(Q66679118)

pattern recognition receptors

title

Comparative Structure and Function Analysis of the RIG-I-Like Receptors: RIG-I and MDA5 (English)

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main subject

object has role

subject heading

object named as

PPRs

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DExD/H-box helicase 58

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Interferon induced with helicase C domain 1

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CARD

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pathogen-associated molecular pattern

object has role

subject heading

object named as

PAMP

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Creative Commons Attribution 4.0 International

author name string

Morgan Brisse

series ordinal

1

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Hinh Ly

series ordinal

2

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language of work or name

English

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publication date

2019

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17 July 2019

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25 May 2022

Frontiers in Immunology

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25 May 2022

10

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page(s)

1586

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copyright license

1 reference

Europe PubMed Central

Defective interfering particles with covalently linked [±]RNA induce interferon

25 May 2022

cites work

1 reference

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Defective interfering viruses

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Structure and origin of a novel class of defective interfering particle of vesicular stomatitis virus

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Reversal of the interferon-sensitive phenotype of a vaccinia virus lacking E3L by expression of the reovirus S4 gene.

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PACT, a protein activator of the interferon-induced protein kinase, PKR.

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Differential viral induction of distinct interferon-alpha genes by positive feedback through interferon regulatory factor-7

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Viral persistence: mechanisms and consequences

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Molecular evolution of glutamate receptors: a primitive signaling mechanism that existed before plants and animals diverged

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CARD9 is a novel caspase recruitment domain-containing protein that interacts with BCL10/CLAP and activates NF-kappa B

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Crystal structure of a DEAD box protein from the hyperthermophile Methanococcus jannaschii

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12 December 2020

PACT, a double-stranded RNA binding protein acts as a positive regulator for type I interferon gene induced by Newcastle disease virus.

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12 December 2020

mda-5: An interferon-inducible putative RNA helicase with double-stranded RNA-dependent ATPase activity and melanoma growth-suppressive properties

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12 December 2020

Retinoic acid-inducible gene-I is induced in endothelial cells by LPS and regulates expression of COX-2.

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12 December 2020

Overexpression of Helicard, a CARD-containing helicase cleaved during apoptosis, accelerates DNA degradation

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12 December 2020

IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway

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12 December 2020

Triggering the interferon antiviral response through an IKK-related pathway

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12 December 2020

The origin of polynucleotide phosphorylase domains

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12 December 2020

Retinoic acid-inducible gene-I is induced by interferon-gamma and regulates the expression of interferon-gamma stimulated gene 15 in MCF-7 cells

1 reference

12 December 2020

The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses

1 reference

12 December 2020

Expression of retinoic acid-inducible gene-I in vascular smooth muscle cells stimulated with interferon-gamma

1 reference

12 December 2020

Unlocking the DEAD-box: a key to cryptococcal virulence?

1 reference

12 December 2020

NOD-LRR proteins: role in host-microbial interactions and inflammatory disease

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12 December 2020

NACHT-LRR proteins (NLRs) in bacterial infection and immunity

1 reference

12 December 2020

Cell type-specific involvement of RIG-I in antiviral response

1 reference

12 December 2020

Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity

1 reference

12 December 2020

Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3

1 reference

12 December 2020

IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction

1 reference

12 December 2020

VISA is an adapter protein required for virus-triggered IFN-beta signaling

1 reference

12 December 2020

The interferon response circuit: induction and suppression by pathogenic viruses

1 reference

12 December 2020

Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses

1 reference

12 December 2020

Induction of IRF-3 and IRF-7 phosphorylation following activation of the RIG-I pathway

1 reference

12 December 2020

A novel role for viral-defective interfering particles in enhancing dendritic cell maturation.

1 reference

12 December 2020

RIG-I-mediated antiviral responses to single-stranded RNA bearing 5'-phosphates

1 reference

12 December 2020

5'-Triphosphate RNA is the ligand for RIG-I

1 reference

12 December 2020

Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2

1 reference

12 December 2020

MDA-5 is cleaved in poliovirus-infected cells

1 reference

12 December 2020

Multiple functions of the IKK-related kinase IKKepsilon in interferon-mediated antiviral immunity

1 reference

12 December 2020

TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity

1 reference

12 December 2020

Human TRBP and PACT directly interact with each other and associate with dicer to facilitate the production of small interfering RNA

1 reference

12 December 2020

Negative regulation of the RIG-I signaling by the ubiquitin ligase RNF125

1 reference

12 December 2020

Cytokine-independent upregulation of MDA5 in viral infection

1 reference

12 December 2020

Activation of the beta interferon promoter by unnatural Sendai virus infection requires RIG-I and is inhibited by viral C proteins

1 reference

12 December 2020

Rig-I-/- mice develop colitis associated with downregulation of G alpha i2.

1 reference

12 December 2020

Distinct RIG-I and MDA5 Signaling by RNA Viruses in Innate Immunity

1 reference

12 December 2020

Establishment and Maintenance of the Innate Antiviral Response to West Nile Virus Involves both RIG-I and MDA5 Signaling through IPS-1

1 reference

12 December 2020

A phylogenetic and functional overview of inflammatory caspases and caspase-1-related CARD-only proteins.

1 reference

12 December 2020

Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures

1 reference

12 December 2020

Nonself RNA-sensing mechanism of RIG-I helicase and activation of antiviral immune responses

1 reference

12 December 2020

The C-terminal regulatory domain is the RNA 5'-triphosphate sensor of RIG-I

1 reference

12 December 2020

Essential role of the N-terminal domain in the regulation of RIG-I ATPase activity

1 reference

12 December 2020

Porcine reproductive and respiratory syndrome virus (PRRSV) suppresses interferon-beta production by interfering with the RIG-I signaling pathway

1 reference

12 December 2020

MDA5 participates in the detection of paramyxovirus infection and is essential for the early activation of dendritic cells in response to Sendai Virus defective interfering particles

1 reference

12 December 2020

Biology of immune responses to vaccines in elderly persons

1 reference

12 December 2020

Processing of Genome 5′ Termini as a Strategy of Negative-Strand RNA Viruses to Avoid RIG-I-Dependent Interferon Induction

1 reference

12 December 2020

Innate immunity induced by composition-dependent RIG-I recognition of hepatitis C virus RNA

1 reference

12 December 2020

Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5

1 reference

12 December 2020

Viral targeting of DEAD box protein 3 reveals its role in TBK1/IKKepsilon-mediated IRF activation

1 reference

12 December 2020

Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmune diseases.

