release of dopamine induced by L-DOPA in a rat model of Parkinson's disease

1 reference

12 December 2020

Regulation of a protein phosphatase cascade allows convergent dopamine and glutamate signals to activate ERK in the striatum

1 reference

12 December 2020

Pallidal border cells: an anatomical and electrophysiological study in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated monkey

1 reference

12 December 2020

The origin of motor fluctuations in Parkinson's disease: importance of dopaminergic innervation and basal ganglia circuits.

1 reference

12 December 2020

Biotransformation of L-DOPA to dopamine in the substantia nigra of freely moving rats: effect of dopamine receptor agonists and antagonists

1 reference

12 December 2020

Blockade of nociceptin/orphanin FQ receptor signaling in rat substantia nigra pars reticulata stimulates nigrostriatal dopaminergic transmission and motor behavior.

1 reference

12 December 2020

10.1523/JNEUROSCI.6408-11.2012

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23152595%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

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18 February 2020

PubMed publication ID

23152595

1 reference