(Q88741254)

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High-Throughput Screening Enhances Kidney Organoid Differentiation from Human Pluripotent Stem Cells and Enables Automated Multidimensional Phenotyping

scientific article published on 17 May 2018

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scholarly article

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27 March 2020

High-Throughput Screening Enhances Kidney Organoid Differentiation from Human Pluripotent Stem Cells and Enables Automated Multidimensional Phenotyping (English)

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27 March 2020

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Matthias Kretzler

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Matthias Kretzler

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27 March 2020

Jonathan Himmelfarb

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Jonathan Himmelfarb

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27 March 2020

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Stefan M Czerniecki

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27 March 2020

Nelly M Cruz

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27 March 2020

Jennifer L Harder

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27 March 2020

Rajasree Menon

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27 March 2020

James Annis

5

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27 March 2020

Edgar A Otto

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27 March 2020

Ramila E Gulieva

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27 March 2020

Laura V Islas

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27 March 2020

Yong Kyun Kim

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27 March 2020

Linh M Tran

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27 March 2020

Timothy J Martins

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27 March 2020

Jeffrey W Pippin

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27 March 2020

Hongxia Fu

13

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27 March 2020

Stuart J Shankland

15

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27 March 2020

Randall T Moon

17

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27 March 2020

Neal Paragas

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27 March 2020

Benjamin S Freedman

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27 March 2020

publication date

17 May 2018

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27 March 2020

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27 March 2020

22

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27 March 2020

6

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27 March 2020

929-940.e4

1 reference

Europe PubMed Central

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27 March 2020

Embryonic stem cell lines derived from human blastocysts

1 reference

https://pubmed.ncbi.nlm.nih.gov/29779890

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

1 reference

https://pubmed.ncbi.nlm.nih.gov/29779890

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human and porcine early kidney precursors as a new source for transplantation

1 reference

https://pubmed.ncbi.nlm.nih.gov/29779890

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dissecting temporal and spatial control of cytokinesis with a myosin II Inhibitor

1 reference

https://pubmed.ncbi.nlm.nih.gov/29779890

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Defects in cell adhesion and the visceral endoderm following ablation of nonmuscle myosin heavy chain II-A in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/29779890

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of pluripotent stem cells from adult human fibroblasts by defined factors

1 reference

https://pubmed.ncbi.nlm.nih.gov/29779890

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cisplatin nephrotoxicity: mechanisms and renoprotective strategies

1 reference

https://pubmed.ncbi.nlm.nih.gov/29779890

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New regulators of Wnt/beta-catenin signaling revealed by integrative molecular screening

1 reference

https://pubmed.ncbi.nlm.nih.gov/29779890

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pericytes and perivascular fibroblasts are the primary source of collagen-producing cells in obstructive fibrosis of the kidney

1 reference

https://pubmed.ncbi.nlm.nih.gov/29779890

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A small molecule that directs differentiation of human ESCs into the pancreatic lineage.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29779890

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Non-muscle myosin II takes centre stage in cell adhesion and migration

1 reference

https://pubmed.ncbi.nlm.nih.gov/29779890

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/29779890

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genes that confer the identity of the renin cell

1 reference

https://pubmed.ncbi.nlm.nih.gov/29779890

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induced pluripotent stem cells--opportunities for disease modelling and drug discovery

1 reference

https://pubmed.ncbi.nlm.nih.gov/29779890

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A 3-D organoid kidney culture model engineered for high-throughput nephrotoxicity assays

1 reference

https://pubmed.ncbi.nlm.nih.gov/29779890

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transgelin is a marker of repopulating mesangial cells after injury and promotes their proliferation and migration

1 reference

https://pubmed.ncbi.nlm.nih.gov/29779890

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Vertebrate kidney tubules elongate using a planar cell polarity-dependent, rosette-based mechanism of convergent extension

1 reference

https://pubmed.ncbi.nlm.nih.gov/29779890

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Monitoring and robust induction of nephrogenic intermediate mesoderm from human pluripotent stem cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/29779890

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A small molecule screen in stem-cell-derived motor neurons identifies a kinase inhibitor as a candidate therapeutic for ALS.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29779890

