(Q79306638)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17068503%20AND%20SRC:MED&resulttype=core&format=json

21 December 2019

title

p53 downstream target genes and tumor suppression: a classical view in evolution (English)

1 reference

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21 December 2019

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17068503%20AND%20SRC:MED&resulttype=core&format=json

21 December 2019

author name string

Rozan LM

series ordinal

1

1 reference

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21 December 2019

publication date

27 October 2006

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17068503%20AND%20SRC:MED&resulttype=core&format=json

Cell Death & Differentiation

21 December 2019

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17068503%20AND%20SRC:MED&resulttype=core&format=json

21 December 2019

volume

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17068503%20AND%20SRC:MED&resulttype=core&format=json

21 December 2019

issue

1

1 reference

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21 December 2019

page(s)

3-9

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17068503%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1038/sj.cdd.4402058

21 December 2019

exact match

0 references

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Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity

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c-Jun and p53 Activity Is Modulated by SUMO-1 Modification

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7 January 2021

SUMO-1 modification activates the transcriptional response of p53

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7 January 2021

Slug antagonizes p53-mediated apoptosis of hematopoietic progenitors by repressing puma

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7 January 2021

The BCL6 proto-oncogene suppresses p53 expression in germinal-centre B cells

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7 January 2021

Human MUC1 oncoprotein regulates p53-responsive gene transcription in the genotoxic stress response

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7 January 2021

ASPP1 and ASPP2: common activators of p53 family members

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7 January 2021

Bnip3L is induced by p53 under hypoxia, and its knockdown promotes tumor growth

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7 January 2021

Endoplasmic reticulum stress accelerates p53 degradation by the cooperative actions of Hdm2 and glycogen synthase kinase 3beta

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7 January 2021

A novel human p53 isoform is an essential element of the ATR-intra-S phase checkpoint

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7 January 2021

The C terminus of p53 family proteins is a cell fate determinant

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7 January 2021

p53 isoforms can regulate p53 transcriptional activity.

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7 January 2021

p53 polymorphism influences response in cancer chemotherapy via modulation of p73-dependent apoptosis

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7 January 2021

Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis

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7 January 2021

Transcription-independent pro-apoptotic functions of p53.

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7 January 2021

p53 has a direct apoptogenic role at the mitochondria

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7 January 2021

Death signal-induced localization of p53 protein to mitochondria. A potential role in apoptotic signaling

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7 January 2021

Mitochondrially targeted p53 has tumor suppressor activities in vivo

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7 January 2021

In vivo mitochondrial p53 translocation triggers a rapid first wave of cell death in response to DNA damage that can precede p53 target gene activation

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7 January 2021

Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex.

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7 January 2021

Selective evolution of stromal mesenchyme with p53 loss in response to epithelial tumorigenesis.

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7 January 2021

p53 regulates mitochondrial respiration

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7 January 2021

Functional analysis of the roles of posttranslational modifications at the p53 C terminus in regulating p53 stability and activity

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7 January 2021

Mono- versus polyubiquitination: differential control of p53 fate by Mdm2.

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7 January 2021

Polyubiquitination of p53 by a ubiquitin ligase activity of p300.

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7 January 2021

Dynamics of the p53-Mdm2 feedback loop in individual cells

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7 January 2021

The oncoprotein gankyrin binds to MDM2/HDM2, enhancing ubiquitylation and degradation of p53

1 reference

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7 January 2021

Yin Yang 1 is a negative regulator of p53.

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7 January 2021

Physical and functional interactions of the Arf tumor suppressor protein with nucleophosmin/B23

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7 January 2021

Tumor suppressor ARF degrades B23, a nucleolar protein involved in ribosome biogenesis and cell proliferation.

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7 January 2021

Nucleolar protein NPM interacts with HDM2 and protects tumor suppressor protein p53 from HDM2-mediated degradation

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7 January 2021

DNA damage disrupts the p14ARF-B23(nucleophosmin) interaction and triggers a transient subnuclear redistribution of p14ARF.

1 reference

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7 January 2021

Nucleophosmin (B23) targets ARF to nucleoli and inhibits its function

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7 January 2021

The ubiquitin ligase COP1 is a critical negative regulator of p53

1 reference

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7 January 2021

Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation

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7 January 2021

ATM engages autodegradation of the E3 ubiquitin ligase COP1 after DNA damage

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7 January 2021

ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor

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7 January 2021

The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults

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7 January 2021

The prolyl isomerase Pin1 is a regulator of p53 in genotoxic response.

