(Q64061529)

English

Apigenin Combined With Gefitinib Blocks Autophagy Flux and Induces Apoptotic Cell Death Through Inhibition of HIF-1α, c-Myc, p-EGFR, and Glucose Metabolism in EGFR L858R+T790M-Mutated H1975 Cells

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scholarly article

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Apigenin Combined With Gefitinib Blocks Autophagy Flux and Induces Apoptotic Cell Death Through Inhibition of HIF-1α, c-Myc, p-EGFR, and Glucose Metabolism in EGFR L858R+T790M-Mutated H1975 Cells (English)

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apoptotic process

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author name string

ZiSheng Chen

1

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Dongbo Tian

2

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Xiaowen Liao

3

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Yifei Zhang

4

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Jinghua Xiao

5

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Weiping Chen

6

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Qingxia Liu

7

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Yun Chen

8

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Dongmin Li

9

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Lianyu Zhu

10

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Shaoxi Cai

11

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language of work or name

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publication date

2019

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Frontiers in Pharmacology

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10

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260

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copyright license

Creative Commons Attribution 4.0 International

22 March 2019

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April 2022 Public Data File from Crossref

copyright status

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Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors

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https://pubmed.ncbi.nlm.nih.gov/30967777

12 December 2020

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Principles of CDK regulation

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https://pubmed.ncbi.nlm.nih.gov/30967777

12 December 2020

based on heuristic

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Flavonoids are potential inhibitors of glucose uptake in U937 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30967777

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apigenin inhibits expression of vascular endothelial growth factor and angiogenesis in human lung cancer cells: implication of chemoprevention of lung cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/30967777

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Monitoring tumor glucose utilization by positron emission tomography for the prediction of treatment response to epidermal growth factor receptor kinase inhibitors

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https://pubmed.ncbi.nlm.nih.gov/30967777

12 December 2020

based on heuristic

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Epidermal growth factor receptor mutations in lung cancer

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https://pubmed.ncbi.nlm.nih.gov/30967777

12 December 2020

based on heuristic

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Blockade of beta-catenin signaling by plant flavonoid apigenin suppresses prostate carcinogenesis in TRAMP mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/30967777

12 December 2020

based on heuristic

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Efficacy, pharmacokinetics, tisssue distribution, and metabolism of the Myc-Max disruptor, 10058-F4 [Z,E]-5-[4-ethylbenzylidine]-2-thioxothiazolidin-4-one, in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/30967777

12 December 2020

based on heuristic

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Apigenin inhibits the GLUT-1 glucose transporter and the phosphoinositide 3-kinase/Akt pathway in human pancreatic cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30967777

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypoxia, HIF1 and glucose metabolism in the solid tumour

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https://pubmed.ncbi.nlm.nih.gov/30967777

12 December 2020

based on heuristic

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Autophagy: renovation of cells and tissues

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https://pubmed.ncbi.nlm.nih.gov/30967777

12 December 2020

based on heuristic

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Synergistic effects of apigenin and paclitaxel on apoptosis of cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30967777

12 December 2020

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Hypoxia induces gefitinib resistance in non-small-cell lung cancer with both mutant and wild-type epidermal growth factor receptors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30967777

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucose transporters in cancer metabolism

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https://pubmed.ncbi.nlm.nih.gov/30967777

12 December 2020

based on heuristic

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Silencing of GLUT-1 inhibits sensitization of oral cancer cells to cisplatin during hypoxia

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https://pubmed.ncbi.nlm.nih.gov/30967777

12 December 2020

based on heuristic

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Epidermal growth factor receptor (EGFR) signaling regulates global metabolic pathways in EGFR-mutated lung adenocarcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/30967777

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Erlotinib-cisplatin combination inhibits growth and angiogenesis through c-MYC and HIF-1α in EGFR-mutated lung cancer in vitro and in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/30967777

12 December 2020

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The road to effective tobacco control in China

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https://pubmed.ncbi.nlm.nih.gov/30967777

12 December 2020

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Chloroquine enhances gefitinib cytotoxicity in gefitinib-resistant nonsmall cell lung cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30967777

12 December 2020

based on heuristic

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Lung cancer incidence trends by gender, race and histology in the United States, 1973-2010

1 reference

https://pubmed.ncbi.nlm.nih.gov/30967777

12 December 2020

based on heuristic

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AZD9291 in EGFR inhibitor-resistant non-small-cell lung cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/30967777

12 December 2020

based on heuristic

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The cell cycle regulator 14-3-3σ opposes and reverses cancer metabolic reprogramming

1 reference

https://pubmed.ncbi.nlm.nih.gov/30967777

12 December 2020

based on heuristic

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Epidemiology of lung cancer in China

1 reference

https://pubmed.ncbi.nlm.nih.gov/30967777

12 December 2020

based on heuristic

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Molecular Epidemiology of EGFR Mutations in Asian Patients with Advanced Non-Small-Cell Lung Cancer of Adenocarcinoma Histology - Mainland China Subset Analysis of the PIONEER study

1 reference

https://pubmed.ncbi.nlm.nih.gov/30967777

12 December 2020

based on heuristic

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BIM and mTOR expression levels predict outcome to erlotinib in EGFR-mutant non-small-cell lung cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/30967777

12 December 2020

based on heuristic

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Drug Resistance to EGFR Inhibitors in Lung Cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/30967777

12 December 2020

based on heuristic

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Third-generation inhibitors targeting EGFR T790M mutation in advanced non-small cell lung cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/30967777

12 December 2020

based on heuristic

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PARP Inhibition Suppresses Growth of EGFR-Mutant Cancers by Targeting Nuclear PKM2

1 reference

https://pubmed.ncbi.nlm.nih.gov/30967777

12 December 2020

based on heuristic

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Simvastatin induces cell cycle arrest and inhibits proliferation of bladder cancer cells via PPARγ signalling pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/30967777

12 December 2020

based on heuristic

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Role of Apigenin in Cancer Prevention via the Induction of Apoptosis and Autophagy

1 reference

https://pubmed.ncbi.nlm.nih.gov/30967777

12 December 2020

based on heuristic

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Targeting MYC Dependence by Metabolic Inhibitors in Cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/30967777

12 December 2020

based on heuristic

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GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30967777

12 December 2020

based on heuristic

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The distinct metabolic phenotype of lung squamous cell carcinoma defines selective vulnerability to glycolytic inhibition.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30967777

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeting Hypoxia to Improve Non-Small Cell Lung Cancer Outcome

1 reference

https://pubmed.ncbi.nlm.nih.gov/30967777

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of glucose transporter 1 and prognosis in non-small cell lung cancer: a pooled analysis of 1665 patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/30967777

12 December 2020

based on heuristic

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Apigenin in cancer therapy: anti-cancer effects and mechanisms of action.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30967777

12 December 2020

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Understanding and targeting resistance mechanisms in NSCLC.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30967777

12 December 2020

based on heuristic

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Identifiers

10.3389/FPHAR.2019.00260

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