(Q60045126)

English

Integrative system biology analyses of CRISPR-edited iPSC-derived neurons and human brains reveal deficiencies of presynaptic signaling in FTLD and PSP

scientific article published on 13 December 2018

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14 April 2020

Integrative system biology analyses of CRISPR-edited iPSC-derived neurons and human brains reveal deficiencies of presynaptic signaling in FTLD and PSP (English)

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30546007%20AND%20SRC:MED&resulttype=core&format=json

14 April 2020

biological psychiatry

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3

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14 April 2020

4

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14 April 2020

Jorge L Del-Aguila

5

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14 April 2020

6

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14 April 2020

Celeste M Karch

15

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14 April 2020

10

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Nigel J Cairns

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14 April 2020

Carlos Cruchaga

14

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Carlos Cruchaga

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14 April 2020

13

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Oscar Harari

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14 April 2020

8

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Simon Hsu

1 reference

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14 April 2020

author name string

Shan Jiang

1

1 reference

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14 April 2020

Rita Martinez

7

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30546007%20AND%20SRC:MED&resulttype=core&format=json

14 April 2020

Maria V Fernandez

9

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14 April 2020

Natalie Wen

2

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14 April 2020

Dominantly Inherited Alzheimer Network (DIAN)

11

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30546007%20AND%20SRC:MED&resulttype=core&format=json

14 April 2020

International FTD-Genomics Consortium (IFGC)

12

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30546007%20AND%20SRC:MED&resulttype=core&format=json

14 April 2020

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13 December 2018

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14 April 2020

Translational Psychiatry

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30546007%20AND%20SRC:MED&resulttype=core&format=json

14 April 2020

8

1 reference

Europe PubMed Central

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14 April 2020

1

1 reference

Europe PubMed Central

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14 April 2020

265

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14 April 2020

describes a project that uses

object named as

Cytoscape

2 references

Europe PubMed Central

9 June 2022

https://europepmc.org/search?query=(METHODS:'Cytoscape')

based on heuristic

inferred from PubMed Central ID database lookup

CZ Software Mentions: A large dataset of software mentions in the biomedical literature

object named as

DESeq2

1 reference

CZ Software Mentions: A large dataset of software mentions in the biomedical literature

https://scigraph.springernature.com/pub.10.1038/s41398-018-0319-z

0 references

Neuropathologic diagnostic and nosologic criteria for frontotemporal lobar degeneration: consensus of the Consortium for Frontotemporal Lobar Degeneration

1 reference

https://api.crossref.org/works/10.1038%2FS41398-018-0319-Z

7 January 2021

based on heuristic

inferred from DOI database lookup

Nomenclature and nosology for neuropathologic subtypes of frontotemporal lobar degeneration: an update

1 reference

https://api.crossref.org/works/10.1038%2FS41398-018-0319-Z

7 January 2021

based on heuristic

inferred from DOI database lookup

A mutation in the microtubule-associated protein tau in pallido-nigro-luysian degeneration.

1 reference

https://api.crossref.org/works/10.1038%2FS41398-018-0319-Z

7 January 2021

based on heuristic

inferred from DOI database lookup

Invited review: Frontotemporal dementia caused by microtubule-associated protein tau gene (MAPT) mutations: a chameleon for neuropathology and neuroimaging

1 reference

https://api.crossref.org/works/10.1038%2FS41398-018-0319-Z

7 January 2021

based on heuristic

inferred from DOI database lookup

Retiring the term FTDP-17 as MAPT mutations are genetic forms of sporadic frontotemporal tauopathies.

1 reference

https://api.crossref.org/works/10.1038%2FS41398-018-0319-Z

7 January 2021

based on heuristic

inferred from DOI database lookup

Locus-specific mutation databases for neurodegenerative brain diseases

1 reference

https://api.crossref.org/works/10.1038%2FS41398-018-0319-Z

7 January 2021

based on heuristic

inferred from DOI database lookup

Hereditary frontotemporal dementia caused by Tau gene mutations.

