(Q58048739)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21264369%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

title

Cytochromes P450 as useful biocatalysts: addressing the limitations (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21264369%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

1

1 reference

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20 January 2020

Sabine Flitsch

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21264369%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

Nicholas J. Turner

series ordinal

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21264369%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

author name string

Valentin Köhler

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21264369%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

language of work or name

English

0 references

publication date

24 January 2011

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21264369%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

published in

Chemical Communications

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21264369%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

volume

47

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21264369%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

issue

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21264369%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

page(s)

2490-2501

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21264369%20AND%20SRC:MED&resulttype=core&format=json

Mechanism of oxidation reactions catalyzed by cytochrome p450 enzymes.

20 January 2020

cites work

1 reference

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Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity

21 January 2018

1 reference

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Cytochrome P450 systems--biological variations of electron transport chains.

21 January 2018

1 reference

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Insights into the function and evolution of P450s in plant steroid metabolism.

21 January 2018

1 reference

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25-Hydroxyvitamin D3 1alpha-hydroxylase and vitamin D synthesis

21 January 2018

1 reference

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Overview of regulatory cytochrome P450 enzymes of the vitamin D pathway

21 January 2018

1 reference

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The role of cytochrome P450 in the regulation of cholesterol biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CC03165H

Functional analysis of MycCI and MycG, cytochrome P450 enzymes involved in biosynthesis of mycinamicin macrolide antibiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CC03165H

Function of human cytochrome P450s: characterization of the orphans

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CC03165H

Introductory remarks on human CYPs

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CC03165H

57 varieties: the human cytochromes P450.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CC03165H

Cytochrome P450s and other enzymes in drug metabolism and toxicity

21 January 2018

1 reference

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Metabolism and toxicity of drugs. Two decades of progress in industrial drug metabolism

21 January 2018

1 reference

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Pharmaceutical innovation by the seven UK-owned pharmaceutical companies (1964-1985)

21 January 2018

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Recombinant human cytochrome P450 monooxygenases for drug metabolite synthesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CC03165H

Engineering cytochrome P450 biocatalysts for biotechnology, medicine and bioremediation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CC03165H

Metabolism of benzo[a]pyrene and benzo[a]pyrene-7,8-diol by human cytochrome P450 1B1

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CC03165H

Engineering cytochrome P450 BM-3 for oxidation of polycyclic aromatic hydrocarbons

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CC03165H

Protein engineering of Bacillus megaterium CYP102. The oxidation of polycyclic aromatic hydrocarbons

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CC03165H

Biodegradation of dioxins by recombinant Escherichia coli expressing rat CYP1A1 or its mutant

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CC03165H

Biodegradation of polychlorinated dibenzo-p-dioxins by recombinant yeast expressing rat CYP1A subfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CC03165H

Plant cytochromes P450: tools for pharmacology, plant protection and phytoremediation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CC03165H

An explosive-degrading cytochrome P450 activity and its targeted application for the phytoremediation of RDX.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CC03165H

A highly active single-mutation variant of P450BM3 (CYP102A1)

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CC03165H

Directed enzyme evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CC03165H

Directed evolution: new parts and optimized function

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CC03165H

Engineering and improvement of the efficiency of a chimeric [P450cam-RhFRed reductase domain] enzyme.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CC03165H

Hepatic metabolism of diclofenac: role of human CYP in the minor oxidative pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CC03165H

Directed evolution of enzyme catalysts

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CC03165H

Directed evolution of biocatalysts

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CC03165H

Directed evolution drives the next generation of biocatalysts

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CC03165H

Directed evolution of enzymes for applied biocatalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CC03165H

Directed evolution of an amine oxidase possessing both broad substrate specificity and high enantioselectivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CC03165H

Laboratory evolution of a soluble, self-sufficient, highly active alkane hydroxylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CC03165H

Direct conversion of ethane to ethanol by engineered cytochrome P450 BM3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CC03165H

Extending the capabilities of nature's most versatile catalysts: directed evolution of mammalian xenobiotic-metabolizing P450s.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CC03165H

