(Q77087878)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11684411%20AND%20SRC:MED&resulttype=core&format=json

2 December 2019

title

Insulin resistance: a phosphorylation-based uncoupling of insulin signaling (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11684411%20AND%20SRC:MED&resulttype=core&format=json

2 December 2019

1 reference

Y Zick

1

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2 December 2019

publication date

1 November 2001

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11684411%20AND%20SRC:MED&resulttype=core&format=json

2 December 2019

published in

Trends in Cell Biology

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11684411%20AND%20SRC:MED&resulttype=core&format=json

2 December 2019

volume

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11684411%20AND%20SRC:MED&resulttype=core&format=json

2 December 2019

issue

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11684411%20AND%20SRC:MED&resulttype=core&format=json

2 December 2019

page(s)

437-441

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11684411%20AND%20SRC:MED&resulttype=core&format=json

Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistance

2 December 2019

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7 January 2021

Recent advances in our understanding of insulin action and insulin resistance

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7 January 2021

Obesity and insulin resistance

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Deconstructing type 2 diabetes

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New perspectives into the molecular pathogenesis and treatment of type 2 diabetes

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7 January 2021

A rapamycin-sensitive pathway down-regulates insulin signaling via phosphorylation and proteasomal degradation of insulin receptor substrate-1.

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7 January 2021

Mammalian target of rapamycin pathway regulates insulin signaling via subcellular redistribution of insulin receptor substrate 1 and integrates nutritional signals and metabolic signals of insulin

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7 January 2021

Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene

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7 January 2021

Phosphorylation of insulin receptor substrate-1 (IRS-1) by protein kinase B positively regulates IRS-1 function

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7 January 2021

A molecular basis for insulin resistance. Elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtamembrane region of the insulin receptor and impairs their ability to undergo insulin-induced tyrosine phosphory

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7 January 2021

Insulin stimulates PKCzeta -mediated phosphorylation of insulin receptor substrate-1 (IRS-1). A self-attenuated mechanism to negatively regulate the function of IRS proteins

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7 January 2021

Phosphorylation of insulin receptor substrate-1 on multiple serine residues, 612, 632, 662, and 731, modulates insulin action

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7 January 2021

Oxidative stress disrupts insulin-induced cellular redistribution of insulin receptor substrate-1 and phosphatidylinositol 3-kinase in 3T3-L1 adipocytes. A putative cellular mechanism for impaired protein kinase B activation and GLUT4 translocation

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7 January 2021

Release of insulin receptor substrate proteins from an intracellular complex coincides with the development of insulin resistance.

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7 January 2021

Serine/threonine phosphorylation of IRS-1 triggers its degradation: possible regulation by tyrosine phosphorylation

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7 January 2021

IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance

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7 January 2021

Modulation of insulin receptor substrate-1 tyrosine phosphorylation by an Akt/phosphatidylinositol 3-kinase pathway

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7 January 2021

A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1.

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7 January 2021

Protein kinase C-zeta as a downstream effector of phosphatidylinositol 3-kinase during insulin stimulation in rat adipocytes. Potential role in glucose transport

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7 January 2021

Protein kinase C-zeta phosphorylates insulin receptor substrate-1 and impairs its ability to activate phosphatidylinositol 3-kinase in response to insulin.

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7 January 2021

Activation of IkappaB kinase beta by protein kinase C isoforms

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7 January 2021

Negative feedback regulation and desensitization of insulin- and epidermal growth factor-stimulated p21ras activation

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7 January 2021

Insulin-induced desensitization of extracellular signal-regulated kinase activation results from an inhibition of Raf activity independent of Ras activation and dissociation of the Grb2-SOS complex

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7 January 2021

Potential role of TNF-alpha in the pathogenesis of insulin resistance and type 2 diabetes

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7 January 2021

Regulation of nuclear factor kappa B transactivation. Implication of phosphatidylinositol 3-kinase and protein kinase C zeta in c-Rel activation by tumor necrosis factor alpha

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7 January 2021

FAN, a novel WD-repeat protein, couples the p55 TNF-receptor to neutral sphingomyelinase

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7 January 2021

PKC zeta is a molecular switch in signal transduction of TNF-alpha, bifunctionally regulated by ceramide and arachidonic acid

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7 January 2021

Sphingomyelinase and ceramide suppress insulin-induced tyrosine phosphorylation of the insulin receptor substrate-1

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7 January 2021

The interaction of p62 with RIP links the atypical PKCs to NF-kappaB activation

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7 January 2021

The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-beta

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7 January 2021

Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta

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7 January 2021

The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307)

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7 January 2021

Insulin/IGF-1 and TNF-alpha stimulate phosphorylation of IRS-1 at inhibitory Ser307 via distinct pathways

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7 January 2021

Modulation of insulin receptor substrate-1 tyrosine phosphorylation and function by mitogen-activated protein kinase

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7 January 2021

Cellular mechanisms of insulin resistance

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7 January 2021

Obesity and the regulation of energy balance

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7 January 2021

Prevention of fat-induced insulin resistance by salicylate

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7 January 2021

Alterations in the expression and cellular localization of protein kinase C isozymes epsilon and theta are associated with insulin resistance in skeletal muscle of the high-fat-fed rat

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7 January 2021

The hormone resistin links obesity to diabetes

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7 January 2021

Signaling pathways in insulin action: molecular targets of insulin resistance

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7 January 2021

Tyrosine phosphorylation of insulin receptor substrate-1 in vivo depends upon the presence of its pleckstrin homology region

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7 January 2021

Structure of the IRS-1 PTB domain bound to the juxtamembrane region of the insulin receptor

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7 January 2021

10.1016/S0962-8924(01)02129-8

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11684411%20AND%20SRC:MED&resulttype=core&format=json

2 December 2019

1 reference