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Inhibition of glutamine transport into mitochondria protects astrocytes from ammonia toxicity
scientific article published on 01 June 2007
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scholarly article
1 reference
stated in
Europe PubMed Central
PubMed publication ID
17357151
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17357151%20AND%20SRC:MED&resulttype=core&format=json
retrieved
27 December 2019
title
Inhibition of glutamine transport into mitochondria protects astrocytes from ammonia toxicity
(English)
1 reference
stated in
Europe PubMed Central
PubMed publication ID
17357151
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17357151%20AND%20SRC:MED&resulttype=core&format=json
retrieved
27 December 2019
main subject
astrocyte
1 reference
based on heuristic
inferred from title
ammonia
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author name string
V B R Pichili
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed publication ID
17357151
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17357151%20AND%20SRC:MED&resulttype=core&format=json
retrieved
27 December 2019
K V Rama Rao
series ordinal
2
1 reference
stated in
Europe PubMed Central
PubMed publication ID
17357151
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17357151%20AND%20SRC:MED&resulttype=core&format=json
retrieved
27 December 2019
A R Jayakumar
series ordinal
3
1 reference
stated in
Europe PubMed Central
PubMed publication ID
17357151
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17357151%20AND%20SRC:MED&resulttype=core&format=json
retrieved
27 December 2019
M D Norenberg
series ordinal
4
1 reference
stated in
Europe PubMed Central
PubMed publication ID
17357151
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17357151%20AND%20SRC:MED&resulttype=core&format=json
retrieved
27 December 2019
publication date
1 June 2007
1 reference
stated in
Europe PubMed Central
PubMed publication ID
17357151
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17357151%20AND%20SRC:MED&resulttype=core&format=json
retrieved
27 December 2019
published in
Glia
1 reference
stated in
Europe PubMed Central
PubMed publication ID
17357151
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17357151%20AND%20SRC:MED&resulttype=core&format=json
retrieved
27 December 2019
volume
55
1 reference
stated in
Europe PubMed Central
PubMed publication ID
17357151
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17357151%20AND%20SRC:MED&resulttype=core&format=json
retrieved
27 December 2019
issue
8
1 reference
stated in
Europe PubMed Central
PubMed publication ID
17357151
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17357151%20AND%20SRC:MED&resulttype=core&format=json
retrieved
27 December 2019
page(s)
801-809
1 reference
stated in
Europe PubMed Central
PubMed publication ID
17357151
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17357151%20AND%20SRC:MED&resulttype=core&format=json
retrieved
27 December 2019
cites work
Modulation of glutamine uptake and phosphate-activated glutaminase activity in rat brain mitochondria by amino acids and their synthetic analogues
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGLIA.20499
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hepatic encephalopathy: molecular mechanisms underlying the clinical syndrome.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGLIA.20499
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Glutamine: a Trojan horse in ammonia neurotoxicity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGLIA.20499
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A rapid method for the isolation of metabolically active mitochondria from rat neurons and astrocytes in primary culture
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGLIA.20499
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Ammonia induces the mitochondrial permeability transition in primary cultures of rat astrocytes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGLIA.20499
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The mitochondrial permeability transition
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGLIA.20499
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
[Liver transplantation and transfusion]
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGLIA.20499
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Pathophysiology of cerebral edema in fulminant hepatic failure.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGLIA.20499
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hyperammonemic encephalopathy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGLIA.20499
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Pathophysiology of hepatic encephalopathy: a new look at ammonia
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGLIA.20499
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Fulminant hepatic failure. Clinical features, etiology, epidemiology, and current management
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGLIA.20499
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Permeabilization of the inner mitochondrial membrane by Ca2+ ions is stimulated by t-butyl hydroperoxide and mediated by reactive oxygen species generated by mitochondria
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGLIA.20499
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Effects of hypothermia on brain glucose metabolism in acute liver failure: a H/C-nuclear magnetic resonance study.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGLIA.20499
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The glutamine commute: take the N line and transfer to the A
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGLIA.20499
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cerebral herniation in patients with acute liver failure is correlated with arterial ammonia concentration
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGLIA.20499
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Ammonia stimulates glutamine uptake to the cerebral non-synaptic mitochondria of the rat.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGLIA.20499
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The benzodiazepine receptor in cultured astrocytes from genetically epilepsy-prone rats
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGLIA.20499
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Oxidative stress, thiol reagents, and membrane potential modulate the mitochondrial permeability transition by affecting nucleotide binding to the adenine nucleotide translocase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGLIA.20499
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hyperammonaemia does not impair brain function in the absence of net glutamine synthesis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGLIA.20499
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Effect of reducing brain glutamine synthesis on metabolic symptoms of hepatic encephalopathy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGLIA.20499
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cerebrospinal Fluid Glutamine as a Measure of Hepatic Encephalopathy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGLIA.20499
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Glutamine-induced free radical production in cultured astrocytes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGLIA.20499
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Glutamine in the mechanism of ammonia-induced astrocyte swelling
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGLIA.20499
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Neurology and the liver
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGLIA.20499
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Astrocytic swelling in cerebral ischemia as a possible cause of injury and target for therapy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGLIA.20499