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A functional CFTR assay using primary cystic fibrosis intestinal organoids

1 reference

https://pubmed.ncbi.nlm.nih.gov/29779890

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Laminin and type IV collagen isoform substitutions occur in temporally and spatially distinct patterns in developing kidney glomerular basement membranes

1 reference

https://pubmed.ncbi.nlm.nih.gov/29779890

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cerebral organoids model human brain development and microcephaly

1 reference

https://pubmed.ncbi.nlm.nih.gov/29779890

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of human nephron progenitors capable of generation of kidney structures and functional repair of chronic renal disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29779890

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Redefining the in vivo origin of metanephric nephron progenitors enables generation of complex kidney structures from pluripotent stem cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/29779890

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rapid and efficient differentiation of human pluripotent stem cells into intermediate mesoderm that forms tubules expressing kidney proximal tubular markers

1 reference

https://pubmed.ncbi.nlm.nih.gov/29779890

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo clonal analysis reveals lineage-restricted progenitor characteristics in mammalian kidney development, maintenance, and regeneration.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29779890

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Generation of functional human pancreatic β cells in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/29779890

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modelling human development and disease in pluripotent stem-cell-derived gastric organoids

1 reference

https://pubmed.ncbi.nlm.nih.gov/29779890

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A high-throughput platform for stem cell niche co-cultures and downstream gene expression analysis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29779890

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prediction of drug-induced nephrotoxicity and injury mechanisms with human induced pluripotent stem cell-derived cells and machine learning methods.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29779890

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/29779890

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nephron organoids derived from human pluripotent stem cells model kidney development and injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/29779890

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modelling kidney disease with CRISPR-mutant kidney organoids derived from human pluripotent epiblast spheroids

1 reference

https://pubmed.ncbi.nlm.nih.gov/29779890

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell- and patient-derived tumor organoids

1 reference

https://pubmed.ncbi.nlm.nih.gov/29779890

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Co-ordinated ocular development from human iPS cells and recovery of corneal function

1 reference

https://pubmed.ncbi.nlm.nih.gov/29779890

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CD146(+) cells are essential for kidney vasculature development.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29779890

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A High-Throughput Screening Assay to Identify Kidney Toxic Compounds

1 reference

https://pubmed.ncbi.nlm.nih.gov/29779890

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of Polycystin-1 Function by Calmodulin Binding

1 reference

https://pubmed.ncbi.nlm.nih.gov/29779890

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Generating high-purity cardiac and endothelial derivatives from patterned mesoderm using human pluripotent stem cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/29779890

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Drug discovery for Diamond-Blackfan anemia using reprogrammed hematopoietic progenitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/29779890

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High-throughput screening of tyrosine kinase inhibitor cardiotoxicity with human induced pluripotent stem cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29779890

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Can podocytes be regenerated in adults?

1 reference

https://pubmed.ncbi.nlm.nih.gov/29779890

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endoglin controls blood vessel diameter through endothelial cell shape changes in response to haemodynamic cues.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29779890

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endoglin prevents vascular malformation by regulating flow-induced cell migration and specification through VEGFR2 signalling

1 reference

https://pubmed.ncbi.nlm.nih.gov/29779890

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Psychrophilic proteases dramatically reduce single-cell RNA-seq artifacts: a molecular atlas of kidney development

1 reference

https://pubmed.ncbi.nlm.nih.gov/29779890

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gene-Edited Human Kidney Organoids Reveal Mechanisms of Disease in Podocyte Development

1 reference

https://pubmed.ncbi.nlm.nih.gov/29779890

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Organoid cystogenesis reveals a critical role of microenvironment in human polycystic kidney disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29779890

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endomucin inhibits VEGF-induced endothelial cell migration, growth, and morphogenesis by modulating VEGFR2 signaling.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29779890

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29779890

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.STEM.2018.04.022

1 reference

Europe PubMed Central

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27 March 2020

PMC publication ID

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29779890%20AND%20SRC:MED&resulttype=core&format=json

27 March 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29779890%20AND%20SRC:MED&resulttype=core&format=json

27 March 2020

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