(Q73850206)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10837537%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

title

Inhibition of DNA repair as a means of increasing the antitumor activity of DNA reactive agents (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10837537%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

author name string

Eileen Dolan M

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10837537%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

publication date

1 July 1997

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10837537%20AND%20SRC:MED&resulttype=core&format=json

Advanced Drug Delivery Reviews

7 November 2019

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10837537%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

volume

26

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10837537%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

issue

2-3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10837537%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

page(s)

105-118

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10837537%20AND%20SRC:MED&resulttype=core&format=json

Nitrosoureas from chemist to physician: classification and recent approaches to drug design

7 November 2019

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8

7 January 2021

Phase I trial of temozolomide (CCRG 81045: M&B 39831: NSC 362856)

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8

7 January 2021

Comparison of postoperative radiotherapy and combined postoperative radiotherapy and chemotherapy in the multidisciplinary management of malignant gliomas. A joint Radiation Therapy Oncology Group and Eastern Cooperative Oncology Group study

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8

7 January 2021

Systemic chemotherapy for malignant melanoma

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8

7 January 2021

Incidence of second cancers in patients treated for Hodgkin's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8

7 January 2021

The secondary leukemias: challenges and research directions

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8

7 January 2021

Site-specific mutagenesis: retrospective and prospective

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8

7 January 2021

DNA alkylation by the haloethylnitrosoureas: nature of modifications produced and their enzymatic repair or removal

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8

7 January 2021

Metabolism of the chloroethylnitrosoureas

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8

7 January 2021

Cross-linking of DNA induced by chloroethyinitrosourea is prevented by O6-methyiguanine-DNA methyttransferase

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8

7 January 2021

Isolation and purification of O6-alkylguanine-DNA alkyltransferase from human leukemic cells. Prevention of chloroethylnitrosourea-induced cross-links by purified enzyme

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8

7 January 2021

Importance of the DNA repair enzyme O6-alkyl guanine alkyltransferase (AT) in cancer chemotherapy.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8

7 January 2021

DNA-repair methyltransferase as a molecular device for preventing mutation and cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8

7 January 2021

Repair of O6-propylguanine and O6-butylguanine in DNA by O6-alkylguanine-DNA alkyltransferases from rat liver and E. coli

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8

7 January 2021

Formation of covalent complexes between human O6-alkylguanine-DNA alkyltransferase and BCNU-treated defined length synthetic oligodeoxynucleotides

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8

7 January 2021

Defective repair of alkylated DNA by human tumour and SV40-transformed human cell strains

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8

7 January 2021

Lack of the DNA repair protein O6-methylguanine-DNA methyltransferase in histologically normal brain adjacent to primary human brain tumors

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8

7 January 2021

Cell type-specific expression of the O6-alkylguanine-DNA alkyltransferase gene in normal human liver tissues as revealed by in situ hybridization.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8

7 January 2021

Repair of premutagenic DNA lesions in human fetal tissues: evidence for low levels of O6-methylguanine-DNA methyltransferase and uracil-DNA glycosylase activity in some tissues

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8

7 January 2021

Expression of O6-alkylguanine-DNA-alkyltransferase in situ in ovarian and Hodgkin's tumours

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8

7 January 2021

O6-methylguanine-DNA methyltransferase activity in human liver tumors.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8

7 January 2021

Measurement of O6-methylguanine-type adducts in DNA and O6-alkylguanine-DNA-alkyltransferase repair activity in normal and neoplastic human tissues

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8

7 January 2021

O6-methylguanine-DNA methyltransferase activity in breast and brain tumors.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8

7 January 2021

Comparison of O-6-methylguanine DNA methyltransferase (MGMT) mRNA levels in Mer+ and Mer- human tumor cell lines containing the MGMT gene by the polymerase chain reaction technique

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8

7 January 2021

Organization and expression of the human gene for O6-methylguanine-DNA methyltransferase

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8

7 January 2021

The origin of O6-methylguanine-DNA methyltransferase in Chinese hamster ovary cells transfected with human DNA.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8

7 January 2021

Isolation and cDNA cloning of a rat O6-alkylguanine-DNA-alkyltransferase gene, molecular analysis of expression in rat liver

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8

7 January 2021

Isolation and structural characterization of a cDNA clone encoding the human DNA repair protein for O6-alkylguanine

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8

7 January 2021

Targeting of O6-methylguanine-DNA methyltransferase (MGMT) activity by antimessenger oligonucleotide sensitizes CHO/Mex+ transfected cells to mitozolomide.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8

7 January 2021

Pretreatment of normal human fibroblasts and human colon carcinoma cells with MNNG allows chloroethylnitrosourea to produce DNA interstrand crosslinks not observed in cells treated with chloroethylnitrosourea alone.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8

7 January 2021

Inhibition of a specific DNA repair system and nitrosourea cytotoxicity in resistant human cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8

7 January 2021

Phase I study of streptozocin- and carmustine-sequenced administration in patients with advanced cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8

7 January 2021

Modulation of O6-alkylguanine alkyltransferase-directed DNA repair in metastatic colon cancers

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8

7 January 2021

Activity and unexpected lung toxicity of the sequential administration of two alkylating agents--dacarbazine and fotemustine--in patients with melanoma.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8

7 January 2021

Effect of temozolomide and dacarbazine on O6-alkylguanine-DNA alkyltransferase activity and sensitivity of human tumor cells and xenografts to 1,3-bis(2-chloroethyl)-1-nitrosourea

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8

7 January 2021

Anti-neoplastic activity of sequenced administration of O6-benzylguanine, streptozotocin, and 1,3-bis(2-chloroethyl)-1-nitrosourea in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8

7 January 2021

Possible depletion of a DNA repair enzyme in human lymphoma cells by subversive repair