1 reference

https://api.crossref.org/works/10.1038%2FS41398-018-0319-Z

7 January 2021

based on heuristic

inferred from DOI database lookup

Autosomal dominant dementia with widespread neurofibrillary tangles.

1 reference

https://api.crossref.org/works/10.1038%2FS41398-018-0319-Z

7 January 2021

based on heuristic

inferred from DOI database lookup

Phenotypic variation in hereditary frontotemporal dementia with tau mutations.

1 reference

https://api.crossref.org/works/10.1038%2FS41398-018-0319-Z

7 January 2021

based on heuristic

inferred from DOI database lookup

Alzheimer disease-like clinical phenotype in a family with FTDP-17 caused by a MAPT R406W mutation.

1 reference

https://api.crossref.org/works/10.1038%2FS41398-018-0319-Z

7 January 2021

based on heuristic

inferred from DOI database lookup

Molecular analysis of mutant and wild-type tau deposited in the brain affected by the FTDP-17 R406W mutation

1 reference

https://api.crossref.org/works/10.1038%2FS41398-018-0319-Z

7 January 2021

based on heuristic

inferred from DOI database lookup

Retarded axonal transport of R406W mutant tau in transgenic mice with a neurodegenerative tauopathy.

1 reference

https://api.crossref.org/works/10.1038%2FS41398-018-0319-Z

7 January 2021

based on heuristic

inferred from DOI database lookup

Tau filament formation and associative memory deficit in aged mice expressing mutant (R406W) human tau.

1 reference

https://api.crossref.org/works/10.1038%2FS41398-018-0319-Z

7 January 2021

based on heuristic

inferred from DOI database lookup

FTDP-17 mutations compromise the ability of tau to regulate microtubule dynamics in cells

1 reference

https://api.crossref.org/works/10.1038%2FS41398-018-0319-Z

7 January 2021

based on heuristic

inferred from DOI database lookup

Fibrillogenic nuclei composed of P301L mutant tau induce elongation of P301L tau but not wild-type tau

1 reference

https://api.crossref.org/works/10.1038%2FS41398-018-0319-Z

7 January 2021

based on heuristic

inferred from DOI database lookup

Interaction of tau with the neural plasma membrane mediated by tau's amino-terminal projection domain

1 reference

https://api.crossref.org/works/10.1038%2FS41398-018-0319-Z

7 January 2021

based on heuristic

inferred from DOI database lookup

The frontotemporal dementia mutation R406W blocks tau's interaction with the membrane in an annexin A2-dependent manner.

1 reference

https://api.crossref.org/works/10.1038%2FS41398-018-0319-Z

7 January 2021

based on heuristic

inferred from DOI database lookup

Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors

1 reference

https://api.crossref.org/works/10.1038%2FS41398-018-0319-Z

7 January 2021

based on heuristic

inferred from DOI database lookup

Efficient generation of transgene-free human induced pluripotent stem cells (iPSCs) by temperature-sensitive Sendai virus vectors

1 reference

https://api.crossref.org/works/10.1038%2FS41398-018-0319-Z

7 January 2021

based on heuristic

inferred from DOI database lookup

Expression of novel Alzheimer's disease risk genes in control and Alzheimer's disease brains

1 reference

https://api.crossref.org/works/10.1038%2FS41398-018-0319-Z

7 January 2021

based on heuristic

inferred from DOI database lookup

Genetic variants associated with Alzheimer's disease confer different cerebral cortex cell-type population structure.