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7 January 2021

Role of Pin1 in the regulation of p53 stability and p21 transactivation, and cell cycle checkpoints in response to DNA damage

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7 January 2021

Mutations in proline 82 of p53 impair its activation by Pin1 and Chk2 in response to DNA damage

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7 January 2021

A mouse p53 mutant lacking the proline-rich domain rescues Mdm4 deficiency and provides insight into the Mdm2-Mdm4-p53 regulatory network

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7 January 2021

BRCA1 directs a selective p53-dependent transcriptional response towards growth arrest and DNA repair targets

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7 January 2021

ASPP proteins specifically stimulate the apoptotic function of p53

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7 January 2021

iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human.

1 reference

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7 January 2021

A large-scale RNAi screen in human cells identifies new components of the p53 pathway

1 reference

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7 January 2021

Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans

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7 January 2021

Role of the histone acetyl transferase Tip60 in the p53 pathway

1 reference

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7 January 2021

Tip60 and p400 are both required for UV-induced apoptosis but play antagonistic roles in cell cycle progression

1 reference

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7 January 2021

p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities

1 reference

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7 January 2021

p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402058

7 January 2021

An anti-apoptotic role for the p53 family member, p73, during developmental neuron death

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402058

7 January 2021

Small-molecule modulators of p53 family signaling and antitumor effects in p53-deficient human colon tumor xenografts.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402058

7 January 2021

Chemosensitivity linked to p73 function

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402058

7 January 2021

p73 or p53 directly regulates human p53 transcription to maintain cell cycle checkpoints.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402058

7 January 2021

Tumor predisposition in mice mutant for p63 and p73: evidence for broader tumor suppressor functions for the p53 family

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402058

7 January 2021

Induction of the growth inhibitor IGF-binding protein 3 by p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402058

7 January 2021

P53 and IGFBP-3: apoptosis and cancer protection

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402058

7 January 2021

Transcriptional activation of the human epidermal growth factor receptor promoter by human p53.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402058

7 January 2021

Activation of c-myc gene expression by tumor-derived p53 mutants requires a discrete C-terminal domain

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402058

7 January 2021

Tumor-derived p53 mutants induce oncogenesis by transactivating growth-promoting genes.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402058

7 January 2021

The biological impact of the human master regulator p53 can be altered by mutations that change the spectrum and expression of its target genes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402058

7 January 2021

Repression of the MSP/MST-1 gene contributes to the antiapoptotic gain of function of mutant p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402058

7 January 2021

Mutant p53 gain of function: repression of CD95(Fas/APO-1) gene expression by tumor-associated p53 mutants

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402058

7 January 2021

Mutant p53 gain of function: reduction of tumor malignancy of human cancer cell lines through abrogation of mutant p53 expression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402058

7 January 2021

Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402058

7 January 2021

Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402058

7 January 2021

Mice expressing a mammary gland-specific R270H mutation in the p53 tumor suppressor gene mimic human breast cancer development.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402058

7 January 2021

The differential effects of mutant p53 alleles on advanced murine lung cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402058

7 January 2021

Late viral RNA export, rather than p53 inactivation, determines ONYX-015 tumor selectivity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402058

7 January 2021

A global map of p53 transcription-factor binding sites in the human genome

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402058

7 January 2021

Profiling of gene expression changes caused by p53 gain-of-function mutant alleles in prostate cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402058

7 January 2021

Murine fibroblasts lacking p21 undergo senescence and are resistant to transformation by oncogenic Ras.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402058

7 January 2021

Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402058

7 January 2021

AMP-activated protein kinase induces a p53-dependent metabolic checkpoint

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402058

7 January 2021

TIGAR, a p53-inducible regulator of glycolysis and apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402058

7 January 2021

Transcriptional regulation by p53: one protein, many possibilities

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402058

7 January 2021

Direct p53 transcriptional repression: in vivo analysis of CCAAT-containing G2/M promoters.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402058

7 January 2021

Transcriptional repression mediated by the p53 tumour suppressor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402058

7 January 2021

p53-Dependent transcriptional repression of c-myc is required for G1 cell cycle arrest

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402058

7 January 2021

Pharmacologic activation of p53 elicits Bax-dependent apoptosis in the absence of transcription

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402058

7 January 2021

PUMA couples the nuclear and cytoplasmic proapoptotic function of p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402058

7 January 2021

Heterogeneous tumor evolution initiated by loss of pRb function in a preclinical prostate cancer model

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402058

7 January 2021

DRAM, a p53-induced modulator of autophagy, is critical for apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402058

7 January 2021