(Q64282814)

1

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Stephen T Guest

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Victoria J Findlay

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Robin C Muise-Helmericks

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Kent Armeson

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Stephen P Ethier

Ultrastructural and immunocytochemical characterization of an immortalized human breast epithelial cell line, MCF-10

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language of work or name

English

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publication date

23 May 2019

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published in

BMC Cancer

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volume

19

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issue

1

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page(s)

491

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cites work

1 reference

12 December 2020

Tumor progression in four mammary epithelial cell lines derived from the same patient

1 reference

12 December 2020

The Translation Initiation Factor eIF-4E Binds to a Common Motif Shared by the Translation Factor eIF-4γ and the Translational Repressors 4E-Binding Proteins

1 reference

12 December 2020

FGFRI andPLAT genes and DNA amplification at 8p 12 in breast and ovarian cancers

1 reference

12 December 2020

Characterization of the region of the short arm of chromosome 8 amplified in breast carcinoma.

1 reference

12 December 2020

Phosphorylation of PHAS-I by mitogen-activated protein (MAP) kinase. Identification of a site phosphorylated by MAP kinase in vitro and in response to insulin in rat adipocytes

1 reference

12 December 2020

Differential isolation of normal luminal mammary epithelial cells and breast cancer cells from primary and metastatic sites using selective media

1 reference

12 December 2020

Cap-binding protein (eukaryotic initiation factor 4E) and 4E-inactivating protein BP-1 independently regulate cap-dependent translation

1 reference

12 December 2020

Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin

1 reference

12 December 2020

Mapping of DNA amplifications at 15 chromosomal localizations in 1875 breast tumors: definition of phenotypic groups

1 reference

12 December 2020

Chromosome region 8p11-p21: Refined mapping and molecular alterations in breast cancer

1 reference

12 December 2020

Differential expression assay of chromosome arm 8p genes identifies Frizzled-related (FRP1/FRZB) and Fibroblast Growth Factor Receptor 1 (FGFR1) as candidate breast cancer genes

1 reference

12 December 2020

Protein kinase B localization and activation differentially affect S6 kinase 1 activity and eukaryotic translation initiation factor 4E-binding protein 1 phosphorylation

1 reference

12 December 2020

Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism

1 reference

12 December 2020

Dissociation of the eukaryotic initiation factor-4E/4E-BP1 complex involves phosphorylation of 4E-BP1 by an mTOR-associated kinase

1 reference

12 December 2020

Molecular cytogenetic analysis of 11 new breast cancer cell lines

1 reference

12 December 2020

Substrate specificities and identification of putative substrates of ATM kinase family members

1 reference

12 December 2020

Human breast cancer cell lines as models of growth regulation and disease progression

1 reference

12 December 2020

Participation of ATM in insulin signalling through phosphorylation of eIF-4E-binding protein 1.

1 reference

12 December 2020

Cell cycle-dependent phosphorylation of the translational repressor eIF-4E binding protein-1 (4E-BP1)

1 reference

12 December 2020

Hierarchical phosphorylation of the translation inhibitor 4E-BP1

1 reference

12 December 2020

Phosphorylation of 4E-BP1 is mediated by the p38/MSK1 pathway in response to UVB irradiation

1 reference

12 December 2020

Gene expression profiling predicts clinical outcome of breast cancer

1 reference

12 December 2020

The mammalian target of rapamycin (mTOR) partner, raptor, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motif

1 reference

12 December 2020

Target of rapamycin (TOR)-signaling and RAIP motifs play distinct roles in the mammalian TOR-dependent phosphorylation of initiation factor 4E-binding protein 1

1 reference

12 December 2020

Genomic and expression analysis of the 8p11-12 amplicon in human breast cancer cell lines

1 reference

12 December 2020

eIF4E binding protein 1 and H-Ras are novel substrates for the protein kinase activity of class-I phosphoinositide 3-kinase

1 reference

12 December 2020

Genomic organization of the 8p11-p12 amplicon in three breast cancer cell lines

1 reference

12 December 2020

Transforming potential of alternatively spliced variants of fibroblast growth factor receptor 2 in human mammary epithelial cells

1 reference

12 December 2020

Prognostic relevance of gene amplifications and coamplifications in breast cancer

1 reference

12 December 2020

Distinct signaling events downstream of mTOR cooperate to mediate the effects of amino acids and insulin on initiation factor 4E-binding proteins

1 reference

12 December 2020

A 1 Mb minimal amplicon at 8p11-12 in breast cancer identifies new candidate oncogenes

1 reference

12 December 2020

Paclitaxel induces the phosphorylation of the eukaryotic translation initiation factor 4E-binding protein 1 through a Cdk1-dependent mechanism

1 reference

12 December 2020

Comprehensive profiling of 8p11-12 amplification in breast cancer

1 reference

12 December 2020

Activation of mammalian target of rapamycin (mTOR) by insulin is associated with stimulation of 4EBP1 binding to dimeric mTOR complex 1

1 reference

12 December 2020

Transforming function of the LSM1 oncogene in human breast cancers with the 8p11-12 amplicon

