(Q67541455)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:1380407%20AND%20SRC:MED&resulttype=core&format=json

14 September 2019

title

Biochemical modulation of 5-fluorouracil with or without leucovorin by a low dose of brequinar in MGH-U1 cells (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:1380407%20AND%20SRC:MED&resulttype=core&format=json

14 September 2019

1 reference

2

C Erlichman

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:1380407%20AND%20SRC:MED&resulttype=core&format=json

14 September 2019

author name string

T. L. Chen

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1380407

20 September 2022

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=1380407

20 September 2022

publication date

1 January 1992

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:1380407%20AND%20SRC:MED&resulttype=core&format=json

Cancer Chemotherapy and Pharmacology

14 September 2019

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:1380407%20AND%20SRC:MED&resulttype=core&format=json

14 September 2019

volume

30

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:1380407%20AND%20SRC:MED&resulttype=core&format=json

14 September 2019

issue

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:1380407%20AND%20SRC:MED&resulttype=core&format=json

14 September 2019

page(s)

370-376

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:1380407%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1007/bf00689965

14 September 2019

exact match

0 references

cites work

Sensitivity of human, murine, and rat cells to 5-fluorouracil and 5'-deoxy-5-fluorouridine in relation to drug-metabolizing enzymes

1 reference

12 December 2020

Fluorouracil and leucovorin for metastatic colorectal cancer

1 reference

12 December 2020

Inhibition of pyrimidine de novo synthesis by DUP-785 (NSC 368390)

1 reference

12 December 2020

Mechanisms of innate resistance to thymidylate synthase inhibition after 5-fluorouracil

1 reference

12 December 2020

Clinical pharmacology of 5-fluorouracil

1 reference

12 December 2020

An Isotopic Assay for Thymidylate Synthetase*

1 reference

12 December 2020

A phase I clinical and pharmacokinetic study of Brequinar sodium, DUP 785 (NSC 368390), using a weekly and a biweekly schedule

1 reference

12 December 2020

Activity of a novel 4-quinolinecarboxylic acid, NSC 368390 [6-fluoro-2-(2'-fluoro-1,1'-biphenyl-4-yl)-3-methyl-4-quinolinecarb oxylic acid sodium salt], against experimental tumors.

1 reference

12 December 2020

The relation between inhibition of cell growth and of dihydroorotic acid dehydrogenase by brequinar sodium

1 reference

12 December 2020

Biochemical rationale for the 5-fluorouracil leucovorin combination and update of clinical experience

1 reference

12 December 2020

The pharmacology of the fluoropyrimidines

1 reference

12 December 2020

Overview of current status and future direction of clinical trials with 5-fluorouracil in combination with folinic acid

1 reference

12 December 2020

Clinical trial with 5-fluorouracil and leucovorin

1 reference

12 December 2020

Biochemical interactions between N-(phosphonacetyl)-L-aspartate and 5-fluorouracil

1 reference

12 December 2020

Biochemical rationale for the synergism of 5-fluorouracil and folinic acid

1 reference

12 December 2020

Biochemistry and clinical activity of N-(phosphonacetyl)-L-aspartate: a review

1 reference

12 December 2020

Fluorinated pyrimidines and their nucleosides

1 reference

12 December 2020

Phase II study of biochemical modulation of fluorouracil by low-dose PALA in patients with colorectal cancer

1 reference

12 December 2020

Phase I and pharmacokinetic study of brequinar sodium (NSC 368390).

1 reference

12 December 2020

Mechanism of action of the novel anticancer agent 6-fluoro-2-(2'-fluoro-1,1'-biphenyl-4-yl)-3-methyl-4-quinolinecarbo xylic acid sodium salt (NSC 368390): inhibition of de novo pyrimidine nucleotide biosynthesis

1 reference

12 December 2020

A comparison of 5-fluorouracil metabolism in human colorectal cancer and colon mucosa

1 reference

12 December 2020

Effects of 5-fluorouracil and leucovorin in spheroids: a model for solid tumours

1 reference

12 December 2020

Phase I clinical and pharmacokinetic trial of Brequinar sodium (DuP 785; NSC 368390).

1 reference

12 December 2020

The activity of the pyrimidine biosynthetic pathway in MGH-U1 transitional carcinoma cells grown in tissue culture

1 reference

12 December 2020

DUP 785 (NSC 368390): schedule-dependency of growth-inhibitory and antipyrimidine effects

1 reference

12 December 2020

Therapeutic utility of utilizing low doses of N-(phosphonacetyl)-L-aspartic acid in combination with 5-fluorouracil: a murine study with clinical relevance

1 reference

12 December 2020

Antitumor activity of brequinar sodium (Dup-785) against human head and neck squamous cell carcinoma xenografts

1 reference

12 December 2020

Efficacy and toxicity of 5-fluorouracil and folates in advanced colon cancer

1 reference

12 December 2020

Biochemical determinants of tumor sensitivity to 5-fluorouracil: Ultrasensitive methods for the determination of 5-fluoro-2′-deoxyuridylate, 2′-deoxyuridylate, and thymidylate synthetase

1 reference

12 December 2020

Enhancement of the antitumor effects of 5-fluorouracil by folinic acid

1 reference

12 December 2020

5-Fluorouracil (FUra)

1 reference

12 December 2020

Leucovorin enhancement of the effects of the fluoropyrimidines on thymidylate synthase

1 reference

12 December 2020

Fluorouracil: biochemistry and pharmacology

1 reference

12 December 2020

Distribution of the novel anticancer drug candidate brequinar sodium (DuP 785, NSC 368390) into normal and tumor tissues of nude mice bearing human colon carcinoma xenografts

1 reference

12 December 2020

Application of biochemical modulation with a therapeutically inactive modulating agent in clinical trials of cancer chemotherapy

1 reference

12 December 2020

A randomized phase I and II study of short-term infusion of high-dose fluorouracil with or without N-(phosphonacetyl)-L-aspartic acid in patients with advanced pancreatic and colorectal cancers

1 reference

12 December 2020

Phase I and clinical pharmacological evaluation of biochemical modulation of 5-fluorouracil with N-(phosphonacetyl)-L-aspartic acid

1 reference

12 December 2020

Biochemical modulation: application of laboratory models to the clinic

1 reference

12 December 2020