1 reference

https://api.crossref.org/works/10.1038%2FS41398-018-0319-Z

7 January 2021

based on heuristic

inferred from DOI database lookup

Human whole genome genotype and transcriptome data for Alzheimer's and other neurodegenerative diseases

1 reference

https://api.crossref.org/works/10.1038%2FS41398-018-0319-Z

7 January 2021

based on heuristic

inferred from DOI database lookup

STAR: ultrafast universal RNA-seq aligner

1 reference

https://api.crossref.org/works/10.1038%2FS41398-018-0319-Z

7 January 2021

based on heuristic

inferred from DOI database lookup

Integrative genomics viewer

1 reference

https://api.crossref.org/works/10.1038%2FS41398-018-0319-Z

7 January 2021

based on heuristic

inferred from DOI database lookup

Fast and accurate short read alignment with Burrows-Wheeler transform

1 reference

https://api.crossref.org/works/10.1038%2FS41398-018-0319-Z

7 January 2021

based on heuristic

inferred from DOI database lookup

The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data

1 reference

https://api.crossref.org/works/10.1038%2FS41398-018-0319-Z

7 January 2021

based on heuristic

inferred from DOI database lookup

Salmon provides fast and bias-aware quantification of transcript expression

1 reference

https://api.crossref.org/works/10.1038%2FS41398-018-0319-Z

7 January 2021

based on heuristic

inferred from DOI database lookup

Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

1 reference

https://api.crossref.org/works/10.1038%2FS41398-018-0319-Z

7 January 2021

based on heuristic

inferred from DOI database lookup

Taming Human Genetic Variability: Transcriptomic Meta-Analysis Guides the Experimental Design and Interpretation of iPSC-Based Disease Modeling

1 reference

https://api.crossref.org/works/10.1038%2FS41398-018-0319-Z

7 January 2021

based on heuristic

inferred from DOI database lookup

Effects of dependence in high-dimensional multiple testing problems

1 reference

https://api.crossref.org/works/10.1038%2FS41398-018-0319-Z

7 January 2021

based on heuristic

inferred from DOI database lookup

CellMix: a comprehensive toolbox for gene expression deconvolution

1 reference

https://api.crossref.org/works/10.1038%2FS41398-018-0319-Z

7 January 2021

based on heuristic

inferred from DOI database lookup

Semi-supervised Nonnegative Matrix Factorization for gene expression deconvolution: a case study

1 reference

https://api.crossref.org/works/10.1038%2FS41398-018-0319-Z

7 January 2021

based on heuristic

inferred from DOI database lookup

GeneMANIA Cytoscape plugin: fast gene function predictions on the desktop

1 reference

https://api.crossref.org/works/10.1038%2FS41398-018-0319-Z

7 January 2021

based on heuristic

inferred from DOI database lookup

WebGestalt 2017: a more comprehensive, powerful, flexible and interactive gene set enrichment analysis toolkit.

1 reference

https://api.crossref.org/works/10.1038%2FS41398-018-0319-Z

7 January 2021

based on heuristic

inferred from DOI database lookup

A genome-wide gene-expression analysis and database in transgenic mice during development of amyloid or tau pathology

1 reference

https://api.crossref.org/works/10.1038%2FS41398-018-0319-Z

7 January 2021

based on heuristic

inferred from DOI database lookup

Spatio-temporal transcriptome of the human brain

1 reference

https://api.crossref.org/works/10.1038%2FS41398-018-0319-Z

7 January 2021

based on heuristic

inferred from DOI database lookup

Frontotemporal dementia and its subtypes: a genome-wide association study

1 reference

https://api.crossref.org/works/10.1038%2FS41398-018-0319-Z

7 January 2021

based on heuristic

inferred from DOI database lookup

i-GSEA4GWAS: a web server for identification of pathways/gene sets associated with traits by applying an improved gene set enrichment analysis to genome-wide association study

1 reference

https://api.crossref.org/works/10.1038%2FS41398-018-0319-Z

7 January 2021

based on heuristic

inferred from DOI database lookup

Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap.