1 reference

12 December 2020

FGFR1 emerges as a potential therapeutic target for lobular breast carcinomas

1 reference

12 December 2020

Genomic and transcriptional aberrations linked to breast cancer pathophysiologies

1 reference

12 December 2020

Multiple interacting oncogenes on the 8p11-p12 amplicon in human breast cancer

1 reference

12 December 2020

4E-binding protein 1, a cell signaling hallmark in breast cancer that correlates with pathologic grade and prognosis

1 reference

12 December 2020

Human eukaryotic release factor 3a depletion causes cell cycle arrest at G1 phase through inhibition of the mTOR pathway

1 reference

12 December 2020

The endoplasmic reticulum stress-inducible protein Niban regulates eIF2alpha and S6K1/4E-BP1 phosphorylation

1 reference

12 December 2020

Effects of protein phosphorylation on ubiquitination and stability of the translational inhibitor protein 4E-BP1.

1 reference

12 December 2020

4E-binding protein 1: a key molecular "funnel factor" in human cancer with clinical implications

1 reference

12 December 2020

Regulation of cyclin D1 expression by mTORC1 signaling requires eukaryotic initiation factor 4E-binding protein 1.

1 reference

12 December 2020

A hypoxia-controlled cap-dependent to cap-independent translation switch in breast cancer.

1 reference

12 December 2020

Characterization of the recurrent 8p11-12 amplicon identifies PPAPDC1B, a phosphatase protein, as a new therapeutic target in breast cancer

1 reference

12 December 2020

S6 kinase 1 regulates estrogen receptor alpha in control of breast cancer cell proliferation

1 reference

12 December 2020

Co-amplified genes at 8p12 and 11q13 in breast tumors cooperate with two major pathways in oncogenesis

1 reference

12 December 2020

Combined analysis of eIF4E and 4E-binding protein expression predicts breast cancer survival and estimates eIF4E activity

1 reference

12 December 2020

RCP is a human breast cancer-promoting gene with Ras-activating function

1 reference

12 December 2020

mTOR/S6K1 and MAPK/RSK signaling pathways coordinately regulate estrogen receptor alpha serine 167 phosphorylation

1 reference

12 December 2020

An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patients

1 reference

12 December 2020

FGFR1 amplification drives endocrine therapy resistance and is a therapeutic target in breast cancer

1 reference

12 December 2020

Control of contact-inhibition by 4E-BP1 upregulation

1 reference

12 December 2020

A functional link between polo-like kinase 1 and the mammalian target-of-rapamycin pathway?

1 reference

12 December 2020

Predictive biomarkers of sensitivity to the phosphatidylinositol 3' kinase inhibitor GDC-0941 in breast cancer preclinical models

1 reference

12 December 2020

Hyperactivation of phosphatidylinositol-3 kinase promotes escape from hormone dependence in estrogen receptor-positive human breast cancer

1 reference

12 December 2020

4E-BP1 is a key effector of the oncogenic activation of the AKT and ERK signaling pathways that integrates their function in tumors

1 reference

12 December 2020

Transforming Properties of 8p11-12 Amplified Genes in Human Breast Cancer

1 reference

12 December 2020

ZNF703 gene amplification at 8p12 specifies luminal B breast cancer

1 reference

12 December 2020

ZNF703 is a common Luminal B breast cancer oncogene that differentially regulates luminal and basal progenitors in human mammary epithelium

1 reference

12 December 2020

Who is in the driver's seat in 8p12 amplifications? ZNF703 in luminal B breast tumors

1 reference

12 December 2020

Association between LRRK2 and 4E-BP1 protein levels in normal and malignant cells

1 reference

12 December 2020

Estrogenic regulation of S6K1 expression creates a positive regulatory loop in control of breast cancer cell proliferation

1 reference

12 December 2020

Inhibition of PI3K/mTOR leads to adaptive resistance in matrix-attached cancer cells

1 reference

12 December 2020

The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups

1 reference

12 December 2020

The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data

1 reference

12 December 2020

ERLIN2 promotes breast cancer cell survival by modulating endoplasmic reticulum stress pathways.

1 reference

12 December 2020

Amplified loci on chromosomes 8 and 17 predict early relapse in ER-positive breast cancers

1 reference

12 December 2020

4E-BP1 participates in maintaining spindle integrity and genomic stability via interacting with PLK1.

1 reference

12 December 2020

Mechanistic target of rapamycin complex 1 (mTORC1)-mediated phosphorylation is governed by competition between substrates for interaction with raptor

1 reference

12 December 2020

Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal

1 reference

12 December 2020

Glycogen synthase kinase-3β positively regulates protein synthesis and cell proliferation through the regulation of translation initiation factor 4E-binding protein 1.

1 reference

12 December 2020

Vitronectin-αvβ3 integrin engagement directs hypoxia-resistant mTOR activity and sustained protein synthesis linked to invasion by breast cancer cells.

1 reference

12 December 2020

Association of maternal mRNA and phosphorylated EIF4EBP1 variants with the spindle in mouse oocytes: localized translational control supporting female meiosis in mammals

1 reference

12 December 2020

PPAPDC1B and WHSC1L1 are common drivers of the 8p11-12 amplicon, not only in breast tumors but also in pancreatic adenocarcinomas and lung tumors.