1 reference

12 December 2020

The role of PACT in mediating gene induction, PKR activation, and apoptosis in response to diverse stimuli

1 reference

12 December 2020

The Th2 transcription factor c-Maf inhibits IL-12p35 gene expression in activated macrophages by targeting NF-kappaB nuclear translocation

1 reference

12 December 2020

A brilliant disguise for self RNA: 5'-end and internal modifications of primary transcripts suppress elements of innate immunity

1 reference

12 December 2020

Roles of RIG-I N-terminal tandem CARD and splice variant in TRIM25-mediated antiviral signal transduction

1 reference

12 December 2020

Evolution of MDA-5/RIG-I-dependent innate immunity: independent evolution by domain grafting

1 reference

12 December 2020

Riplet/RNF135, a RING finger protein, ubiquitinates RIG-I to promote interferon-beta induction during the early phase of viral infection

1 reference

12 December 2020

Cytosolic viral sensor RIG-I is a 5'-triphosphate-dependent translocase on double-stranded RNA.

1 reference

12 December 2020

Approaching the RNA ligand for RIG-I?

1 reference

12 December 2020

Inhibition of RIG-I and MDA5-dependent antiviral response by gC1qR at mitochondria

1 reference

12 December 2020

MAVS self-association mediates antiviral innate immune signaling

1 reference

12 December 2020

Human respiratory syncytial virus nonstructural protein NS2 antagonizes the activation of beta interferon transcription by interacting with RIG-I

1 reference

12 December 2020

Nucleotide Sequences and Modifications That Determine RIG-I/RNA Binding and Signaling Activities

1 reference

12 December 2020

The levels of retinoic acid-inducible gene I are regulated by heat shock protein 90-alpha

1 reference

12 December 2020

Multiple-hit inhibition of infection by defective interfering particles

1 reference

12 December 2020

The RIG-I-like receptor LGP2 recognizes the termini of double-stranded RNA

1 reference

12 December 2020

Influenza A virus NS1 targets the ubiquitin ligase TRIM25 to evade recognition by the host viral RNA sensor RIG-I

1 reference

12 December 2020

REUL is a novel E3 ubiquitin ligase and stimulator of retinoic-acid-inducible gene-I

1 reference

12 December 2020

Structural basis of double-stranded RNA recognition by the RIG-I like receptor MDA5

1 reference

12 December 2020

Vaccination in the elderly: an immunological perspective

1 reference

12 December 2020

5'-triphosphate RNA requires base-paired structures to activate antiviral signaling via RIG-I

1 reference

12 December 2020

Recognition of 5' triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus

1 reference

12 December 2020

RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate

1 reference

12 December 2020

RIG-I is cleaved during picornavirus infection

1 reference

12 December 2020

RIG-I activation inhibits ebolavirus replication

1 reference

12 December 2020

RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway

1 reference

12 December 2020

Activation of MDA5 requires higher-order RNA structures generated during virus infection

1 reference

12 December 2020

An essential role for RIG-I in toll-like receptor-stimulated phagocytosis

1 reference

12 December 2020

The mechanism of ATP-dependent RNA unwinding by DEAD box proteins

1 reference

12 December 2020

Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1 beta production

1 reference

12 December 2020

Influenza A: understanding the viral life cycle

1 reference

12 December 2020

RIGorous detection: exposing virus through RNA sensing.

1 reference

12 December 2020

LGP2 is a positive regulator of RIG-I- and MDA5-mediated antiviral responses

1 reference

12 December 2020

Melanoma Differentiation-Associated Gene 5 (MDA5) Is Involved in the Innate Immune Response to Paramyxoviridae Infection In Vivo

1 reference

12 December 2020

LGP2: positive about viral sensing

1 reference

12 December 2020

RIG-I detects viral genomic RNA during negative-strand RNA virus infection

1 reference

12 December 2020

Pattern recognition receptors and inflammation

1 reference

12 December 2020

Association of RIG-I with innate immunity of ducks to influenza

1 reference

12 December 2020

Unpaired 5' ppp-nucleotides, as found in arenavirus double-stranded RNA panhandles, are not recognized by RIG-I

1 reference

12 December 2020

Reconstitution of the RIG-I pathway reveals a signaling role of unanchored polyubiquitin chains in innate immunity

1 reference

12 December 2020

Negative role of RIG-I serine 8 phosphorylation in the regulation of interferon-beta production

1 reference

12 December 2020

Respiratory syncytial virus-mediated NF-kappa B p65 phosphorylation at serine 536 is dependent on RIG-I, TRAF6, and IKK beta

1 reference

12 December 2020

NLRC5 negatively regulates the NF-kappaB and type I interferon signaling pathways

1 reference

12 December 2020

A common polymorphism in the caspase recruitment domain of RIG-I modifies the innate immune response of human dendritic cells

1 reference

12 December 2020

RIG-I mediates nonsegmented negative-sense RNA virus-induced inflammatory immune responses of primary human astrocytes

1 reference

12 December 2020

Structural and functional insights into 5′-ppp RNA pattern recognition by the innate immune receptor RIG-I

1 reference

12 December 2020

The Structural Basis of 5′ Triphosphate Double-Stranded RNA Recognition by RIG-I C-Terminal Domain

1 reference

12 December 2020

Preference of RIG-I for short viral RNA molecules in infected cells revealed by next-generation sequencing

1 reference

12 December 2020

Caspase-12 controls West Nile virus infection via the viral RNA receptor RIG-I.

1 reference

12 December 2020

RNase L releases a small RNA from HCV RNA that refolds into a potent PAMP.

