(Q58860055)

7

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author name string

Pascal Amoa Onguéné

2

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Michael Scharfe

3

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Luc C. Owono Owono

4

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Eugene Megnassan

5

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Luc Meva'a Mbaze

6

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Simon M. N. Efange

Drug discovery and natural products: end of an era or an endless frontier?

8

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publication date

2014

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published in

RSC Advances

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volume

4

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issue

1

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page(s)

409-419

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cites work

1 reference

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Developing a drug-like natural product library

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Cheminformatic Analysis of Natural Products and their Chemical Space

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Scaffold diversity of natural products: inspiration for combinatorial library design

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Natural products in drug discovery

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Natural products as leads to potential drugs: an old process or the new hope for drug discovery?

21 January 2018

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Integrating virtual screening in lead discovery

21 January 2018

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Virtual screening for anti-HIV-1 RT and anti-HIV-1 PR inhibitors from the Thai medicinal plants database: a combined docking with neural networks approach.

21 January 2018

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The evolving role of natural products in drug discovery

21 January 2018

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Virtual ligand screening: strategies, perspectives and limitations

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Protein-based virtual screening of chemical databases. 1. Evaluation of different docking/scoring combinations.

21 January 2018

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The price of innovation: new estimates of drug development costs

21 January 2018

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Combining ethnopharmacology and virtual screening for lead structure discovery: COX-inhibitors as application example.

21 January 2018

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Virtual Screening on Natural Products for Discovering Active Compounds and Target Information

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Natural products: sources and databases

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SuperNatural: a searchable database of available natural compounds

21 January 2018

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A 3D structure database of components from Chinese traditional medicinal herbs

21 January 2018

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StreptomeDB: a resource for natural compounds isolated from Streptomyces species

21 January 2018

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A database for the predicted pharmacophoric features of medicinal compounds

21 January 2018

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Database on pharmacophore analysis of active principles, from medicinal plants

21 January 2018

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TCM Database@Taiwan: the world's largest traditional Chinese medicine database for drug screening in silico

21 January 2018

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CamMedNP: building the Cameroonian 3D structural natural products database for virtual screening

21 January 2018

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Cameroonian medicinal plants: pharmacology and derived natural products

21 January 2018

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Potential of Cameroonian plants and derived products against microbial infections: a review

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Bioactive natural products derived from the Central African flora against neglected tropical diseases and HIV.

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Cameroonian medicinal plants: a bioactivity versus ethnobotanical survey and chemotaxonomic classification

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Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

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Drug-like properties and the causes of poor solubility and poor permeability

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Pursuing the leadlikeness concept in pharmaceutical research.

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Current trends in lead discovery: are we looking for the appropriate properties?

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Trends in virtual combinatorial library design

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Improved protein-ligand docking using GOLD

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Property distributions: differences between drugs, natural products, and molecules from combinatorial chemistry

21 January 2018

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Prediction of Physicochemical Parameters by Atomic Contributions

21 January 2018

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ADME evaluation in drug discovery. 4. Prediction of aqueous solubility based on atom contribution approach.

21 January 2018

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Fast Calculation of Molecular Polar Surface Area as a Sum of Fragment-Based Contributions and Its Application to the Prediction of Drug Transport Properties

21 January 2018

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Structural diversity of biologically interesting datasets: a scaffold analysis approach

21 January 2018

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Prediction of drug solubility from structure

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Prediction of drug solubility from Monte Carlo simulations.

21 January 2018

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Prediction of the brain-blood distribution of a large set of drugs from structurally derived descriptors using partial least-squares (PLS) modeling.

21 January 2018

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Designing libraries with CNS activity

21 January 2018

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Organising evidence on QT prolongation and occurrence of Torsades de Pointes with non-antiarrhythmic drugs: a call for consensus

21 January 2018

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Cheminformatic models to predict binding affinities to human serum albumin.

21 January 2018

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Correlating partitioning and caco-2 cell permeability of structurally diverse small molecular weight compounds

21 January 2018

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MDCK (Madin-Darby canine kidney) cells: A tool for membrane permeability screening

21 January 2018

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Experimental and computational screening models for the prediction of intestinal drug absorption

21 January 2018

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Predicting skin permeability

21 January 2018

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A predictive algorithm for skin permeability: the effects of molecular size and hydrogen bond activity

21 January 2018

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In silico drug metabolism and pharmacokinetic profiles of natural products from medicinal plants in the Congo basin.

21 January 2018

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21 January 2018

Drug Discovery in Africa

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Merck molecular force field. I. Basis, form, scope, parameterization, and performance of MMFF94

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RECAP--retrosynthetic combinatorial analysis procedure: a powerful new technique for identifying privileged molecular fragments with useful applications in combinatorial chemistry

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Use of natural products as chemical library for drug discovery and network pharmacology

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Natural-product-derived fragments for fragment-based ligand discovery

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Recent developments in fragment-based drug discovery

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Fragment-based lead discovery: leads by design

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21 January 2018

Marine natural products

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Toward a pharmacophore for drugs inducing the long QT syndrome: insights from a CoMFA study of HERG K(+) channel blockers

20 July 2023

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A marine natural product database

20 July 2023

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Polar molecular surface as a dominating determinant for oral absorption and brain penetration of drugs

20 July 2023

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Drug discovery from natural sources.

20 July 2023

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