(Q38967233)

8 September 2017

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title

The burgeoning field of innate immune-mediated disease and autoinflammation (English)

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8 September 2017

3

Sinisa Savic

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Michael McDermott

series ordinal

4

object named as

Michael F McDermott

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Thomas Scambler

object named as

Thomas Scambler

series ordinal

2

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Daniel Peckham

series ordinal

1

object named as

Daniel Peckham

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8 September 2017

publication date

29 September 2016

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full work available at URL

8 September 2017

http://eprints.whiterose.ac.uk/107921/

content deliverer

White Rose Research Online

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1 reference

8 September 2017

volume

241

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8 September 2017

issue

2

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8 September 2017

page(s)

123-139

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Ancient Missense Mutations in a New Member of the RoRet Gene Family Are Likely to Cause Familial Mediterranean Fever

8 September 2017

cites work

1 reference

A candidate gene for familial Mediterranean fever

21 January 2018

1 reference

Molecular mechanisms in genetically defined autoinflammatory diseases: disorders of amplified danger signaling

21 January 2018

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Autoinflammatory syndromes and cellular responses to stress: pathophysiology, diagnosis and new treatment perspectives

21 January 2018

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Germline mutations in the extracellular domains of the 55 kDa TNF receptor, TNFR1, define a family of dominantly inherited autoinflammatory syndromes.

21 January 2018

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The autoinflammatory syndromes

21 January 2018

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An update on autoinflammatory diseases

21 January 2018

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Old Dogs, New Tricks: Monogenic Autoinflammatory Disease Unleashed

21 January 2018

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A proposed classification of the immunological diseases

21 January 2018

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Pharmacological treatment of monogenic disease

21 January 2018

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Mutations in the gene encoding mevalonate kinase cause hyper-IgD and periodic fever syndrome. International Hyper-IgD Study Group.

21 January 2018

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Mutations in MVK, encoding mevalonate kinase, cause hyperimmunoglobulinaemia D and periodic fever syndrome

21 January 2018

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New monogenic autoinflammatory diseases--a clinical overview

21 January 2018

1 reference

The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta

21 January 2018

1 reference

Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome

21 January 2018

1 reference

New mutations of CIAS1 that are responsible for Muckle-Wells syndrome and familial cold urticaria: a novel mutation underlies both syndromes

21 January 2018

1 reference

Association of mutations in the NALP3/CIAS1/PYPAF1 gene with a broad phenotype including recurrent fever, cold sensitivity, sensorineural deafness, and AA amyloidosis

21 January 2018

1 reference

Chronic infantile neurological cutaneous and articular syndrome is caused by mutations in CIAS1, a gene highly expressed in polymorphonuclear cells and chondrocytes

21 January 2018

1 reference

De novo CIAS1 mutations, cytokine activation, and evidence for genetic heterogeneity in patients with neonatal-onset multisystem inflammatory disease (NOMID): a new member of the expanding family of pyrin-associated autoinflammatory diseases

21 January 2018

1 reference

Interleukin-1-receptor antagonist in the Muckle-Wells syndrome.

21 January 2018

1 reference

Neonatal-onset multisystem inflammatory disease responsive to interleukin-1beta inhibition

21 January 2018

1 reference

Interleukin-1 blockade by anakinra improves clinical symptoms in patients with neonatal-onset multisystem inflammatory disease

21 January 2018

1 reference

Canakinumab treatment for patients with active recurrent or chronic TNF receptor-associated periodic syndrome (TRAPS): an open-label, phase II study

21 January 2018

1 reference

Familial Mediterranean fever and related periodic fever syndromes/autoinflammatory diseases

21 January 2018

1 reference

An autoinflammatory disease with deficiency of the interleukin-1-receptor antagonist

21 January 2018

1 reference

Interleukin-36-receptor antagonist deficiency and generalized pustular psoriasis

21 January 2018

1 reference

Mutations in IL36RN/IL1F5 are associated with the severe episodic inflammatory skin disease known as generalized pustular psoriasis.

21 January 2018

1 reference

Canakinumab in pediatric rheumatic diseases

21 January 2018

1 reference

Use of canakinumab in the cryopyrin-associated periodic syndrome

21 January 2018

1 reference

Anti-interleukin-1 therapy in the management of gout

21 January 2018

1 reference

The pattern of response to anti-interleukin-1 treatment distinguishes two subsets of patients with systemic-onset juvenile idiopathic arthritis

21 January 2018

1 reference

Treating inflammation by blocking interleukin-1 in humans

21 January 2018

1 reference

Somatic mosaicism of CIAS1 in a patient with chronic infantile neurologic, cutaneous, articular syndrome.

