(Q86263513)

English

Differing impact of the deletion of hemochromatosis-associated molecules HFE and transferrin receptor-2 on the iron phenotype of mice lacking bone morphogenetic protein 6 or hemojuvelin

scientific article published on 12 November 2015

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24 February 2020

Differing impact of the deletion of hemochromatosis-associated molecules HFE and transferrin receptor-2 on the iron phenotype of mice lacking bone morphogenetic protein 6 or hemojuvelin (English)

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24 February 2020

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Laura Silvestri

4

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24 February 2020

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24 February 2020

author name string

Chloé Latour

1

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24 February 2020

Céline Besson-Fournier

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24 February 2020

Delphine Meynard

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24 February 2020

Ophélie Gourbeyre

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24 February 2020

Patricia Aguilar-Martinez

6

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24 February 2020

Paul J Schmidt

7

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24 February 2020

Marie-Paule Roth

9

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24 February 2020

Hélène Coppin

10

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24 February 2020

publication date

12 November 2015

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24 February 2020

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24 February 2020

63

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24 February 2020

1

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24 February 2020

126-137

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24 February 2020

A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis

1 reference

https://api.crossref.org/works/10.1002%2FHEP.28254

7 January 2021

based on heuristic

inferred from DOI database lookup

The hemochromatosis founder mutation in HLA-H disrupts beta2-microglobulin interaction and cell surface expression

1 reference

https://api.crossref.org/works/10.1002%2FHEP.28254

7 January 2021

based on heuristic

inferred from DOI database lookup

Crystal structure of the hemochromatosis protein HFE and characterization of its interaction with transferrin receptor

1 reference

https://api.crossref.org/works/10.1002%2FHEP.28254

7 January 2021

based on heuristic

inferred from DOI database lookup

The gene TFR2 is mutated in a new type of haemochromatosis mapping to 7q22.

1 reference

https://api.crossref.org/works/10.1002%2FHEP.28254

7 January 2021

based on heuristic

inferred from DOI database lookup

Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis

1 reference

https://api.crossref.org/works/10.1002%2FHEP.28254

7 January 2021

based on heuristic

inferred from DOI database lookup

Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis

1 reference

https://api.crossref.org/works/10.1002%2FHEP.28254

7 January 2021

based on heuristic

inferred from DOI database lookup

Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization

1 reference

https://api.crossref.org/works/10.1002%2FHEP.28254

7 January 2021

based on heuristic

inferred from DOI database lookup

Iron regulates phosphorylation of Smad1/5/8 and gene expression of Bmp6, Smad7, Id1, and Atoh8 in the mouse liver

1 reference

https://api.crossref.org/works/10.1002%2FHEP.28254

7 January 2021

based on heuristic

inferred from DOI database lookup

BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism

1 reference

https://api.crossref.org/works/10.1002%2FHEP.28254

7 January 2021

based on heuristic

inferred from DOI database lookup

Lack of the bone morphogenetic protein BMP6 induces massive iron overload

1 reference

https://api.crossref.org/works/10.1002%2FHEP.28254

7 January 2021

based on heuristic

inferred from DOI database lookup

A mouse model of juvenile hemochromatosis

1 reference

https://api.crossref.org/works/10.1002%2FHEP.28254

7 January 2021

based on heuristic

inferred from DOI database lookup

Hemojuvelin is essential for dietary iron sensing, and its mutation leads to severe iron overload

1 reference

https://api.crossref.org/works/10.1002%2FHEP.28254

7 January 2021

based on heuristic

inferred from DOI database lookup

Transferrin receptor 2: a new molecule in iron metabolism

1 reference

https://api.crossref.org/works/10.1002%2FHEP.28254

7 January 2021

based on heuristic

inferred from DOI database lookup

Hereditary hemochromatosis protein, HFE, interaction with transferrin receptor 2 suggests a molecular mechanism for mammalian iron sensing

1 reference

https://api.crossref.org/works/10.1002%2FHEP.28254

7 January 2021

based on heuristic

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Interaction of the hereditary hemochromatosis protein HFE with transferrin receptor 2 is required for transferrin-induced hepcidin expression

1 reference

https://api.crossref.org/works/10.1002%2FHEP.28254

7 January 2021

based on heuristic

inferred from DOI database lookup

The transferrin receptor modulates Hfe-dependent regulation of hepcidin expression

1 reference

https://api.crossref.org/works/10.1002%2FHEP.28254

7 January 2021

based on heuristic

inferred from DOI database lookup

In situ proximity ligation assays indicate that hemochromatosis proteins Hfe and transferrin receptor 2 (Tfr2) do not interact.

1 reference

https://api.crossref.org/works/10.1002%2FHEP.28254

7 January 2021

based on heuristic

inferred from DOI database lookup

Transgenic HFE-dependent induction of hepcidin in mice does not require transferrin receptor-2.

1 reference

https://api.crossref.org/works/10.1002%2FHEP.28254

7 January 2021

based on heuristic

inferred from DOI database lookup

Combined deletion of Hfe and transferrin receptor 2 in mice leads to marked dysregulation of hepcidin and iron overload.

1 reference

https://api.crossref.org/works/10.1002%2FHEP.28254

7 January 2021

based on heuristic

inferred from DOI database lookup

The hemochromatosis proteins HFE, TfR2, and HJV form a membrane-associated protein complex for hepcidin regulation

1 reference

https://api.crossref.org/works/10.1002%2FHEP.28254

7 January 2021

based on heuristic

inferred from DOI database lookup

Testosterone perturbs systemic iron balance through activation of epidermal growth factor receptor signaling in the liver and repression of hepcidin

1 reference

https://api.crossref.org/works/10.1002%2FHEP.28254

7 January 2021

based on heuristic

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Comparison of 3 Tfr2-deficient murine models suggests distinct functions for Tfr2-alpha and Tfr2-beta isoforms in different tissues.

