(Q59654517)

English

Susceptibility of Nrf2-null mice to steatohepatitis and cirrhosis upon consumption of a high-fat diet is associated with oxidative stress, perturbation of the unfolded protein response, and disturbance in the expression of metabolic enzymes but not w

scholarly article by Paul Meakin published in September 2014

In more languages

Statements

scholarly article

0 references

Susceptibility of Nrf2-null mice to steatohepatitis and cirrhosis upon consumption of a high-fat diet is associated with oxidative stress, perturbation of the unfolded protein response, and disturbance in the expression of metabolic enzymes but not w (English)

0 references

molecular biology

0 references

object named as

Paul J Meakin

1

0 references

Rory J. McCrimmon

object named as

Rory J McCrimmon

6

0 references

object named as

John D Hayes

9

0 references

Albena Dinkova-Kostova

object named as

Albena T Dinkova-Kostova

7

0 references

object named as

John F Dillon

8

0 references

author name string

Sudhir Chowdhry

2

0 references

Ritu S Sharma

3

0 references

Fiona B Ashford

4

0 references

Shaun V Walsh

5

0 references

Michael L J Ashford

10

0 references

language of work or name

0 references

publication date

September 2014

0 references

full work available at URL

http://eprints.whiterose.ac.uk/138558

content deliverer

White Rose Research Online

object has role

published version

copyright license

Creative Commons Attribution 3.0 Unported

0 references

Molecular and Cellular Biology

0 references

34

0 references

17

0 references

3305-20

0 references

copyright license

Creative Commons Attribution 3.0 Unported

1 September 2014

1 reference

April 2023 Public Data File from Crossref

copyright status

0 references

Measurement of ER stress response and inflammation in the mouse model of nonalcoholic fatty liver disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24958099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

From endoplasmic-reticulum stress to the inflammatory response

1 reference

https://pubmed.ncbi.nlm.nih.gov/24958099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Detecting and quantifying apoptosis in tissue sections

1 reference

https://pubmed.ncbi.nlm.nih.gov/24958099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reactive oxygen species enhance insulin sensitivity

1 reference

https://pubmed.ncbi.nlm.nih.gov/24958099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antioxidants reduce endoplasmic reticulum stress and improve protein secretion

1 reference

https://pubmed.ncbi.nlm.nih.gov/24958099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements

1 reference

https://pubmed.ncbi.nlm.nih.gov/24958099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nrf2 deletion causes "benign" simple steatosis to develop into nonalcoholic steatohepatitis in mice fed a high-fat diet

1 reference

https://pubmed.ncbi.nlm.nih.gov/24958099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

C/EBP homologous protein (CHOP) contributes to suppression of metabolic genes during endoplasmic reticulum stress in the liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/24958099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/24958099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatic gene expression profiling in Nrf2 knockout mice after long-term high-fat diet-induced obesity

1 reference

https://pubmed.ncbi.nlm.nih.gov/24958099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The stress-regulated transcription factor CHOP promotes hepatic inflammatory gene expression, fibrosis, and oncogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/24958099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Extracellular matrix degradation in liver fibrosis: Biochemistry and regulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/24958099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NASH is an Inflammatory Disorder: Pathogenic, Prognostic and Therapeutic Implications.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24958099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genomic structure and variation of nuclear factor (erythroid-derived 2)-like 2

1 reference

https://pubmed.ncbi.nlm.nih.gov/24958099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nrf2 inhibits LXRα-dependent hepatic lipogenesis by competing with FXR for acetylase binding.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24958099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nonalcoholic fatty liver disease (NAFLD) activity score and the histopathologic diagnosis in NAFLD: distinct clinicopathologic meanings

1 reference

https://pubmed.ncbi.nlm.nih.gov/24958099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of a novel Nrf2-regulated antioxidant response element (ARE) in the mouse NAD(P)H:quinone oxidoreductase 1 gene: reassessment of the ARE consensus sequence

1 reference

https://pubmed.ncbi.nlm.nih.gov/24958099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CCAAT/enhancer-binding protein beta deletion reduces adiposity, hepatic steatosis, and diabetes in Lepr(db/db) mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/24958099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NF-E2-related factor 2 inhibits lipid accumulation and oxidative stress in mice fed a high-fat diet.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24958099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beneficial role of Nrf2 in regulating NADPH generation and consumption

1 reference

https://pubmed.ncbi.nlm.nih.gov/24958099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24958099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dysregulated expression of fatty acid oxidation enzymes and iron-regulatory genes in livers of Nrf2-null mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/24958099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Free radical biology for medicine: learning from nonalcoholic fatty liver disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/24958099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Farnesoid X receptor: a molecular link between bile acid and lipid and glucose metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/24958099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Conditional deletion of Nrf2 in airway epithelium exacerbates acute lung injury and impairs the resolution of inflammation

1 reference

https://pubmed.ncbi.nlm.nih.gov/24958099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deletion of Nrf2 leads to rapid progression of steatohepatitis in mice fed atherogenic plus high-fat diet

1 reference

https://pubmed.ncbi.nlm.nih.gov/24958099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Degradation of Keap1 activates BH3-only proteins Bim and PUMA during hepatocyte lipoapoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/24958099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Translation attenuation through eIF2alpha phosphorylation prevents oxidative stress and maintains the differentiated state in beta cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/24958099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Loss of Nrf2 markedly exacerbates nonalcoholic steatohepatitis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24958099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

