(Q82036620)

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Effects of rs6234/rs6235 and rs6232/rs6234/rs6235 PCSK1 single-nucleotide polymorphism clusters on proprotein convertase 1/3 biosynthesis and activity

scientific article published on 24 September 2011

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14 January 2020

Effects of rs6234/rs6235 and rs6232/rs6234/rs6235 PCSK1 single-nucleotide polymorphism clusters on proprotein convertase 1/3 biosynthesis and activity (English)

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14 January 2020

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Michel Chrétien

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Ajoy Basak

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Francine Sirois

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Francine Sirois

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Kabwe K Nkongolo

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Molecular Genetics and Metabolism

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14 January 2020

Proprotein and prohormone convertases: a family of subtilases generating diverse bioactive polypeptides

1 reference

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Precursor convertases in the secretory pathway, cytosol and extracellular milieu

1 reference

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7 January 2021

The activation and physiological functions of the proprotein convertases

1 reference

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Chromosomal assignments of the genes for neuroendocrine convertase PC1 (NEC1) to human 5q15–21, neuroendocrine convertase PC2 (NEC2) to human 20p11.1–11.2, and furin (mouse 7[D1-E2] region)

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7 January 2021

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Two activation states of the prohormone convertase PC1 in the secretory pathway

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Mammalian subtilisin/kexin isozyme SKI-1: A widely expressed proprotein convertase with a unique cleavage specificity and cellular localization

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Gene expression of prohormone and proprotein convertases in the rat CNS: a comparative in situ hybridization analysis.

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Cellular localization of the prohormone convertases in the hypothalamic paraventricular and supraoptic nuclei: selective regulation of PC1 in corticotrophin-releasing hormone parvocellular neurons mediated by glucocorticoids

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7 January 2021

Appetite control

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7 January 2021

The proprotein convertases

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Proinsulin processing by the subtilisin-related proprotein convertases furin, PC2, and PC3

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Role of the prohormone convertase PC3 in the processing of proglucagon to glucagon-like peptide 1.

1 reference

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7 January 2021

Disruption of PC1/3 expression in mice causes dwarfism and multiple neuroendocrine peptide processing defects

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7 January 2021

On the processing of proghrelin to ghrelin

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Agouti-related protein is posttranslationally cleaved by proprotein convertase 1 to generate agouti-related protein (AGRP)83-132: interaction between AGRP83-132 and melanocortin receptors cannot be influenced by syndecan-3

1 reference

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7 January 2021

Genetic inactivation of prohormone convertase (PC1) causes a reduction in cholecystokinin (CCK) levels in the hippocampus, amygdala, pons and medulla in mouse brain that correlates with the degree of colocalization of PC1 and CCK mRNA in these struc

1 reference

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7 January 2021

Role of prohormone convertases in pro-neuropeptide Y processing: coexpression and in vitro kinetic investigations

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7 January 2021

Furin and prohormone convertase 1/3 are major convertases in the processing of mouse pro-growth hormone-releasing hormone

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7 January 2021

Precursor-protein convertase 1 gene expression in the mouse hypothalamus: differential regulation by ob gene mutation, energy deficit and administration of leptin, and coexpression with prepro-orexin.

1 reference

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7 January 2021

Biological processing of the cocaine and amphetamine-regulated transcript precursors by prohormone convertases, PC2 and PC1/3.

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7 January 2021

PC1 and PC2 are proprotein convertases capable of cleaving proopiomelanocortin at distinct pairs of basic residues

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7 January 2021

A targeted deletion/insertion in the mouse Pcsk1 locus is associated with homozygous embryo preimplantation lethality, mutant allele preferential transmission and heterozygous female susceptibility to dietary fat.

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7 January 2021

Obesity, hyperphagia and increased metabolic efficiency in Pc1 mutant mice

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7 January 2021

Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene

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7 January 2021

Small-intestinal dysfunction accompanies the complex endocrinopathy of human proprotein convertase 1 deficiency

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7 January 2021

Hyperphagia and early-onset obesity due to a novel homozygous missense mutation in prohormone convertase 1/3.

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7 January 2021

Common nonsynonymous variants in PCSK1 confer risk of obesity

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7 January 2021

Association of variants in the PCSK1 gene with obesity in the EPIC-Norfolk study

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7 January 2021

Common PCSK1 haplotypes are associated with obesity in the Chinese population

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7 January 2021

Association of PCSK1 rs6234 with obesity and related traits in a Chinese Han population

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Association of obesity risk SNPs in PCSK1 with insulin sensitivity and proinsulin conversion

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7 January 2021

A predicted alpha -helix mediates targeting of the proprotein convertase PC1 to the regulated secretory pathway

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Differences of pancreatic expression of 7B2 between C57BL/6J and C3H/HeJ mice and genetic polymorphisms at its locus (Sgne1).

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A novel enediynyl peptide inhibitor of furin that blocks processing of proPDGF-A, B and proVEGF-C.

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Prohormone convertase 1/3 is essential for processing of the glucose-dependent insulinotropic polypeptide precursor

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A Hydrophobic Patch in a Charged α-Helix Is Sufficient to Target Proteins to Dense Core Secretory Granules

1 reference

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7 January 2021

The C-terminal region of the proprotein convertase 1/3 (PC1/3) exerts a bimodal regulation of the enzyme activity in vitro

1 reference

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Sending proteins to dense core secretory granules: still a lot to sort out.

1 reference

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The Arg617-Arg618 cleavage site in the C-terminal domain of PC1 plays a major role in the processing and targeting of the enzyme within the regulated secretory pathway

1 reference

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7 January 2021

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10.1016/J.YMGME.2011.09.027

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Europe PubMed Central

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14 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22000902%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

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