21 January 2018

1 reference

Acquired familial Mediterranean fever associated with a somatic MEFV mutation in a patient with JAK2 associated post-polycythemia myelofibrosis

21 January 2018

1 reference

Brief Report: Association of Tumor Necrosis Factor Receptor-Associated Periodic Syndrome With Gonosomal Mosaicism of a Novel 24-Nucleotide TNFRSF1A Deletion

21 January 2018

1 reference

Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 cause Aicardi-Goutières syndrome at the AGS1 locus

21 January 2018

1 reference

Type I interferonopathies in pediatric rheumatology

21 January 2018

1 reference

Type I interferonopathies: mendelian type I interferon up-regulation

21 January 2018

1 reference

Trex1 prevents cell-intrinsic initiation of autoimmunity

21 January 2018

1 reference

Mutations involved in Aicardi-Goutières syndrome implicate SAMHD1 as regulator of the innate immune response

21 January 2018

1 reference

Human disease phenotypes associated with mutations in TREX1.

21 January 2018

1 reference

Familial chilblain lupus, a monogenic form of cutaneous lupus erythematosus, maps to chromosome 3p.

21 January 2018

1 reference

Gain-of-function mutations in IFIH1 cause a spectrum of human disease phenotypes associated with upregulated type I interferon signaling

21 January 2018

1 reference

Clinical genetics in 2014: New monogenic diseases span the immunological disease continuum.

21 January 2018

1 reference

Mutations in proteasome subunit β type 8 cause chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature with evidence of genetic and phenotypic heterogeneity.

21 January 2018

1 reference

Activated STING in a vascular and pulmonary syndrome

21 January 2018

1 reference

Perception of self: distinguishing autoimmunity from autoinflammation

21 January 2018

1 reference

The role of Resveratrol-induced mitophagy/autophagy in peritoneal mesothelial cells inflammatory injury via NLRP3 inflammasome activation triggered by mitochondrial ROS.

21 January 2018

1 reference

The cooperation between the autophagy machinery and the inflammasome to implement an appropriate innate immune response: do they regulate each other?

21 January 2018

1 reference

Mitochondrial damage contributes to Pseudomonas aeruginosa activation of the inflammasome and is downregulated by autophagy

21 January 2018

1 reference

HMGB1-DNA complex-induced autophagy limits AIM2 inflammasome activation through RAGE

21 January 2018

1 reference

Autophagy in microglia degrades extracellular β-amyloid fibrils and regulates the NLRP3 inflammasome

21 January 2018

1 reference

Regulation where autophagy intersects the inflammasome.

21 January 2018

1 reference

Inhibition of autophagy induces IL-1β release from ARPE-19 cells via ROS mediated NLRP3 inflammasome activation under high glucose stress

21 January 2018

1 reference

Protein misfolding and dysregulated protein homeostasis in autoinflammatory diseases and beyond

21 January 2018

1 reference

Autophagy contributes to inflammation in patients with TNFR-associated periodic syndrome (TRAPS).

21 January 2018

1 reference

Tumor necrosis factor receptor-associated periodic syndrome as a model linking autophagy and inflammation in protein aggregation diseases

21 January 2018

1 reference

Defective CFTR induces aggresome formation and lung inflammation in cystic fibrosis through ROS-mediated autophagy inhibition

21 January 2018

1 reference

Targeting autophagy as a novel strategy for facilitating the therapeutic action of potentiators on ΔF508 cystic fibrosis transmembrane conductance regulator

21 January 2018

1 reference

IFN-γ stimulates autophagy-mediated clearance of Burkholderia cenocepacia in human cystic fibrosis macrophages

21 January 2018

1 reference

Burkholderia cenocepacia J2315 escapes to the cytosol and actively subverts autophagy in human macrophages.

21 January 2018

1 reference

Additive loss-of-function proteasome subunit mutations in CANDLE/PRAAS patients promote type I IFN production

21 January 2018

1 reference

21 January 2018

1 reference

21 January 2018

1 reference

Regulation of the inflammasome by ceramide in cystic fibrosis lungs.

21 January 2018

1 reference

Ceramide in Pseudomonas aeruginosa infections and cystic fibrosis

21 January 2018

1 reference

The arthropathy of cystic fibrosis

21 January 2018

1 reference

Inflammatory cytokines in cystic fibrosis lungs

21 January 2018

1 reference

Gout and hyperuricaemia in adults with cystic fibrosis.

21 January 2018

1 reference

Proinflammatory mediators disrupt glucose homeostasis in airway surface liquid

21 January 2018

1 reference

Gout-associated uric acid crystals activate the NALP3 inflammasome

21 January 2018

1 reference

The role of uric acid as an endogenous danger signal in immunity and inflammation

21 January 2018

1 reference

Extracellular acidosis is a novel danger signal alerting innate immunity via the NLRP3 inflammasome.

