(Q89334340)

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The Alzheimer's Prevention Initiative Autosomal-Dominant Alzheimer's Disease Trial: A study of crenezumab versus placebo in preclinical PSEN1 E280A mutation carriers to evaluate efficacy and safety in the treatment of autosomal-dominant Alzheimer's

scientific article published on 08 March 2018

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3 April 2020

The Alzheimer's Prevention Initiative Autosomal-Dominant Alzheimer's Disease Trial: A study of crenezumab versus placebo in preclinical PSEN1 E280A mutation carriers to evaluate efficacy and safety in the treatment of autosomal-dominant Alzheimer's disease, including a placebo-treated noncarrier cohort (English)

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3 April 2020

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Alzheimer's disease

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author name string

Pierre N Tariot

1

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3 April 2020

Francisco Lopera

2

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3 April 2020

Jessica B Langbaum

3

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3 April 2020

Ronald G Thomas

4

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3 April 2020

Suzanne Hendrix

5

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3 April 2020

Lon S Schneider

6

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3 April 2020

Silvia Rios-Romenets

7

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3 April 2020

Margarita Giraldo

8

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3 April 2020

Natalia Acosta

9

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3 April 2020

Carlos Tobon

10

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3 April 2020

Claudia Ramos

11

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3 April 2020

Alejandro Espinosa

12

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3 April 2020

William Cho

13

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3 April 2020

Michael Ward

14

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3 April 2020

David Clayton

15

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3 April 2020

Michael Friesenhahn

16

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3 April 2020

Howard Mackey

17

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3 April 2020

Lee Honigberg

18

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3 April 2020

Sandra Sanabria Bohorquez

19

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3 April 2020

Kewei Chen

20

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3 April 2020

Trisha Walsh

21

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3 April 2020

Carolyn Langlois

22

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3 April 2020

Eric M Reiman

23

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3 April 2020

Alzheimer's Prevention Initiative

24

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Europe PubMed Central

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3 April 2020

publication date

8 March 2018

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3 April 2020

Alzheimer's & dementia (New York, N. Y.)

1 reference

Europe PubMed Central

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3 April 2020

4

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3 April 2020

150-160

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3 April 2020

Prevalence of Alzheimer's disease in a community population of older persons. Higher than previously reported.

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7 January 2021

Dementia incidence continues to increase with age in the oldest old: the 90+ study

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7 January 2021

The amyloid hypothesis of Alzheimer's disease at 25 years

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7 January 2021

Homozygosity of the autosomal dominant Alzheimer disease presenilin 1 E280A mutation

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7 January 2021

List of Drugs in Development for Neurodegenerative Diseases: Update June 2010

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The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

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Soluble oligomers of the amyloid beta-protein impair synaptic plasticity and behavior

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Projections of Alzheimer's disease in the United States and the public health impact of delaying disease onset.

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Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

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E280A PS-1 mutation causes Alzheimer's disease but age of onset is not modified by ApoE alleles

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Clinical features of early-onset Alzheimer disease in a large kindred with an E280A presenilin-1 mutation.

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Pre-dementia clinical stages in presenilin 1 E280A familial early-onset Alzheimer's disease: a retrospective cohort study.

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Cognitive changes in the preclinical phase of familial Alzheimer's disease

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Florbetapir PET analysis of amyloid-β deposition in the presenilin 1 E280A autosomal dominant Alzheimer's disease kindred: a cross-sectional study

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Deposition of hyperphosphorylated tau in cerebellum of PS1 E280A Alzheimer's disease

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Structure of Crenezumab Complex with Aβ Shows Loss of β-Hairpin

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An effector-reduced anti-β-amyloid (Aβ) antibody with unique aβ binding properties promotes neuroprotection and glial engulfment of Aβ.

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Deglycosylated anti-amyloid-beta antibodies eliminate cognitive deficits and reduce parenchymal amyloid with minimal vascular consequences in aged amyloid precursor protein transgenic mice.

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Self-ratings of Spoken Language Dominance: A Multi-Lingual Naming Test (MINT) and Preliminary Norms for Young and Aging Spanish-English Bilinguals

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based on heuristic

inferred from DOI database lookup

Functional assessment staging (FAST) in Alzheimer's disease: reliability, validity, and ordinality.

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRCI.2018.02.002

7 January 2021

based on heuristic

inferred from DOI database lookup

Development of cognitive instruments for use in clinical trials of antidementia drugs: additions to the Alzheimer's Disease Assessment Scale that broaden its scope. The Alzheimer's Disease Cooperative Study.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29955659

12 December 2020

based on heuristic

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10.1016/J.TRCI.2018.02.002

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29955659%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

PMC publication ID

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29955659%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29955659%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

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