(Q58812776)

1

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Kersten S. Rabe

2

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Karolina Z. Kalbarczyk

3

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Amulya Tata

4

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Thomas Heel

5

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Rebekah Z. Kitto

Directed enzyme evolution: beyond the low-hanging fruit

6

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publication date

26 March 2013

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published in

Angewandte Chemie

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volume

125

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issue

21

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page(s)

5681-5684

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cites work

1 reference

https://api.crossref.org/works/10.1002%2FANGE.201301362

Strategy and success for the directed evolution of enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANGE.201301362

Exploring protein fitness landscapes by directed evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANGE.201301362

The biosynthesis of C5-C25 terpenoid compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANGE.201301362

Unearthing the roots of the terpenome

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANGE.201301362

Terpenoid synthase structures: a so far incomplete view of complex catalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANGE.201301362

Combining metabolic and protein engineering of a terpenoid biosynthetic pathway for overproduction and selectivity control

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANGE.201301362

Isoprenoid Pathway Optimization for Taxol Precursor Overproduction in Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANGE.201301362

Identifying and manipulating structural determinates linking catalytic specificities in terpene synthases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANGE.201301362

Quantitative exploration of the catalytic landscape separating divergent plant sesquiterpene synthases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANGE.201301362

Designed divergent evolution of enzyme function

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANGE.201301362

Engineering cotton (+)-delta-cadinene synthase to an altered function: germacrene D-4-ol synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANGE.201301362

Structural and mechanistic analysis of trichodiene synthase using site-directed mutagenesis: probing the catalytic function of tyrosine-295 and the asparagine-225/serine-229/glutamate-233-Mg2+B motif

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANGE.201301362

Activation-independent cyclization of monoterpenoids

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANGE.201301362

Interception of the enzymatic conversion of farnesyl diphosphate to 5-epi-aristolochene by using a fluoro substrate analogue: 1-fluorogermacrene A from (2E,6Z)-6-fluorofarnesyl diphosphate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANGE.201301362

6- and 14-Fluoro farnesyl diphosphate: mechanistic probes for the reaction catalysed by aristolochene synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANGE.201301362

Probing the reaction mechanism of aristolochene synthase with 12,13-difluorofarnesyl diphosphate

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANGE.201301362

Aristolochene synthase-catalyzed cyclization of 2-fluorofarnesyl-diphosphate to 2-fluorogermacrene A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANGE.201301362

Farnesyl diphosphate analogues with omega-bioorthogonal azide and alkyne functional groups for protein farnesyl transferase-catalyzed ligation reactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANGE.201301362

Sesquiterpene synthase from the botrydial biosynthetic gene cluster of the phytopathogen Botrytis cinerea

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANGE.201301362

Genome mining in Streptomyces clavuligerus: expression and biochemical characterization of two new cryptic sesquiterpene synthases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANGE.201301362

(+)-Germacrene A biosynthesis . The committed step in the biosynthesis of bitter sesquiterpene lactones in chicory

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANGE.201301362

Conformational Analysis of (+)-Germacrene A by Variable Temperature NMR and NOE Spectroscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANGE.201301362

Chemoenzymatic preparation of germacrene analogues

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANGE.201301362

Ab initio analysis of the Cope rearrangement of germacrane sesquiterpenoids

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANGE.201301362

Comparison of three colorimetric reagents in the determination of methanol with alcohol oxidase. Application to the assay of pectin methylesterase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANGE.201301362

Iterative saturation mutagenesis on the basis of B factors as a strategy for increasing protein thermostability

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANGE.201301362

Enhancing the thermal robustness of an enzyme by directed evolution: least favorable starting points and inferior mutants can map superior evolutionary pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANGE.201301362

Computational design and selections for an engineered, thermostable terpene synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANGE.201301362

Genome mining in Streptomyces coelicolor: molecular cloning and characterization of a new sesquiterpene synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANGE.201301362

Genome mining in Streptomyces avermitilis: cloning and characterization of SAV_76, the synthase for a new sesquiterpene, avermitilol

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANGE.201301362

A multiproduct terpene synthase from Medicago truncatula generates cadalane sesquiterpenes via two different mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANGE.201301362

Expression and mechanistic analysis of a germacradienol synthase from Streptomyces coelicolor implicated in geosmin biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANGE.201301362

Diversity of sesquiterpene synthases in the basidiomycete Coprinus cinereus

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANGE.201301362

Identification of sesquiterpene synthases from Nostoc punctiforme PCC 73102 and Nostoc sp. strain PCC 7120

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANGE.201301362