1 reference

12 December 2020

Green tea catechin, epigallocatechin gallate, suppresses signaling by the dsRNA innate immune receptor RIG-I

1 reference

12 December 2020

Crystal structure of RIG-I C-terminal domain bound to blunt-ended double-strand RNA without 5' triphosphate

1 reference

12 December 2020

Phosphorylation of RIG-I by casein kinase II inhibits its antiviral response.

1 reference

12 December 2020

Retinoic acid inducible gene-I and melanoma differentiation-associated gene 5 are induced but not essential for dengue virus induced type I interferon response

1 reference

12 December 2020

Short double-stranded RNAs with an overhanging 5' ppp-nucleotide, as found in arenavirus genomes, act as RIG-I decoys

1 reference

12 December 2020

RIG-I/MDA5/MAVS are required to signal a protective IFN response in rotavirus-infected intestinal epithelium

1 reference

12 December 2020

New insights into the role of RNase L in innate immunity

1 reference

12 December 2020

Mechanism of inhibiting type I interferon induction by hepatitis B virus X protein

1 reference

12 December 2020

ARF-like protein 16 (ARL16) inhibits RIG-I by binding with its C-terminal domain in a GTP-dependent manner

1 reference

12 December 2020

Activation of IFN-β expression by a viral mRNA through RNase L and MDA5

1 reference

12 December 2020

RIG-I, MDA5 and TLR3 synergistically play an important role in restriction of dengue virus infection

1 reference

12 December 2020

Structure of the Lassa virus nucleoprotein reveals a dsRNA-specific 3' to 5' exonuclease activity essential for immune suppression

1 reference

12 December 2020

Differential recognition of viral RNA by RIG-I.

1 reference

12 December 2020

Characterization of chicken Mda5 activity: regulation of IFN-β in the absence of RIG-I functionality.

1 reference

12 December 2020

IRF7: activation, regulation, modification and function

1 reference

12 December 2020

The double-stranded RNA-binding protein PACT functions as a cellular activator of RIG-I to facilitate innate antiviral response

1 reference

12 December 2020

Immune signaling by RIG-I-like receptors

1 reference

12 December 2020

Molecular mechanism of signal perception and integration by the innate immune sensor retinoic acid-inducible gene-I (RIG-I).

1 reference

12 December 2020

Expression and functional characterization of the RIG-I-like receptors MDA5 and LGP2 in Rainbow trout (Oncorhynchus mykiss).

1 reference

12 December 2020

DDX1, DDX21, and DHX36 helicases form a complex with the adaptor molecule TRIF to sense dsRNA in dendritic cells

1 reference

12 December 2020

MAVS forms functional prion-like aggregates to activate and propagate antiviral innate immune response

1 reference

12 December 2020

DDX60, a DEXD/H box helicase, is a novel antiviral factor promoting RIG-I-like receptor-mediated signaling

1 reference

12 December 2020

Mitochondria in innate immunity

1 reference

12 December 2020

Vaccination in the elderly

1 reference

12 December 2020

Ubiquitin-mediated modulation of the cytoplasmic viral RNA sensor RIG-I.

1 reference

12 December 2020

DHX9 pairs with IPS-1 to sense double-stranded RNA in myeloid dendritic cells

1 reference

12 December 2020

The RIG-I ATPase domain structure reveals insights into ATP-dependent antiviral signalling

1 reference

12 December 2020

Structural basis for the activation of innate immune pattern-recognition receptor RIG-I by viral RNA

1 reference

12 December 2020

H5N1 influenza virus-induced mediators upregulate RIG-I in uninfected cells by paracrine effects contributing to amplified cytokine cascades

1 reference

12 December 2020

Chicken cells sense influenza A virus infection through MDA5 and CARDIF signaling involving LGP2.

1 reference

12 December 2020

Arterivirus and nairovirus ovarian tumor domain-containing Deubiquitinases target activated RIG-I to control innate immune signaling

1 reference

12 December 2020

Conventional protein kinase C-α (PKC-α) and PKC-β negatively regulate RIG-I antiviral signal transduction

1 reference

12 December 2020

Rotavirus nonstructural protein 1 antagonizes innate immune response by interacting with retinoic acid inducible gene I

1 reference

12 December 2020

Cooperative assembly and dynamic disassembly of MDA5 filaments for viral dsRNA recognition

1 reference

12 December 2020

Signaling in innate immunity and inflammation

1 reference

12 December 2020

Herpes simplex virus 1 tegument protein US11 downmodulates the RLR signaling pathway via direct interaction with RIG-I and MDA-5

1 reference

12 December 2020

MDA5 cooperatively forms dimers and ATP-sensitive filaments upon binding double-stranded RNA

1 reference

12 December 2020

Pathogen recognition receptors in channel catfish: II. Identification, phylogeny and expression of retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs).

1 reference

12 December 2020

Emerging role of ubiquitination in antiviral RIG-I signaling

1 reference

12 December 2020

The 3' untranslated regions of influenza genomic sequences are 5'PPP-independent ligands for RIG-I

1 reference

12 December 2020

The mitochondrial targeting chaperone 14-3-3ε regulates a RIG-I translocon that mediates membrane association and innate antiviral immunity.

1 reference

12 December 2020

The NS1 protein of influenza A virus blocks RIG-I-mediated activation of the noncanonical NF-κB pathway and p52/RelB-dependent gene expression in lung epithelial cells

1 reference

12 December 2020

Visualisation of direct interaction of MDA5 and the dsRNA replicative intermediate form of positive strand RNA viruses

1 reference

12 December 2020

TBK1-associated protein in endolysosomes (TAPE)/CC2D1A is a key regulator linking RIG-I-like receptors to antiviral immunity.

1 reference

12 December 2020

Critical role of an antiviral stress granule containing RIG-I and PKR in viral detection and innate immunity

1 reference

12 December 2020

Visualizing the Determinants of Viral RNA Recognition by Innate Immune Sensor RIG-I

1 reference

12 December 2020

The thermodynamic basis for viral RNA detection by the RIG-I innate immune sensor

1 reference

12 December 2020

Structure and Dynamics of the Second CARD of Human RIG-I Provide Mechanistic Insights into Regulation of RIG-I Activation

1 reference

12 December 2020

Goose RIG-I functions in innate immunity against Newcastle disease virus infections

1 reference

12 December 2020

MDA5 assembles into a polar helical filament on dsRNA.

