(Q68642203)

English

Physiological modeling of drug and metabolite: disposition of oxazepam and oxazepam glucuronides in the recirculating perfused mouse liver preparation

scientific article published on 01 October 1990

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:2266497%20AND%20SRC:MED&resulttype=core&format=json

26 September 2019

Physiological modeling of drug and metabolite: disposition of oxazepam and oxazepam glucuronides in the recirculating perfused mouse liver preparation (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:2266497%20AND%20SRC:MED&resulttype=core&format=json

26 September 2019

author name string

M V St-Pierre

1

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Europe PubMed Central

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26 September 2019

D van den Berg

2

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:2266497%20AND%20SRC:MED&resulttype=core&format=json

26 September 2019

K S Pang

3

1 reference

Europe PubMed Central

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26 September 2019

publication date

1 October 1990

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Europe PubMed Central

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26 September 2019

Journal of Pharmacokinetics and Pharmacodynamics

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:2266497%20AND%20SRC:MED&resulttype=core&format=json

26 September 2019

18

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26 September 2019

5

1 reference

Europe PubMed Central

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26 September 2019

423-448

1 reference

Europe PubMed Central

PubMed publication ID

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26 September 2019

https://scigraph.springernature.com/pub.10.1007/bf01061703

0 references

Renal handling of enalapril and enalaprilat: studies in the isolated red blood cell-perfused rat kidney

1 reference

https://pubmed.ncbi.nlm.nih.gov/2266497

12 December 2020

based on heuristic

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Species-dependent glucuronidation of drugs by immobilized rabbit, rhesus monkey, and human UDP-glucuronyltransferases

1 reference

https://pubmed.ncbi.nlm.nih.gov/2266497

12 December 2020

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Pharmacokinetic procedures for the estimation of organ clearances for the formation of short-lived metabolites. Acetaminophen-induced glutathione depletion in hamster liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/2266497

12 December 2020

based on heuristic

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Sequential first-pass elimination of a metabolite derived from a precursor

1 reference

https://pubmed.ncbi.nlm.nih.gov/2266497

12 December 2020

based on heuristic

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Comparative Single-Dose Kinetics of Oxazolam, Prazepam, and Clorazepate: Three Precursors of Desmethyldiazepam

1 reference

https://pubmed.ncbi.nlm.nih.gov/2266497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of perfusate flow rate on measured blood volume, disse space, intracellular water space, and drug extraction in the perfused rat liver preparation: characterization by the multiple indicator dilution technique

1 reference

https://pubmed.ncbi.nlm.nih.gov/2266497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of a diffusional barrier to a metabolite across hepatocytes on its kinetics in "enzyme-distributed" models: a computer-aided simulation study

1 reference

https://pubmed.ncbi.nlm.nih.gov/2266497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The metabolic disposition of oxazepam in rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/2266497

12 December 2020

based on heuristic

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Physiological model for the pharmacokinetics of cis-dichlorodiammineplatinum (II) (DDP) in the tumored rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/2266497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein binding of oxazepam and its glucuronide conjugates to human albumin.

1 reference

https://pubmed.ncbi.nlm.nih.gov/2266497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Influence of administration route and blood sampling site on the area under the curve. Assessment of gut wall, liver, and lung metabolism from a physiological model

1 reference

https://pubmed.ncbi.nlm.nih.gov/2266497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kinetics of drug metabolism inhibition: Use of metabolite concentration-time profiles

1 reference

https://pubmed.ncbi.nlm.nih.gov/2266497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clearance of prednisone in isolated perfused livers of normal and uremic rats. Effects of acute and chronic cyclosporin A administration

1 reference

https://pubmed.ncbi.nlm.nih.gov/2266497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolite to parent drug concentration ratio as a function of parent drug extraction ratio: Cases of nonportal route of administration

1 reference

https://pubmed.ncbi.nlm.nih.gov/2266497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ABSORPTION, METABOLISM, AND EXCRETION OF OXAZEPAM AND ITS SUCCINATE HALF-ESTER

1 reference

https://pubmed.ncbi.nlm.nih.gov/2266497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Drug metabolite kinetics: noncompartmental analysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/2266497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of diffusional barriers on drug and metabolite kinetics

1 reference

https://pubmed.ncbi.nlm.nih.gov/2266497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An area function method for calculating the apparent elimination rate constant of a metabolite

1 reference

https://pubmed.ncbi.nlm.nih.gov/2266497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The multiple-indicator dilution technique for characterization of normal and retrograde flow in once-through rat liver perfusions

1 reference

https://pubmed.ncbi.nlm.nih.gov/2266497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatic clearance of drugs. II. Experimental evidence for acceptance of the “well-stirred” model over the “parallel tube” model using lidocaine in the perfused rat liverin situ preparation