1 reference

https://api.crossref.org/works/10.1038%2FS41398-018-0319-Z

7 January 2021

based on heuristic

inferred from DOI database lookup

Common genetic variation drives molecular heterogeneity in human iPSCs

1 reference

https://api.crossref.org/works/10.1038%2FS41398-018-0319-Z

7 January 2021

based on heuristic

inferred from DOI database lookup

Tau Kinetics in Neurons and the Human Central Nervous System

1 reference

https://api.crossref.org/works/10.1038%2FS41398-018-0319-Z

7 January 2021

based on heuristic

inferred from DOI database lookup

Layer-specific markers as probes for neuron type identity in human neocortex and malformations of cortical development

1 reference

https://api.crossref.org/works/10.1038%2FS41398-018-0319-Z

7 January 2021

based on heuristic

inferred from DOI database lookup

Structural brain imaging in frontotemporal dementia.

1 reference

https://api.crossref.org/works/10.1038%2FS41398-018-0319-Z

7 January 2021

based on heuristic

inferred from DOI database lookup

Selective functional, regional, and neuronal vulnerability in frontotemporal dementia

1 reference

https://api.crossref.org/works/10.1038%2FS41398-018-0319-Z

7 January 2021

based on heuristic

inferred from DOI database lookup

Anterior insula degeneration in frontotemporal dementia

1 reference

https://api.crossref.org/works/10.1038%2FS41398-018-0319-Z

7 January 2021

based on heuristic

inferred from DOI database lookup

Expression and function of SNAP-25 as a universal SNARE component in GABAergic neurons.

1 reference

https://api.crossref.org/works/10.1038%2FS41398-018-0319-Z

7 January 2021

based on heuristic

inferred from DOI database lookup

Neuropathologic differentiation of progressive supranuclear palsy and corticobasal degeneration

1 reference

https://api.crossref.org/works/10.1038%2FS41398-018-0319-Z

7 January 2021

based on heuristic

inferred from DOI database lookup

Genome-wide association study of corticobasal degeneration identifies risk variants shared with progressive supranuclear palsy

1 reference

https://api.crossref.org/works/10.1038%2FS41398-018-0319-Z

7 January 2021

based on heuristic

inferred from DOI database lookup

Shared genetic risk between corticobasal degeneration, progressive supranuclear palsy, and frontotemporal dementia

1 reference

https://api.crossref.org/works/10.1038%2FS41398-018-0319-Z

7 January 2021

based on heuristic

inferred from DOI database lookup

Glutamate and GABA receptor signalling in the developing brain.

1 reference

https://api.crossref.org/works/10.1038%2FS41398-018-0319-Z

7 January 2021

based on heuristic

inferred from DOI database lookup

GAD65, GAD67, and GABAT immunostaining in human brain and apparent GAD65 loss in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1038%2FS41398-018-0319-Z

7 January 2021

based on heuristic

inferred from DOI database lookup

APache Is an AP2-Interacting Protein Involved in Synaptic Vesicle Trafficking and Neuronal Development

1 reference

https://api.crossref.org/works/10.1038%2FS41398-018-0319-Z

7 January 2021

based on heuristic

inferred from DOI database lookup

Tau pathology induces loss of GABAergic interneurons leading to altered synaptic plasticity and behavioral impairments.

1 reference

https://api.crossref.org/works/10.1038%2FS41398-018-0319-Z

7 January 2021

based on heuristic

inferred from DOI database lookup

Genetic correction of tauopathy phenotypes in neurons derived from human induced pluripotent stem cells

1 reference

https://api.crossref.org/works/10.1038%2FS41398-018-0319-Z

7 January 2021

based on heuristic

inferred from DOI database lookup

Tau mutant A152T, a risk factor for FTD/PSP, induces neuronal dysfunction and reduced lifespan independently of aggregation in a C. elegans Tauopathy model

1 reference

https://api.crossref.org/works/10.1038%2FS41398-018-0319-Z

7 January 2021

based on heuristic

inferred from DOI database lookup

γ-Aminobutyric acid type A (GABAA) receptor activation modulates tau phosphorylation.

