(Q87149797)

English

Structural Elucidation and Synthesis of Eudistidine A: An Unusual Polycyclic Marine Alkaloid that Blocks Interaction of the Protein Binding Domains of p300 and HIF-1α

scientific article published on 20 April 2015

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25892103%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

Structural Elucidation and Synthesis of Eudistidine A: An Unusual Polycyclic Marine Alkaloid that Blocks Interaction of the Protein Binding Domains of p300 and HIF-1α (English)

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25892103%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

Susanna T S Chan

1

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6 March 2020

Andrew K L Goey

6

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6 March 2020

Kristina M Cook

7

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6 March 2020

Martin J Schnermann

10

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6 March 2020

author name string

Paresma R Patel

2

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6 March 2020

Tanya R Ransom

3

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6 March 2020

Curtis J Henrich

4

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6 March 2020

Tawnya C McKee

5

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6 March 2020

William D Figg

8

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6 March 2020

James B McMahon

9

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6 March 2020

Kirk R Gustafson

11

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6 March 2020

language of work or name

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Journal of the American Chemical Society

publication date

20 April 2015

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6 March 2020

Journal of the American Chemical Society

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6 March 2020

137

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6 March 2020

16

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6 March 2020

5569-5575

1 reference

Europe PubMed Central

PMC publication ID

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6 March 2020

Molecular mechanism of hypoxia-inducible factor 1alpha -p300 interaction. A leucine-rich interface regulated by a single cysteine

1 reference

https://pubmed.ncbi.nlm.nih.gov/25892103

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypoxia--a key regulatory factor in tumour growth

1 reference

https://pubmed.ncbi.nlm.nih.gov/25892103

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1 alpha

1 reference

https://pubmed.ncbi.nlm.nih.gov/25892103

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Polyubiquitination of p53 by a ubiquitin ligase activity of p300.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25892103

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Three conformational states of the p300 CH1 domain define its functional properties

1 reference

https://pubmed.ncbi.nlm.nih.gov/25892103

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeting HIF-1 for cancer therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/25892103

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Polyisoprenylated benzophenone, garcinol, a natural histone acetyltransferase inhibitor, represses chromatin transcription and alters global gene expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/25892103

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/25892103

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evaluation of HIF-1 inhibitors as anticancer agents

1 reference

https://pubmed.ncbi.nlm.nih.gov/25892103

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reaching for high-hanging fruit in drug discovery at protein-protein interfaces

1 reference

https://pubmed.ncbi.nlm.nih.gov/25892103

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isolation, structure elucidation, and synthesis of eudistomides A and B, lipopeptides from a Fijian ascidian Eudistoma sp.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25892103

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epidithiodiketopiperazines block the interaction between hypoxia-inducible factor-1alpha (HIF-1alpha) and p300 by a zinc ejection mechanism

1 reference

https://pubmed.ncbi.nlm.nih.gov/25892103

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CBP and p300 are cytoplasmic E4 polyubiquitin ligases for p53.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25892103

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Direct inhibition of hypoxia-inducible transcription factor complex with designed dimeric epidithiodiketopiperazine

1 reference

https://pubmed.ncbi.nlm.nih.gov/25892103

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Virtual ligand screening of the p300/CBP histone acetyltransferase: identification of a selective small molecule inhibitor

1 reference

https://pubmed.ncbi.nlm.nih.gov/25892103

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High throughput extraction of plant, marine and fungal specimens for preservation of biologically active molecules.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25892103

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Life and death of transcriptional co-activator p300.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25892103

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Assessing helical protein interfaces for inhibitor design

1 reference

https://pubmed.ncbi.nlm.nih.gov/25892103

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural biology and drug discovery of difficult targets: the limits of ligandability

1 reference

https://pubmed.ncbi.nlm.nih.gov/25892103

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of VEGF transcription through blockade of the hypoxia inducible factor-1α-p300 interaction by a small molecule.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25892103

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

HIFs, angiogenesis, and cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/25892103

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypoxia-regulated target genes implicated in tumor metastasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/25892103

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Direct One-Pot Synthesis of Luotonin F and Analogues via Rational Logical Design

1 reference

https://pubmed.ncbi.nlm.nih.gov/25892103

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of α-helix-mediated protein-protein interactions using designed molecules

1 reference

https://pubmed.ncbi.nlm.nih.gov/25892103

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Design and synthesis of 2-acylbenzothiazoles via in situ cross-trapping strategy from benzothiazoles with aryl ketones.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25892103

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Suppression of tumor growth by designed dimeric epidithiodiketopiperazine targeting hypoxia-inducible transcription factor complex.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25892103

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Discovery and characterization of protein-modifying natural products by MALDI mass spectrometry reveal potent SIRT1 and p300 inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/25892103

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Menadione and ethacrynic acid inhibit the hypoxia-inducible factor (HIF) pathway by disrupting HIF-1α interaction with p300.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25892103

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Small-molecule inhibitors of acetyltransferase p300 identified by high-throughput screening are potent anticancer agents.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25892103

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel function of novobiocin: disrupting the interaction of HIF 1α and p300/CBP through direct binding to the HIF1α C-terminal activation domain

1 reference

https://pubmed.ncbi.nlm.nih.gov/25892103

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations

1 reference

https://pubmed.ncbi.nlm.nih.gov/25892103

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New steroids with a rearranged skeleton as (h)P300 inhibitors from the sponge Theonella swinhoei.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25892103

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of the HIF1α-p300 interaction by quinone- and indandione-mediated ejection of structural Zn(II).

1 reference

https://pubmed.ncbi.nlm.nih.gov/25892103

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

1 reference

https://pubmed.ncbi.nlm.nih.gov/25892103

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/25892103

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/JACS.5B02156

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25892103%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25892103%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25892103%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

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