1 reference

12 December 2020

A structure-based model of RIG-I activation

1 reference

12 December 2020

MDA5 detects the double-stranded RNA replicative form in picornavirus-infected cells.

1 reference

12 December 2020

Species-specific inhibition of RIG-I ubiquitination and IFN induction by the influenza A virus NS1 protein

1 reference

12 December 2020

Structural and biochemical studies of RIG-I antiviral signaling.

1 reference

12 December 2020

Structural basis for dsRNA recognition, filament formation, and antiviral signal activation by MDA5

1 reference

12 December 2020

Paramyxovirus V proteins disrupt the fold of the RNA sensor MDA5 to inhibit antiviral signaling

1 reference

12 December 2020

Induction of Siglec-G by RNA viruses inhibits the innate immune response by promoting RIG-I degradation

1 reference

12 December 2020

RAVER1 is a coactivator of MDA5-mediated cellular antiviral response.

1 reference

12 December 2020

Innate immunity of finfish: primordial conservation and function of viral RNA sensors in teleosts.

1 reference

12 December 2020

Dephosphorylation of the RNA sensors RIG-I and MDA5 by the phosphatase PP1 is essential for innate immune signaling

1 reference

12 December 2020

A Mammalian Pre-mRNA 5′ End Capping Quality Control Mechanism and an Unexpected Link of Capping to Pre-mRNA Processing

1 reference

12 December 2020

Molecular mechanisms of RNA interference

1 reference

12 December 2020

RNA silencing and its suppression: novel insights from in planta analyses

1 reference

12 December 2020

ATPase-driven oligomerization of RIG-I on RNA allows optimal activation of type-I interferon

1 reference

12 December 2020

Chicken MDA5 senses short double-stranded RNA with implications for antiviral response against avian influenza viruses in chicken.

1 reference

12 December 2020

Defining the functional determinants for RNA surveillance by RIG-I

1 reference

12 December 2020

The immunity regulator BAK1 contributes to resistance against diverse RNA viruses

1 reference

12 December 2020

A distinct role of Riplet-mediated K63-Linked polyubiquitination of the RIG-I repressor domain in human antiviral innate immune responses

1 reference

12 December 2020

The essential, nonredundant roles of RIG-I and MDA5 in detecting and controlling West Nile virus infection

1 reference

12 December 2020

RIG-I forms signaling-competent filaments in an ATP-dependent, ubiquitin-independent manner.

1 reference

12 December 2020

The interaction between the helicase DHX33 and IPS-1 as a novel pathway to sense double-stranded RNA and RNA viruses in myeloid dendritic cells

1 reference

12 December 2020

RIG-I and MDA-5 detection of viral RNA-dependent RNA polymerase activity restricts positive-strand RNA virus replication

1 reference

12 December 2020

Identification and expression profiling analysis of goose melanoma differentiation associated gene 5 (MDA5) gene

1 reference

12 December 2020

Mechanisms of MAVS regulation at the mitochondrial membrane

1 reference

12 December 2020

RIG-I-like receptors evolved adaptively in mammals, with parallel evolution at LGP2 and RIG-I.

1 reference

12 December 2020

RNase III: Genetics and function; structure and mechanism

1 reference

12 December 2020

Cell type-specific subcellular localization of phospho-TBK1 in response to cytoplasmic viral DNA

1 reference

12 December 2020

USP3 inhibits type I interferon signaling by deubiquitinating RIG-I-like receptors

1 reference

12 December 2020

The ubiquitin-specific protease USP15 promotes RIG-I-mediated antiviral signaling by deubiquitylating TRIM25

1 reference

12 December 2020

Deficiency of melanoma differentiation-associated protein 5 results in exacerbated chronic postviral lung inflammation

1 reference

12 December 2020

Toward a crystal-clear view of the viral RNA sensing and response by RIG-I-like receptors

1 reference

12 December 2020

Activation of duck RIG-I by TRIM25 is independent of anchored ubiquitin

1 reference

12 December 2020

Autoimmune disorders associated with gain of function of the intracellular sensor MDA5.

1 reference

12 December 2020

Identification of an LGP2-associated MDA5 agonist in picornavirus-infected cells

1 reference

12 December 2020

Structural basis for the prion-like MAVS filaments in antiviral innate immunity

1 reference

12 December 2020

Mitophagy enhances oncolytic measles virus replication by mitigating DDX58/RIG-I-like receptor signaling

1 reference

12 December 2020

Defective interfering influenza virus RNAs: time to reevaluate their clinical potential as broad-spectrum antivirals?

1 reference

12 December 2020

Structural basis for ubiquitin-mediated antiviral signal activation by RIG-I

1 reference

12 December 2020

Mechanisms of RIG-I-like receptor activation and manipulation by viral pathogens

1 reference

12 December 2020

DHX36 enhances RIG-I signaling by facilitating PKR-mediated antiviral stress granule formation

1 reference

12 December 2020

Nucleic acid-induced antiviral immunity in invertebrates: an evolutionary perspective

1 reference

12 December 2020

Gain-of-function mutations in IFIH1 cause a spectrum of human disease phenotypes associated with upregulated type I interferon signaling

1 reference

12 December 2020

In vivo ligands of MDA5 and RIG-I in measles virus-infected cells

1 reference

12 December 2020

TRIM4 modulates type I interferon induction and cellular antiviral response by targeting RIG-I for K63-linked ubiquitination

1 reference

12 December 2020

The DEAH-box RNA helicase DHX15 activates NF-κB and MAPK signaling downstream of MAVS during antiviral responses

1 reference

12 December 2020

Sustained activation of interferon regulatory factor 3 during infection by paramyxoviruses requires MDA5.

1 reference

12 December 2020

MDA5 and LGP2: accomplices and antagonists of antiviral signal transduction

1 reference

12 December 2020

Parts, assembly and operation of the RIG-I family of motors

1 reference

12 December 2020

Segmented negative-strand RNA viruses and RIG-I: divide (your genome) and rule

1 reference

12 December 2020

Antiviral activity of human OASL protein is mediated by enhancing signaling of the RIG-I RNA sensor

1 reference

12 December 2020

Interactions between the influenza A virus RNA polymerase components and retinoic acid-inducible gene I.