1 reference

https://pubmed.ncbi.nlm.nih.gov/2266497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Control of gluconeogenesis and glycogenolysis in perfused livers of normal mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/2266497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isolated perfusion of murine liver in situ: technique and validation

1 reference

https://pubmed.ncbi.nlm.nih.gov/2266497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A pharmacokinetic analysis program (multi) for microcomputer

1 reference

https://pubmed.ncbi.nlm.nih.gov/2266497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Species-related differences in the stereoselective glucuronidation of oxazepam

1 reference

https://pubmed.ncbi.nlm.nih.gov/2266497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Drug metabolite kinetics

1 reference

https://pubmed.ncbi.nlm.nih.gov/2266497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Commentary: a physiological approach to hepatic drug clearance

1 reference

https://pubmed.ncbi.nlm.nih.gov/2266497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetic modeling of the anticonvulsant response of oxazepam in rats using the pentylenetetrazol threshold concentration as pharmacodynamic measure

1 reference

https://pubmed.ncbi.nlm.nih.gov/2266497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolism of diazepam in rat, dog, and man.

1 reference

https://pubmed.ncbi.nlm.nih.gov/2266497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A model for the kinetics of distribution of actinomycin-D in the beagle dog

1 reference

https://pubmed.ncbi.nlm.nih.gov/2266497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Drug metabolite concentration-time profiles: influence of route of drug administration

1 reference

https://pubmed.ncbi.nlm.nih.gov/2266497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clearance concepts in pharmacokinetics

1 reference

https://pubmed.ncbi.nlm.nih.gov/2266497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A review of the applications of physiologically based pharmacokinetic modeling

1 reference

https://pubmed.ncbi.nlm.nih.gov/2266497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Primary, secondary, and tertiary metabolite kinetics.

1 reference

https://pubmed.ncbi.nlm.nih.gov/2266497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A review of metabolite kinetics

1 reference

https://pubmed.ncbi.nlm.nih.gov/2266497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Assessment of liver function in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/2266497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A simple method for obtaining the mean residence time of metabolites in the body

1 reference

https://pubmed.ncbi.nlm.nih.gov/2266497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Influence of sampling on drug kinetics in liver perfusion

1 reference

https://pubmed.ncbi.nlm.nih.gov/2266497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Physiologically Based Pharmacokinetic Modeling: Principles and Applications

1 reference

https://pubmed.ncbi.nlm.nih.gov/2266497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cisplatin pharmacokinetics: applications of a physiological model

1 reference

https://pubmed.ncbi.nlm.nih.gov/2266497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The area under the curve of metabolites for drugs and metabolites cleared by the liver and extrahepatic organs. Its dependence on the administration route of precursor drug

1 reference

https://pubmed.ncbi.nlm.nih.gov/2266497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A simple integrated method for drug and derived metabolite kinetics. An application of the statistical moment theory

1 reference

https://pubmed.ncbi.nlm.nih.gov/2266497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A commentary: methods and assumptions in the kinetic estimation of metabolite formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/2266497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The metabolic fate of oxazepam in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/2266497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Iminocyclophosphamide as a chemically reactive metabolite of cyclophosphamide

1 reference

https://pubmed.ncbi.nlm.nih.gov/2266497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacologically active drug metabolites: therapeutic and toxic activities, plasma and urine data in man, accumulation in renal failure

1 reference

https://pubmed.ncbi.nlm.nih.gov/2266497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A preliminary pharmacokinetic model for several chlorinated biphenyls in the rat

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Statistical moment theory in chemical kinetics.

1 reference

https://pubmed.ncbi.nlm.nih.gov/2266497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A physiological model for renal drug metabolism: enalapril esterolysis to enalaprilat in the isolated perfused rat kidney

1 reference

https://pubmed.ncbi.nlm.nih.gov/2266497

12 December 2020

based on heuristic

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Physiologically based pharmacokinetics of radioiodinated human beta-endorphin in rats. An application of the capillary membrane-limited model.

1 reference

https://pubmed.ncbi.nlm.nih.gov/2266497

12 December 2020

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The biotransformation of oxazepam (7-chloro-1,3-dihydro-3-hydroxy-5-phenyl-2H-1,4-benzodiazepin-2-one) in man, miniature swine and rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/2266497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Determination of diazepam and its metabolites by high-performance liquid chromatography and thin-layer chromatography

1 reference

https://pubmed.ncbi.nlm.nih.gov/2266497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tissue distribution of 14C-diazepam and its metabolites in rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/2266497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/BF01061703

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:2266497%20AND%20SRC:MED&resulttype=core&format=json

26 September 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:2266497%20AND%20SRC:MED&resulttype=core&format=json

26 September 2019

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