(Q64976796)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29487216%20AND%20SRC:MED&resulttype=core&format=json

18 March 2020

title

Identification of a highly neurotoxic α-synuclein species inducing mitochondrial damage and mitophagy in Parkinson's disease (English)

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18 March 2020

1 reference

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5

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18 March 2020

author name string

Diego Grassi

1

1 reference

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18 March 2020

Shannon Howard

2

1 reference

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18 March 2020

Minghai Zhou

3

1 reference

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18 March 2020

Natalia Diaz-Perez

4

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18 March 2020

Debbie Guerrero-Given

6

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18 March 2020

Naomi Kamasawa

7

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18 March 2020

Laura A Volpicelli-Daley

8

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18 March 2020

Philip LoGrasso

9

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18 March 2020

Corinne Ida Lasmézas

10

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18 March 2020

publication date

27 February 2018

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Proceedings of the National Academy of Sciences of the United States of America

18 March 2020

published in

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18 March 2020

volume

115

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18 March 2020

issue

11

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18 March 2020

page(s)

E2634-E2643

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High rates of fatty acid oxidation during reperfusion of ischemic hearts are associated with a decrease in malonyl-CoA levels due to an increase in 5'-AMP-activated protein kinase inhibition of acetyl-CoA carboxylase

18 March 2020

cites work

1 reference

12 December 2020

Alpha-synuclein in Lewy bodies

1 reference

12 December 2020

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

1 reference

12 December 2020

alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies

1 reference

12 December 2020

NACP/alpha-synuclein immunoreactivity in fibrillary components of neuronal and oligodendroglial cytoplasmic inclusions in the pontine nuclei in multiple system atrophy

1 reference

12 December 2020

Antibodies to alpha-synuclein detect Lewy bodies in many Down's syndrome brains with Alzheimer's disease.

1 reference

12 December 2020

Etiology and pathogenesis of Parkinson's disease

1 reference

12 December 2020

Genetic analysis of families with Parkinson disease that carry the Ala53Thr mutation in the gene encoding alpha-synuclein

1 reference

12 December 2020

Cytochrome c release from mitochondria: all or nothing

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12 December 2020

alpha-synuclein promotes mitochondrial deficit and oxidative stress

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12 December 2020

Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

1 reference

12 December 2020

Management of cellular energy by the AMP-activated protein kinase system

1 reference

12 December 2020

JNK-mediated induction of cyclooxygenase 2 is required for neurodegeneration in a mouse model of Parkinson's disease

1 reference

12 December 2020

The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia

1 reference

12 December 2020

Efficacy of MitoTracker Green and CMXrosamine to measure changes in mitochondrial membrane potentials in living cells and tissues

1 reference

12 December 2020

Gene dosage and pathogenesis of Parkinson's disease

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12 December 2020

Arsenic stimulates release of cytochrome c from isolated mitochondria via induction of mitochondrial permeability transition

1 reference

12 December 2020

Failures and successes of clinical trials for Parkinson disease treatments

1 reference

12 December 2020

A specific amyloid-beta protein assembly in the brain impairs memory

1 reference

12 December 2020

In vitro and in vivo neurotoxicity of prion protein oligomers.

1 reference

12 December 2020

Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease

1 reference

12 December 2020

Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation

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12 December 2020

Impaired mitochondrial dynamics and function in the pathogenesis of Parkinson's disease

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12 December 2020

Exogenous alpha-synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells

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12 December 2020

α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells

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12 December 2020

In vivo demonstration that alpha-synuclein oligomers are toxic

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12 December 2020

Recent advances in the genetics of Parkinson's disease

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12 December 2020

Exogenous α-synuclein fibrils induce Lewy body pathology leading to synaptic dysfunction and neuron death

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12 December 2020

Exosomal cell-to-cell transmission of alpha synuclein oligomers.

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12 December 2020

Mitochondrial reactive oxygen species enhance AMP-activated protein kinase activation in the endothelium of patients with coronary artery disease and diabetes

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12 December 2020

Pathological α-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice

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12 December 2020

Blocking c-Jun N-terminal kinase (JNK) translocation to the mitochondria prevents 6-hydroxydopamine-induced toxicity in vitro and in vivo.

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12 December 2020

The many faces of α-synuclein: from structure and toxicity to therapeutic target

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12 December 2020

Lewy body-like α-synuclein aggregates resist degradation and impair macroautophagy

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12 December 2020

Ubiquitin-independent proteasomal degradation

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12 December 2020

Calcium entry and α-synuclein inclusions elevate dendritic mitochondrial oxidant stress in dopaminergic neurons

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12 December 2020

Distinct α-synuclein strains differentially promote tau inclusions in neurons

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12 December 2020

New functions of mitochondria associated membranes in cellular signaling.

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12 December 2020

Addition of exogenous α-synuclein preformed fibrils to primary neuronal cultures to seed recruitment of endogenous α-synuclein to Lewy body and Lewy neurite-like aggregates.

1 reference

12 December 2020

Formation of α-synuclein Lewy neurite-like aggregates in axons impedes the transport of distinct endosomes

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12 December 2020

The endoplasmic reticulum/mitochondria interface: a subcellular platform for the orchestration of the functions of the PINK1-Parkin pathway?

1 reference

12 December 2020

α-Synuclein and Lewy pathology in Parkinson's disease

1 reference

12 December 2020

Aggregated α-synuclein and complex I deficiency: exploration of their relationship in differentiated neurons

1 reference

12 December 2020

Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism

1 reference

12 December 2020

MitoCarta2.0: an updated inventory of mammalian mitochondrial proteins

1 reference

12 December 2020

Oxidative Stress Attenuates Lipid Synthesis and Increases Mitochondrial Fatty Acid Oxidation in Hepatoma Cells Infected with Hepatitis C Virus

1 reference

12 December 2020

Metabolism. AMP-activated protein kinase mediates mitochondrial fission in response to energy stress

1 reference

12 December 2020

Mutations of glucocerebrosidase gene and susceptibility to Parkinson's disease: An updated meta-analysis in a European population

1 reference

12 December 2020

There's Something Wrong with my MAM; the ER-Mitochondria Axis and Neurodegenerative Diseases

1 reference

12 December 2020

Functionally different α-synuclein inclusions yield insight into Parkinson's disease pathology.

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12 December 2020

Implication of Alpha-Synuclein Phosphorylation at S129 in Synucleinopathies: What Have We Learned in the Last Decade?

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12 December 2020

α-Synuclein binds to TOM20 and inhibits mitochondrial protein import in Parkinson's disease

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12 December 2020

T cells from patients with Parkinson's disease recognize α-synuclein peptides

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12 December 2020

Asparagine endopeptidase cleaves α-synuclein and mediates pathologic activities in Parkinson's disease.

1 reference

12 December 2020

A conserved mammalian mitochondrial isoform of acetyl-CoA carboxylase ACC1 provides the malonyl-CoA essential for mitochondrial biogenesis in tandem with ACSF3.

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.1713849115

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29487216%20AND%20SRC:MED&resulttype=core&format=json

18 March 2020

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18 March 2020

PubMed publication ID

29487216

1 reference