(Q58549806)

English

A dual regulatory circuit consisting of S-adenosylmethionine decarboxylase protein and its reaction product controls expression of the paralogous activator prozyme in Trypanosoma brucei

scientific article published on 26 October 2018

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30365568%20AND%20SRC:MED&resulttype=core&format=json

30 April 2020

A dual regulatory circuit consisting of S-adenosylmethionine decarboxylase protein and its reaction product controls expression of the paralogous activator prozyme in Trypanosoma brucei (English)

1 reference

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30 April 2020

Trypanosoma brucei

0 references

S-adenosylmethionine decarboxylase

1 reference

5 February 2019

S-adenosylmethionine decarboxylase

1 reference

5 February 2019

S-adenosylmethionine decarboxylaseregulator

1 reference

5 February 2019

S-adenosylmethionine synthetase

1 reference

5 February 2019

S-adenosylmethionine synthetase

1 reference

5 February 2019

S-adenosylmethionine synthetase

1 reference

5 February 2019

S-adenosylmethionine synthetase

1 reference

5 February 2019

S-adenosylmethionine synthetase

1 reference

5 February 2019

S-adenosylmethionine synthetase

1 reference

5 February 2019

S-adenosylmethionine synthetase

1 reference

5 February 2019

S-adenosylmethionine synthetase

1 reference

5 February 2019

S-adenosylmethionine synthetase

1 reference

5 February 2019

1

1 reference

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30 April 2020

2

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30 April 2020

Christopher Leija

3

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30 April 2020

Margaret A. Phillips

5

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30 April 2020

author name string

Andrew Lemoff

4

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30 April 2020

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26 October 2018

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30 April 2020

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30 April 2020

14

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30 April 2020

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30 April 2020

e1007404

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30 April 2020

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Creative Commons Attribution 4.0 International

26 October 2018

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ImageQuant TL

2 references

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC6221367/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

CZ Software Mentions: A large dataset of software mentions in the biomedical literature

The use of a spectrophotometric assay to study the interaction of S-adenosylmethionine synthetase with methionine analogues

1 reference

https://pubmed.ncbi.nlm.nih.gov/30365568

12 December 2020

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inferred from PubMed ID database lookup

Amino acid residues necessary for putrescine stimulation of human S-adenosylmethionine decarboxylase proenzyme processing and catalytic activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/30365568

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Autoregulation of human thymidylate synthase messenger RNA translation by thymidylate synthase

1 reference

https://pubmed.ncbi.nlm.nih.gov/30365568

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cure of Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense infections in mice with an irreversible inhibitor of S-adenosylmethionine decarboxylase

1 reference

https://pubmed.ncbi.nlm.nih.gov/30365568

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dihydrofolate reductase protein inhibits its own translation by binding to dihydrofolate reductase mRNA sequences within the coding region

1 reference

https://pubmed.ncbi.nlm.nih.gov/30365568

12 December 2020

based on heuristic

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A tightly regulated inducible expression system for conditional gene knock-outs and dominant-negative genetics in Trypanosoma brucei

1 reference

https://pubmed.ncbi.nlm.nih.gov/30365568

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Single-turnover kinetic analysis of Trypanosoma cruzi S-adenosylmethionine decarboxylase

1 reference

https://pubmed.ncbi.nlm.nih.gov/30365568

12 December 2020

based on heuristic

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A new mathematical model for relative quantification in real-time RT-PCR

1 reference

https://pubmed.ncbi.nlm.nih.gov/30365568

12 December 2020

based on heuristic

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Cloning expression and characterization of methionine adenosyltransferase in Leishmania infantum promastigotes

1 reference

https://pubmed.ncbi.nlm.nih.gov/30365568

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Divergent regulation of dihydrofolate reductase between malaria parasite and human host

1 reference

https://pubmed.ncbi.nlm.nih.gov/30365568

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

RNAit: an automated web-based tool for the selection of RNAi targets in Trypanosoma brucei.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30365568

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inactive enzyme-homologues find new function in regulatory processes

1 reference

https://pubmed.ncbi.nlm.nih.gov/30365568

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Axenic culture of African trypanosome bloodstream forms

1 reference

https://pubmed.ncbi.nlm.nih.gov/30365568

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Key role for p27Kip1, retinoblastoma protein Rb, and MYCN in polyamine inhibitor-induced G1 cell cycle arrest in MYCN-amplified human neuroblastoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30365568

