(Q60624306)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10862817%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

title

Effect of substituents on microsomal reduction of benzo(c)fluorene N-oxides (English)

1 reference

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7 November 2019

1

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7 November 2019

Barbora Szotáková

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10862817%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

Vladimír Wsól

4

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7 November 2019

Vladimír Kubíček

5

1 reference

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7 November 2019

author name string

M Nobilis

2

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7 November 2019

V Baliharová

6

1 reference

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7 November 2019

E Kvasnicková

7

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7 November 2019

publication date

1 June 2000

1 reference

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Chemico-biological Interactions

7 November 2019

published in

1 reference

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7 November 2019

volume

126

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7 November 2019

issue

3

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7 November 2019

page(s)

185-200

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Rationale for the use of aliphatic N-oxides of cytotoxic anthraquinones as prodrug DNA binding agents: a new class of bioreductive agent

7 November 2019

cites work

1 reference

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Hypoxia-selective antitumor agents. 11. Chlorambucil N-oxide: a reappraisal of its synthesis, stability, and selective toxicity for hypoxic cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900164-2

Adaptation of human tumor cells to tirapazamine under aerobic conditions: implications of increased antioxidant enzyme activity to mechanism of aerobic cytotoxicity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900164-2

Pharmacokinetics of the hypoxic cell cytotoxic agent tirapazamine and its major bioreductive metabolites in mice and humans: retrospective analysis of a pharmacokinetically guided dose-escalation strategy in a phase I trial

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900164-2

Hypoxia-selective agents derived from quinoxaline 1,4-di-N-oxides

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900164-2

Bis-bioreductive agents as hypoxia-selective cytotoxins: nitracrine N-oxide

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900164-2

Enzymology of the reduction of the novel fused pyrazine mono-n-oxide bioreductive drug, RB90740 roles for P450 reductase and cytochrome b5 reductase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900164-2

Enzymology of the reduction of the potent benzotriazine-di-n-oxide hypoxic cell cytotoxin SR 4233 (win 59075) by NAD(P)H: (Quinone acceptor) oxidoreductase (EC 1.6.99.2) purified from walker 256 rat tumour cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900164-2

Reduction of 3-amino-1,2,4-benzotriazine-1,4-di-N-oxide (tirapazamine, WIN 59075, SR 4233) to a DNA-damaging species: a direct role for NADPH:cytochrome P450 oxidoreductase.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900164-2

The role of cytochrome P450 and cytochrome P450 reductase in the reductive bioactivation of the novel benzotriazine di-N-oxide hypoxic cytotoxin 3-amino-l,2,4-benzotriazine-l ,4-dioxide (SR 4233, WIN 59075) by mouse liver

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900164-2

Oxygen and xenobiotic reductase activities of cytochrome P450.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900164-2

Primary screening and inhibition of macromolecular biosynthesis in Ehrlich ascites cells by benzo(C)fluorene derivatives

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900164-2

Effects of benfluron and its two metabolites on respiratory processes in P388 murine leukemia and Ehrlich ascites cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900164-2

Study of the biotransformation of a potential benzo[c]fluorene antineoplastic using high-performance liquid chromatography with high-speed-scanning ultraviolet detection

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900164-2

Initial characterization of the major mouse cytochrome P450 enzymes involved in the reductive metabolism of the hypoxic cytotoxin 3-amino-1,2,4-benzotriazine-1,4-di-N-oxide (tirapazamine, SR 4233, WIN 59075)

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900164-2

Chromatographic characterization of in vitro metabolites of 5-[2-(N,N-dimethylamino)ethoxy]-7-oxo-7H-benzo[c]fluorene

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900164-2

Effect of substituents on the metabolism of nitracrine in rat

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900164-2

Hypoxia-selective antitumor agents. 13. Effects of acridine substitution on the hypoxia-selective cytotoxicity and metabolic reduction of the bis-bioreductive agent nitracrine N-oxide

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2800%2900164-2

10.1016/S0009-2797(00)00164-2

7 January 2021

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10862817%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

1 reference