(Q38494648)

3 September 2017

1 reference

title

Protein misfolding and dysregulated protein homeostasis in autoinflammatory diseases and beyond (English)

1 reference

3 September 2017

4

Michael F McDermott

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author name string

Amma F Agyemang

series ordinal

1

1 reference

3 September 2017

Stephanie R Harrison

series ordinal

2

1 reference

3 September 2017

Richard M Siegel

series ordinal

3

1 reference

3 September 2017

publication date

21 May 2015

1 reference

full work available at URL

3 September 2017

http://eprints.whiterose.ac.uk/86335/

content deliverer

White Rose Research Online

object has role

postprint

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published in

Seminars in Immunopathology

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3 September 2017

volume

37

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3 September 2017

issue

4

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3 September 2017

page(s)

335-347

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The unfolded protein response: integrating stress signals through the stress sensor IRE1α

3 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

From acute ER stress to physiological roles of the Unfolded Protein Response

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Autophagy genes in immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Autophagy in the Pathogenesis of Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Lighting the fires within: the cell biology of autoinflammatory diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Germline mutations in the extracellular domains of the 55 kDa TNF receptor, TNFR1, define a family of dominantly inherited autoinflammatory syndromes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

A proposed classification of the immunological diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Autoinflammatory syndromes and cellular responses to stress: pathophysiology, diagnosis and new treatment perspectives

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Autoinflammatory diseases: an update of clinical and genetic aspects

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Tumour necrosis factor receptor-associated periodic syndrome (TRAPS): state of the art and future perspectives

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Concerted action of wild-type and mutant TNF receptors enhances inflammation in TNF receptor 1-associated periodic fever syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Tumor necrosis factor (TNF) receptor shedding controls thresholds of innate immune activation that balance opposing TNF functions in infectious and inflammatory diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Shedding of mutant tumor necrosis factor receptor superfamily 1A associated with tumor necrosis factor receptor-associated periodic syndrome: differences between cell types

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Mutant tumor necrosis factor receptor associated with tumor necrosis factor receptor-associated periodic syndrome is altered antigenically and is retained within patients' leukocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Mutant forms of tumour necrosis factor receptor I that occur in TNF-receptor-associated periodic syndrome retain signalling functions but show abnormal behaviour.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Modeling of tumor necrosis factor receptor superfamily 1A mutants associated with tumor necrosis factor receptor-associated periodic syndrome indicates misfolding consistent with abnormal function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Abnormal disulfide-linked oligomerization results in ER retention and altered signaling by TNFR1 mutants in TNFR1-associated periodic fever syndrome (TRAPS)

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Tumor necrosis factor receptor I from patients with tumor necrosis factor receptor-associated periodic syndrome interacts with wild-type tumor necrosis factor receptor I and induces ligand-independent NF-kappaB activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Abnormal tumor necrosis factor receptor I cell surface expression and NF-kappaB activation in tumor necrosis factor receptor-associated periodic syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Involvement of X-box binding protein 1 and reactive oxygen species pathways in the pathogenesis of tumour necrosis factor receptor-associated periodic syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS)

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

A novel TNFRSF1A splice mutation associated with increased nuclear factor kappaB (NF-kappaB) transcription factor activation in patients with tumour necrosis factor receptor associated periodic syndrome (TRAPS).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Persistent efficacy of anakinra in patients with tumor necrosis factor receptor-associated periodic syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Autophagy contributes to inflammation in patients with TNFR-associated periodic syndrome (TRAPS).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Tumor necrosis factor receptor-associated periodic syndrome as a model linking autophagy and inflammation in protein aggregation diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

p62 at the crossroads of autophagy, apoptosis, and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Defects in mitochondrial clearance predispose human monocytes to interleukin-1β hypersecretion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

PSMB8 encoding the β5i proteasome subunit is mutated in joint contractures, muscle atrophy, microcytic anemia, and panniculitis-induced lipodystrophy syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Proteasome assembly defect due to a proteasome subunit beta type 8 (PSMB8) mutation causes the autoinflammatory disorder, Nakajo-Nishimura syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

A mutation in the immunoproteasome subunit PSMB8 causes autoinflammation and lipodystrophy in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Mutations in proteasome subunit β type 8 cause chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature with evidence of genetic and phenotypic heterogeneity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Immunoproteasomes preserve protein homeostasis upon interferon-induced oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Inflammasomes in health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Cryopyrin/NALP3 binds ATP/dATP, is an ATPase, and requires ATP binding to mediate inflammatory signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Uncoupling protein 2 deficiency aggravates astrocytic endoplasmic reticulum stress and nod-like receptor protein 3 inflammasome activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Gain-of-function Pyrin mutations induce NLRP3 protein-independent interleukin-1β activation and severe autoinflammation in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