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for a second class of S-adenosylmethionine riboswitches and other regulatory RNA motifs in alpha-proteobacteria

1 reference

https://pubmed.ncbi.nlm.nih.gov/30365568

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The S(MK) box is a new SAM-binding RNA for translational regulation of SAM synthetase

1 reference

https://pubmed.ncbi.nlm.nih.gov/30365568

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of allosteric regulation of Trypanosoma cruzi S-adenosylmethionine decarboxylase.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30365568

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Allosteric regulation of an essential trypanosome polyamine biosynthetic enzyme by a catalytically dead homolog

1 reference

https://pubmed.ncbi.nlm.nih.gov/30365568

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclic changes in metabolic state during the life of a yeast cell

1 reference

https://pubmed.ncbi.nlm.nih.gov/30365568

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CRE recombinase-based positive-negative selection systems for genetic manipulation in Trypanosoma brucei

1 reference

https://pubmed.ncbi.nlm.nih.gov/30365568

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Riboswitches that sense S-adenosylhomocysteine and activate genes involved in coenzyme recycling

1 reference

https://pubmed.ncbi.nlm.nih.gov/30365568

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulated expression of an essential allosteric activator of polyamine biosynthesis in African trypanosomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/30365568

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Novel S-adenosylmethionine decarboxylase inhibitors for the treatment of human African trypanosomiasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30365568

12 December 2020

based on heuristic

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RNA interference-mediated silencing of ornithine decarboxylase and spermidine synthase genes in Trypanosoma brucei provides insight into regulation of polyamine biosynthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30365568

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Trypanocidal activity of 8-methyl-5'-{[(Z)-4-aminobut-2-enyl]-(methylamino)}adenosine (Genz-644131), an adenosylmethionine decarboxylase inhibitor

1 reference

https://pubmed.ncbi.nlm.nih.gov/30365568

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glycine N-methyltransferase and regulation of S-adenosylmethionine levels

1 reference

https://pubmed.ncbi.nlm.nih.gov/30365568

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Species-specific differences in translational regulation of dihydrofolate reductase

1 reference

https://pubmed.ncbi.nlm.nih.gov/30365568

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mammalian polyamine metabolism and function

1 reference

https://pubmed.ncbi.nlm.nih.gov/30365568

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TriTrypDB: a functional genomic resource for the Trypanosomatidae

1 reference

https://pubmed.ncbi.nlm.nih.gov/30365568

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural biology of S-adenosylmethionine decarboxylase

1 reference

https://pubmed.ncbi.nlm.nih.gov/30365568

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Skyline: an open source document editor for creating and analyzing targeted proteomics experiments

1 reference

https://pubmed.ncbi.nlm.nih.gov/30365568

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selection of reference genes for mRNA quantification in Trypanosoma brucei.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30365568

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NECT is next: implementing the new drug combination therapy for Trypanosoma brucei gambiense sleeping sickness

1 reference

https://pubmed.ncbi.nlm.nih.gov/30365568

12 December 2020

based on heuristic

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Novel Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase with Anti-malarial Activity in the Mouse Model

1 reference

https://pubmed.ncbi.nlm.nih.gov/30365568

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Current status of the polyamine research field

1 reference

https://pubmed.ncbi.nlm.nih.gov/30365568

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

State of the art in African trypanosome drug discovery

1 reference

https://pubmed.ncbi.nlm.nih.gov/30365568

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A Gateway® compatible vector for gene silencing in bloodstream form Trypanosoma brucei

1 reference

https://pubmed.ncbi.nlm.nih.gov/30365568

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recognition of S-adenosylmethionine by riboswitches

1 reference

https://pubmed.ncbi.nlm.nih.gov/30365568

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation and function of polyamines in African trypanosomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/30365568

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Untargeted metabolomics reveals a lack of synergy between nifurtimox and eflornithine against Trypanosoma brucei

1 reference

https://pubmed.ncbi.nlm.nih.gov/30365568

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Untreated human infections by Trypanosoma brucei gambiense are not 100% fatal

1 reference

https://pubmed.ncbi.nlm.nih.gov/30365568

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Influence of threonine metabolism on S-adenosylmethionine and histone methylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/30365568

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical features, diagnosis, and treatment of human African trypanosomiasis (sleeping sickness).