21 January 2018

1 reference

Role of endoplasmic reticulum stress in cystic fibrosis-related airway inflammatory responses

21 January 2018

1 reference

A novel treatment of cystic fibrosis acting on-target: cysteamine plus epigallocatechin gallate for the autophagy-dependent rescue of class II-mutated CFTR

21 January 2018

1 reference

Regulation of inflammasomes by autophagy

21 January 2018

1 reference

Autophagy in inflammatory diseases

21 January 2018

1 reference

Pharmacological modulation of the AKT/microRNA-199a-5p/CAV1 pathway ameliorates cystic fibrosis lung hyper-inflammation

21 January 2018

1 reference

IL-1 receptor antagonist ameliorates inflammasome-dependent inflammation in murine and human cystic fibrosis

21 January 2018

1 reference

Infevers: an evolving mutation database for auto-inflammatory syndromes

21 January 2018

1 reference

An activating NLRC4 inflammasome mutation causes autoinflammation with recurrent macrophage activation syndrome

21 January 2018

1 reference

Atypical activation of the unfolded protein response in cystic fibrosis airway cells contributes to p38 MAPK-mediated innate immune responses.

21 January 2018

1 reference

Ultrasound and magnetic resonance imaging assessment of joint disease in symptomatic patients with cystic fibrosis arthropathy

21 January 2018

1 reference

Neutrophil-mediated phagocytic host defense defect in myeloid Cftr-inactivated mice

21 January 2018

1 reference

A neutrophil intrinsic impairment affecting Rab27a and degranulation in cystic fibrosis is corrected by CFTR potentiator therapy

21 January 2018

1 reference

Role of CFTR expressed by neutrophils in modulating acute lung inflammation and injury in mice

21 January 2018

1 reference

Profound functional and signaling changes in viable inflammatory neutrophils homing to cystic fibrosis airways

21 January 2018

1 reference

Aspergillus fumigatus stimulates the NLRP3 inflammasome through a pathway requiring ROS production and the Syk tyrosine kinase.

21 January 2018

1 reference

The RNA- and TRIM25-Binding Domains of Influenza Virus NS1 Protein Are Essential for Suppression of NLRP3 Inflammasome-Mediated Interleukin-1β Secretion

21 January 2018

1 reference

Rhinovirus-induced calcium flux triggers NLRP3 and NLRC5 activation in bronchial cells

21 January 2018

1 reference

Clinical outcome of Burkholderia cepacia complex infection in cystic fibrosis adults

21 January 2018

1 reference

The role of respiratory viruses in adult patients with cystic fibrosis receiving intravenous antibiotics for a pulmonary exacerbation

21 January 2018

1 reference

Incidence and clinical impact of respiratory viruses in adults with cystic fibrosis

21 January 2018

1 reference

The NLRP3 inflammasome mediates in vivo innate immunity to influenza A virus through recognition of viral RNA.

21 January 2018

1 reference

Activation of the pyrin inflammasome by intracellular Burkholderia cenocepacia

21 January 2018

1 reference

Autophagy stimulation by rapamycin suppresses lung inflammation and infection by Burkholderia cenocepacia in a model of cystic fibrosis.

21 January 2018

1 reference

Persistent cystic fibrosis isolate Pseudomonas aeruginosa strain RP73 exhibits an under-acylated LPS structure responsible of its low inflammatory activity.

21 January 2018

1 reference

TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages.

21 January 2018

1 reference

Toll-like receptor-mediated IRE1α activation as a therapeutic target for inflammatory arthritis

21 January 2018

1 reference

Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS)

21 January 2018

1 reference

Involvement of X-box binding protein 1 and reactive oxygen species pathways in the pathogenesis of tumour necrosis factor receptor-associated periodic syndrome.

21 January 2018

1 reference

Airway epithelial inflammation-induced endoplasmic reticulum Ca2+ store expansion is mediated by X-box binding protein-1.

21 January 2018

1 reference

Mitochondrial Ca2+-dependent NLRP3 activation exacerbates the Pseudomonas aeruginosa-driven inflammatory response in cystic fibrosis.

21 January 2018

1 reference

Redox regulation of NLRP3 inflammasomes: ROS as trigger or effector?