Preparation of human metabolites of propranolol using laboratory-evolved bacterial cytochromes P450.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CC03165H

A panel of cytochrome P450 BM3 variants to produce drug metabolites and diversify lead compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CC03165H

Biocatalytic conversion of avermectin to 4''-oxo-avermectin: improvement of cytochrome p450 monooxygenase specificity by directed evolution.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CC03165H

Hyperthermophilic enzymes: sources, uses, and molecular mechanisms for thermostability

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CC03165H

New understandings of thermostable and peizostable enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CC03165H

Cloning of a potential cytochrome P450 from the archaeon Sulfolobus solfataricus

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CC03165H

Characterization of a cytochrome P450 from the acidothermophilic archaea Sulfolobus solfataricus

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CC03165H

Crystal structure of a thermophilic cytochrome P450 from the archaeon Sulfolobus solfataricus

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CC03165H

Thermophilic cytochrome P450 (CYP119) from Sulfolobus solfataricus: high resolution structure and functional properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CC03165H

Homology modeling, molecular dynamics simulations, and analysis of CYP119, a P450 enzyme from extreme acidothermophilic archaeon Sulfolobus solfataricus

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CC03165H

A self-sufficient peroxide-driven hydroxylation biocatalyst

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CC03165H

Thermostabilization of a cytochrome p450 peroxygenase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CC03165H

A diverse family of thermostable cytochrome P450s created by recombination of stabilizing fragments

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CC03165H

Structure and chemistry of cytochrome P450.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CC03165H

Variations on a (t)heme--novel mechanisms, redox partners and catalytic functions in the cytochrome P450 superfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CC03165H

P450 enzymes: their structure, reactivity, and selectivity-modeled by QM/MM calculations

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CC03165H

Expression and characterization of the two flavodoxin proteins of Bacillus subtilis, YkuN and YkuP: biophysical properties and interactions with cytochrome P450 BioI.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CC03165H

Expression, purification and characterisation of a Bacillus subtilis ferredoxin: a potential electron transfer donor to cytochrome P450 BioI.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CC03165H

Crystal Structure of Putidaredoxin, the [2Fe–2S] Component of the P450cam Monooxygenase System from Pseudomonas putida

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CC03165H

Probing electron transfer in flavocytochrome P-450 BM3 and its component domains.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CC03165H

A novel class of self-sufficient cytochrome P450 monooxygenases in prokaryotes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CC03165H

Identification of a new class of cytochrome P450 from a Rhodococcus sp.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CC03165H

Cytochrome P450--redox partner fusion enzymes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CC03165H

Analysis of the domain properties of the novel cytochrome P450 RhF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CC03165H

A self-sufficient cytochrome p450 with a primary structural organization that includes a flavin domain and a [2Fe-2S] redox center

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CC03165H

Probing the substrate specificity of the catalytically self-sufficient cytochrome P450 RhF from a Rhodococcus sp

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CC03165H

Functional expression system for cytochrome P450 genes using the reductase domain of self-sufficient P450RhF from Rhodococcus sp. NCIMB 9784.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CC03165H

LICRED: a versatile drop-in vector for rapid generation of redox-self-sufficient cytochrome P450s

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CC03165H

Engineering and analysis of a self-sufficient biosynthetic cytochrome P450 PikC fused to the RhFRED reductase domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CC03165H

Design of a novel P450: a functional bacterial-human cytochrome P450 chimera.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CC03165H

Expression, purification, and biochemical characterization of a human cytochrome P450 CYP2D6-NADPH cytochrome P450 reductase fusion protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CC03165H

Molecular characterization of specifically active recombinant fused enzymes consisting of CYP3A4, NADPH-cytochrome P450 oxidoreductase, and cytochrome b5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CC03165H

Functional characterisation of an engineered multidomain human P450 2E1 by molecular Lego.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CC03165H

Engineering human cytochrome P450 enzymes into catalytically self-sufficient chimeras using molecular Lego.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CC03165H

Evaluation of the effects of hydrophilic organic solvents on CYP3A-mediated drug-drug interaction in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CC03165H