1 reference

12 December 2020

Plant pattern-recognition receptors.

1 reference

12 December 2020

DHX15 senses double-stranded RNA in myeloid dendritic cells

1 reference

12 December 2020

Aicardi-Goutières syndrome is caused by IFIH1 mutations.

1 reference

12 December 2020

Antagonism of the phosphatase PP1 by the measles virus V protein is required for innate immune escape of MDA5.

1 reference

12 December 2020

Molecular imprinting as a signal-activation mechanism of the viral RNA sensor RIG-I.

1 reference

12 December 2020

Regulation of RIG-I-like receptor signaling by host and viral proteins

1 reference

12 December 2020

The SKIV2L RNA exosome limits activation of the RIG-I-like receptors

1 reference

12 December 2020

Antiviral RNA recognition and assembly by RLR family innate immune sensors

1 reference

12 December 2020

Pattern Recognition and Signaling Mechanisms of RIG-I and MDA5

1 reference

12 December 2020

Antiviral immunity via RIG-I-mediated recognition of RNA bearing 5'-diphosphates

1 reference

12 December 2020

Exonuclease domain of the Lassa virus nucleoprotein is critical to avoid RIG-I signaling and to inhibit the innate immune response

1 reference

12 December 2020

Solid-state NMR resonance assignments of the filament-forming CARD domain of the innate immunity signaling protein MAVS.

1 reference

12 December 2020

Negative regulation of melanoma differentiation-associated gene 5 (MDA5)-dependent antiviral innate immune responses by Arf-like protein 5B

1 reference

12 December 2020

Higher antiviral response of RIG-I through enhancing RIG-I/MAVS-mediated signaling by its long insertion variant in zebrafish

1 reference

12 December 2020

Multiple functions of DDX3 RNA helicase in gene regulation, tumorigenesis, and viral infection

1 reference

12 December 2020

High-resolution HDX-MS reveals distinct mechanisms of RNA recognition and activation by RIG-I and MDA5.

1 reference

12 December 2020

The Z proteins of pathogenic but not nonpathogenic arenaviruses inhibit RIG-I-like receptor-dependent interferon production

1 reference

12 December 2020

Viral RNA detection by RIG-I-like receptors

1 reference

12 December 2020

Mitochondrial dynamics and viral infections: A close nexus

1 reference

12 December 2020

Proteomics. Tissue-based map of the human proteome

1 reference

12 December 2020

Influenza virus adaptation PB2-627K modulates nucleocapsid inhibition by the pathogen sensor RIG-I.

1 reference

12 December 2020

Interferons and viruses: an evolutionary arms race of molecular interactions

1 reference

12 December 2020

RIG-I ATPase activity and discrimination of self-RNA versus non-self-RNA.

1 reference

12 December 2020

RIG-I in RNA virus recognition

1 reference

12 December 2020

Influenza A Virus Panhandle Structure Is Directly Involved in RIG-I Activation and Interferon Induction

1 reference

12 December 2020

RIOK3-mediated phosphorylation of MDA5 interferes with its assembly and attenuates the innate immune response

1 reference

12 December 2020

In vitro and in vivo characterizations of pichinde viral nucleoprotein exoribonuclease functions.

1 reference

12 December 2020

Structural and functional analysis reveals that human OASL binds dsRNA to enhance RIG-I signaling

1 reference

12 December 2020

How RIG-I like receptors activate MAVS.

1 reference

12 December 2020

MAVS Coordination of Antiviral Innate Immunity.

1 reference

12 December 2020

Blockade of interferon Beta, but not interferon alpha, signaling controls persistent viral infection

1 reference

12 December 2020

DDX60 Is Involved in RIG-I-Dependent and Independent Antiviral Responses, and Its Function Is Attenuated by Virus-Induced EGFR Activation

1 reference

12 December 2020

Bipartite Nuclear Localization Signal Controls Nuclear Import and DNA-Binding Activity of IFN Regulatory Factor 3.

1 reference

12 December 2020

Global analysis of RNA cleavage by 5'-hydroxyl RNA sequencing.

1 reference

12 December 2020

Sequence-Specific Modifications Enhance the Broad-Spectrum Antiviral Response Activated by RIG-I Agonists

1 reference

12 December 2020

Structural basis and functional analysis of the SARS coronavirus nsp14-nsp10 complex

1 reference

12 December 2020

The catcher in the RIG-I.

1 reference

12 December 2020

RNA helicase DDX3: at the crossroad of viral replication and antiviral immunity.

1 reference

12 December 2020

Sensors of Infection: Viral Nucleic Acid PRRs in Fish

1 reference

12 December 2020

A Conserved Histidine in the RNA Sensor RIG-I Controls Immune Tolerance to N1-2'O-Methylated Self RNA.

1 reference

12 December 2020

Kinetic discrimination of self/non-self RNA by the ATPase activity of RIG-I and MDA5

1 reference

12 December 2020

RIG-I Mediates an Antiviral Response to Crimean-Congo Hemorrhagic Fever Virus

1 reference

12 December 2020

Regulation of MDA5-MAVS Antiviral Signaling Axis by TRIM25 through TRAF6-Mediated NF-κB Activation

1 reference

12 December 2020

Establishing the role of ATP for the function of the RIG-I innate immune sensor

1 reference

12 December 2020

Identification of a Natural Viral RNA Motif That Optimizes Sensing of Viral RNA by RIG-I.

1 reference

12 December 2020

PACT- and RIG-I-Dependent Activation of Type I Interferon Production by a Defective Interfering RNA Derived from Measles Virus Vaccine

1 reference

12 December 2020

ATP hydrolysis by the viral RNA sensor RIG-I prevents unintentional recognition of self-RNA.

1 reference

12 December 2020

Links between recognition and degradation of cytoplasmic viral RNA in innate immune response.