AMPK beta1 deletion reduces appetite, preventing obesity and hepatic insulin resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/24958099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New insights into ER stress-induced insulin resistance.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24958099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24958099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proteomic analysis of Nrf2 deficient transgenic mice reveals cellular defence and lipid metabolism as primary Nrf2-dependent pathways in the liver.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24958099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic versus chemoprotective activation of Nrf2 signaling: overlapping yet distinct gene expression profiles between Keap1 knockout and triterpenoid-treated mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24958099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial dysfunction and oxidative stress in the pathogenesis of alcohol- and obesity-induced fatty liver diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/24958099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oltipraz upregulates the nuclear factor (erythroid-derived 2)-like 2 [corrected](NRF2) antioxidant system and prevents insulin resistance and obesity induced by a high-fat diet in C57BL/6J mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24958099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endoplasmic reticulum stress and oxidative stress in cell fate decision and human disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/24958099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Use of cells expressing gamma subunit variants to identify diverse mechanisms of AMPK activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/24958099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transcription factor Nrf2 mediates an adaptive response to sulforaphane that protects fibroblasts in vitro against the cytotoxic effects of electrophiles, peroxides and redox-cycling agents

1 reference

https://pubmed.ncbi.nlm.nih.gov/24958099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of oxidative stress in the pathogenesis of nonalcoholic steatohepatitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/24958099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In the regulation of cytochrome P450 genes, phenobarbital targets LKB1 for necessary activation of AMP-activated protein kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/24958099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Emerging role of high-mobility group box 1 (HMGB1) in liver diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/24958099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhanced expression of Nrf2 in mice attenuates the fatty liver produced by a methionine- and choline-deficient diet

1 reference

https://pubmed.ncbi.nlm.nih.gov/24958099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nrf2 represses FGF21 during long-term high-fat diet-induced obesity in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/24958099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhanced Nrf2 activity worsens insulin resistance, impairs lipid accumulation in adipose tissue, and increases hepatic steatosis in leptin-deficient mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24958099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

AMP-activated protein kinase, a metabolic master switch: possible roles in type 2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/24958099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state

1 reference

https://pubmed.ncbi.nlm.nih.gov/24958099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of hepatic lipogenesis by the transcription factor XBP1

1 reference

https://pubmed.ncbi.nlm.nih.gov/24958099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased hepatic myeloperoxidase activity in obese subjects with nonalcoholic steatohepatitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/24958099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of Nrf2 in prevention of high-fat diet-induced obesity by synthetic triterpenoid CDDO-imidazolide

1 reference

https://pubmed.ncbi.nlm.nih.gov/24958099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24958099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Keap1 perceives stress via three sensors for the endogenous signaling molecules nitric oxide, zinc, and alkenals

1 reference

https://pubmed.ncbi.nlm.nih.gov/24958099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic control of de novo lipogenesis: role in diet-induced obesity

1 reference

https://pubmed.ncbi.nlm.nih.gov/24958099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nonalcoholic fatty liver disease: from steatosis to cirrhosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/24958099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deletion of nuclear factor-E2-related factor-2 leads to rapid onset and progression of nutritional steatohepatitis in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/24958099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Keap1-Nrf2 system prevents onset of diabetes mellitus

1 reference

https://pubmed.ncbi.nlm.nih.gov/24958099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cancer chemoprevention mechanisms mediated through the Keap1-Nrf2 pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/24958099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity

1 reference

https://pubmed.ncbi.nlm.nih.gov/24958099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PERK-dependent activation of Nrf2 contributes to redox homeostasis and cell survival following endoplasmic reticulum stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/24958099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/24958099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Markedly enhanced colon tumorigenesis in Apc(Min) mice lacking glutathione S-transferase Pi.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24958099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

HMGB1 in cancer: good, bad, or both?

1 reference

https://pubmed.ncbi.nlm.nih.gov/24958099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Toward clinical application of the Keap1-Nrf2 pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/24958099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/24958099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Steatohepatitis: a tale of two "hits"?

1 reference

https://pubmed.ncbi.nlm.nih.gov/24958099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lipotoxicity in NASH.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24958099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dephosphorylation of translation initiation factor 2alpha enhances glucose tolerance and attenuates hepatosteatosis in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/24958099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reactive oxygen species and insulin resistance: the good, the bad and the ugly

1 reference

https://pubmed.ncbi.nlm.nih.gov/24958099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/24958099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The interaction of hepatic lipid and glucose metabolism in liver diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/24958099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The antioxidant defense system Keap1-Nrf2 comprises a multiple sensing mechanism for responding to a wide range of chemical compounds

1 reference

https://pubmed.ncbi.nlm.nih.gov/24958099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transcription factor Nrf2 regulates SHP and lipogenic gene expression in hepatic lipid metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/24958099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/24958099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Keap1 knockdown increases markers of metabolic syndrome after long-term high fat diet feeding

1 reference

https://pubmed.ncbi.nlm.nih.gov/24958099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative inactivation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase and subunit cross-linking involve different dithiol/disulfide centers.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24958099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular mediators of hepatic steatosis and liver injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/24958099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nrf2 deficiency improves glucose tolerance in mice fed a high-fat diet

1 reference

https://pubmed.ncbi.nlm.nih.gov/24958099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Liver lipid metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/24958099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chemoprevention of aflatoxin B1 hepatocarcinogenesis by coumarin, a natural benzopyrone that is a potent inducer of aflatoxin B1-aldehyde reductase, the glutathione S-transferase A5 and P1 subunits, and NAD(P)H:quinone oxidoreductase in rat liver.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24958099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The gasotransmitter hydrogen sulfide induces nrf2-target genes by inactivating the keap1 ubiquitin ligase substrate adaptor through formation of a disulfide bond between cys-226 and cys-613.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24958099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human fatty liver disease: old questions and new insights

1 reference

https://pubmed.ncbi.nlm.nih.gov/24958099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2

1 reference

https://pubmed.ncbi.nlm.nih.gov/24958099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1128/MCB.00677-14

0 references

PMC publication ID

0 references

PubMed publication ID

0 references

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q59654517&oldid=1903199631"