1 reference

https://pubmed.ncbi.nlm.nih.gov/30365568

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Trypanosoma brucei S-adenosylmethionine decarboxylase N terminus is essential for allosteric activation by the regulatory subunit prozyme

1 reference

https://pubmed.ncbi.nlm.nih.gov/30365568

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Allosteric activation of trypanosomatid deoxyhypusine synthase by a catalytically dead paralog

1 reference

https://pubmed.ncbi.nlm.nih.gov/30365568

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolomics guides rational development of a simplified cell culture medium for drug screening against Trypanosoma brucei.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30365568

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Product feedback regulation implicated in translational control of the Trypanosoma brucei S-adenosylmethionine decarboxylase regulatory subunit prozyme

1 reference

https://pubmed.ncbi.nlm.nih.gov/30365568

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of essential and non-essential protein kinases by a fusion PCR method for efficient production of transgenic Trypanosoma brucei

1 reference

https://pubmed.ncbi.nlm.nih.gov/30365568

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Strategies to construct null and conditional null Trypanosoma brucei mutants using Cre-recombinase and loxP.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30365568

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The emerging role of RNA-binding proteins in the life cycle of Trypanosoma brucei

1 reference

https://pubmed.ncbi.nlm.nih.gov/30365568

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparative ribosome profiling reveals extensive translational complexity in different Trypanosoma brucei life cycle stages.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30365568

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidation of alpha-ketoglutarate is required for reductive carboxylation in cancer cells with mitochondrial defects.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30365568

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The hypusine-containing translation factor eIF5A.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30365568

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Extensive stage-regulation of translation revealed by ribosome profiling of Trypanosoma brucei

1 reference

https://pubmed.ncbi.nlm.nih.gov/30365568

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

GMP synthase is essential for viability and infectivity of Trypanosoma brucei despite a redundant purine salvage pathway.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30365568

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi

1 reference

https://pubmed.ncbi.nlm.nih.gov/30365568

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deoxyhypusine Modification of Eukaryotic Translation Initiation Factor 5A (eIF5A) Is Essential for Trypanosoma brucei Growth and for Expression of Polyprolyl-containing Proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/30365568

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gene expression in Kinetoplastids

1 reference

https://pubmed.ncbi.nlm.nih.gov/30365568

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functions of Polyamines in Mammals

1 reference

https://pubmed.ncbi.nlm.nih.gov/30365568

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biosynthesis of polyamines and polyamine-containing molecules

1 reference

https://pubmed.ncbi.nlm.nih.gov/30365568

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Riboswitch-Mediated Gene Regulation: Novel RNA Architectures Dictate Gene Expression Responses

1 reference

https://pubmed.ncbi.nlm.nih.gov/30365568

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The skin is a significant but overlooked anatomical reservoir for vector-borne African trypanosomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/30365568

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pyrimidine Salvage Enzymes Are Essential for De Novo Biosynthesis of Deoxypyrimidine Nucleotides in Trypanosoma brucei

1 reference

https://pubmed.ncbi.nlm.nih.gov/30365568

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relief of autoinhibition by conformational switch explains enzyme activation by a catalytically dead paralog

1 reference

https://pubmed.ncbi.nlm.nih.gov/30365568

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Major Protein Arginine Methyltransferase in Trypanosoma brucei Functions as an Enzyme-Prozyme Complex.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30365568

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of Trypanosoma brucei AdoMetDC Inhibitors Using a High-Throughput Mass Spectrometry-Based Assay.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30365568

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

eIF5A Functions Globally in Translation Elongation and Termination.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30365568

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bio-Zombie: the rise of pseudoenzymes in biology

1 reference

https://pubmed.ncbi.nlm.nih.gov/30365568

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human African trypanosomiasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30365568

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Live and let die: insights into pseudoenzyme mechanisms from structure

1 reference

https://pubmed.ncbi.nlm.nih.gov/30365568

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis and evaluation of analogs of 5'-(((Z)-4-amino-2-butenyl)methylamino)-5'-deoxyadenosine (MDL 73811, or AbeAdo) - An inhibitor of S-adenosylmethionine decarboxylase with antitrypanosomal activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/30365568

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

HMDB 4.0: the human metabolome database for 2018.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30365568

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Species-Selective Pyrimidineamine Inhibitors of Trypanosoma brucei S-Adenosylmethionine Decarboxylase.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30365568

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PPAT.1007404

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30365568%20AND%20SRC:MED&resulttype=core&format=json

30 April 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30365568%20AND%20SRC:MED&resulttype=core&format=json

30 April 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30365568%20AND%20SRC:MED&resulttype=core&format=json

30 April 2020

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