1 reference

https://api.crossref.org/works/10.1002%2FHEP.28254

7 January 2021

based on heuristic

inferred from DOI database lookup

Inactivation of the hemochromatosis gene differentially regulates duodenal expression of iron-related mRNAs between mouse strains

1 reference

https://api.crossref.org/works/10.1002%2FHEP.28254

7 January 2021

based on heuristic

inferred from DOI database lookup

A competitive enzyme-linked immunosorbent assay specific for murine hepcidin-1: correlation with hepatic mRNA expression in established and novel models of dysregulated iron homeostasis

1 reference

https://api.crossref.org/works/10.1002%2FHEP.28254

7 January 2021

based on heuristic

inferred from DOI database lookup

Statistical analysis of real-time PCR data

1 reference

https://api.crossref.org/works/10.1002%2FHEP.28254

7 January 2021

based on heuristic

inferred from DOI database lookup

Hereditary hemochromatosis: effects of C282Y and H63D mutations on association with beta2-microglobulin, intracellular processing, and cell surface expression of the HFE protein in COS-7 cells

1 reference

https://api.crossref.org/works/10.1002%2FHEP.28254

7 January 2021

based on heuristic

inferred from DOI database lookup

Defective iron homeostasis in beta 2-microglobulin knockout mice recapitulates hereditary hemochromatosis in man.

1 reference

https://api.crossref.org/works/10.1002%2FHEP.28254

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification of erythroferrone as an erythroid regulator of iron metabolism

1 reference

https://api.crossref.org/works/10.1002%2FHEP.28254

7 January 2021

based on heuristic

inferred from DOI database lookup

Effect of phlebotomy on hepcidin expression in hemojuvelin-mutant mice.

1 reference

https://api.crossref.org/works/10.1002%2FHEP.28254

7 January 2021

based on heuristic

inferred from DOI database lookup

Contributions of beta2-microglobulin-dependent molecules and lymphocytes to iron regulation: insights from HfeRag1(-/-) and beta2mRag1(-/-) double knock-out mice

1 reference

https://api.crossref.org/works/10.1002%2FHEP.28254

7 January 2021

based on heuristic

inferred from DOI database lookup

Genes that modify the hemochromatosis phenotype in mice

1 reference

https://api.crossref.org/works/10.1002%2FHEP.28254

7 January 2021

based on heuristic

inferred from DOI database lookup

Comparative study between Hfe-/- and beta2m-/- mice: progression with age of iron status and liver pathology

1 reference

https://api.crossref.org/works/10.1002%2FHEP.28254

7 January 2021

based on heuristic

inferred from DOI database lookup

Molecular analysis of iron overload in β2-microglobulin-deficient mice

1 reference

https://api.crossref.org/works/10.1002%2FHEP.28254

7 January 2021

based on heuristic

inferred from DOI database lookup

Modulation of bone morphogenetic protein signaling in vivo regulates systemic iron balance

1 reference

https://api.crossref.org/works/10.1002%2FHEP.28254

7 January 2021

based on heuristic

inferred from DOI database lookup

Repulsive guidance molecule (RGM) family proteins exhibit differential binding kinetics for bone morphogenetic proteins (BMPs)

1 reference

https://api.crossref.org/works/10.1002%2FHEP.28254

7 January 2021

based on heuristic

inferred from DOI database lookup

Hfe and Hjv exhibit overlapping functions for iron signaling to hepcidin.

1 reference

https://api.crossref.org/works/10.1002%2FHEP.28254

7 January 2021

based on heuristic

inferred from DOI database lookup

HJV and HFE Play Distinct Roles in Regulating Hepcidin.

1 reference

https://api.crossref.org/works/10.1002%2FHEP.28254

7 January 2021

based on heuristic

inferred from DOI database lookup

Evidence for distinct pathways of hepcidin regulation by acute and chronic iron loading in mice

1 reference

https://api.crossref.org/works/10.1002%2FHEP.28254

7 January 2021

based on heuristic

inferred from DOI database lookup

Repulsive guidance molecule is a structural bridge between neogenin and bone morphogenetic protein

1 reference

https://api.crossref.org/works/10.1002%2FHEP.28254

7 January 2021

based on heuristic

inferred from DOI database lookup

RGM co-receptors add complexity to BMP signaling.

1 reference

https://api.crossref.org/works/10.1002%2FHEP.28254

7 January 2021

based on heuristic

inferred from DOI database lookup

The mode of bone morphogenetic protein (BMP) receptor oligomerization determines different BMP-2 signaling pathways.

1 reference

https://api.crossref.org/works/10.1002%2FHEP.28254

7 January 2021

based on heuristic

inferred from DOI database lookup

Bmp6 expression in murine liver non parenchymal cells: a mechanism to control their high iron exporter activity and protect hepatocytes from iron overload?

1 reference

https://api.crossref.org/works/10.1002%2FHEP.28254

7 January 2021

based on heuristic

inferred from DOI database lookup

Perturbation of hepcidin expression by BMP type I receptor deletion induces iron overload in mice

1 reference

https://api.crossref.org/works/10.1002%2FHEP.28254

7 January 2021

based on heuristic

inferred from DOI database lookup

BMP6 treatment compensates for the molecular defect and ameliorates hemochromatosis in Hfe knockout mice

1 reference

https://api.crossref.org/works/10.1002%2FHEP.28254

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1002/HEP.28254

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Europe PubMed Central

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24 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26406355%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

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