(Q35976355)

11 August 2017

1 reference

title

The complexity of PTEN: mutation, marker and potential target for therapeutic intervention (English)

1 reference

11 August 2017

1

Linda S Steelman

1 reference

11 August 2017

3

James A McCubrey

1 reference

11 August 2017

Fred E Bertrand

2

1 reference

PubMed ID

15584861

11 August 2017

language of work or name

English

0 references

publication date

1 December 2004

1 reference

Expert Opinion on Therapeutic Targets

11 August 2017

1 reference

11 August 2017

8

1 reference

11 August 2017

537-550

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11 August 2017

6

1 reference

Genetic markers in glioblastoma: prognostic significance and future therapeutic implications

11 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.537

Novel germline mutation of the PTEN gene in a Japanese family with Cowden disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.537

Regulation of cell migration by the C2 domain of the tumor suppressor PTEN.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.537

Involvement of PI3K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.537

Phosphorylation-regulated cleavage of the tumor suppressor PTEN by caspase-3: implications for the control of protein stability and PTEN-protein interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.537

PTEN: sometimes taking it off can be better than putting it on.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.537

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.537

PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.537

P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.537

PTEN coordinates G(1) arrest by down-regulating cyclin D1 via its protein phosphatase activity and up-regulating p27 via its lipid phosphatase activity in a breast cancer model

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.537

PTEN induces apoptosis and cell cycle arrest through phosphoinositol-3-kinase/Akt-dependent and -independent pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.537

PTEN: one gene, many syndromes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.537

Protean PTEN: form and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.537

HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.537

Biological role of phosphatase PTEN in cancer and tissue injury healing

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.537

The multiple roles of PTEN in tumor suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.537

Conditional knock-out of integrin-linked kinase demonstrates an essential role in protein kinase B/Akt activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.537

A novel positive feedback loop mediated by the docking protein Gab1 and phosphatidylinositol 3-kinase in epidermal growth factor receptor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.537

Inactivation of platelet-derived growth factor receptor by the tumor suppressor PTEN provides a novel mechanism of action of the phosphatase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.537

The lipid phosphatase activity of PTEN is critical for its tumor supressor function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.537

JAK/STAT, Raf/MEK/ERK, PI3K/Akt and BCR-ABL in cell cycle progression and leukemogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.537

Phosphorylation of the PTEN tail acts as an inhibitory switch by preventing its recruitment into a protein complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.537

PTEN inhibits insulin-stimulated MEK/MAPK activation and cell growth by blocking IRS-1 phosphorylation and IRS-1/Grb-2/Sos complex formation in a breast cancer model

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.537

PTEN expression causes feedback upregulation of insulin receptor substrate 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.537

A chemical genetic screen identifies inhibitors of regulated nuclear export of a Forkhead transcription factor in PTEN-deficient tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.537

Germline mutations in the PTEN/MMAC1 gene in patients with Cowden disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.537

Mutation spectrum and genotype-phenotype analyses in Cowden disease and Bannayan-Zonana syndrome, two hamartoma syndromes with germline PTEN mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.537

Cowden disease and Lhermitte-Duclos disease: characterization of a new phakomatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.537

Involvement of PTEN in airway hyperresponsiveness and inflammation in bronchial asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.537

Promoter methylation and silencing of PTEN in gastric carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.537

Hypermethylation of tumor suppressor genes in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.537

Caveolin-1, a putative tumour suppressor gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.537

Some protein tyrosine phosphatases target in part to lipid rafts and interact with caveolin-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.537

PTEN gene mutations in colorectal cancers displaying microsatellite instability

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.537

Frequent inactivation of PTEN by promoter hypermethylation in microsatellite instability-high sporadic colorectal cancers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.537

AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.537

PTEN augments staurosporine-induced apoptosis in PTEN-null Ishikawa cells by downregulating PI3K/Akt signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.537

The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.537

Chemosensitivity of prostate cancer cell lines and expression of multidrug resistance-related proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.537

PTEN induces chemosensitivity in PTEN-mutated prostate cancer cells by suppression of Bcl-2 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.537

A highly conserved processed PTEN pseudogene is located on chromosome band 9p21

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.537

Clinical development of mammalian target of rapamycin inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.537

Interplay between insulin and nutrients in the regulation of translation factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.537

An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.537

mTOR, a novel target in breast cancer: the effect of CCI-779, an mTOR inhibitor, in preclinical models of breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.537

Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.537

Tumor suppressor PTEN inhibits integrin- and growth factor-mediated mitogen-activated protein (MAP) kinase signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.537

PTEN interactions with focal adhesion kinase and suppression of the extracellular matrix-dependent phosphatidylinositol 3-kinase/Akt cell survival pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.537

The tumour suppressor PTEN: involvement of a tumour suppressor candidate protein in PTEN turnover

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.537

Dual neuroprotective signaling mediated by downregulating two distinct phosphatase activities of PTEN.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.537

Silencing of thePTENtumor-suppressor gene in anaplastic thyroid cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.537

21 January 2018

Identifiers

DOI

10.1517/14728222.8.6.537

1 reference

11 August 2017

1 reference

PubMed ID

15584861