(Q38082945)

28 August 2017

Inhibition of α-helix-mediated protein-protein interactions using designed molecules (English)

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protein-protein interaction

28 August 2017

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4

Andrew J Wilson

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author name string

Valeria Azzarito

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1

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28 August 2017

Kérya Long

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2

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28 August 2017

Natasha S Murphy

series ordinal

3

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28 August 2017

1 March 2013

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28 August 2017

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28 August 2017

5

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28 August 2017

161-173

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28 August 2017

3

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https://scigraph.springernature.com/pub.10.1038/nchem.1568

28 August 2017

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Design and application of an alpha-helix-mimetic scaffold based on an oligoamide-foldamer strategy: antagonism of the Bak BH3/Bcl-xL complex

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Conformational consequences of i, i + 3 cystine linkages: nucleation for alpha-helicity?

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Core structure of gp41 from the HIV envelope glycoprotein

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Enhanced metabolic stability and protein-binding properties of artificial alpha helices derived from a hydrogen-bond surrogate: application to Bcl-xL.

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Synthesis and biological evaluation of a 5-6-5 imidazole-phenyl-thiazole based alpha-helix mimetic

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Rational Design of Proteolytically Stable, Cell-Permeable Peptide-Based Selective Mcl-1 Inhibitors

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Structural and biological mimicry of protein surface recognition by / -peptide foldamers

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Development of α-helical calpain probes by mimicking a natural protein-protein interaction

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Peptidomimetic design

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12 December 2020

Structure-based design of novel inhibitors of the MDM2-p53 interaction

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12 December 2020

Hydrocarbon double-stapling remedies the proteolytic instability of a lengthy peptide therapeutic

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12 December 2020

Design of a protein surface antagonist based on alpha-helix mimicry: inhibition of gp41 assembly and viral fusion

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12 December 2020

Structural insights into the degradation of Mcl-1 induced by BH3 domains

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12 December 2020

Structural biology and drug discovery of difficult targets: the limits of ligandability

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12 December 2020

Assessing helical protein interfaces for inhibitor design

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12 December 2020

An orthosteric inhibitor of the Ras-Sos interaction

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12 December 2020

Oligooxopiperazines as nonpeptidic alpha-helix mimetics

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12 December 2020

Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

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12 December 2020

Synthesis of functionalised aromatic oligamide rods

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12 December 2020

Evaluation of Diverse α/β-Backbone Patterns for Functional α-Helix Mimicry: Analogues of the Bim BH3 Domain

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12 December 2020

Inhibiting HIV fusion with a beta-peptide foldamer

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12 December 2020

ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor

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12 December 2020

Novel amphiphilic alpha-helix mimetics based on a bis-benzamide scaffold

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12 December 2020

Sequence-based design of alpha/beta-peptide foldamers that mimic BH3 domains.

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12 December 2020

N-alkylated oligoamide alpha-helical proteomimetics

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12 December 2020

Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

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12 December 2020

Direct inhibition of the NOTCH transcription factor complex

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12 December 2020

Discovery and cocrystal structure of benzodiazepinedione HDM2 antagonists that activate p53 in cells.

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A stapled p53 helix overcomes HDMX-mediated suppression of p53.

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12 December 2020

Controlling curvature in a family of oligoamide alpha-helix mimetics.

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Identification of scavenger receptor SR-BI as a high density lipoprotein receptor

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The MCL-1 BH3 helix is an exclusive MCL-1 inhibitor and apoptosis sensitizer

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12 December 2020

Helix mimetics as inhibitors of the interaction of the estrogen receptor with coactivator peptides

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(alpha/beta+alpha)-peptide antagonists of BH3 domain/Bcl-x(L) recognition: toward general strategies for foldamer-based inhibition of protein-protein interactions

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Trastuzumab--mechanism of action and use in clinical practice

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Novel pyrrolopyrimidine-based α-helix mimetics: cell-permeable inhibitors of protein−protein interactions

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12 December 2020

A stapled BID BH3 helix directly binds and activates BAX

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12 December 2020

Computational design, synthesis, and evaluation of miniproteins as androgen receptor coactivator mimics

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12 December 2020

Structure-activity studies in a family of beta-hairpin protein epitope mimetic inhibitors of the p53-HDM2 protein-protein interaction

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12 December 2020

Helical beta-peptide inhibitors of the p53-hDM2 interaction.

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12 December 2020

Photocontrollable peptide-based switches target the anti-apoptotic protein Bcl-xL.