1 reference

12 December 2020

The microRNA miR-485 targets host and influenza virus transcripts to regulate antiviral immunity and restrict viral replication

1 reference

12 December 2020

Cytoplasmic STAT4 Promotes Antiviral Type I IFN Production by Blocking CHIP-Mediated Degradation of RIG-I.

1 reference

12 December 2020

Structural basis for m7G recognition and 2'-O-methyl discrimination in capped RNAs by the innate immune receptor RIG-I.

1 reference

12 December 2020

HDAC6 regulates cellular viral RNA sensing by deacetylation of RIG-I.

1 reference

12 December 2020

Regulation of antiviral innate immune signaling by stress-induced RNA granules

1 reference

12 December 2020

Filament assemblies in foreign nucleic acid sensors

1 reference

12 December 2020

PKR Transduces MDA5-Dependent Signals for Type I IFN Induction

1 reference

12 December 2020

Ubiquitin-like modifier FAT10 attenuates RIG-I mediated antiviral signaling by segregating activated RIG-I from its signaling platform

1 reference

12 December 2020

Comparative analysis of viral RNA signatures on different RIG-I-like receptors

1 reference

12 December 2020

Robust Lys63-Linked Ubiquitination of RIG-I Promotes Cytokine Eruption in Early Influenza B Virus Infection

1 reference

12 December 2020

Viral evasion of intracellular DNA and RNA sensing

1 reference

12 December 2020

Standing on three legs: antiviral activities of RIG-I against influenza viruses

1 reference

12 December 2020

A Hierarchical Mechanism of RIG-I Ubiquitination Provides Sensitivity, Robustness and Synergy in Antiviral Immune Responses

1 reference

12 December 2020

A novel phosphoserine motif in the LCMV matrix protein Z regulates the release of infectious virus and defective interfering particles

1 reference

12 December 2020

Mechanism of TRIM25 Catalytic Activation in the Antiviral RIG-I Pathway.

1 reference

12 December 2020

RNF122 suppresses antiviral type I interferon production by targeting RIG-I CARDs to mediate RIG-I degradation

1 reference

12 December 2020

Zika Virus Disrupts Phospho-TBK1 Localization and Mitosis in Human Neuroepithelial Stem Cells and Radial Glia

1 reference

12 December 2020

Loss of RIG-I leads to a functional replacement with MDA5 in the Chinese tree shrew

1 reference

12 December 2020

RNAs Containing Modified Nucleotides Fail To Trigger RIG-I Conformational Changes for Innate Immune Signaling

1 reference

12 December 2020

The burgeoning field of innate immune-mediated disease and autoinflammation

1 reference

12 December 2020

Foot-and-Mouth Disease Virus Viroporin 2B Antagonizes RIG-I-Mediated Antiviral Effects by Inhibition of Its Protein Expression

1 reference

12 December 2020

Subcellular Localizations of RIG-I, TRIM25, and MAVS Complexes

1 reference

12 December 2020

Post-translational Control of Intracellular Pathogen Sensing Pathways

1 reference

12 December 2020

A Viral Deamidase Targets the Helicase Domain of RIG-I to Block RNA-Induced Activation

1 reference

12 December 2020

Viral Evasion Strategies in Type I IFN Signaling - A Summary of Recent Developments

1 reference

12 December 2020

TRIM25 Identification in the Chinese Goose: Gene Structure, Tissue Expression Profiles, and Antiviral Immune Responses In Vivo and In Vitro

1 reference

12 December 2020

HIV-1 blocks the signaling adaptor MAVS to evade antiviral host defense after sensing of abortive HIV-1 RNA by the host helicase DDX3.

1 reference

12 December 2020

TRIM65-catalized ubiquitination is essential for MDA5-mediated antiviral innate immunity

1 reference

12 December 2020

Host and Viral Modulation of RIG-I-Mediated Antiviral Immunity

1 reference

12 December 2020

The Long Noncoding RNA NEAT1 Exerts Antihantaviral Effects by Acting as Positive Feedback for RIG-I Signaling

1 reference

12 December 2020

RNA modifications go viral.

1 reference

12 December 2020

Negative regulators of the RIG-I-like receptor signaling pathway

1 reference

12 December 2020

Caenorhabditis elegans RIG-I Homolog Mediates Antiviral RNA Interference Downstream of Dicer-Dependent Biogenesis of Viral Small Interfering RNAs

1 reference

12 December 2020

Interferon-Inducible Oligoadenylate Synthetase-Like Protein Acts as an Antiviral Effector against Classical Swine Fever Virus via the MDA5-Mediated Type I Interferon-Signaling Pathway

1 reference

12 December 2020

Ube2D3 and Ube2N are essential for RIG-I-mediated MAVS aggregation in antiviral innate immunity

1 reference

12 December 2020

Molecular mechanisms of Dicer: endonuclease and enzymatic activity

1 reference

12 December 2020

Discrimination of Self and Non-Self Ribonucleic Acids

1 reference

12 December 2020

A Role for Neutrophils in Viral Respiratory Disease.

1 reference

12 December 2020

Sensing Self and Foreign Circular RNAs by Intron Identity.

1 reference

12 December 2020

West Nile Virus NS1 Antagonizes Interferon Beta Production by Targeting RIG-I and MDA5.

1 reference

12 December 2020

Ten Strategies of Interferon Evasion by Viruses

1 reference

12 December 2020

Zyxin stabilizes RIG-I and MAVS interactions and promotes type I interferon response.

1 reference

12 December 2020

Stratified ubiquitination of RIG-I creates robust immune response and induces selective gene expression.

1 reference

12 December 2020

Viral inhibitions of PACT-induced RIG-I activation

1 reference

12 December 2020

TRIM25 in the Regulation of the Antiviral Innate Immunity

1 reference

12 December 2020

Assembly of the WHIP-TRIM14-PPP6C Mitochondrial Complex Promotes RIG-I-Mediated Antiviral Signaling.

1 reference

12 December 2020

Inducible MicroRNA-3570 Feedback Inhibits the RIG-I-Dependent Innate Immune Response to Rhabdovirus in Teleost Fish by Targeting MAVS/IPS-1.