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A method using 3-O-methyl-D-glucose and phloretin for the determination of intracellular water space of cells in monolayer culture
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGLIA.20499
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Properties of phosphate activated glutaminase in astrocytes cultured from mouse brain
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGLIA.20499
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification of a mitochondrial form of kynurenine aminotransferase/glutamine transaminase K from rat brain
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGLIA.20499
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Proton spectroscopy of brain glutamine in acute liver failure
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGLIA.20499
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Glutamine uptake by isolated rat brain mitochondria
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGLIA.20499
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Ammonia-induced production of free radicals in primary cultures of rat astrocytes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGLIA.20499
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Astroglial dysfunction in hepatic encephalopathy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGLIA.20499
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Ammonia-induced astrocyte swelling in primary culture
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGLIA.20499
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Oxidative stress in the pathogenesis of hepatic encephalopathy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGLIA.20499
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Fine structural localization of glutamine synthetase in astrocytes of rat brain
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGLIA.20499
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mechanisms of ammonia-induced astrocyte swelling
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGLIA.20499
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Protective effect of histidine on para-nonylphenol-enhanced hydroxyl free radical generation induced by 1-methyl-4-phenylpyridinium ion (MPP+) in rat striatum
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGLIA.20499
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Parkinsonism induced by MPTP and free radical generation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGLIA.20499
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Correlations between energy metabolism, ion transport, and water content in astrocytes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGLIA.20499
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Energy-dependent volume regulation in primary cultured cerebral astrocytes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGLIA.20499
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibition of glutamine transport depletes glutamate and GABA neurotransmitter pools: further evidence for metabolic compartmentation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGLIA.20499
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Ammonia neurotoxicity: role of the mitochondrial permeability transition
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGLIA.20499
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Induction of the mitochondrial permeability transition in cultured astrocytes by glutamine
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGLIA.20499
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Differential response of glutamine in cultured neurons and astrocytes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGLIA.20499
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Role of oxidative stress in the ammonia-induced mitochondrial permeability transition in cultured astrocytes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGLIA.20499
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cerebral energy metabolism in hepatic encephalopathy and hyperammonemia
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGLIA.20499
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Manganese induces the mitochondrial permeability transition in cultured astrocytes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGLIA.20499
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Plasma and Brain Amino Acids in Fulminant Hepatic Failure and their Relationship to Hepatic Encephalopathy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGLIA.20499
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Glutamine transport in rat brain synaptic and non-synaptic mitochondria
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGLIA.20499
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The kinetic properties of citrate synthase from rat liver mitochondria
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGLIA.20499
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Preferential glutamine uptake in rat brain synaptic mitochondria
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGLIA.20499
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Ammonia and related amino acids in the pathogenesis of brain edema in acute ischemic liver failure in rats
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGLIA.20499
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Restoration of cerebrovascular CO2 responsivity by glutamine synthesis inhibition in hyperammonemic rats
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGLIA.20499
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Persistent arterial hyperammonemia increases the concentration of glutamine and alanine in the brain and correlates with intracranial pressure in patients with fulminant hepatic failure
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGLIA.20499
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Alpha-ketoglutaramate: increased concentrations in the cerebrospinal fluid of patients in hepatic coma.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGLIA.20499
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibition of glutamine synthetase reduces ammonia-induced astrocyte swelling in rat
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGLIA.20499
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Astrocyte metabolism of [15N]glutamine: implications for the glutamine-glutamate cycle
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGLIA.20499
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Analysis of glutamine accumulation in rat brain mitochondria in the presence of a glutamine uptake inhibitor, histidine, reveals glutamine pools with a distinct access to deamidation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGLIA.20499
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
An update on the role of brain glutamine synthesis and its relation to cell-specific energy metabolism in the hyperammonemic brain: further studies using NMR spectroscopy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGLIA.20499
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Selective alterations of brain osmolytes in acute liver failure: protective effect of mild hypothermia
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGLIA.20499
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1002/GLIA.20499
1 reference
stated in
Europe PubMed Central
PubMed publication ID
17357151
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17357151%20AND%20SRC:MED&resulttype=core&format=json
retrieved
27 December 2019
PubMed publication ID
17357151
1 reference
stated in
Europe PubMed Central
PubMed publication ID
17357151
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17357151%20AND%20SRC:MED&resulttype=core&format=json
retrieved
27 December 2019
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