(Q77388156)

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The ability of p53 to activate downstream genes p21(WAF1/cip1) and MDM2, and cell cycle arrest following DNA damage is delayed and attenuated in scid cells deficient in the DNA-dependent protein kinase

scientific article published on 01 May 1999

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10224064%20AND%20SRC:MED&resulttype=core&format=json

5 December 2019

The ability of p53 to activate downstream genes p21(WAF1/cip1) and MDM2, and cell cycle arrest following DNA damage is delayed and attenuated in scid cells deficient in the DNA-dependent protein kinase (English)

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Europe PubMed Central

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5 December 2019

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L A Kachnic

1

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5 December 2019

B Wu

2

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5 December 2019

H Wunsch

3

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5 December 2019

K L Mekeel

4

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5 December 2019

J S DeFrank

5

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5 December 2019

W Tang

6

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5 December 2019

S N Powell

7

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5 December 2019

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1 May 1999

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5 December 2019

Journal of Biological Chemistry

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5 December 2019

274

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5 December 2019

19

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5 December 2019

13111-13117

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5 December 2019

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.19.13111

21 January 2018

WAF1, a potential mediator of p53 tumor suppression

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.19.13111

21 January 2018

The p53-mdm-2 autoregulatory feedback loop

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.19.13111

21 January 2018

p53 transactivation and protein accumulation are independently regulated by UV light in different phases of the cell cycle

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.19.13111

21 January 2018

Stabilization and activation of p53 are regulated independently by different phosphorylation events

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.19.13111

21 January 2018

Interactions between p53 and MDM2 in a mammalian cell cycle checkpoint pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.19.13111

21 January 2018

p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.19.13111

21 January 2018

A DNA-activated protein kinase from HeLa cell nuclei

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.19.13111

21 January 2018

Human cells contain a DNA-activated protein kinase that phosphorylates simian virus 40 T antigen, mouse p53, and the human Ku autoantigen

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.19.13111

21 January 2018

DNA-dependent protein kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.19.13111

21 January 2018

Ku autoantigen is the regulatory component of a template-associated protein kinase that phosphorylates RNA polymerase II

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.19.13111

21 January 2018

The DNA-dependent protein kinase: requirement for DNA ends and association with Ku antigen

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.19.13111

21 January 2018

Human DNA-activated protein kinase phosphorylates serines 15 and 37 in the amino-terminal transactivation domain of human p53.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.19.13111

21 January 2018

DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.19.13111

21 January 2018

DNA damage induces phosphorylation of the amino terminus of p53

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.19.13111

21 January 2018

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.19.13111

21 January 2018

DNA-dependent kinase (p350) as a candidate gene for the murine SCID defect

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.19.13111

21 January 2018

Gene for the catalytic subunit of mouse DNA-dependent protein kinase maps to the scid locus

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.19.13111

21 January 2018

Biochemical and genetic defects in the DNA-dependent protein kinase in murine scid lymphocytes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.19.13111

21 January 2018

A severe combined immunodeficiency mutation in the mouse

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.19.13111

21 January 2018

The defect in murine severe combined immune deficiency: joining of signal sequences but not coding segments in V(D)J recombination

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.19.13111

21 January 2018

scid mutation in mice confers hypersensitivity to ionizing radiation and a deficiency in DNA double-strand break repair

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.19.13111

21 January 2018

A link between double-strand break-related repair and V(D)J recombination: the scid mutation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.19.13111

21 January 2018

The scid mutation in mice causes a general defect in DNA repair

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.19.13111

21 January 2018

Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.19.13111

21 January 2018

Ku80: product of the XRCC5 gene and its role in DNA repair and V(D)J recombination

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.19.13111

21 January 2018

Restoration of X-ray resistance and V(D)J recombination in mutant cells by Ku cDNA.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.19.13111

21 January 2018

Hypersensitivity of Ku80-deficient cell lines and mice to DNA damage: the effects of ionizing radiation on growth, survival, and development

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.19.13111

21 January 2018

The DNA damage response in DNA-dependent protein kinase-deficient SCID mouse cells: replication protein A hyperphosphorylation and p53 induction.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.19.13111

21 January 2018

p53 induction, cell cycle checkpoints, and apoptosis in DNAPK-deficient scid mice.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.19.13111

21 January 2018

V(D)J recombination activates a p53-dependent DNA damage checkpoint in scid lymphocyte precursors.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.19.13111

21 January 2018

DNA-dependent protein kinase acts upstream of p53 in response to DNA damage

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.19.13111

21 January 2018

Menage à trois: double strand break repair, V(D)J recombination and DNA-PK.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.19.13111

21 January 2018

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.19.13111

21 January 2018

Differential induction of transcriptionally active p53 following UV or ionizing radiation: defects in chromosome instability syndromes?

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.19.13111

21 January 2018

Inactivation of p53 results in high rates of homologous recombination

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.19.13111

21 January 2018

Mapping of the p53 and mdm-2 Interaction Domains

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.19.13111

21 January 2018

Sensitivity and selectivity of the DNA damage sensor responsible for activating p53-dependent G1 arrest

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.19.13111

21 January 2018

Delayed Initiation of DNA Synthesis in Irradiated Human Diploid Cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.19.13111

21 January 2018

Protein synthesis required to anchor a mutant p53 protein which is temperature-sensitive for nuclear transport

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.19.13111

21 January 2018

Ubiquitination of p53 and p21 is differentially affected by ionizing and UV radiation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.19.13111

21 January 2018

A p53-dependent mouse spindle checkpoint

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.19.13111

21 January 2018

Requirement for Ku80 in growth and immunoglobulin V(D)J recombination

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.19.13111

21 January 2018

A targeted DNA-PKcs-null mutation reveals DNA-PK-independent functions for KU in V(D)J recombination

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.19.13111

21 January 2018

Targeted disruption of the catalytic subunit of the DNA-PK gene in mice confers severe combined immunodeficiency and radiosensitivity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.19.13111

21 January 2018

Studies on mammalian mutants defective in rejoining double-strand breaks in DNA.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.19.13111

21 January 2018

A p53-independent Pathway for Activation of WAF1/CIP1 Expression Following Oxidative Stress

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.19.13111

21 January 2018

Evidence for DNA-PK-dependent and -independent DNA double-strand break repair pathways in mammalian cells as a function of the cell cycle

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.19.13111

21 January 2018

Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.19.13111

21 January 2018

p53 functions as a cell cycle control protein in osteosarcomas

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.19.13111

21 January 2018

Identifiers

10.1074/JBC.274.19.13111

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10224064%20AND%20SRC:MED&resulttype=core&format=json

5 December 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10224064%20AND%20SRC:MED&resulttype=core&format=json

5 December 2019

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