(Q58326709)

English

Simvastatin inhibits secretion of Th17-polarizing cytokines and antigen presentation by DCs in patients with relapsing remitting multiple sclerosis

scientific article published on 06 December 2012

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scholarly article

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Europe PubMed Central

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15 February 2020

Simvastatin inhibits secretion of Th17-polarizing cytokines and antigen presentation by DCs in patients with relapsing remitting multiple sclerosis (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23076801%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

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multiple sclerosis

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relapsing-remitting multiple sclerosis

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1 reference

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inferred from title

1

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15 February 2020

Rafael Garcia-Mata

4

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15 February 2020

author name string

Yazhong Tao

2

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15 February 2020

Jinzhao Wang

3

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15 February 2020

Silva Markovic-Plese

5

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15 February 2020

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publication date

6 December 2012

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15 February 2020

European Journal of Immunology

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15 February 2020

43

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15 February 2020

1

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15 February 2020

281-289

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15 February 2020

Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242566

21 January 2018

Development, cytokine profile and function of human interleukin 17-producing helper T cells

1 reference

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21 January 2018

IL-21 and TGF-beta are required for differentiation of human T(H)17 cells

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242566

21 January 2018

TH17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/STAT1.

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242566

21 January 2018

Phenotypic and functional features of human Th17 cells

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242566

21 January 2018

The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor RORgammat

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242566

21 January 2018

CNS myeloid DCs presenting endogenous myelin peptides 'preferentially' polarize CD4+ T(H)-17 cells in relapsing EAE.

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242566

21 January 2018

IFN-beta1a inhibits the secretion of Th17-polarizing cytokines in human dendritic cells via TLR7 up-regulation.

1 reference

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21 January 2018

Glatiramer Acetate (Copolymer-1, Copaxone) Promotes Th2 Cell Development and Increased IL-10 Production Through Modulation of Dendritic Cells

1 reference

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21 January 2018

HMG-CoA reductase inhibitors suppress maturation of human dendritic cells: new implications for atherosclerosis

1 reference

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21 January 2018

A pivotal role of Rho GTPase in the regulation of morphology and function of dendritic cells

1 reference

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21 January 2018

Small rho GTPases regulate antigen presentation in dendritic cells

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242566

21 January 2018

Therapeutic potential of statins in multiple sclerosis: immune modulation, neuroprotection and neurorepair

1 reference

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21 January 2018

GTPases and T cell activation

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242566

21 January 2018

Statin therapy and autoimmune disease: from protein prenylation to immunomodulation

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242566

21 January 2018

Inhibition of protein geranylgeranylation and RhoA/RhoA kinase pathway induces apoptosis in human endothelial cells

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242566

21 January 2018

Isoprenoids as mediators of the biological effects of statins

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242566

21 January 2018

Differential effects of statins on relevant functions of human monocyte-derived dendritic cells

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242566

21 January 2018

Rab39a binds caspase-1 and is required for caspase-1-dependent interleukin-1beta secretion

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242566

21 January 2018

Oral simvastatin treatment in relapsing-remitting multiple sclerosis

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242566

21 January 2018

Simvastatin inhibits IL-17 secretion by targeting multiple IL-17-regulatory cytokines and by inhibiting the expression of IL-17 transcription factor RORC in CD4+ lymphocytes.

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242566

21 January 2018

IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242566

21 January 2018

Regulation of STAT3 by direct binding to the Rac1 GTPase

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242566

21 January 2018

Rho family GTPases are required for activation of Jak/STAT signaling by G protein-coupled receptors

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242566

21 January 2018

Distinct regulation of interleukin-17 in human T helper lymphocytes

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242566

21 January 2018

Regulation of suppressors of cytokine signaling as a therapeutic approach in autoimmune diseases, with an emphasis on multiple sclerosis

1 reference

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21 January 2018

Suppressors of cytokine signaling and immunity

1 reference

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21 January 2018

STAT3 tyrosine phosphorylation is critical for interleukin 1 beta and interleukin-6 production in response to lipopolysaccharide and live bacteria

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242566

21 January 2018

SOCS-3 negatively regulates innate and adaptive immune mechanisms in acute IL-1-dependent inflammatory arthritis

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242566

21 January 2018

Simvastatin inhibits IFN regulatory factor 4 expression and Th17 cell differentiation in CD4+ T cells derived from patients with multiple sclerosis.

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242566

21 January 2018

Simvastatin inhibits the MHC class II pathway of antigen presentation by impairing Ras superfamily GTPases.

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242566

21 January 2018

Recommended diagnostic criteria for multiple sclerosis: Guidelines from the international panel on the diagnosis of multiple sclerosis

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242566

21 January 2018

Immunology of multiple sclerosis

1 reference

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7 January 2021

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Relationship of Apolipoprotein E and Age at Onset to Parkinson Disease Neuropathology

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242566

7 January 2021

based on heuristic

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Multiple sclerosis is associated with high levels of circulating dendritic cells secreting pro-inflammatory cytokines

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242566

7 January 2021

based on heuristic

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Statins as a newly recognized type of immunomodulator

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242566

7 January 2021

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Immunomodulatory effects of 3-hydroxy-3-methylglutaryl coenzyme-A reductase inhibitors, potential therapy for relapsing remitting multiple sclerosis

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242566

7 January 2021

based on heuristic

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Dendritic cells transduced with SOCS-3 exhibit a tolerogenic/DC2 phenotype that directs type 2 Th cell differentiation in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242566

7 January 2021

based on heuristic

inferred from DOI database lookup

Small GTP-binding proteins

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242566

7 January 2021

based on heuristic

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Cholesterol-lowering statins possess anti-inflammatory activity that might be useful for treatment of MS

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201242566

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1002/EJI.201242566

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23076801%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23076801%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

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