(Q84279172)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22659133%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

title

The Werner syndrome gene product (WRN): a repressor of hypoxia-inducible factor-1 activity (English)

1 reference

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3 February 2020

1 reference

8

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3 February 2020

author name string

Adam Labbé

1

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3 February 2020

Véronique N Lafleur

2

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3 February 2020

David A Patten

3

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3 February 2020

Geneviève A Robitaille

4

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3 February 2020

Chantal Garand

5

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3 February 2020

Laurent Lamalice

6

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3 February 2020

Michel Lebel

7

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3 February 2020

publication date

31 May 2012

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Experimental Cell Research

3 February 2020

published in

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3 February 2020

volume

318

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3 February 2020

issue

14

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3 February 2020

page(s)

1620-1632

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A Review of its Symptomatology, Natural History, Pathologic Features, Genetics And Relationship to the Natural Aging Process

3 February 2020

cites work

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.010

The spectrum of WRN mutations in Werner syndrome patients

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.010

The gene responsible for Werner syndrome may be a cell division "counting" gene

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.010

Spectral karyotyping of Werner syndrome fibroblast cultures.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.010

Characterization of the human and mouse WRN 3'-->5' exonuclease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.010

Werner syndrome protein. II. Characterization of the integral 3' --> 5' DNA exonuclease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.010

Werner syndrome protein. I. DNA helicase and dna exonuclease reside on the same polypeptide.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.010

Werner syndrome protein: functions in the response to DNA damage and replication stress in S-phase.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.010

Werner protein protects nonproliferating cells from oxidative DNA damage

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.010

Increased insulin, triglycerides, reactive oxygen species, and cardiac fibrosis in mice with a mutation in the helicase domain of the Werner syndrome gene homologue

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.010

In vivo prooxidant state in Werner syndrome (WS): results from three WS patients and two WS heterozygotes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.010

Vitamin C restores healthy aging in a mouse model for Werner syndrome

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.010

Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.010

Increased oxidative stress in obesity and its impact on metabolic syndrome

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.010

Tranilast attenuates cardiac matrix deposition in experimental diabetes: role of transforming growth factor-beta

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.010

Mitochondrial metabolism of reactive oxygen species.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.010

Targeting HIF-1 for cancer therapy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.010

Hypoxia-inducible factors and the response to hypoxic stress

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.010

Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.010

Regulation of oxygen homeostasis by hypoxia-inducible factor 1.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.010

p53 and p66 proteins compete for hypoxia-inducible factor 1 alpha stabilization in young and old rat hearts exposed to intermittent hypoxia

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.010

Review: hypoxia-inducible factor-1 (HIF-1): a novel transcription factor in immune reactions.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.010

The effect of age and calorie restriction on HIF-1-responsive genes in aged liver

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.010

Inhibition of respiration extends C. elegans life span via reactive oxygen species that increase HIF-1 activity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.010

HIF-1 modulates longevity and healthspan in a temperature-dependent manner

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.010

HIF-1alpha cytoplasmic accumulation is associated with cell death in old rat cerebral cortex exposed to intermittent hypoxia

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.010

Hypoxia inducible factor (HIF) function in innate immunity and infection

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.010

p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1alpha (HIF-1alpha) and enhance the transcriptional activity of HIF-1.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.010

(2R)-[(4-Biphenylylsulfonyl)amino]-N-hydroxy-3-phenylpropionamide (BiPS), a matrix metalloprotease inhibitor, is a novel and potent activator of hypoxia-inducible factors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.010

The selective detection of mitochondrial superoxide by live cell imaging

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.010

Depletion of intracellular ascorbate by the carcinogenic metals nickel and cobalt results in the induction of hypoxic stress

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.010

Hypoxia-inducible factor-1alpha stabilization in nonhypoxic conditions: role of oxidation and intracellular ascorbate depletion

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.010

A plate reader method for the measurement of NAD, NADP, glutathione, and ascorbate in tissue extracts: Application to redox profiling during Arabidopsis rosette development

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.010

HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.010

Sphingosine-1-phosphate: a novel nonhypoxic activator of hypoxia-inducible factor-1 in vascular cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.010

Hypoxia-inducible factor-1 activation in nonhypoxic conditions: the essential role of mitochondrial-derived reactive oxygen species.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.010

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.010

The Qo site of the mitochondrial complex III is required for the transduction of hypoxic signaling via reactive oxygen species production

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.010

Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.010

Thrombopoietin (TPO) regulates HIF-1alpha levels through generation of mitochondrial reactive oxygen species

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.010

Mitochondrial complex III regulates hypoxic activation of HIF.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.010

A targeted antioxidant reveals the importance of mitochondrial reactive oxygen species in the hypoxic signaling of HIF-1alpha.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.010

Stabilization of hypoxia-inducible factor-1alpha protein in hypoxia occurs independently of mitochondrial reactive oxygen species production.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.010

Relief of oxidative stress by ascorbic acid delays cellular senescence of normal human and Werner syndrome fibroblast cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.010

Prolyl 4-hydroxylases and their protein disulfide isomerase subunit

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.010

The role of ascorbate in the modulation of HIF-1alpha protein and HIF-dependent transcription by chromium(VI) and nickel(II)

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.010

Differential effects of glucose on dehydroascorbic acid transport and intracellular ascorbate accumulation in astrocytes and skeletal myocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.010

7 January 2021

Vitamin C transporters.

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.010

Glucose transporter isoforms GLUT1 and GLUT3 transport dehydroascorbic acid

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.010

Increased frequency of multiradial chromosome structures in mouse embryonic fibroblasts lacking functional Werner syndrome protein and poly(ADP-ribose) polymerase-1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.010

Aneuploidy analysis in fibroblasts of human premature aging syndromes by FISH during in vitro cellular aging

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.010

Werner syndrome protein prevents DNA breaks upon chromatin structure alteration

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.010

Cobalt-induced oxidant stress in cultured endothelial cells: prevention by ascorbate in relation to HIF-1alpha

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.010

Signalling hypoxia by HIF hydroxylases

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.010

The Werner syndrome protein affects the expression of genes involved in adipogenesis and inflammation in addition to cell cycle and DNA damage responses.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.010

High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C--dependent activation of NAD(P)H oxidase in cultured vascular cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.010

Mitochondrial dysfunction in some oxidative stress-related genetic diseases: Ataxia-Telangiectasia, Down Syndrome, Fanconi Anaemia and Werner Syndrome

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.010

Resveratrol improves insulin resistance hyperglycemia and hepatosteatosis but not hypertriglyceridemia, inflammation, and life span in a mouse model for Werner syndrome

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.010

Mitochondrial kinases in cell signaling: Facts and perspectives

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.010

Depletion of WRN protein causes RACK1 to activate several protein kinase C isoforms

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.04.010

10.1016/J.YEXCR.2012.04.010

7 January 2021

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22659133%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

1 reference