(Q37057973)

English

Triazolopyrimidine-based dihydroorotate dehydrogenase inhibitors with potent and selective activity against the malaria parasite Plasmodium falciparum.

scientific article published on 04 June 2008

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18522386%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

Triazolopyrimidine-based dihydroorotate dehydrogenase inhibitors with potent and selective activity against the malaria parasite Plasmodium falciparum (English)

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18522386%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

Plasmodium falciparum

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Nicholas A Malmquist

3

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8 January 2020

Margaret A. Phillips

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Margaret A Phillips

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8 January 2020

Pradipsinh K. Rathod

7

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Pradipsinh K Rathod

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8 January 2020

Farah El Mazouni

5

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Farah El Mazouni

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8 January 2020

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Ramesh Gujjar

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8 January 2020

author name string

Jeffrey Baldwin

6

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8 January 2020

John White

4

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8 January 2020

language of work or name

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publication date

4 June 2008

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8 January 2020

Journal of Medicinal Chemistry

1 reference

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8 January 2020

51

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8 January 2020

12

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8 January 2020

3649-3653

1 reference

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8 January 2020

Analysis of flavin oxidation and electron-transfer inhibition in Plasmodium falciparum dihydroorotate dehydrogenase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2624570

29 September 2017

Specific role of mitochondrial electron transport in blood-stage Plasmodium falciparum

1 reference

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29 September 2017

Quinolines and artemisinin: chemistry, biology and history.

1 reference

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29 September 2017

Opportunities and Challenges in Antiparasitic Drug Discovery

1 reference

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29 September 2017

High-throughput screening for potent and selective inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2624570

29 September 2017

Antimalarial drug resistance

1 reference

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29 September 2017

Genome sequence of the human malaria parasite Plasmodium falciparum

1 reference

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29 September 2017

Medical need, scientific opportunity and the drive for antimalarial drugs

1 reference

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29 September 2017

Drug-like properties and the causes of poor solubility and poor permeability

1 reference

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29 September 2017

Leflunomide, a novel immunomodulator for the treatment of active rheumatoid arthritis

1 reference

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29 September 2017

Leflunomide: an immunomodulatory drug for the treatment of rheumatoid arthritis and other autoimmune diseases

1 reference

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29 September 2017

Potent and selective activity of a combination of thymidine and 1843U89, a folate-based thymidylate synthase inhibitor, against Plasmodium falciparum

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2624570

29 September 2017

Structures of human dihydroorotate dehydrogenase in complex with antiproliferative agents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2624570

29 September 2017

Estimating mortality, morbidity and disability due to malaria among Africa's non-pregnant population.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2624570

29 September 2017

Drug resistance in malaria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2624570

29 September 2017

Variations in frequencies of drug resistance in Plasmodium falciparum

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2624570

29 September 2017

Susceptibility of Plasmodium falciparum to a combination of thymidine and ICI D1694, a quinazoline antifolate directed at thymidylate synthase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2624570

29 September 2017

Pyrimidine Nucleotide Biosynthesis in Animals: Genes, Enzymes, and Regulation of UMP Biosynthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2624570

29 September 2017

Selective activity of 5-fluoroorotic acid against Plasmodium falciparum in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2624570

29 September 2017

Purines and pyrimidines in malarial parasites.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2624570

29 September 2017

Divergent evolution of pyrimidine biosynthesis between anaerobic and aerobic yeasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2624570

29 September 2017

Quantitative assessment of antimalarial activity in vitro by a semiautomated microdilution technique

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2624570

29 September 2017

Biochemistry of Plasmodium (malarial parasites)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2624570

29 September 2017

Design and synthesis of potent inhibitors of the malaria parasite dihydroorotate dehydrogenase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2624570

27 June 2018

3-Carboxy-5-methyl-N-[4-(trifluoromethyl)phenyl]-4-isoxazolecarboxamide, new prodrug for the antiarthritic agent 2-cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-butenamide

1 reference

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27 June 2018

Detergent-dependent kinetics of truncated Plasmodium falciparum dihydroorotate dehydrogenase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2624570

4 September 2018

Structure of Plasmodium falciparum dihydroorotate dehydrogenase with a bound inhibitor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2624570

4 September 2018

Malarial dihydroorotate dehydrogenase. Substrate and inhibitor specificity.

1 reference

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4 September 2018

The intolerable burden of malaria: a new look at the numbers.

1 reference

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4 September 2018

Enzymes of purine and pyrimidine metabolism from the human malaria parasite, Plasmodium falciparum

1 reference

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4 September 2018

Incorporation of Radioactive Precursors into DNA and RNA of Plasmodium knowlesi in vitro

1 reference

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4 September 2018

Evaluation of enzyme inhibitors in drug discovery. A guide for medicinal chemists and pharmacologists

1 reference

https://pubmed.ncbi.nlm.nih.gov/18522386

12 December 2020

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10.1021/JM8001026

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Europe PubMed Central

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8 January 2020

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Europe PubMed Central

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8 January 2020

PubMed publication ID

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Europe PubMed Central

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8 January 2020

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