21 January 2018

1 reference

IL-1 receptor antagonist reduces endotoxin-induced airway inflammation in healthy volunteers

21 January 2018

1 reference

Endoplasmic Reticulum Stress Activates the Inflammasome via NLRP3- and Caspase-2-Driven Mitochondrial Damage

21 January 2018

1 reference

X-Box-Binding Protein 1 and Innate Immune Responses of Human Cystic Fibrosis Alveolar Macrophages

21 January 2018

1 reference

TLR dependent XBP-1 activation induces an autocrine loop in rheumatoid arthritis synoviocytes

21 January 2018

1 reference

The Relationship between NALP3 and Autoinflammatory Syndromes

21 January 2018

1 reference

Efficacy of interleukin-1-targeting drugs in mevalonate kinase deficiency

21 January 2018

1 reference

Pyrin inflammasome activation and RhoA signaling in the autoinflammatory diseases FMF and HIDS

21 January 2018

1 reference

Is caspase 1 central to activation of interleukin-1?

21 January 2018

1 reference

Knockdown of MVK does not lead to changes in NALP3 expression or activation

21 January 2018

1 reference

Mevalonate kinase deficiency leads to decreased prenylation of Rab GTPases.

21 January 2018

1 reference

The role of membrane-trafficking small GTPases in the regulation of autophagy.

21 January 2018

1 reference

Innate immune sensing of bacterial modifications of Rho GTPases by the Pyrin inflammasome

21 January 2018

1 reference

Autophagy controls IL-1beta secretion by targeting pro-IL-1beta for degradation

21 January 2018

1 reference

Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction

21 January 2018

1 reference

A new metabolic muscle disease due to abnormal hexokinase activity

21 January 2018

1 reference

Spliced X-box binding protein 1 couples the unfolded protein response to hexosamine biosynthetic pathway

21 January 2018

1 reference

Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS.

21 January 2018

1 reference

Atorvastatin suppresses NLRP3 inflammasome activation via TLR4/MyD88/NF-κB signaling in PMA-stimulated THP-1 monocytes

21 January 2018

1 reference

Blockade of XBP1 splicing by inhibition of IRE1α is a promising therapeutic option in multiple myeloma

21 January 2018

1 reference

Immunological function of familial Mediterranean fever disease protein Pyrin

21 January 2018

1 reference

Familial autoinflammation with neutrophilic dermatosis reveals a regulatory mechanism of pyrin activation.

21 January 2018

1 reference

Loss-of-function mutations in TNFAIP3 leading to A20 haploinsufficiency cause an early-onset autoinflammatory disease

21 January 2018

1 reference

De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling

21 January 2018

1 reference

The immunogenetics of Behçet's disease: A comprehensive review

21 January 2018

1 reference

Biallelic hypomorphic mutations in a linear deubiquitinase define otulipenia, an early-onset autoinflammatory disease

21 January 2018

1 reference

Brief Report: Involvement of TNFRSF11A molecular defects in autoinflammatory disorders

21 January 2018

1 reference

Molecular mechanisms regulating NLRP3 inflammasome activation

21 January 2018

1 reference

Brief Report: Severe Inflammation Following Vaccination Against Streptococcus pneumoniae in Patients With Cryopyrin-Associated Periodic Syndromes

21 January 2018

1 reference

Mitochondrial cardiolipin is required for Nlrp3 inflammasome activation

21 January 2018

1 reference

Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome

21 January 2018

1 reference

Synovial phenotypes in rheumatoid arthritis correlate with response to biologic therapeutics.

21 January 2018

1 reference

Inflammasomes link vascular disease with neuroinflammation and brain disorders

21 January 2018

1 reference

NLRP3 inflammasome: from a danger signal sensor to a regulatory node of oxidative stress and inflammatory diseases.

21 January 2018

1 reference

Recommendations for the management of autoinflammatory diseases.

21 January 2018

1 reference

Autoinflammation. Management of hereditary recurrent fevers--SHARE experience.

21 January 2018

1 reference

Cold urticaria, immunodeficiency, and autoimmunity related to PLCG2 deletions

21 January 2018

1 reference

Immune dysregulation in human subjects with heterozygous germline mutations in CTLA4

21 January 2018

1 reference

DNA polymerase-α regulates the activation of type I interferons through cytosolic RNA:DNA synthesis

21 January 2018

1 reference

Early-onset stroke and vasculopathy associated with mutations in ADA2

21 January 2018

1 reference

Mutant adenosine deaminase 2 in a polyarteritis nodosa vasculopathy.

21 January 2018

1 reference

The human microbiome and autoimmunity

21 January 2018

1 reference

Role of the microbiota in immunity and inflammation

21 January 2018

1 reference

Cystic fibrosis: A disorder with defective autophagy

21 January 2018

1 reference

Nucleic acid by-products and chronic inflammation

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1002/PATH.4812

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Dimensions Publication ID

8 September 2017

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1012334585

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1 reference