(Q83937839)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16757325%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

title

Genetic and pharmacologic dissection of Ras effector utilization in oncogenesis (English)

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29 January 2020

2

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29 January 2020

author name string

Paul M Campbell

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16757325%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

Falina J Williams

3

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29 January 2020

Karen Frantz

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16757325%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

Aylin S Ulkü

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16757325%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

Grant G Kelley

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16757325%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

Channing J Der

7

1 reference

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29 January 2020

publication date

1 January 2006

1 reference

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29 January 2020

published in

Methods in Enzymology

1 reference

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29 January 2020

volume

407

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16757325%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

page(s)

195-217

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16757325%20AND%20SRC:MED&resulttype=core&format=json

Mitogen-activated protein kinase kinase 2 activation is essential for progression through the G2/M checkpoint arrest in cells exposed to ionizing radiation.

29 January 2020

cites work

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7 January 2021

PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo

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7 January 2021

Crucial role of phospholipase Cepsilon in chemical carcinogen-induced skin tumor development

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7 January 2021

The sevenmaker gain-of-function mutation in p42 MAP kinase leads to enhanced signalling and reduced sensitivity to dual specificity phosphatase action

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7 January 2021

Two distinct Raf domains mediate interaction with Ras

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7 January 2021

Phosphoinositide kinases

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7 January 2021

Coding sequences of human ralA and ralB cDNAs

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7 January 2021

RAL GTPases are linchpin modulators of human tumour-cell proliferation and survival

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7 January 2021

The mitogen-activated protein kinase phosphatases PAC1, MKP-1, and MKP-2 have unique substrate specificities and reduced activity in vivo toward the ERK2 sevenmaker mutation

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7 January 2021

Ras family signaling: therapeutic targeting

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7 January 2021

Mutations of the BRAF gene in human cancer

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7 January 2021

Specificity and mechanism of action of some commonly used protein kinase inhibitors

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7 January 2021

PI 3-kinase, Akt and cell survival

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7 January 2021

MEK inhibitors: the chemistry and biological activity of U0126, its analogs, and cyclization products

1 reference

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7 January 2021

Tiam1 mutations in human renal-cell carcinomas

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7 January 2021

Akt, a target of phosphatidylinositol 3-kinase, inhibits apoptosis in a differentiating neuronal cell line

1 reference

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7 January 2021

Critical tyrosine residues regulate the enzymatic and biological activity of Raf-1 kinase

1 reference

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7 January 2021

Tools of the trade: use of dominant-inhibitory mutants of Ras-family GTPases

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2907017-5

7 January 2021

Cell signaling: life or death decisions of ras proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2907017-5

7 January 2021

Rational design and characterization of a Rac GTPase-specific small molecule inhibitor

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2907017-5

7 January 2021

RalGDS is required for tumor formation in a model of skin carcinogenesis.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2907017-5

7 January 2021

Dissection of Ras-dependent signaling pathways controlling aggressive tumor growth of human fibrosarcoma cells: evidence for a potential novel pathway

1 reference

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7 January 2021

Distinct requirements for Ras oncogenesis in human versus mouse cells

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2907017-5

7 January 2021

Ras proteins: different signals from different locations

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2907017-5

7 January 2021

Stimulation of membrane ruffling and MAP kinase activation by distinct effectors of RAS.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2907017-5

7 January 2021

Bridging Ral GTPase to Rho pathways. RLIP76, a Ral effector with CDC42/Rac GTPase-activating protein activity

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2907017-5

7 January 2021

Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2907017-5

7 January 2021

Inhibitors of Ras/Raf-1 interaction identified by two-hybrid screening revert Ras-dependent transformation phenotypes in human cancer cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2907017-5

7 January 2021

Phospholipase C(epsilon): a novel Ras effector

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2907017-5

7 January 2021

Activation of Rac1, RhoA, and mitogen-activated protein kinases is required for Ras transformation

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2907017-5

7 January 2021

Oncogenic Ras activation of Raf/mitogen-activated protein kinase-independent pathways is sufficient to cause tumorigenic transformation

1 reference

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7 January 2021

Akt, a pleckstrin homology domain containing kinase, is activated primarily by phosphorylation

1 reference

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7 January 2021

Raf-1 protein kinase is required for growth of induced NIH/3T3 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2907017-5

7 January 2021

BRAF mutations are common somatic events in melanocytic nevi.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2907017-5

7 January 2021

Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2907017-5

7 January 2021

Activation of RalA is critical for Ras-induced tumorigenesis of human cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2907017-5

7 January 2021

A novel Cdc42Hs mutant induces cellular transformation

1 reference

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7 January 2021

Discovery of a novel Raf kinase inhibitor

1 reference

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7 January 2021

Mice deficient in the Rac activator Tiam1 are resistant to Ras-induced skin tumours.

1 reference

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7 January 2021

RAS oncogenes: the first 30 years.

1 reference

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7 January 2021

Transformation of mammalian cells by constitutively active MAP kinase kinase

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7 January 2021

Oncogenic Ras blocks anoikis by activation of a novel effector pathway independent of phosphatidylinositol 3-kinase

1 reference

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7 January 2021

Regulated membrane localization of Tiam1, mediated by the NH2-terminal pleckstrin homology domain, is required for Rac-dependent membrane ruffling and C-Jun NH2-terminal kinase activation

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2907017-5

7 January 2021

Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2907017-5

7 January 2021

Involvement of phosphatidylinositol 3-kinase, but not RalGDS, in TC21/R-Ras2-mediated transformation

1 reference

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7 January 2021

Renewing the conspiracy theory debate: does Raf function alone to mediate Ras oncogenesis?

1 reference

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7 January 2021

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1 reference

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7 January 2021

Phosphatidylinositol-3-OH kinase as a direct target of Ras

1 reference

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7 January 2021

Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2907017-5

7 January 2021

High frequency of mutations of the PIK3CA gene in human cancers

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2907017-5

7 January 2021

Opinion: Searching for the elusive targets of farnesyltransferase inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2907017-5

7 January 2021

RalA but not RalB enhances polarized delivery of membrane proteins to the basolateral surface of epithelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2907017-5

7 January 2021

Definition of the human raf amino-terminal regulatory region by deletion mutagenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2907017-5

7 January 2021

The complexity of PTEN: mutation, marker and potential target for therapeutic intervention

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2907017-5

7 January 2021

Activation of Raf as a result of recruitment to the plasma membrane

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2907017-5

7 January 2021

Cell cycle-dependent activation of Ras.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2907017-5

7 January 2021

RASSF2 is a novel K-Ras-specific effector and potential tumor suppressor

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2907017-5

7 January 2021

The RAS effector RIN1 directly competes with RAF and is regulated by 14-3-3 proteins.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2907017-5

7 January 2021

The RAF proteins take centre stage

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2907017-5

7 January 2021

V599EB-RAF is an oncogene in melanocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2907017-5

7 January 2021

Role of phosphoinositide 3-kinase in activation of ras and mitogen-activated protein kinase by epidermal growth factor

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2907017-5

7 January 2021

Multiple Ras functions can contribute to mammalian cell transformation

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2907017-5

7 January 2021

BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2907017-5

7 January 2021

Cellular N-Ras promotes cell survival by downregulation of Jun N-terminal protein kinase and p38

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2907017-5

7 January 2021

Stimulation of gene induction and cell growth by the Ras effector Rlf

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2907017-5

7 January 2021

Activation of the small GTPase Ral in platelets.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2907017-5

7 January 2021

10.1016/S0076-6879(05)07017-5

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16757325%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

1 reference