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A novel exon within the mdm2 gene modulates translation initiation in vitro and disrupts the p53-binding domain of mdm2 protein
scientific article published on 01 November 1999
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Europe PubMed Central
PubMed publication ID
10597303
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10597303%20AND%20SRC:MED&resulttype=core&format=json
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2 November 2019
title
A novel exon within the mdm2 gene modulates translation initiation in vitro and disrupts the p53-binding domain of mdm2 protein
(English)
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10597303
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10597303%20AND%20SRC:MED&resulttype=core&format=json
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2 November 2019
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N Veldhoen
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1
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Europe PubMed Central
PubMed publication ID
10597303
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10597303%20AND%20SRC:MED&resulttype=core&format=json
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2 November 2019
S Metcalfe
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2
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Europe PubMed Central
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10597303
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2 November 2019
J Milner
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3
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PubMed publication ID
10597303
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2 November 2019
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1 November 1999
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PubMed publication ID
10597303
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retrieved
2 November 2019
published in
Oncogene
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PubMed publication ID
10597303
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10597303%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 November 2019
volume
18
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Europe PubMed Central
PubMed publication ID
10597303
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2 November 2019
issue
50
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Europe PubMed Central
PubMed publication ID
10597303
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2 November 2019
page(s)
7026-7033
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Europe PubMed Central
PubMed publication ID
10597303
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2 November 2019
exact match
https://scigraph.springernature.com/pub.10.1038/sj.onc.1203182
0 references
cites work
Testicular tissue-specific expression of the p53 suppressor gene
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203182
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of mdm2 expression by p53: alternative promoters produce transcripts with nonidentical translation potential
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203182
retrieved
7 January 2021
based on heuristic
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Molecular characterization of the hdm2-p53 interaction
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203182
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A non-AUG translational initiation event generates novel WT1 isoforms
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203182
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Molecular analysis and chromosomal mapping of amplified genes isolated from a transformed mouse 3T3 cell line
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203182
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mapping of the p53 and mdm-2 interaction domains
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203182
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Evidence for allosteric variants of wild-type p53, a tumour suppressor protein
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203182
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The MDM2 oncoprotein binds specifically to RNA through its RING finger domain
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203182
retrieved
7 January 2021
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inferred from DOI database lookup
A genetic approach to mapping the p53 binding site in the MDM2 protein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203182
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Evidence that immunological variants of p53 represent alternative protein conformations
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203182
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Human endometrial stromal cells express novel isoforms of the transcriptional modulator CREM and up-regulate ICER in the course of decidualization
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203182
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The mdm2 proto-oncogene
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203182
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Physical and functional interaction between wild-type p53 and mdm2 proteins
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203182
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mdm2 promotes the rapid degradation of p53
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203182
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203182
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203182
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Genomic organization of the mouse double minute 2 gene
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203182
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The Mdm2 oncoprotein interacts with the cell fate regulator Numb
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203182
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Expression of alternatively spliced mdm2 transcripts correlates with stabilized wild-type p53 protein in human glioblastoma cells.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203182
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Keeping an old friend under control: regulation of p53 stability
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203182
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203182
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Targeted expression of MDM2 uncouples S phase from mitosis and inhibits mammary gland development independent of p53.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203182
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The ribosomal L5 protein is associated with mdm-2 and mdm-2-p53 complexes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203182
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Conservation of structural domains and biochemical activities of the MDM2 protein from Xenopus laevis.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203182
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Stimulation of E2F1/DP1 transcriptional activity by MDM2 oncoprotein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203182
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Translational termination efficiency in mammals is influenced by the base following the stop codon.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203182
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The MDM2 gene amplification database
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203182
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mdm-2: "big brother" of p53.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203182
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203182
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The organization and expression of the mdm2 gene
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203182
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203182
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Amplification of a gene encoding a p53-associated protein in human sarcomas
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203182
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203182
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Splicing of messenger RNA precursors
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203182
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mdm2: keeping p53 under control
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203182
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203182
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mice with reduced levels of p53 protein exhibit the testicular giant-cell degenerative syndrome
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203182
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Multiple murine double minute gene 2 (MDM2) proteins are induced by ultraviolet light
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203182
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Alternatively spliced mdm2 transcripts with loss of p53 binding domain sequences: transforming ability and frequent detection in human cancer.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203182
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p53-independent role of MDM2 in TGF-beta1 resistance
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203182
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Isolation of canine p53 cDNA and detailed characterization of the full length canine p53 protein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203182
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Interaction between the retinoblastoma protein and the oncoprotein MDM2
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1203182
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1038/SJ.ONC.1203182
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10597303
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10597303%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 November 2019
Dimensions Publication ID
1037698792
0 references
PubMed publication ID
10597303
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10597303
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10597303%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 November 2019
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