(Q84596559)

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Antileukemic activity of combined epigenetic agents, DNMT inhibitors zebularine and RG108 with HDAC inhibitors, against promyelocytic leukemia HL-60 cells

scientific article published on 20 July 2012

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22820861%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

Antileukemic activity of combined epigenetic agents, DNMT inhibitors zebularine and RG108 with HDAC inhibitors, against promyelocytic leukemia HL-60 cells (English)

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Europe PubMed Central

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8 February 2020

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Jurate Savickiene

1

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Europe PubMed Central

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8 February 2020

Grazina Treigyte

2

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8 February 2020

Veronika-Viktorija Borutinskaite

3

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8 February 2020

Ruta Navakauskiene

4

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Europe PubMed Central

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8 February 2020

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20 July 2012

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8 February 2020

Cellular & Molecular Biology Letters

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8 February 2020

17

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Europe PubMed Central

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8 February 2020

4

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22820861%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

501-525

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22820861%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

https://scigraph.springernature.com/pub.10.2478/s11658-012-0024-5

0 references

Combined DNA methyltransferase and histone deacetylase inhibition in the treatment of myeloid neoplasms

1 reference

https://pubmed.ncbi.nlm.nih.gov/22820861

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Butyrates, as a single drug, induce histone acetylation and granulocytic maturation: possible selectivity on core binding factor-acute myeloid leukemia blasts.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22820861

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Precipitous release of methyl-CpG binding protein 2 and histone deacetylase 1 from the methylated human multidrug resistance gene (MDR1) on activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/22820861

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multicenter, phase II study of decitabine for the first-line treatment of older patients with acute myeloid leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/22820861

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

E-cadherin expression is silenced by 5' CpG island methylation in acute leukemia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22820861

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Methylation profiling in acute myeloid leukemia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22820861

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of a novel DNA methyltransferase inhibitor zebularine on human breast cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/22820861

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA methyltransferase and histone deacetylase inhibitors in the treatment of myelodysplastic syndromes

1 reference

https://pubmed.ncbi.nlm.nih.gov/22820861

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Histone methylation in transcriptional control

1 reference

https://pubmed.ncbi.nlm.nih.gov/22820861

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase 1 study of low-dose prolonged exposure schedules of the hypomethylating agent 5-aza-2'-deoxycytidine (decitabine) in hematopoietic malignancies

1 reference

https://pubmed.ncbi.nlm.nih.gov/22820861

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Methylation of p15(INK4b) and E-cadherin genes is independently correlated with poor prognosis in acute myeloid leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/22820861

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypermethylation-associated inactivation indicates a tumor suppressor role for p15INK4B.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22820861

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The absence of p53 is critical for the induction of apoptosis by 5-aza-2'-deoxycytidine

1 reference

https://pubmed.ncbi.nlm.nih.gov/22820861

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Histone acetylation in chromatin structure and transcription

1 reference

https://pubmed.ncbi.nlm.nih.gov/22820861

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The PML-RARα fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR

1 reference

https://pubmed.ncbi.nlm.nih.gov/22820861

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Zebularine inhibits human acute myeloid leukemia cell growth in vitro in association with p15INK4B demethylation and reexpression.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22820861

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell division is required for de novo methylation of CpG islands in bladder cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/22820861

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distinct patterns of inactivation of p15INK4B and p16INK4A characterize the major types of hematological malignancies

1 reference

https://pubmed.ncbi.nlm.nih.gov/22820861

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypermethylation of GpG islands in the promoter region of p15(INK4b) in acute promyelocytic leukemia represses p15(INK4b) expression and correlates with poor prognosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22820861

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of expression of p15, p73 and E-cadherin in leukemic cells by different concentrations of 5-aza-2'-deoxycytidine (Decitabine).

1 reference

https://pubmed.ncbi.nlm.nih.gov/22820861

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The language of covalent histone modifications

1 reference

https://pubmed.ncbi.nlm.nih.gov/22820861

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential cell fates induced by all-trans retinoic acid-treated HL-60 human leukemia cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/22820861

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Independent dynamic regulation of histone phosphorylation and acetylation during immediate-early gene induction

1 reference

https://pubmed.ncbi.nlm.nih.gov/22820861

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CpG hypermethylation of promoter region and inactivation of E-cadherin gene in human bladder cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/22820861

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel retinoic acid receptor (RAR)-selective antagonist inhibits differentiation and apoptosis of HL-60 cells: implications of RARalpha-mediated signals in myeloid leukemic cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/22820861

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison of biological effects of non-nucleoside DNA methylation inhibitors versus 5-aza-2'-deoxycytidine.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22820861

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of DNA methyltransferases DNMT1, 3A, and 3B in normal hematopoiesis and in acute and chronic myelogenous leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/22820861

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p15(INK4B) CpG island methylation in primary acute leukemia is heterogeneous and suggests density as a critical factor for transcriptional silencing

1 reference

https://pubmed.ncbi.nlm.nih.gov/22820861

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The novel histone deacetylase inhibitor BML-210 exerts growth inhibitory, proapoptotic and differentiation stimulating effects on the human leukemia cell lines

1 reference

https://pubmed.ncbi.nlm.nih.gov/22820861

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p21WAF1/CIP1 interacts with protein kinase CK2

1 reference

https://pubmed.ncbi.nlm.nih.gov/22820861

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Continuous zebularine treatment effectively sustains demethylation in human bladder cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/22820861

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The DNA methyltransferase inhibitors azacitidine, decitabine and zebularine exert differential effects on cancer gene expression in acute myeloid leukemia cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/22820861