1 reference

12 December 2020

The E3 Ubiquitin Ligase TRIM40 Attenuates Antiviral Immune Responses by Targeting MDA5 and RIG-I.

1 reference

12 December 2020

Viral unmasking of cellular 5S rRNA pseudogene transcripts induces RIG-I-mediated immunity.

1 reference

12 December 2020

Alternative Splicing Transcripts of Zebrafish LGP2 Gene Differentially Contribute to IFN Antiviral Response

1 reference

12 December 2020

Circular RNAs: A novel type of non-coding RNA and their potential implications in antiviral immunity

1 reference

12 December 2020

Aging impairs both primary and secondary RIG-I signaling for interferon induction in human monocytes.

1 reference

12 December 2020

A single amino acid substitution within the Paramyxovirus Sendai virus nucleoprotein is a critical determinant for production of IFN-beta-inducing copyback-type defective interfering genomes

1 reference

12 December 2020

Fundamental properties of the mammalian innate immune system revealed by multispecies comparison of type I interferon responses.

1 reference

12 December 2020

The human papillomavirus E6 oncoprotein targets USP15 and TRIM25 to suppress RIG-I-mediated innate immune signaling.

1 reference

12 December 2020

LRRC25 inhibits type I IFN signaling by targeting ISG15-associated RIG-I for autophagic degradation.

1 reference

12 December 2020

The Effects of Dendritic Cell Hypersensitivity on Persistent Viral Infection.

1 reference

12 December 2020

Paramyxovirus V proteins interact with the RIG-I/TRIM25 regulatory complex and inhibit RIG-I signaling

1 reference

12 December 2020

The RIG-I-like receptor LGP2 inhibits Dicer-dependent processing of long double-stranded RNA and blocks RNA interference in mammalian cells

1 reference

12 December 2020

Regulation of RIG-I Activation by K63-Linked Polyubiquitination

1 reference

12 December 2020

Breaching Self-Tolerance to Alu Duplex RNA Underlies MDA5-Mediated Inflammation.

1 reference

12 December 2020

Cell fate in antiviral response arises in the crosstalk of IRF, NF-κB and JAK/STAT pathways.

1 reference

12 December 2020

microRNA-210 participates in regulating RIG-I signaling pathway via targeting DUBA in miiuy croaker after poly(I:C) stimulation.

1 reference

12 December 2020

DHX29 functions as an RNA co-sensor for MDA5-mediated EMCV-specific antiviral immunity.

1 reference

12 December 2020

A minimal RNA ligand for potent RIG-I activation in living mice.

1 reference

12 December 2020

Hepatitis D virus replication is sensed by MDA5 and induces IFN-β/λ responses in hepatocytes.

1 reference

12 December 2020

LINE1 contributes to autoimmunity through both RIG-I- and MDA5-mediated RNA sensing pathways

1 reference

12 December 2020

MLL5 suppresses antiviral innate immune response by facilitating STUB1-mediated RIG-I degradation.

1 reference

12 December 2020

Visualization of arenavirus RNA species in individual cells by single-molecule fluorescence in situ hybridization (smFISH) suggests a model of cyclical infection and clearance during persistence.

1 reference

12 December 2020

RLRs and TLRs Signaling Pathways Cause Aberrant Production of Inflammatory Cytokines/Chemokines in an SFTSV Infection Mouse Model.

1 reference

12 December 2020

Arenaviral Nucleoproteins Suppress PACT-Induced Augmentation of RIG-I Function To Inhibit Type I Interferon Production

1 reference

12 December 2020

RIG-I and Other RNA Sensors in Antiviral Immunity.

1 reference

12 December 2020

Self-Recognition of an Inducible Host lncRNA by RIG-I Feedback Restricts Innate Immune Response.

1 reference

12 December 2020

Molecular mechanism of influenza A NS1-mediated TRIM25 recognition and inhibition.

1 reference

12 December 2020

The Role of Optineurin in Antiviral Type I Interferon Production.

1 reference

12 December 2020

Expression of immune genes RIG-I and Mx in mallard ducks infected with low pathogenic avian influenza (LPAI): A dataset.

1 reference

12 December 2020

RIG-I Detects Kaposi's Sarcoma-Associated Herpesvirus Transcripts in a RNA Polymerase III-Independent Manner.

1 reference

12 December 2020

RIG-I-Like Receptors as Novel Targets for Pan-Antivirals and Vaccine Adjuvants Against Emerging and Re-Emerging Viral Infections.

1 reference

12 December 2020

DDX3 suppresses type I interferons and favors viral replication during Arenavirus infection

1 reference

12 December 2020

Energetics of Preferential Binding of Retinoic Acid-Inducible Gene-I to Double-Stranded Viral RNAs with 5' Tri-/Diphosphate over 5' Monophosphate.

1 reference

12 December 2020

Mitochondrial double-stranded RNA triggers antiviral signalling in humans

1 reference

12 December 2020

Characterization of a bafinivirus exoribonuclease activity

1 reference

12 December 2020

Nuclear-resident RIG-I senses viral replication inducing antiviral immunity

1 reference

12 December 2020

Within-season influenza vaccine waning suggests potential net benefits to delayed vaccination in older adults in the United States

1 reference

12 December 2020

The Zinc-Finger Protein ZCCHC3 Binds RNA and Facilitates Viral RNA Sensing and Activation of the RIG-I-like Receptors

1 reference

12 December 2020

Mini viral RNAs act as innate immune agonists during influenza virus infection

1 reference

12 December 2020

Defective (interfering) viral genomes re-explored: impact on antiviral immunity and virus persistence

1 reference

12 December 2020

RIG-I Uses an ATPase-Powered Translocation-Throttling Mechanism for Kinetic Proofreading of RNAs and Oligomerization

1 reference

12 December 2020

Microvesicles from malaria-infected red blood cells activate natural killer cells via MDA5 pathway

1 reference

12 December 2020

Virus Sensor RIG-I Represses RNA Interference by Interacting with TRBP through LGP2 in Mammalian Cells

1 reference

12 December 2020

Identification and characterization of an atypical RIG-I encoded by planarian Dugesia japonica and its essential role in the immune response

