(Q58842619)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9756885%20AND%20SRC:MED&resulttype=core&format=json

5 December 2019

title

Protein farnesyltransferase from Trypanosoma brucei. A heterodimer of 61- and 65-kda subunits as a new target for antiparasite therapeutics (English)

1 reference

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5 December 2019

Trypanosoma brucei

1 reference

K Yokoyama

1

1 reference

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5 December 2019

P Trobridge

2

1 reference

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5 December 2019

F S Buckner

3

1 reference

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5 December 2019

W C Van Voorhis

4

1 reference

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5 December 2019

K D Stuart

5

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5 December 2019

M H Gelb

6

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5 December 2019

language of work or name

English

0 references

publication date

1 October 1998

1 reference

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Journal of Biological Chemistry

5 December 2019

published in

1 reference

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5 December 2019

volume

273

1 reference

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5 December 2019

issue

41

1 reference

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5 December 2019

page(s)

26497-26505

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Identification of geranylgeranyl-modified proteins in HeLa cells

5 December 2019

cites work

1 reference

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Prenyl proteins in eukaryotic cells: a new type of membrane anchor

21 January 2018

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Protein prenylation: molecular mechanisms and functional consequences

21 January 2018

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Protein isoprenylation and methylation at carboxyl-terminal cysteine residues

21 January 2018

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Brain G protein gamma subunits contain an all-trans-geranylgeranylcysteine methyl ester at their carboxyl termini

21 January 2018

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G protein gamma subunits contain a 20-carbon isoprenoid

21 January 2018

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The hepatitis delta virus large antigen is farnesylated both in vitro and in animal cells

21 January 2018

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Protein prenylation: a mediator of protein-protein interactions

21 January 2018

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Evidence for a high affinity, saturable, prenylation-dependent p21Ha-ras binding site in plasma membranes

21 January 2018

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Protein prenyltransferases.

21 January 2018

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Protein prenyltransferases

21 January 2018

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Inhibition of purified p21ras farnesyl:protein transferase by Cys-AAX tetrapeptides

21 January 2018

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Rab geranylgeranyl transferase catalyzes the geranylgeranylation of adjacent cysteines in the small GTPases Rab1A, Rab3A, and Rab5A

21 January 2018

1 reference

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Protein farnesyltransferase and geranylgeranyltransferase share a common alpha subunit

21 January 2018

1 reference

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Protein geranylgeranyltransferase of Saccharomyces cerevisiae is specific for Cys-Xaa-Xaa-Leu motif proteins and requires the CDC43 gene product but not the DPR1 gene product

21 January 2018

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Mutants of Saccharomyces cerevisiae defective in the farnesylation of Ras proteins

21 January 2018

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Purification of component A of Rab geranylgeranyl transferase: possible identity with the choroideremia gene product

21 January 2018

1 reference

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cDNA cloning of component A of Rab geranylgeranyl transferase and demonstration of its role as a Rab escort protein

21 January 2018

1 reference

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Benzodiazepine peptidomimetics: potent inhibitors of Ras farnesylation in animal cells

21 January 2018

1 reference

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Selective inhibition of ras-dependent transformation by a farnesyltransferase inhibitor

21 January 2018

1 reference

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Resistance of K-RasBV12 proteins to farnesyltransferase inhibitors in Rat1 cells

21 January 2018

1 reference

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Both farnesyltransferase and geranylgeranyltransferase I inhibitors are required for inhibition of oncogenic K-Ras prenylation but each alone is sufficient to suppress human tumor growth in nude mouse xenografts

21 January 2018

1 reference

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K- and N-Ras are geranylgeranylated in cells treated with farnesyl protein transferase inhibitors

21 January 2018

1 reference

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The geranylgeranyltransferase-I inhibitor GGTI-298 arrests human tumor cells in G0/G1 and induces p21(WAF1/CIP1/SDI1) in a p53-independent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.41.26497

