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Inhibition of DNA repair as a means of increasing the antitumor activity of DNA reactive agents
scientific article published on 01 July 1997
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1 reference
stated in
Europe PubMed Central
PubMed publication ID
10837537
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10837537%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 November 2019
title
Inhibition of DNA repair as a means of increasing the antitumor activity of DNA reactive agents
(English)
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10837537
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10837537%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 November 2019
author name string
Eileen Dolan M
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10837537
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10837537%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 November 2019
publication date
1 July 1997
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10837537
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10837537%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 November 2019
published in
Advanced Drug Delivery Reviews
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10837537
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10837537%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 November 2019
volume
26
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10837537
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10837537%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 November 2019
issue
2-3
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10837537
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10837537%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 November 2019
page(s)
105-118
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10837537
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10837537%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 November 2019
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Nitrosoureas from chemist to physician: classification and recent approaches to drug design
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Phase I trial of temozolomide (CCRG 81045: M&B 39831: NSC 362856)
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Comparison of postoperative radiotherapy and combined postoperative radiotherapy and chemotherapy in the multidisciplinary management of malignant gliomas. A joint Radiation Therapy Oncology Group and Eastern Cooperative Oncology Group study
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Incidence of second cancers in patients treated for Hodgkin's disease
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7 January 2021
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The secondary leukemias: challenges and research directions
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Site-specific mutagenesis: retrospective and prospective
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DNA alkylation by the haloethylnitrosoureas: nature of modifications produced and their enzymatic repair or removal
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7 January 2021
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Metabolism of the chloroethylnitrosoureas
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7 January 2021
based on heuristic
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Cross-linking of DNA induced by chloroethyinitrosourea is prevented by O6-methyiguanine-DNA methyttransferase
1 reference
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7 January 2021
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Isolation and purification of O6-alkylguanine-DNA alkyltransferase from human leukemic cells. Prevention of chloroethylnitrosourea-induced cross-links by purified enzyme
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8
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7 January 2021
based on heuristic
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Importance of the DNA repair enzyme O6-alkyl guanine alkyltransferase (AT) in cancer chemotherapy.
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8
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7 January 2021
based on heuristic
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DNA-repair methyltransferase as a molecular device for preventing mutation and cancer
1 reference
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Crossref
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7 January 2021
based on heuristic
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Repair of O6-propylguanine and O6-butylguanine in DNA by O6-alkylguanine-DNA alkyltransferases from rat liver and E. coli
1 reference
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7 January 2021
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Formation of covalent complexes between human O6-alkylguanine-DNA alkyltransferase and BCNU-treated defined length synthetic oligodeoxynucleotides
1 reference
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7 January 2021
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Defective repair of alkylated DNA by human tumour and SV40-transformed human cell strains
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7 January 2021
based on heuristic
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Smoking-related increase in O6-alkylguanine-DNA alkyltransferase activity in human lung tissue
1 reference
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https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8
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7 January 2021
based on heuristic
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Lack of the DNA repair protein O6-methylguanine-DNA methyltransferase in histologically normal brain adjacent to primary human brain tumors
1 reference
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7 January 2021
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Cell type-specific expression of the O6-alkylguanine-DNA alkyltransferase gene in normal human liver tissues as revealed by in situ hybridization.
1 reference
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7 January 2021
based on heuristic
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Repair of premutagenic DNA lesions in human fetal tissues: evidence for low levels of O6-methylguanine-DNA methyltransferase and uracil-DNA glycosylase activity in some tissues
1 reference
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7 January 2021
based on heuristic
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Expression of O6-alkylguanine-DNA-alkyltransferase in situ in ovarian and Hodgkin's tumours
1 reference
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Crossref
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7 January 2021
based on heuristic
inferred from DOI database lookup
O6-methylguanine-DNA methyltransferase activity in human liver tumors.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8
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7 January 2021
based on heuristic
inferred from DOI database lookup
Measurement of O6-methylguanine-type adducts in DNA and O6-alkylguanine-DNA-alkyltransferase repair activity in normal and neoplastic human tissues
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8
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7 January 2021
based on heuristic
inferred from DOI database lookup
O6-methylguanine-DNA methyltransferase activity in breast and brain tumors.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8
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7 January 2021
based on heuristic
inferred from DOI database lookup
Comparison of O-6-methylguanine DNA methyltransferase (MGMT) mRNA levels in Mer+ and Mer- human tumor cell lines containing the MGMT gene by the polymerase chain reaction technique
1 reference
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7 January 2021
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Organization and expression of the human gene for O6-methylguanine-DNA methyltransferase
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7 January 2021
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The origin of O6-methylguanine-DNA methyltransferase in Chinese hamster ovary cells transfected with human DNA.
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7 January 2021
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Isolation and cDNA cloning of a rat O6-alkylguanine-DNA-alkyltransferase gene, molecular analysis of expression in rat liver
1 reference
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7 January 2021
based on heuristic
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Isolation and structural characterization of a cDNA clone encoding the human DNA repair protein for O6-alkylguanine
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7 January 2021
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Targeting of O6-methylguanine-DNA methyltransferase (MGMT) activity by antimessenger oligonucleotide sensitizes CHO/Mex+ transfected cells to mitozolomide.
1 reference
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7 January 2021
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Pretreatment of normal human fibroblasts and human colon carcinoma cells with MNNG allows chloroethylnitrosourea to produce DNA interstrand crosslinks not observed in cells treated with chloroethylnitrosourea alone.