The clinical continuum of cryopyrinopathies: novel CIAS1 mutations in North American patients and a new cryopyrin model

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Familial cold autoinflammatory syndrome: phenotype and genotype of an autosomal dominant periodic fever

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

New mutations of CIAS1 that are responsible for Muckle-Wells syndrome and familial cold urticaria: a novel mutation underlies both syndromes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

De novo CIAS1 mutations, cytokine activation, and evidence for genetic heterogeneity in patients with neonatal-onset multisystem inflammatory disease (NOMID): a new member of the expanding family of pyrin-associated autoinflammatory diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Chronic infantile neurological cutaneous and articular syndrome is caused by mutations in CIAS1, a gene highly expressed in polymorphonuclear cells and chondrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Autophagy controls IL-1beta secretion by targeting pro-IL-1beta for degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Neonatal-onset multisystem inflammatory disease responsive to interleukin-1beta inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Interleukin-1-receptor antagonist in the Muckle-Wells syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

An activating NLRC4 inflammasome mutation causes autoinflammation with recurrent macrophage activation syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Mutation of NLRC4 causes a syndrome of enterocolitis and autoinflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

HLA-B27 misfolding is associated with aberrant intermolecular disulfide bond formation (dimerization) in the endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

HLA-B27 up-regulation causes accumulation of misfolded heavy chains and correlates with the magnitude of the unfolded protein response in transgenic rats: Implications for the pathogenesis of spondylarthritis-like disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

HLA-B27 misfolding in transgenic rats is associated with activation of the unfolded protein response.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Evidence that autophagy, but not the unfolded protein response, regulates the expression of IL-23 in the gut of patients with ankylosing spondylitis and subclinical gut inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

HLA-B27 misfolding and the unfolded protein response augment interleukin-23 production and are associated with Th17 activation in transgenic rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

No evidence for a critical role of the unfolded protein response in synovium and blood of patients with ankylosing spondylitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

IL-23 induces spondyloarthropathy by acting on ROR-γt+ CD3+CD4-CD8- entheseal resident T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Molecular identification of a danger signal that alerts the immune system to dying cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Engagement of CD14 mediates the inflammatory potential of monosodium urate crystals.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Gout-associated uric acid crystals activate the NALP3 inflammasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Urate crystals stimulate production of tumor necrosis factor alpha from human blood monocytes and synovial cells. Cytokine mRNA and protein kinetics, and cellular distribution

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

NLRP3 promotes autophagy of urate crystals phagocytized by human osteoblasts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Neutrophil extracellular trap formation is associated with IL-1β and autophagy-related signaling in gout

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

TLR dependent XBP-1 activation induces an autocrine loop in rheumatoid arthritis synoviocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Toll-like receptor-mediated IRE1α activation as a therapeutic target for inflammatory arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

SNAPIN: an endogenous Toll-like receptor ligand in rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

A central role for JNK in obesity and insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Mechanisms for insulin resistance: common threads and missing links

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Dysregulation of the expression and secretion of inflammation-related adipokines by hypoxia in human adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Increase in endoplasmic reticulum stress-related proteins and genes in adipose tissue of obese, insulin-resistant individuals

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Endoplasmic reticulum stress markers are associated with obesity in nondiabetic subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Endoplasmic reticulum stress is reduced in tissues of obese subjects after weight loss

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Adipose tissue hypoxia in obesity and its impact on adipocytokine dysregulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

PPARβ/δ prevents endoplasmic reticulum stress-associated inflammation and insulin resistance in skeletal muscle cells through an AMPK-dependent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

SIRT1 exerts anti-inflammatory effects and improves insulin sensitivity in adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Islet amyloid polypeptide (IAPP) transgenic rodents as models for type 2 diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

IL-1 antagonism reduces hyperglycemia and tissue inflammation in the type 2 diabetic GK rat

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Sustained effects of interleukin-1 receptor antagonist treatment in type 2 diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Alpha-synuclein locus duplication as a cause of familial Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

alpha-Synuclein locus triplication causes Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Systemic exposure to proteasome inhibitors causes a progressive model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Altered proteasomal function in sporadic Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Aggregated and monomeric alpha-synuclein bind to the S6' proteasomal protein and inhibit proteasomal function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

α-Synuclein Is Degraded by Both Autophagy and the Proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Lipopolysaccharide-induced neuroinflammation leads to the accumulation of ubiquitinated proteins and increases susceptibility to neurodegeneration induced by proteasome inhibition in rat hippocampus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Alpha-synuclein in Lewy bodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Glucose regulated protein 78 diminishes α-synuclein neurotoxicity in a rat model of Parkinson disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Loss of autophagy in the central nervous system causes neurodegeneration in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

