(Q27664030)

13

0 references

Shahid M Khan

Shahid M Khan

21

0 references

Dyann Wirth

27

Dyann F Wirth

0 references

Jingwen Lin

Jing-Wen Lin

19

0 references

Chris J Janse

Chris J Janse

20

0 references

Sergio Wittlin

17

Sergio Wittlin

0 references

Manoj Duraisingh

22

Manoj Duraisingh

0 references

Margaret A. Phillips

25

Margaret A Phillips

0 references

Sara Viera

15

Sara Viera

0 references

Renato Skerlj

5

Renato Skerlj

0 references

Amar Bir Sidhu

6

Amar Bir Sidhu

0 references

Cassandra Celatka

8

Cassandra Celatka

0 references

Jose E Guerrero Bravo

10

Jose E Guerrero Bravo

0 references

Keila N Crespo Llado

11

Keila N Crespo Llado

0 references

Adelfa E Serrano

12

Adelfa E Serrano

0 references

Maria Belen Jimenez-Diaz

14

María Belén Jiménez-Díaz

0 references

Petros Papastogiannidis

18

Petros Papastogiannidis

0 references

Bradley I Coleman

23

Bradley Coleman

0 references

Jeffrey D Klinger

28

Jeffrey D Klinger

0 references

Edmund Sybertz

30

Edmund Sybertz

0 references

author name string

Michael L Booker

1

0 references

Cecilia M Bastos

2

0 references

Martin L Kramer

3

0 references

Robert H Barker

4

0 references

Xiaoyi Deng

7

0 references

Joseph F Cortese

9

0 references

Helen Garuti

16

0 references

Elizabeth J Goldsmith

24

0 references

Benito Munoz

26

0 references

Roger Wiegand

Journal of Biological Chemistry

29

0 references

language of work or name

English

0 references

publication date

22 October 2010

0 references

published in

0 references

volume

285

0 references

issue

43

0 references

page(s)

33054-64

0 references

cites work

Structural Plasticity of Malaria Dihydroorotate Dehydrogenase Allows Selective Binding of Diverse Chemical Scaffolds

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963363

MolProbity: all-atom contacts and structure validation for proteins and nucleic acids

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963363

Structures of human dihydroorotate dehydrogenase in complex with antiproliferative agents

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963363

Pyrimidine Nucleotide Biosynthesis in Animals: Genes, Enzymes, and Regulation of UMP Biosynthesis

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963363

Solving structures of protein complexes by molecular replacement with Phaser

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963363

Coot: model-building tools for molecular graphics

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963363

Refinement of macromolecular structures by the maximum-likelihood method

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963363

DaliLite workbench for protein structure comparison

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963363

Catalytic properties of dihydroorotate dehydrogenase from Saccharomyces cerevisiae: studies on pH, alternate substrates, and inhibitors

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963363

Evidence for a gram-positive, eubacterial root of the tree of life

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963363

High-efficiency transfection and drug selection of genetically transformed blood stages of the rodent malaria parasite Plasmodium berghei

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963363

A murine model of falciparum-malaria by in vivo selection of competent strains in non-myelodepleted mice engrafted with human erythrocytes

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963363

High efficiency transfection of Plasmodium berghei facilitates novel selection procedures

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963363

Identification of a metabolically stable triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor with antimalarial activity in mice

24 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963363

Identification and characterization of small molecule inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963363

In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963363

Triazolopyrimidine-based dihydroorotate dehydrogenase inhibitors with potent and selective activity against the malaria parasite Plasmodium falciparum.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963363

Specific role of mitochondrial electron transport in blood-stage Plasmodium falciparum

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963363

hERG potassium channels and cardiac arrhythmia

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963363

Brequinar derivatives and species-specific drug design for dihydroorotate dehydrogenase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963363

A Plasmodium berghei reference line that constitutively expresses GFP at a high level throughout the complete life cycle

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963363

Drug interactions in dentistry: the importance of knowing your CYPs

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963363

ENZYMES OF THE PYRIMIDINE PATHWAY IN ESCHERICHIA COLI. II. INTRACELLULAR LOCALIZATION AND PROPERTIES OF DIHYDROOROTIC DEHYDROGENASE

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963363

Plasmodium knowlesi provides a rapid in vitro and in vivo transfection system that enables double-crossover gene knockout studies

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963363

Pharmacokinetic interactions of antimalarial agents

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963363

The prediction of human pharmacokinetic parameters from preclinical and in vitro metabolism data.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963363

Evidence of cross-contamination among laboratory lines of Plasmodium berghei

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963363

Identification and localization of enzymes of the fumarate reductase and nitrate respiration systems of escherichia coli by crossed immunoelectrophoresis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963363

Biosynthetic Dihydroorotate Dehydrogenase from Lactobacillus bulgaricus

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963363

Pyrimidine Synthesis in Neurospora crassa: Gene-Enzyme Relationships

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963363

Repression of Enzyme Synthesis of the Pyrimidine Pathway in Salmonella typhimurium

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963363

Pyrimidine biosynthesis in Saccharomyces cerevisiae: the ura2 cluster gene, its multifunctional enzyme product, and other structural or regulatory genes involved in de novo UMP synthesis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963363

The cellular location of dihydroorotate dehydrogenase: Relation to de novo biosynthesis of pyrimidines

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963363

Metabolic enzymes as potential drug targets in Plasmodium falciparum

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963363

Distribution, subcellular localization, and product inhibition of dihydroorotate oxidation in the rat

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963363

Human spleen dihydroorotate dehydrogenase: a study of inhibition of the enzyme

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963363

Mitochondria of mammalian Plasmodium spp.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963363

The chemotherapy of rodent malaria, XXII. The value of drug-resistant strains of P. berghei in screening for blood schizontocidal activity

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963363

Enzymes of purine and pyrimidine metabolism from the human malaria parasite, Plasmodium falciparum

2 June 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.162081

Malarial dihydroorotate dehydrogenase. Substrate and inhibitor specificity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.162081

Processing of X-ray diffraction data collected in oscillation mode

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.162081

Modified Phased Translation Functions and their Application to Molecular-Fragment Location

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.162081

Simple and sensitive antimalarial drug screening in vitro and in vivo using transgenic luciferase expressing Plasmodium berghei parasites

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.162081

Plasmodium berghei: the application of cultivation and purification techniques to molecular studies of malaria parasites

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.162081

Quantitative measurement of Plasmodium-infected erythrocytes in murine models of malaria by flow cytometry using bidimensional assessment of SYTO-16 fluorescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.162081

Structure of Plasmodium falciparum dihydroorotate dehydrogenase with a bound inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.162081

Importance of ribonucleotide availability to proliferating T-lymphocytes from healthy humans. Disproportionate expansion of pyrimidine pools and contrasting effects of de novo synthesis inhibitors.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963363

Mammalian dihydroorotate--ubiquinone reducatse complex. II. Correlation with cytochrome oxidase, mode of linkage with the cytochrome chain, and general properties

27 November 2018

1 reference

12 December 2020

A mitochondrial dihydroorotate oxidase system in Neurospora crassa

1 reference

12 December 2020

Dihydroorotat-ubiquinone oxidoreductase links mitochondria in the biosynthesis of pyrimidine nucleotides

1 reference

12 December 2020

Physicochemical high throughput screening: parallel artificial membrane permeation assay in the description of passive absorption processes

1 reference

12 December 2020

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M110.162081

1 reference

1 reference

1 reference

PubMed publication ID

20702404

1 reference