1 reference

12 December 2020

The mTOR effectors 4EBP1 and S6K2 are frequently coexpressed, and associated with a poor prognosis and endocrine resistance in breast cancer: a retrospective study including patients from the randomised Stockholm tamoxifen trials

1 reference

12 December 2020

mTORC1 controls mitochondrial activity and biogenesis through 4E-BP-dependent translational regulation.

1 reference

12 December 2020

Eukaryotic translation initiation is controlled by cooperativity effects within ternary complexes of 4E-BP1, eIF4E, and the mRNA 5' cap

1 reference

12 December 2020

Casein kinase 1ε promotes cell proliferation by regulating mRNA translation

1 reference

12 December 2020

A phase II study of combined fulvestrant and everolimus in patients with metastatic estrogen receptor (ER)-positive breast cancer after aromatase inhibitor (AI) failure

1 reference

12 December 2020

Characterization of the Raptor/4E-BP1 interaction by chemical cross-linking coupled with mass spectrometry analysis

1 reference

12 December 2020

eRF3b, a biomarker for hepatocellular carcinoma, influences cell cycle and phosphoralation status of 4E-BP1.

1 reference

12 December 2020

MiR-99a antitumor activity in human breast cancer cells through targeting of mTOR expression

1 reference

12 December 2020

Sensitization of cancer cells through reduction of total Akt and downregulation of salinomycin-induced pAkt, pGSk3β, pTSC2, and p4EBP1 by cotreatment with MK-2206.

1 reference

12 December 2020

KAT6A, a chromatin modifier from the 8p11-p12 amplicon is a candidate oncogene in luminal breast cancer

1 reference

12 December 2020

Everolimus plus exemestane for hormone-receptor-positive, human epidermal growth factor receptor-2-negative advanced breast cancer: overall survival results from BOLERO-2†.

1 reference

12 December 2020

Absent, small or homeotic 2-like protein (ASH2L) enhances the transcription of the estrogen receptor α gene through GATA-binding protein 3 (GATA3).

1 reference

12 December 2020

CDK1 substitutes for mTOR kinase to activate mitotic cap-dependent protein translation

1 reference

12 December 2020

mTORC1 directly phosphorylates and activates ERα upon estrogen stimulation

1 reference

12 December 2020

Integrated Analysis of PTEN and p4EBP1 Protein Expression as Predictors for pCR in HER2-Positive Breast Cancer.

1 reference

12 December 2020

Eukaryotic initiation factor 4E-binding protein 1 (4E-BP1): a master regulator of mRNA translation involved in tumorigenesis.

1 reference

12 December 2020

Stabilization of p21 by mTORC1/4E-BP1 predicts clinical outcome of head and neck cancers.

1 reference

12 December 2020

4E-BP1, a multifactor regulated multifunctional protein

1 reference

12 December 2020

Amplification of WHSC1L1 regulates expression and estrogen-independent activation of ERα in SUM-44 breast cancer cells and is associated with ERα over-expression in breast cancer

1 reference

12 December 2020

Functional oncogene signatures guide rationally designed combination therapies to synergistically induce breast cancer cell death

1 reference

12 December 2020

Mitotic protein kinase CDK1 phosphorylation of mRNA translation regulator 4E-BP1 Ser83 may contribute to cell transformation

1 reference

12 December 2020

Silencing c-Myc translation as a therapeutic strategy through targeting PI3Kδ and CK1ε in hematological malignancies

1 reference

12 December 2020

Identification of MYST3 as a novel epigenetic activator of ERα frequently amplified in breast cancer

1 reference

12 December 2020

Regulation of 4E-BP1 activity in the mammalian oocyte

1 reference

12 December 2020

A phase II study of combined ridaforolimus and dalotuzumab compared with exemestane in patients with estrogen receptor-positive breast cancer.

1 reference

12 December 2020

Development of mammary hyperplasia, dysplasia, and invasive ductal carcinoma in transgenic mice expressing the 8p11 amplicon oncogene NSD3.

1 reference

12 December 2020

Stabilization of 4E-BP1 by PI3K kinase and its involvement in CHK2 phosphorylation in the cellular response to radiation

1 reference

12 December 2020

Association of FGFR1 with ERαmaintains ligand-independent ER transcription and mediates resistance to estrogen deprivation in ER+ breast cancer.

1 reference

12 December 2020

Defining a Cancer Dependency Map.

1 reference

12 December 2020

Genomic profiling of ER+ breast cancers after short-term estrogen suppression reveals alterations associated with endocrine resistance.

1 reference

12 December 2020

Computational correction of copy number effect improves specificity of CRISPR-Cas9 essentiality screens in cancer cells.

1 reference

12 December 2020

Meeting the meiotic challenge: Specializations in mammalian oocyte spindle formation

1 reference

12 December 2020

Genome-wide multi-omics profiling of the 8p11-p12 amplicon in breast carcinoma.

1 reference

12 December 2020

Improved estimation of cancer dependencies from large-scale RNAi screens using model-based normalization and data integration

1 reference

12 December 2020