1 reference

12 December 2020

TARBP2 negatively regulates IFN-β production and innate antiviral response by targeting MAVS

1 reference

12 December 2020

Cryo-EM Structures of MDA5-dsRNA Filaments at Different Stages of ATP Hydrolysis

1 reference

12 December 2020

RIG-I like receptor sensing of host RNAs facilitates the cell-intrinsic immune response to KSHV infection

1 reference

12 December 2020

USP14 promotes K63-linked RIG-I deubiquitination and suppresses antiviral immune responses

1 reference

12 December 2020

The RNA helicase DDX3X is an essential mediator of innate antimicrobial immunity

1 reference

12 December 2020

Vaccination in the elderly: The challenge of immune changes with aging

1 reference

12 December 2020

Zebrafish MVP Recruits and Degrades TBK1 To Suppress IFN Production

1 reference

12 December 2020

Host-Driven Phosphorylation Appears to Regulate the Budding Activity of the Lassa Virus Matrix Protein

1 reference

12 December 2020

Goose MAVS functions in RIG-I-mediated IFN-β signaling activation

1 reference

12 December 2020

HDX-MS reveals dysregulated checkpoints that compromise discrimination against self RNA during RIG-I mediated autoimmunity

1 reference

12 December 2020

SVCV infection triggers fish IFN response through RLR signaling pathway

1 reference

12 December 2020

MDA5 and LGP2 acts as a key regulator though activating NF-κB and IRF3 in RLRs signaling of mandarinfish

1 reference

12 December 2020

Cloning, expression and bioinformatics analysis of a putative pigeon melanoma differentiation-associated gene 5

1 reference

12 December 2020

Inhibition of Ongoing Influenza A Virus Replication Reveals Different Mechanisms of RIG-I Activation

1 reference

12 December 2020

Therapeutic Targeting of RIG-I and MDA5 Might Not Lead to the Same Rome

1 reference

12 December 2020

Immunostimulatory Effects Triggered by Self-Assembled Microspheres with Tandem Repeats of Polymerized RNA Strands

1 reference

12 December 2020

DDX19 Inhibits Type I Interferon Production by Disrupting TBK1-IKKε-IRF3 Interactions and Promoting TBK1 and IKKε Degradation

1 reference

12 December 2020

The 14-3-3η chaperone protein promotes antiviral innate immunity via facilitating MDA5 oligomerization and intracellular redistribution

1 reference

12 December 2020

NDR2 promotes the antiviral immune response via facilitating TRIM25-mediated RIG-I activation in macrophages

1 reference

12 December 2020

RIG-I Selectively Discriminates against 5'-Monophosphate RNA

1 reference

12 December 2020

In vivo cellular and molecular study on duck spleen infected by duck Tembusu virus

1 reference

12 December 2020

Duck RIG-I restricts duck enteritis virus infection

1 reference

12 December 2020

Activation of innate immunity by mitochondrial dsRNA in mouse cells lacking p53 protein

1 reference

12 December 2020

Fueling Type I Interferonopathies: Regulation and Function of Type I Interferon Antiviral Responses

1 reference

12 December 2020

NLRP12 Regulates Anti-viral RIG-I Activation via Interaction with TRIM25

1 reference

12 December 2020

Hemorrhagic Fever-Causing Arenaviruses: Lethal Pathogens and Potent Immune Suppressors

1 reference

12 December 2020

Comparative study on pattern recognition receptors in non-teleost ray-finned fishes and their evolutionary significance in primitive vertebrates

1 reference

12 December 2020

Induction of Selenoprotein P mRNA during Hepatitis C Virus Infection Inhibits RIG-I-Mediated Antiviral Immunity

1 reference

12 December 2020

Co-degradation of interferon signaling factor DDX3 by PB1-F2 as a basis for high virulence of 1918 pandemic influenza

1 reference

12 December 2020

Ubiquitin-Dependent and -Independent Roles of E3 Ligase RIPLET in Innate Immunity

1 reference

12 December 2020

The long noncoding RNA Lnczc3h7a promotes a TRIM25-mediated RIG-I antiviral innate immune response

1 reference

12 December 2020

Activation of RIG-I signaling to increase the pro-inflammatory phenotype of a tumor

1 reference

12 December 2020

RIG-I Activation by a Designer Short RNA Ligand Protects Human Immune Cells against Dengue Virus Infection without Causing Cytotoxicity

1 reference

12 December 2020

Immunotherapeutic effects of intratumoral nanoplexed poly I:C

1 reference

12 December 2020

E3 ubiquitin ligases, the powerful modulator of innate antiviral immunity

1 reference

12 December 2020

LRRC59 modulates type I interferon signaling by restraining the SQSTM1/p62-mediated autophagic degradation of pattern recognition receptor DDX58/RIG-I

1 reference

12 December 2020

Non-self mutation: double-stranded RNA elicits antiviral pathogenic response in a Drosophila model of expanded CAG repeat neurodegenerative diseases

1 reference

12 December 2020

Apoptotic endothelial cells release small extracellular vesicles loaded with immunostimulatory viral-like RNAs

1 reference

12 December 2020

DHX15 Is a Coreceptor for RLR Signaling That Promotes Antiviral Defense Against RNA Virus Infection

1 reference

12 December 2020

Genomic analysis and adaptive evolution of the RIG-I-like and NOD-like receptors in reptiles

1 reference

12 December 2020

Porcine deltacoronavirus nucleocapsid protein antagonizes IFN-β production by impairing dsRNA and PACT binding to RIG-I

1 reference

12 December 2020

Porcine Deltacoronavirus Nucleocapsid Protein Suppressed IFN-β Production by Interfering Porcine RIG-I dsRNA-Binding and K63-Linked Polyubiquitination

1 reference

12 December 2020

Lactate Is a Natural Suppressor of RLR Signaling by Targeting MAVS

1 reference

12 December 2020

Human Hemoglobin Subunit Beta Functions as a Pleiotropic Regulator of RIG-I/MDA5-Mediated Antiviral Innate Immune Responses

1 reference

12 December 2020

Identifiers

DOI

10.3389/FIMMU.2019.01586

0 references

PMC publication ID

6652118

0 references