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8

7 January 2021

Exposure of HeLa cells to 0(6)-alkylguanines increases sensitivity to the cytotoxic effects of alkylating agents

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8

7 January 2021

Increased cytotoxicity of 1-(2-chloroethyl)-1-nitroso-3(4-methyl)-cyclohexylurea by pretreatment with O6-methylguanine in resistant but not in sensitive human melanoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8

7 January 2021

Depletion of O6-alkylguanine-DNA alkyltransferase activity in mammalian tissues and human tumor xenografts in nude mice by treatment with O6-methylguanine

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8

7 January 2021

Depletion of mammalian O6-alkylguanine-DNA alkyltransferase activity by O6-benzylguanine provides a means to evaluate the role of this protein in protection against carcinogenic and therapeutic alkylating agents

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8

7 January 2021

Comparison of the inactivation of mammalian and bacterial O6-alkylguanine-DNA alkyltransferases by O6-benzylguanine and O6-methylguanine

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8

7 January 2021

Mechanism of inactivation of human O6-alkylguanine-DNA alkyltransferase by O6-benzylguanine

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8

7 January 2021

Use of antibodies to human O6-alkylguanine-DNA alkyltransferase to study the content of this protein in cells treated with O6-benzylguanine or N-methyl-N'-nitro-N-nitrosoguanidine

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8

7 January 2021

Depletion of O6-methylguanine-DNA methyltransferase and potentiation of 1,3-bis(2-chloroethyl)-1-nitrosourea antitumor activity by O6-benzylguanine in vitro.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8

7 January 2021

Sensitization of human colon tumour cell lines to carmustine by depletion of O6-alkylguanine-DNA alkyltransferase.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8

7 January 2021

Depletion of O6-alkylguanine-DNA alkyltransferase correlates with potentiation of temozolomide and CCNU toxicity in human tumour cells

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8

7 January 2021

The effects of O6-benzylguanine and hypoxia on the cytotoxicity of 1,3-bis(2-chloroethyl)-1-nitrosourea in nitrosourea-resistant SF-763 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8

7 January 2021

Modulation of mammalian O6-alkylguanine-DNA alkyltransferase in vivo by O6-benzylguanine and its effect on the sensitivity of a human glioma tumor to 1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8

7 January 2021

Enhancement of nitrosourea activity in medulloblastoma and glioblastoma multiforme.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8

7 January 2021

Potential of O6-methylguanine or O6-benzylguanine in the enhancement of chloroethylnitrosourea cytotoxicity on brain tumours

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8

7 January 2021

Treatment of subcutaneous and intracranial brain tumor xenografts with O6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8

7 January 2021

Effect of O6-benzylguanine on the sensitivity of human colon tumor xenografts to 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU).

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8

7 January 2021

Synergistic efficacy of O6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) in a human colon cancer xenograft completely resistant to BCNU alone

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8

7 January 2021

Effect of O6-benzylguanine on the response to 1,3-bis(2-chloroethyl)-1-nitrosourea in the Dunning R3327G model of prostatic cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8

7 January 2021

Human liver oxidative metabolism of O6-benzylguanine

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8

7 January 2021

Potentiation of the cytotoxicity of chloroethylnitrosourea by O6-arylmethylguanines.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8

7 January 2021

Enhancing effect of O6-alkylguanine derivatives on chloroethylnitrosourea cytotoxicity toward tumor cells

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8

7 January 2021

Structural features of substituted purine derivatives compatible with depletion of human O6-alkylguanine-DNA alkyltransferase

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8

7 January 2021

Substituted O6-benzylguanine derivatives and their inactivation of human O6-alkylguanine-DNA alkyltransferase

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8

7 January 2021

8-Substituted O6-benzylguanine, substituted 6(4)-(benzyloxy)pyrimidine, and related derivatives as inactivators of human O6-alkylguanine-DNA alkyltransferase.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8

7 January 2021

Increased killing of prostate, breast, colon, and lung tumor cells by the combination of inactivators of O6-alkylguanine-DNA alkyltransferase and N,N'-bis(2-chloroethyl)-N-nitrosourea

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8

7 January 2021

Metabolism and disposition of O6-benzyl-2'-deoxyguanosine in Sprague-Dawley rats.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8

7 January 2021

Differential inactivation of mammalian and Escherichia coli O6-alkylguanine-DNA alkyltransferases by O6-benzylguanine

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8

7 January 2021

A polymorphism at codon 160 of human O6 methylguanine-DNA methyltransferase gene in young patients with adult type cancers and functional assay

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8

7 January 2021

Leukaemia complicating treatment for Hodgkin's disease: the experience of the British National Lymphoma Investigation

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8

7 January 2021

O6 alkylguanine-DNA alkyltransferase activity in human myeloid cells

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8

7 January 2021

Retrovirus-mediated transfer of the human O6-methylguanine-DNA methyltransferase gene into a murine hematopoietic stem cell line and resistance to the toxic effects of certain alkylating agents

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8

7 January 2021

Retroviral transduction of a mutant methylguanine DNA methyltransferase gene into human CD34 cells confers resistance to O6-benzylguanine plus 1,3-bis(2-chloroethyl)-1-nitrosourea

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8

7 January 2021

Increasing DNA repair methyltransferase levels via bone marrow stem cell transduction rescues mice from the toxic effects of 1,3-bis(2-chloroethyl)-1-nitrosourea, a chemotherapeutic alkylating agent

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8

7 January 2021

The prevention of thymic lymphomas in transgenic mice by human O6-alkylguanine-DNA alkyltransferase

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8

7 January 2021

O6-methylguanine-DNA methyltransferase protects against nitrosamine-induced hepatocarcinogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8

7 January 2021

10.1016/S0169-409X(97)00028-8

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10837537%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

1 reference