The mechanism of the suicidal, reductive inactivation of microsomal cytochrome P-450 by carbon tetrachloride

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CC03165H

The mechanism of the suicidal reductive inactivation of microsomal cytochrome P-450 by halothane

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CC03165H

Inactivation of rat liver cytochrome P450 (P450) by N,N-dimethylformamide and N,N-dimethylacetamide

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CC03165H

Laboratory evolution of cytochrome p450 BM-3 monooxygenase for organic cosolvents

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CC03165H

Engineering mammalian cytochrome P450 2B1 by directed evolution for enhanced catalytic tolerance to temperature and dimethyl sulfoxide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CC03165H

Functionalization of the cytochrome P450cam monooxygenase system in the cell-like aqueous compartments of water-in-oil emulsions

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CC03165H

P450cam biocatalysis in surfactant-stabilized two-phase emulsions

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CC03165H

The activity of human CYP2D6 in low water organic solvents

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CC03165H

Progress towards the easier use of P450 enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CC03165H

Non-enzymatic regeneration of nicotinamide and flavin cofactors for monooxygenase catalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CC03165H

Recent developments in pyridine nucleotide regeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CC03165H

Engineering cytochrome P450 enzymes for improved activity towards biomimetic 1,4-NADH cofactors

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CC03165H

Laboratory evolution of peroxide-mediated cytochrome P450 hydroxylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CC03165H

Electrocatalytically driven omega-hydroxylation of fatty acids using cytochrome P450 4A1

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CC03165H

Laboratory evolution of P450 BM-3 for mediated electron transfer

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CC03165H

P450(camr), a cytochrome P450 catalysing the stereospecific 6- endo-hydroxylation of (1 R)-(+)-camphor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CC03165H

Altering the regioselectivity of cytochrome P450 CYP102A3 of Bacillus subtilis by using a new versatile assay system

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CC03165H

A rational approach to Re-engineer cytochrome P450 2B1 regioselectivity based on the crystal structure of cytochrome P450 2C5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CC03165H

Enantioselective alpha-hydroxylation of 2-arylacetic acid derivatives and buspirone catalyzed by engineered cytochrome P450 BM-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CC03165H

Stereoselective hydroxylation of an achiral cyclopentanecarboxylic acid derivative using engineered P450s BM-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CC03165H

A review of LC-MS techniques and high-throughput approaches used to investigate drug metabolism by cytochrome P450s

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CC03165H

High-throughput screening for stability and inhibitory activity of compounds toward cytochrome P450-mediated metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CC03165H

Identification of broad specificity P450CAM variants by primary screening against indole as substrate

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CC03165H

Formation of indigo by recombinant mammalian cytochrome P450.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CC03165H

Colorimetric high-throughput assay for alkene epoxidation catalyzed by cytochrome P450 BM-3 variant 139-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CC03165H

A screening system for the directed evolution of epoxygenases: importance of position 184 in P450 BM3 for stereoselective styrene epoxidation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CC03165H

Aromatic C-H bond hydroxylation by P450 peroxygenases: a facile colorimetric assay for monooxygenation activities of enzymes based on Russig's blue formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CC03165H

Fluorescence-based assays for screening nine cytochrome P450 (P450) activities in intact cells expressing individual human P450 enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CC03165H

Coumarin substrates for cytochrome P450 2D6 fluorescence assays

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CC03165H

Evaluation of alkoxyresorufins as fluorescent substrates for cytochrome P450 BM3 and site-directed mutants.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CC03165H

Heme-iron oxygenases: powerful industrial biocatalysts?

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CC03165H

Towards preparative scale steroid hydroxylation with cytochrome P450 monooxygenase CYP106A2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CC03165H

Synthetic biology for synthetic chemistry

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CC03165H

Production of the antimalarial drug precursor artemisinic acid in engineered yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CC03165H

Inverting the enantioselectivity of P450pyr monooxygenase by directed evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CC03165H

21 January 2018

Identifiers

DOI

10.1039/C0CC03165H

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21264369%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

1 reference