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12 December 2020

A hydrogen bond surrogate approach for stabilization of short peptide sequences in alpha-helical conformation

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12 December 2020

Heterocyclic alpha-helix mimetics for targeting protein-protein interactions

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12 December 2020

Structure and function of benzoylurea-derived alpha-helix mimetics targeting the Bcl-x(L)/Bak binding interface

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12 December 2020

Design and Evolution of a Miniature Bcl-2 Binding Protein We thank the HHMI Biopolymer/Keck Foundation Biotechnology Resource Laboratory (Yale University School of Medicine, New Haven, CT) for oligonucleotide and peptide synthesis and amino acid ana

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12 December 2020

Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition

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12 December 2020

Estimating the size of the human interactome

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12 December 2020

A highly potent and cellularly active beta-peptidic inhibitor of the p53/hDM2 interaction

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12 December 2020

The design of dipeptide helical mimetics: The synthesis, tachykinin receptor affinity and conformational analysis of 1,1,6-trisubstituted indanes

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12 December 2020

Terphenyl-Based Bak BH3 alpha-helical proteomimetics as low-molecular-weight antagonists of Bcl-xL.

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12 December 2020

Molecular Recognition of Protein−Ligand Complexes: Applications to Drug Design

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12 December 2020

Rational development of beta-peptide inhibitors of human cytomegalovirus entry

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12 December 2020

Strategies for targeting protein-protein interactions with synthetic agents.

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12 December 2020

Inhibition of hypoxia inducible factor 1-transcription coactivator interaction by a hydrogen bond surrogate alpha-helix

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12 December 2020

Inhibition of a viral enzyme by a small-molecule dimer disruptor

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12 December 2020

Modulation of protein-protein interactions with small organic molecules

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12 December 2020

Toward proteomimetics: terphenyl derivatives as structural and functional mimics of extended regions of an alpha-helix

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12 December 2020

Benzoylurea oligomers: synthetic foldamers that mimic extended alpha helices.

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12 December 2020

A highly stable short alpha-helix constrained by a main-chain hydrogen-bond surrogate

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12 December 2020

Arylamide derivatives as peptidomimetic inhibitors of calmodulin

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12 December 2020

Novel selective inhibitors of the interaction of individual nuclear hormone receptors with a mutually shared steroid receptor coactivator 2.

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12 December 2020

Transient Pockets on Protein Surfaces Involved in Protein−Protein Interaction

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12 December 2020

Discovery of HIV fusion inhibitors targeting gp41 using a comprehensive α-helix mimetic library

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12 December 2020

High specificity in protein recognition by hydrogen-bond-surrogate α-helices: selective inhibition of the p53/MDM2 complex

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12 December 2020

Design and synthesis of α-helical peptides and mimetics

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12 December 2020

Cyclic parathyroid hormone-related protein antagonists: lysine 13 to aspartic acid 17 [i to (i + 4)] side chain to side chain lactamization

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12 December 2020

Synthetic inhibitors of extended helix-protein interactions based on a biphenyl 4,4'-dicarboxamide scaffold

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12 December 2020

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

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12 December 2020

Coupling of receptor conformation and ligand orientation determine graded activity

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12 December 2020

Photoreactive stapled BH3 peptides to dissect the BCL-2 family interactome.

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12 December 2020

Structure of the stapled p53 peptide bound to Mdm2

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12 December 2020

Proteomimetic libraries: design, synthesis, and evaluation of p53-MDM2 interaction inhibitors.

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12 December 2020

Rational design and engineering of therapeutic proteins

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12 December 2020

Design, synthesis, and evaluation of an alpha-helix mimetic library targeting protein-protein interactions

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12 December 2020

Cyclosporine in severe ulcerative colitis refractory to steroid therapy

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12 December 2020

The mechanism of alpha-helix formation by peptides

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12 December 2020

Relaxation of the rigid backbone of an oligoamide-foldamer-based α-helix mimetic: identification of potent Bcl-xL inhibitors.