1 reference

https://api.crossref.org/works/10.1038%2FS41398-018-0319-Z

7 January 2021

based on heuristic

inferred from DOI database lookup

Neurons and their dendrites in frontotemporal dementia

1 reference

https://api.crossref.org/works/10.1038%2FS41398-018-0319-Z

7 January 2021

based on heuristic

inferred from DOI database lookup

Alterations of GABAergic neurons in the basal ganglia of patients with progressive supranuclear palsy: an in situ hybridization study of GAD67 messenger RNA.

1 reference

https://api.crossref.org/works/10.1038%2FS41398-018-0319-Z

7 January 2021

based on heuristic

inferred from DOI database lookup

PET measures of benzodiazepine receptors in progressive supranuclear palsy

1 reference

https://api.crossref.org/works/10.1038%2FS41398-018-0319-Z

7 January 2021

based on heuristic

inferred from DOI database lookup

Neurotransmitter deficits from frontotemporal lobar degeneration

1 reference

https://api.crossref.org/works/10.1038%2FS41398-018-0319-Z

7 January 2021

based on heuristic

inferred from DOI database lookup

Frontotemporal lobar degeneration: a consensus on clinical diagnostic criteria

1 reference

https://api.crossref.org/works/10.1038%2FS41398-018-0319-Z

7 January 2021

based on heuristic

inferred from DOI database lookup

Clinical features of frontotemporal dementia

1 reference

https://api.crossref.org/works/10.1038%2FS41398-018-0319-Z

7 January 2021

based on heuristic

inferred from DOI database lookup

Treatment Options in Alzheimer´s Disease: The GABA Story

1 reference

https://api.crossref.org/works/10.1038%2FS41398-018-0319-Z

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy

1 reference

https://api.crossref.org/works/10.1038%2FS41398-018-0319-Z

7 January 2021

based on heuristic

inferred from DOI database lookup

A common inversion under selection in Europeans

1 reference

https://api.crossref.org/works/10.1038%2FS41398-018-0319-Z

7 January 2021

based on heuristic

inferred from DOI database lookup

Genome-wide association study reveals genetic risk underlying Parkinson's disease

1 reference

https://api.crossref.org/works/10.1038%2FS41398-018-0319-Z

7 January 2021

based on heuristic

inferred from DOI database lookup

The GABAergic septohippocampal connection is impaired in a mouse model of tauopathy.

1 reference

https://api.crossref.org/works/10.1038%2FS41398-018-0319-Z

7 January 2021

based on heuristic

inferred from DOI database lookup

Selective degeneration of septal and hippocampal GABAergic neurons in a mouse model of amyloidosis and tauopathy

1 reference

https://api.crossref.org/works/10.1038%2FS41398-018-0319-Z

7 January 2021

based on heuristic

inferred from DOI database lookup

Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1038%2FS41398-018-0319-Z

7 January 2021

based on heuristic

inferred from DOI database lookup

Multiscale Analysis of Independent Alzheimer’s Cohorts Finds Disruption of Molecular, Genetic, and Clinical Networks by Human Herpesvirus

1 reference

https://api.crossref.org/works/10.1038%2FS41398-018-0319-Z

7 January 2021

based on heuristic

inferred from DOI database lookup

Pathogenic missense MAPT mutations differentially modulate tau aggregation propensity at nucleation and extension steps

1 reference

https://pubmed.ncbi.nlm.nih.gov/30546007

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A Systems View of the Differences between APOE ε4 Carriers and Non-carriers in Alzheimer's Disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/30546007

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1038/S41398-018-0319-Z

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30546007%20AND%20SRC:MED&resulttype=core&format=json

14 April 2020

Dimensions Publication ID

0 references

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30546007%20AND%20SRC:MED&resulttype=core&format=json

14 April 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30546007%20AND%20SRC:MED&resulttype=core&format=json

14 April 2020

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