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cross-talk between histone modifications in response to histone deacetylase inhibitors: MLL4 links histone H3 acetylation and histone H3K4 methylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/22820861

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional diversity of DNA methyltransferase inhibitors in human cancer cell lines.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22820861

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cancer epigenetics: linking basic biology to clinical medicine.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22820861

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis of pyrimidin-2-one nucleosides as acid-stable inhibitors of cytidine deaminase

1 reference

https://pubmed.ncbi.nlm.nih.gov/22820861

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism-based inhibition of C5-cytosine DNA methyltransferases by 2-H pyrimidinone 1 1Edited by J. Karn

1 reference

https://pubmed.ncbi.nlm.nih.gov/22820861

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

HL-60 cells induced to differentiate towards neutrophils subsequently die via apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22820861

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

E-cadherin regulates metastasis of pancreatic cancer in vivo and is suppressed by a SNAIL/HDAC1/HDAC2 repressor complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/22820861

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Promoter analysis of epigenetically controlled genes in bladder cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22820861

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of DNA methylation and reactivation of silenced genes by zebularine

1 reference

https://pubmed.ncbi.nlm.nih.gov/22820861

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Preferential response of cancer cells to zebularine.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22820861

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolic activation of zebularine, a novel DNA methylation inhibitor, in human bladder carcinoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/22820861

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Zebularine: a unique molecule for an epigenetically based strategy in cancer chemotherapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/22820861

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Histone deacetylases in acute myeloid leukaemia show a distinctive pattern of expression that changes selectively in response to deacetylase inhibitors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22820861

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human DNA-(Cytosine-5) Methyltransferase-PCNA Complex as a Target for p21WAF1

1 reference

https://pubmed.ncbi.nlm.nih.gov/22820861

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epigenetic reactivation of tumor suppressor genes by a novel small-molecule inhibitor of human DNA methyltransferases.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22820861

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypermethylation of E-cadherin in leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/22820861

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p15 (INK4B) and E-cadherin CpG island methylation is frequent in Egyptian acute myeloid leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/22820861

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alterations in DNA methylation: a fundamental aspect of neoplasia

1 reference

https://pubmed.ncbi.nlm.nih.gov/22820861

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Granulocytic differentiation of HL-60 cells results in spontaneous apoptosis mediated by increased caspase expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/22820861

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apoptosis, proliferation and differentiation patterns are influenced by Zebularine and SAHA in pancreatic cancer models

1 reference

https://pubmed.ncbi.nlm.nih.gov/22820861

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epigenomic stress response. Knockdown of DNA methyltransferase 1 triggers an intra-S-phase arrest of DNA replication and induction of stress response genes

1 reference

https://pubmed.ncbi.nlm.nih.gov/22820861

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Electrophoresis of histones: a modified Panyim and Chalkley system for slab gels

1 reference

https://pubmed.ncbi.nlm.nih.gov/22820861

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Zebularine reactivates silenced E-cadherin but unlike 5-Azacytidine does not induce switching from latent to lytic Epstein-Barr virus infection in Burkitt's lymphoma Akata cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/22820861

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Snail mediates E-cadherin repression by the recruitment of the Sin3A/histone deacetylase 1 (HDAC1)/HDAC2 complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/22820861

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epigenetic changes by zebularine leading to enhanced differentiation of human promyelocytic leukemia NB4 and KG1 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/22820861

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of treatment with 5-azacytidine on the in vivo and in vitro hematopoiesis in patients with myelodysplastic syndromes

1 reference

https://pubmed.ncbi.nlm.nih.gov/22820861

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epigenetic mechanisms in AML - a target for therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/22820861

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase I study of decitabine alone or in combination with valproic acid in acute myeloid leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/22820861

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Retinoic acid-induced apoptosis in leukemia cells is mediated by paracrine action of tumor-selective death ligand TRAIL.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22820861

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The HL-60 promyelocytic leukemia cell line: proliferation, differentiation, and cellular oncogene expression.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22820861

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibitors of HDACs--effective drugs against cancer?

1 reference

https://pubmed.ncbi.nlm.nih.gov/22820861

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhancement of antineoplastic action of 5-aza-2'-deoxycytidine by zebularine on L1210 leukemia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22820861

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression levels of histone deacetylases determine the cell fate of hematopoietic progenitors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22820861

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Retinoic acid targets DNA-methyltransferases and histone deacetylases during APL blast differentiation in vitro and in vivo.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22820861

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA

1 reference

https://pubmed.ncbi.nlm.nih.gov/22820861

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aberrant methylation of multiple tumor suppressor genes in acute myeloid leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/22820861

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A systematic profile of DNA methylation in human cancer cell lines

1 reference

https://pubmed.ncbi.nlm.nih.gov/22820861

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Autonomous rexinoid death signaling is suppressed by converging signaling pathways in immature leukemia cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/22820861

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Zebularine: A Novel DNA Methylation Inhibitor that Forms a Covalent Complex with DNA Methyltransferases

1 reference

https://pubmed.ncbi.nlm.nih.gov/22820861

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The histone deacetylase inhibitor valproic acid selectively induces proteasomal degradation of HDAC2

1 reference

https://pubmed.ncbi.nlm.nih.gov/22820861

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/22820861

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The DAC system and associations with acute leukemias and myelodysplastic syndromes

1 reference

https://pubmed.ncbi.nlm.nih.gov/22820861

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.2478/S11658-012-0024-5

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22820861%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

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1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22820861%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22820861%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

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