(Q83603505)

English

The cyclin-dependent kinase inhibitor roscovitine and the nucleoside analog sangivamycin induce apoptosis in caspase-3 deficient breast cancer cells independent of caspase mediated P-glycoprotein cleavage: implications for therapy of drug resistant

scientific article published on 02 May 2009

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19342873%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

The cyclin-dependent kinase inhibitor roscovitine and the nucleoside analog sangivamycin induce apoptosis in caspase-3 deficient breast cancer cells independent of caspase mediated P-glycoprotein cleavage: implications for therapy of drug resistant breast cancers (English)

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19342873%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

author name string

Alessandra Cappellini

1

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Europe PubMed Central

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25 January 2020

Francesca Chiarini

2

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25 January 2020

Andrea Ognibene

3

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25 January 2020

James A McCubrey

4

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25 January 2020

Alberto M Martelli

5

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25 January 2020

publication date

2 May 2009

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25 January 2020

1 reference

Europe PubMed Central

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25 January 2020

8

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25 January 2020

9

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25 January 2020

1421-1425

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Europe PubMed Central

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25 January 2020

Inactivation of caspase-8 on mitochondria of Bcl-xL-expressing MCF7-Fas cells: role for the bifunctional apoptosis regulator protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/19342873

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

You never know: Cdk inhibitors as anti-cancer drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/19342873

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of the Mdr1 isoforms in a p53-deficient mouse model

1 reference

https://pubmed.ncbi.nlm.nih.gov/19342873

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

P-glycoprotein inhibits caspase-8 activation but not formation of the death inducing signal complex (disc) following Fas ligation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19342873

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Down-regulation of caspase 3 in breast cancer: a possible mechanism for chemoresistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/19342873

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutational analysis of P-glycoprotein: suppression of caspase activation in the absence of ATP-dependent drug efflux.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19342873

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dominant selection of hematopoietic progenitor cells with retroviral MDR1 co-expression vectors

1 reference

https://pubmed.ncbi.nlm.nih.gov/19342873

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19342873

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

P-glycoprotein protects leukemia cells against caspase-dependent, but not caspase-independent, cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/19342873

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Roscovitine-induced up-regulation of p53AIP1 protein precedes the onset of apoptosis in human MCF-7 breast cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19342873

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Caspases: pharmacological manipulation of cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/19342873

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Caspase-dependent cleavage of 170-kDa P-glycoprotein during apoptosis of human T-lymphoblastoid CEM cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19342873

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transmembrane segment 1 of human P-glycoprotein contributes to the drug-binding pocket

1 reference

https://pubmed.ncbi.nlm.nih.gov/19342873

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The insulin-like growth factor-I receptor kinase inhibitor NVP-AEW541 induces apoptosis in acute myeloid leukemia cells exhibiting autocrine insulin-like growth factor-I secretion

1 reference

https://pubmed.ncbi.nlm.nih.gov/19342873

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The nucleoside analog sangivamycin induces apoptotic cell death in breast carcinoma MCF7/adriamycin-resistant cells via protein kinase Cdelta and JNK activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19342873

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

P-glycoprotein mediates celecoxib-induced apoptosis in multiple drug-resistant cell lines

1 reference

https://pubmed.ncbi.nlm.nih.gov/19342873

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

What makes tumors multidrug resistant?

1 reference

https://pubmed.ncbi.nlm.nih.gov/19342873

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ABC multidrug transporters: structure, function and role in chemoresistance.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19342873

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The cyclin-dependent kinase inhibitor seliciclib (R-roscovitine; CYC202) decreases the expression of mitotic control genes and prevents entry into mitosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19342873

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proapoptotic activity and chemosensitizing effect of the novel Akt inhibitor perifosine in acute myelogenous leukemia cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19342873

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Strategies to overcome or circumvent P-glycoprotein mediated multidrug resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/19342873

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apoptosis: controlled demolition at the cellular level

1 reference

https://pubmed.ncbi.nlm.nih.gov/19342873

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Caspase 2 is both required for p53-mediated apoptosis and downregulated by p53 in a p21-dependent manner

1 reference

https://pubmed.ncbi.nlm.nih.gov/19342873

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cancer stem cells: Models, mechanisms and implications for improved treatment

1 reference

https://pubmed.ncbi.nlm.nih.gov/19342873

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The novel Akt inhibitor, perifosine, induces caspase-dependent apoptosis and downregulates P-glycoprotein expression in multidrug-resistant human T-acute leukemia cells by a JNK-dependent mechanism

1 reference

https://pubmed.ncbi.nlm.nih.gov/19342873

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Potential for cripto-1 in defining stem cell-like characteristics in human malignant melanoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/19342873

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proapoptotic activity and chemosensitizing effect of the novel Akt inhibitor (2S)-1-(1H-Indol-3-yl)-3-[5-(3-methyl-2H-indazol-5-yl)pyridin-3-yl]oxypropan2-amine (A443654) in T-cell acute lymphoblastic leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/19342873

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

What drives intense apoptosis resistance and propensity for necrosis in glioblastoma? A role for Bcl2L12 as a multifunctional cell death regulator

1 reference

https://pubmed.ncbi.nlm.nih.gov/19342873

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CR8, a potent and selective, roscovitine-derived inhibitor of cyclin-dependent kinases

1 reference

https://pubmed.ncbi.nlm.nih.gov/19342873

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Delphinidin, a dietary anthocyanidin in pigmented fruits and vegetables: a new weapon to blunt prostate cancer growth

1 reference

https://pubmed.ncbi.nlm.nih.gov/19342873

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ceramide promotes apoptosis in chronic myelogenous leukemia-derived K562 cells by a mechanism involving caspase-8 and JNK

1 reference

https://pubmed.ncbi.nlm.nih.gov/19342873

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Use of the human MDR1 promoter for heat-inducible expression of therapeutic genes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19342873

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.4161/CC.8.9.8323

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19342873%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19342873%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19342873%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

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