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12 December 2020

Target practice: lessons from phase III trials with bevacizumab and vatalanib in the treatment of advanced colorectal cancer

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12 December 2020

Disrupting protein-protein interactions with non-peptidic, small molecule alpha-helix mimetics

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12 December 2020

The structure of a Bcl-xL/Bim fragment complex: implications for Bim function

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12 December 2020

Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix

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12 December 2020

NMR solution structure of a photoswitchable apoptosis activating Bak peptide bound to Bcl-xL

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12 December 2020

Inhibition of HIV-1 fusion by hydrogen-bond-surrogate-based alpha helices

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12 December 2020

Short constrained peptides that inhibit HIV-1 entry

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12 December 2020

A hot spot of binding energy in a hormone-receptor interface

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12 December 2020

Probing the structural requirements of peptoids that inhibit HDM2-p53 interactions

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12 December 2020

Binding mode and transcriptional activation potential of high affinity ligands for the CBP KIX domain

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12 December 2020

Phage display selection of miniprotein binders of the Estrogen Receptor

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12 December 2020

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

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12 December 2020

Helix-stabilized cyclic peptides as selective inhibitors of steroid receptor-coactivator interactions

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12 December 2020

Biologic drugs set to top 2012 sales

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12 December 2020

Design of Bcl-2 and Bcl-xL Inhibitors with Subnanomolar Binding Affinities Based upon a New Scaffold

1 reference

12 December 2020

Inhibition of protein-protein interactions using designed molecules

1 reference

12 December 2020

The BH3 alpha-helical mimic BH3-M6 disrupts Bcl-X(L), Bcl-2, and MCL-1 protein-protein interactions with Bax, Bak, Bad, or Bim and induces apoptosis in a Bax- and Bim-dependent manner

1 reference

12 December 2020

Nucleation effects in peptide foldamers

1 reference

12 December 2020

A decade of fragment-based drug design: strategic advances and lessons learned

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12 December 2020

Synthetic alpha-helix mimetics as agonists and antagonists of islet amyloid polypeptide aggregation

1 reference

12 December 2020

Structural mimicry of the α-helix in aqueous solution with an isoatomic α/β/γ-peptide backbone

1 reference

12 December 2020

Structure-based design of potent Bcl-2/Bcl-xL inhibitors with strong in vivo antitumor activity.

1 reference

12 December 2020

Contemporary strategies for the stabilization of peptides in the alpha-helical conformation

1 reference

12 December 2020

Potent inhibitors of LXXLL-based protein-protein interactions.

1 reference

12 December 2020

Structural Basis of Bcl-xL Recognition by a BH3-Mimetic α/β-Peptide Generated by Sequence-Based Design

1 reference

12 December 2020

Microwave assisted solid phase synthesis of highly functionalized N-alkylated oligobenzamide α-helix mimetics

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12 December 2020

Paralog-selective ligands for bcl-2 proteins

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12 December 2020

Design, synthesis and protein-targeting properties of thioether-linked hydrogen bond surrogate helices

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12 December 2020

beta-Peptides: from structure to function

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12 December 2020

Reaching for high-hanging fruit in drug discovery at protein-protein interfaces

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12 December 2020

Synthetic non-peptide mimetics of alpha-helices

1 reference

12 December 2020

Terephthalamide derivatives as mimetics of helical peptides: disruption of the Bcl-x(L)/Bak interaction

1 reference

12 December 2020

Development of a potent Bcl-x(L) antagonist based on alpha-helix mimicry

1 reference

12 December 2020

Beta-peptides with improved affinity for hDM2 and hDMX.

1 reference

12 December 2020

Design and structure of stapled peptides binding to estrogen receptors

1 reference

12 December 2020

High-Resolution Structural Characterization of a Helical α/β-Peptide Foldamer Bound to the Anti-Apoptotic Protein Bcl-xL

1 reference

12 December 2020

N-acylpolyamine inhibitors of HDM2 and HDMX binding to p53.

1 reference

12 December 2020

Downsizing human, bacterial, and viral proteins to short water-stable alpha helices that maintain biological potency

1 reference

12 December 2020

Inhibition of HIV type 1 infectivity by constrained alpha-helical peptides: implications for the viral fusion mechanism

1 reference

12 December 2020

Molecular Recognition of Protein Surfaces: High Affinity Ligands for the CBP KIX Domain

1 reference

12 December 2020

Conformation of poly-.beta.-alanine in aqueous solution from proton magnetic resonance and deuterium exchange studies

1 reference

12 December 2020

Foldamers: A Manifesto

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNCHEM.1568

7 January 2021

inferred from DOI database lookup

Highly Efficient Synthesis of Covalently Cross-Linked Peptide Helices by Ring-Closing Metathesis

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNCHEM.1568

7 January 2021

inferred from DOI database lookup

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNCHEM.1568

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1038/NCHEM.1568

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Dimensions Publication ID

28 August 2017

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