Newly synthesized Rho A, not Ras, is isoprenylated and translocated to membranes coincident with progression of the G1 to S phase of growth-stimulated rat FRTL-5 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.41.26497

Isoprenylation of proteins in the protozoan Giardia lamblia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.41.26497

Characterisation of protein isoprenylation in procyclic form Trypanosoma brucei

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.41.26497

Prenylation of proteins in Trypanosoma brucei

21 January 2018

1 reference

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Characterization of mevalonate-labeled lipids isolated from parasite proteins in Schistosoma mansoni

21 January 2018

1 reference

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Geranylgeranylated proteins

21 January 2018

1 reference

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Evidence for guanosine triphosphate--binding proteins in Trypanosoma cruzi.

21 January 2018

1 reference

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Signal transduction in Trypanosoma cruzi: opposite effects of adenylcyclase and phospholipase C systems in growth control

21 January 2018

1 reference

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Cyclic AMP and adenylate cyclase activators stimulate Trypanosoma cruzi differentiation

21 January 2018

1 reference

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Evidence for the existence of an Ns-type regulatory protein in Trypanosoma cruzi membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.41.26497

Trypanosoma brucei: Characterization of a Life Cycle Stage-Specific G-Protein

21 January 2018

1 reference

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Leishmania donovani: Characterization of a 38-kDa membrane protein that cross-reacts with the mammalian G-protein transducin

21 January 2018

1 reference

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The gamma subunit of transducin is farnesylated

21 January 2018

1 reference

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cDNA expressed sequence tags of Trypanosoma brucei rhodesiense provide new insights into the biology of the parasite.

21 January 2018

1 reference

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Tandem duplication of rab genes followed by sequence divergence and acquisition of distinct functions in Trypanosoma brucei

21 January 2018

1 reference

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Trypanosoma brucei: molecular cloning of homologues of small GTP-binding proteins involved in vesicle trafficking.

21 January 2018

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Cloning and characterization of a Golgi-associated GTP-binding protein homologue from Leishmania major

21 January 2018

1 reference

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A protein geranylgeranyltransferase from bovine brain: implications for protein prenylation specificity

21 January 2018

1 reference

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The Farnesyl Group of H-Ras Facilitates the Activation of a Soluble Upstream Activator of Mitogen-activated Protein Kinase

21 January 2018

1 reference

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Discovery of novel nonpeptide tricyclic inhibitors of Ras farnesyl protein transferase

21 January 2018

1 reference

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Mammalian protein geranylgeranyltransferase-I: substrate specificity, kinetic mechanism, metal requirements, and affinity labeling

21 January 2018

1 reference

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Isoprenoid diphosphate utilization by recombinant human farnesyl:protein transferase: interactive binding between substrates and a preferred kinetic pathway.

21 January 2018

1 reference

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Characterization of recombinant human farnesyl-protein transferase: cloning, expression, farnesyl diphosphate binding, and functional homology with yeast prenyl-protein transferases

21 January 2018

1 reference

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Ras farnesyltransferase: a new therapeutic target

21 January 2018

1 reference

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Farnesyltransferase as a target for anticancer drug design

21 January 2018

1 reference

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Farnesyltransferase inhibitors: a new class of cancer chemotherapeutics

21 January 2018

1 reference

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Protein prenylation: from discovery to prospects for cancer treatment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.41.26497

2-substituted piperazines as constrained amino acids. Application to the synthesis of potent, non carboxylic acid inhibitors of farnesyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.41.26497

Novel tricyclic inhibitors of farnesyl protein transferase. Biochemical characterization and inhibition of Ras modification in transfected Cos cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.41.26497

Crystal structure of protein farnesyltransferase at 2.25 angstrom resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.41.26497

Platelet-derived growth factor receptor tyrosine phosphorylation requires protein geranylgeranylation but not farnesylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.41.26497

21 January 2018

Identifiers

DOI

10.1074/JBC.273.41.26497

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9756885%20AND%20SRC:MED&resulttype=core&format=json

5 December 2019

1 reference