(Q64057301)

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Analysis of the antigenic determinants of the OspC protein of the Lyme disease spirochetes: Evidence that the C10 motif is not immunodominant or required to elicit bactericidal antibody responses

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scholarly article

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Analysis of the antigenic determinants of the OspC protein of the Lyme disease spirochetes: Evidence that the C10 motif is not immunodominant or required to elicit bactericidal antibody responses (English)

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Lyme disease vaccine

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infectious disease

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based on heuristic

inferred from title

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based on heuristic

inferred from title

Edward Breitschwerdt

6

object named as

Edward B Breitschwerdt

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author name string

Jerilyn R Izac

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Andrew C Camire

2

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Christopher G Earnhart

3

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Monica E Embers

4

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Rebecca A Funk

5

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Richard T Marconi

7

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language of work or name

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publication date

17 April 2019

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37

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17

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2401-2407

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A phylogenomic and molecular marker based proposal for the division of the genus Borrelia into two genera: the emended genus Borrelia containing only the members of the relapsing fever Borrelia, and the genus Borreliella gen. nov. containing the mem

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Widespread dispersal of Borrelia burgdorferi-infected ticks collected from songbirds across Canada

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Host, habitat and climate preferences of Ixodes angustus (Acari: Ixodidae) and infection with Borrelia burgdorferi and Anaplasma phagocytophilum in California, USA.

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Borrelia burgdorferi Infection and Lyme Disease in North American Horses: A Consensus Statement.

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ACVIM consensus update on Lyme borreliosis in dogs and cats.

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Temporal regulation of outer surface proteins of the Lyme-disease spirochaete Borrelia burgdorferi

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OspA immunization decreases transmission of Borrelia burgdorferi spirochetes from infected Peromyscus leucopus mice to larval Ixodes scapularis ticks

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Elimination of Borrelia burgdorferi from vector ticks feeding on OspA-immunized mice

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Crystal structure of outer surface protein C (OspC) from the Lyme disease spirochete, Borrelia burgdorferi

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Crystal structure of Lyme disease antigen outer surface protein C from Borrelia burgdorferi

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OspC phylogenetic analyses support the feasibility of a broadly protective polyvalent chimeric Lyme disease vaccine

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Active immunization with pC protein ofBorrelia burgdorferi protects gerbils againstB. burgdorferi infection

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Analysis of antibody response in humans to the type A OspC loop 5 domain and assessment of the potential utility of the loop 5 epitope in Lyme disease vaccine development

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Inferring epitopes of a polymorphic antigen amidst broadly cross-reactive antibodies using protein microarrays: a study of OspC proteins of Borrelia burgdorferi

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Development of an OspC-based tetravalent, recombinant, chimeric vaccinogen that elicits bactericidal antibody against diverse Lyme disease spirochete strains.

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Demonstration of OspC type diversity in invasive human lyme disease isolates and identification of previously uncharacterized epitopes that define the specificity of the OspC murine antibody response.

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An Octavalent Lyme Disease Vaccine Induces Antibodies That Recognize All Incorporated ospC Type-Specific Sequences

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Assessment of the potential contribution of the highly conserved C-terminal motif (C10) of Borrelia burgdorferi outer surface protein C in transmission and infectivity

1 reference

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C-terminal region of outer surface protein C binds borreliacidal antibodies in sera from patients with Lyme disease

1 reference

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Borreliacidal OspC antibodies specific for a highly conserved epitope are immunodominant in human lyme disease and do not occur in mice or hamsters

1 reference

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Borreliacidal OspC antibody response of canines with Lyme disease differs significantly from that of humans with Lyme disease

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Borreliacidal antibody production against outer surface protein C of Borrelia burgdorferi

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Antibody profiling of canine IgG responses to the OspC protein of the Lyme disease spirochetes supports a multivalent approach in vaccine and diagnostic assay development

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Identification of residues within ligand-binding domain 1 (LBD1) of the Borrelia burgdorferi OspC protein required for function in the mammalian environment.

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Five-Antigen Fluorescent Bead-Based Assay for Diagnosis of Lyme Disease

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Investigation of ospC Expression Variation among Borrelia burgdorferi Strains

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Rapid clearance of Lyme disease spirochetes lacking OspC from skin

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Crystallization and preliminary X-ray analysis of Borrelia burgdorferi outer surface protein C (OspC)

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Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi

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Disease severity in a murine model of lyme borreliosis is associated with the genotype of the infecting Borrelia burgdorferi sensu stricto strain

1 reference

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Conformational nature of the Borrelia burgdorferi B31 outer surface protein C protective epitope

1 reference

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based on heuristic

inferred from DOI database lookup

Outer surface protein C (OspC), but not P39, is a protective immunogen against a tick-transmitted Borrelia burgdorferi challenge: evidence for a conformational protective epitope in OspC

1 reference

https://pubmed.ncbi.nlm.nih.gov/30922701

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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1 reference

https://pubmed.ncbi.nlm.nih.gov/30922701

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based on heuristic

inferred from PubMed ID database lookup

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1 reference

https://pubmed.ncbi.nlm.nih.gov/30922701

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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1 reference

https://pubmed.ncbi.nlm.nih.gov/30922701

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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1 reference

https://pubmed.ncbi.nlm.nih.gov/30922701

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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1 reference

https://pubmed.ncbi.nlm.nih.gov/30922701

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhanced Protective Immunogenicity of Homodimeric Borrelia burgdorferi Outer Surface Protein C.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30922701

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based on heuristic

inferred from PubMed ID database lookup

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10.1016/J.VACCINE.2019.02.007

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