α-Synuclein impairs macroautophagy: implications for Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Inflammasome activation leads to Caspase-1-dependent mitochondrial damage and block of mitophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Neuroinflammation and oxidation/nitration of alpha-synuclein linked to dopaminergic neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Tumor necrosis factor-alpha (TNF-alpha) increases both in the brain and in the cerebrospinal fluid from parkinsonian patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Microglial activation-mediated delayed and progressive degeneration of rat nigral dopaminergic neurons: relevance to Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

TNFalpha transport across the blood-brain barrier is abolished in receptor knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Modulation of interleukin-1 and tumor necrosis factor expression by ?-adrenergic agonists in mouse ameboid microglial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Central and systemic IL-1 exacerbates neurodegeneration and motor symptoms in a model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Progressive neurodegeneration and motor disabilities induced by chronic expression of IL-1beta in the substantia nigra.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Rapid appearance and local toxicity of amyloid-beta plaques in a mouse model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

The unfolded protein response is activated in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

The unfolded protein response is activated in pretangle neurons in Alzheimer's disease hippocampus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Phosphorylation of eukaryotic initiation factor-2alpha (eIF2alpha) is associated with neuronal degeneration in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

The NALP3 inflammasome is involved in the innate immune response to amyloid-beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Amyloid-β and tau--a toxic pas de deux in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Disease-associated amyloid and misfolded protein aggregates activate the inflammasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Interleukin-1 beta and interleukin-6 are elevated in the cerebrospinal fluid of Alzheimer's and de novo Parkinson's disease patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Racial differences in the prevalence of age-related macular degeneration: the Baltimore Eye Survey

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Prevalence of age-related macular degeneration in the United States

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Characterization of beta amyloid assemblies in drusen: the deposits associated with aging and age-related macular degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Transformation of the proteasome with age-related macular degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Complement activation and inflammatory processes in Drusen formation and age related macular degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Suppression of retinal degeneration in Drosophila by stimulation of ER-associated degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Induction of endoplasmic reticulum stress genes, BiP and chop, in genetic and environmental models of retinal degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

ER stress protects from retinal degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Complement factor C3a alters proteasome function in human RPE cells and in an animal model of age-related RPE degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Unfolded protein response in a Drosophila model for retinal degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Endoplasmic reticulum stress is activated in light-induced retinal degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

The proteasome: a target of oxidative damage in cultured human retina pigment epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Crosstalk between Hsp70 molecular chaperone, lysosomes and proteasomes in autophagy-mediated proteolysis in human retinal pigment epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Drusen proteome analysis: an approach to the etiology of age-related macular degeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

NLRP3 has a protective role in age-related macular degeneration through the induction of IL-18 by drusen components

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Spliced X-box binding protein 1 couples the unfolded protein response to hexosamine biosynthetic pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

Blockade of XBP1 splicing by inhibition of IRE1α is a promising therapeutic option in multiple myeloma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00281-015-0496-2

TNF-α inhibits PPARβ/δ activity and SIRT1 expression through NF-κB in human adipocytes

21 January 2018

1 reference

12 December 2020

Involvement of ER stress in retinal cell death

1 reference

12 December 2020

Age-related macular degeneration

1 reference

12 December 2020

Interleukin 1 (IL 1) as a mediator of crystal arthritis. Stimulation of T cell and synovial fibroblast mitogenesis by urate crystal-induced IL 1.

1 reference

12 December 2020

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases.

1 reference

12 December 2020

The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice

1 reference

12 December 2020

Aging of the human retina. Differential loss of neurons and retinal pigment epithelial cells

1 reference

12 December 2020

Misfolding of HLA-B27 as a result of its B pocket suggests a novel mechanism for its role in susceptibility to spondyloarthropathies

1 reference

12 December 2020

The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease

1 reference

12 December 2020

Enhanced p62 expression through impaired proteasomal degradation is involved in caspase-1 activation in monosodium urate crystal-induced interleukin-1b expression

1 reference

12 December 2020

Interleukin-1 beta, interleukin-6, epidermal growth factor and transforming growth factor-alpha are elevated in the brain from parkinsonian patients

1 reference

12 December 2020

Dopamine-modified alpha-synuclein blocks chaperone-mediated autophagy

1 reference

12 December 2020

The prevalence of age-related maculopathy in the Rotterdam Study

1 reference

12 December 2020

X-box binding protein 1 is essential for the anti-oxidant defense and cell survival in the retinal pigment epithelium

1 reference

12 December 2020

Relation between Age of Onset of Obesity and Size and Number of Adipose Cells

1 reference

12 December 2020

10.1007/S00281-015-0496-2

Identifiers

DOI

1 reference

10.1007/S00281-015-0496-2

3 September 2017

Altmetric DOI

0 references

Dimensions Publication ID

1035550469

0 references

1 reference