1 reference
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Crossref
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7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibition of a specific DNA repair system and nitrosourea cytotoxicity in resistant human cancer cells
1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
Phase I study of streptozocin- and carmustine-sequenced administration in patients with advanced cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8
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7 January 2021
based on heuristic
inferred from DOI database lookup
Modulation of O6-alkylguanine alkyltransferase-directed DNA repair in metastatic colon cancers
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Activity and unexpected lung toxicity of the sequential administration of two alkylating agents--dacarbazine and fotemustine--in patients with melanoma.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Effect of temozolomide and dacarbazine on O6-alkylguanine-DNA alkyltransferase activity and sensitivity of human tumor cells and xenografts to 1,3-bis(2-chloroethyl)-1-nitrosourea
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Anti-neoplastic activity of sequenced administration of O6-benzylguanine, streptozotocin, and 1,3-bis(2-chloroethyl)-1-nitrosourea in vitro and in vivo
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Possible depletion of a DNA repair enzyme in human lymphoma cells by subversive repair
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Exposure of HeLa cells to 0(6)-alkylguanines increases sensitivity to the cytotoxic effects of alkylating agents
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Increased cytotoxicity of 1-(2-chloroethyl)-1-nitroso-3(4-methyl)-cyclohexylurea by pretreatment with O6-methylguanine in resistant but not in sensitive human melanoma cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Depletion of O6-alkylguanine-DNA alkyltransferase activity in mammalian tissues and human tumor xenografts in nude mice by treatment with O6-methylguanine
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Depletion of mammalian O6-alkylguanine-DNA alkyltransferase activity by O6-benzylguanine provides a means to evaluate the role of this protein in protection against carcinogenic and therapeutic alkylating agents
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Comparison of the inactivation of mammalian and bacterial O6-alkylguanine-DNA alkyltransferases by O6-benzylguanine and O6-methylguanine
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mechanism of inactivation of human O6-alkylguanine-DNA alkyltransferase by O6-benzylguanine
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Use of antibodies to human O6-alkylguanine-DNA alkyltransferase to study the content of this protein in cells treated with O6-benzylguanine or N-methyl-N'-nitro-N-nitrosoguanidine
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Depletion of O6-methylguanine-DNA methyltransferase and potentiation of 1,3-bis(2-chloroethyl)-1-nitrosourea antitumor activity by O6-benzylguanine in vitro.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Sensitization of human colon tumour cell lines to carmustine by depletion of O6-alkylguanine-DNA alkyltransferase.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Depletion of O6-alkylguanine-DNA alkyltransferase correlates with potentiation of temozolomide and CCNU toxicity in human tumour cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The effects of O6-benzylguanine and hypoxia on the cytotoxicity of 1,3-bis(2-chloroethyl)-1-nitrosourea in nitrosourea-resistant SF-763 cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Modulation of mammalian O6-alkylguanine-DNA alkyltransferase in vivo by O6-benzylguanine and its effect on the sensitivity of a human glioma tumor to 1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Enhancement of nitrosourea activity in medulloblastoma and glioblastoma multiforme.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Potential of O6-methylguanine or O6-benzylguanine in the enhancement of chloroethylnitrosourea cytotoxicity on brain tumours
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Treatment of subcutaneous and intracranial brain tumor xenografts with O6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Effect of O6-benzylguanine on the sensitivity of human colon tumor xenografts to 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU).
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Synergistic efficacy of O6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) in a human colon cancer xenograft completely resistant to BCNU alone
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Effect of O6-benzylguanine on the response to 1,3-bis(2-chloroethyl)-1-nitrosourea in the Dunning R3327G model of prostatic cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Human liver oxidative metabolism of O6-benzylguanine
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Potentiation of the cytotoxicity of chloroethylnitrosourea by O6-arylmethylguanines.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Enhancing effect of O6-alkylguanine derivatives on chloroethylnitrosourea cytotoxicity toward tumor cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Structural features of substituted purine derivatives compatible with depletion of human O6-alkylguanine-DNA alkyltransferase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Substituted O6-benzylguanine derivatives and their inactivation of human O6-alkylguanine-DNA alkyltransferase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
8-Substituted O6-benzylguanine, substituted 6(4)-(benzyloxy)pyrimidine, and related derivatives as inactivators of human O6-alkylguanine-DNA alkyltransferase.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Increased killing of prostate, breast, colon, and lung tumor cells by the combination of inactivators of O6-alkylguanine-DNA alkyltransferase and N,N'-bis(2-chloroethyl)-N-nitrosourea
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Metabolism and disposition of O6-benzyl-2'-deoxyguanosine in Sprague-Dawley rats.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Differential inactivation of mammalian and Escherichia coli O6-alkylguanine-DNA alkyltransferases by O6-benzylguanine
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A polymorphism at codon 160 of human O6 methylguanine-DNA methyltransferase gene in young patients with adult type cancers and functional assay
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Leukaemia complicating treatment for Hodgkin's disease: the experience of the British National Lymphoma Investigation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
O6 alkylguanine-DNA alkyltransferase activity in human myeloid cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Retrovirus-mediated transfer of the human O6-methylguanine-DNA methyltransferase gene into a murine hematopoietic stem cell line and resistance to the toxic effects of certain alkylating agents
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Retroviral transduction of a mutant methylguanine DNA methyltransferase gene into human CD34 cells confers resistance to O6-benzylguanine plus 1,3-bis(2-chloroethyl)-1-nitrosourea
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Increasing DNA repair methyltransferase levels via bone marrow stem cell transduction rescues mice from the toxic effects of 1,3-bis(2-chloroethyl)-1-nitrosourea, a chemotherapeutic alkylating agent
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The prevention of thymic lymphomas in transgenic mice by human O6-alkylguanine-DNA alkyltransferase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
O6-methylguanine-DNA methyltransferase protects against nitrosamine-induced hepatocarcinogenesis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2897%2900028-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1016/S0169-409X(97)00028-8
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10837537
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10837537%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 November 2019
PubMed publication ID
10837537
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10837537
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10837537%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 November 2019
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