(Q73551258)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10718341%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

title

Pharmacological properties of a new aziridinylbenzoquinone, RH1 (2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone), in mice (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10718341%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

1

1 reference

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4 November 2019

Roger M. Phillips

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10718341%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

author name string

L E Lim

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10718341%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

M C Bibby

series ordinal

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10718341%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

language of work or name

English

0 references

publication date

1 April 2000

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10718341%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

published in

Biochemical Pharmacology

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10718341%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

volume

59

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10718341%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

page(s)

831-837

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10718341%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

issue

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10718341%20AND%20SRC:MED&resulttype=core&format=json

Cytosolic NAD(P)H:(quinone-acceptor)oxidoreductase in human normal and tumor tissue: effects of cigarette smoking and alcohol

4 November 2019

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900391-3

Reductive metabolism of diaziquone (AZQ) in the S9 fraction of MCF-7 cells. II. Enhancement of the alkylating activity of AZQ by NAD(P)H: quinone-acceptor oxidoreductase (DT-diaphorase)

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900391-3

The Role of NAD(P)H: Quinone Reductase (EC 1.6.99.2, DT-Diaphorase) in the Reductive Bioactivation of the Novel Indoloquinone Antitumor Agent E09

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900391-3

EO9: a novel bioreductive alkylating indoloquinone with preferential solid tumour activity and lack of bone marrow toxicity in preclinical models

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900391-3

Factors affecting sensitivity to EO9 in rodent and human tumour cells in vitro: DT-diaphorase activity and hypoxia

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900391-3

A randomized phase II study with two schedules of the novel indoloquinone EO9 in non-small-cell lung cancer: a study of the EORTC Early Clinical Studies Group (ECSG)

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900391-3

EO9 phase II study in advanced breast, gastric, pancreatic and colorectal carcinoma by the EORTC Early Clinical Studies Group

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900391-3

Evaluation of a novel in vitro assay for assessing drug penetration into avascular regions of tumours.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900391-3

Potentiation of EO9 anti-tumour activity by hydralazine

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900391-3

Activity and immunohistochemistry of DT-diaphorase in hamster and human kidney tumours.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900391-3

United Kingdom Co-ordinating Committee on Cancer Research (UKCCCR) Guidelines for the Welfare of Animals in Experimental Neoplasia (Second Edition)

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900391-3

Bioreductive activation of a series of analogues of 5-aziridinyl-3-hydroxymethyl-1-methyl-2-[1H-indole-4, 7-dione] prop-beta-en-alpha-ol (EO9) by human DT-diaphorase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900391-3

In vitro activity of the novel indoloquinone EO-9 and the influence of pH on cytotoxicity.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900391-3

Influence of hydralazine on the pharmacokinetics of tauromustine (TCNU) in mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900391-3

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900391-3

Inhibition of DT-diaphorase (NAD(P)H:quinone oxidoreductase, EC 1.6.99.2) by 5,6-dimethylxanthenone-4-acetic acid (DMXAA) and flavone-8-acetic acid (FAA): implications for bioreductive drug development

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900391-3

Plasma pharmacokinetics of the antitumour agents 5,6-dimethylxanthenone-4-acetic acid, xanthenone-4-acetic acid and flavone-8-acetic acid in mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900391-3

Development and validation of a sensitive solid-phase extraction and high-performance liquid chromatographic assay for the novel bio-reductive anti-tumor agent RH1 in human and mouse plasma

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900391-3

Development and validation of a spectrophotometric assay for measuring the activity of NADH: cytochrome b5 reductase in human tumour cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900391-3

10.1016/S0006-2952(99)00391-3

7 January 2021

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10718341%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

1 reference