(Q90080352)

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Overcoming Immunological Resistance Enhances the Efficacy of A Novel Anti-tMUC1-CAR T Cell Treatment against Pancreatic Ductal Adenocarcinoma

scientific article published on 11 September 2019

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31514488%20AND%20SRC:MED&resulttype=core&format=json

11 April 2020

Overcoming Immunological Resistance Enhances the Efficacy of A Novel Anti-tMUC1-CAR T Cell Treatment against Pancreatic Ductal Adenocarcinoma (English)

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31514488%20AND%20SRC:MED&resulttype=core&format=json

11 April 2020

invasive ductal carcinoma

1 reference

based on heuristic

inferred from title

pancreatic ductal adenocarcinoma

1 reference

based on heuristic

inferred from title

pancreatic ductal carcinoma

1 reference

based on heuristic

inferred from title

2

object named as

Ru Zhou

1 reference

Europe PubMed Central

PMC publication ID

11 April 2020

9

object named as

Didier Dreau

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31514488%20AND%20SRC:MED&resulttype=core&format=json

11 April 2020

author name string

Mahboubeh Yazdanifar

1

1 reference

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31514488%20AND%20SRC:MED&resulttype=core&format=json

11 April 2020

Priyanka Grover

3

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31514488%20AND%20SRC:MED&resulttype=core&format=json

11 April 2020

Chandra Williams

4

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31514488%20AND%20SRC:MED&resulttype=core&format=json

11 April 2020

Mukulika Bose

5

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31514488%20AND%20SRC:MED&resulttype=core&format=json

11 April 2020

Laura J Moore

6

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31514488%20AND%20SRC:MED&resulttype=core&format=json

11 April 2020

Shu-Ta Wu

7

1 reference

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31514488%20AND%20SRC:MED&resulttype=core&format=json

11 April 2020

John Maher

8

1 reference

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31514488%20AND%20SRC:MED&resulttype=core&format=json

11 April 2020

And Pinku Mukherjee

10

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11 April 2020

publication date

11 September 2019

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31514488%20AND%20SRC:MED&resulttype=core&format=json

11 April 2020

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31514488%20AND%20SRC:MED&resulttype=core&format=json

11 April 2020

8

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31514488%20AND%20SRC:MED&resulttype=core&format=json

11 April 2020

9

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31514488%20AND%20SRC:MED&resulttype=core&format=json

11 April 2020

copyright license

Creative Commons Attribution 4.0 International

11 September 2019

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April 2022 Public Data File from Crossref

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describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC6770201/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

Treatment of patients with metastatic melanoma with autologous tumor-infiltrating lymphocytes and interleukin 2

1 reference

https://pubmed.ncbi.nlm.nih.gov/31514488

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of T cell proliferation by macrophage tryptophan catabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/31514488

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Soluble MUC1 secreted by human epithelial cancer cells mediates immune suppression by blocking T-cell activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/31514488

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Indoleamine 2,3-dioxygenase production by human dendritic cells results in the inhibition of T cell proliferation

1 reference

https://pubmed.ncbi.nlm.nih.gov/31514488

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of allogeneic T cell proliferation by indoleamine 2,3-dioxygenase-expressing dendritic cells: mediation of suppression by tryptophan metabolites

1 reference

https://pubmed.ncbi.nlm.nih.gov/31514488

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tryptophan-derived catabolites are responsible for inhibition of T and natural killer cell proliferation induced by indoleamine 2,3-dioxygenase.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31514488

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MUC1 and MUC2 expression in pancreatic ductal carcinoma obtained by fine-needle aspiration

1 reference

https://pubmed.ncbi.nlm.nih.gov/31514488

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MUC1 and MUC2 in pancreatic neoplasia

1 reference

https://pubmed.ncbi.nlm.nih.gov/31514488

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MUC1 overexpression results in mammary gland tumorigenesis and prolonged alveolar differentiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/31514488

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adoptive cell transfer therapy following non-myeloablative but lymphodepleting chemotherapy for the treatment of patients with refractory metastatic melanoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/31514488

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity

1 reference

https://pubmed.ncbi.nlm.nih.gov/31514488

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytotoxic T lymphocyte-induced killing in the absence of granzymes A and B is unique and distinct from both apoptosis and perforin-dependent lysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/31514488

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Retargeting of human T cells to tumor-associated MUC1: the evolution of a chimeric antigen receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/31514488

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nonmyeloablative chemotherapy followed by T-cell adoptive transfer and dendritic cell-based vaccination results in rejection of established melanoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/31514488

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Galectin-9 increases Tim-3+ dendritic cells and CD8+ T cells and enhances antitumor immunity via galectin-9-Tim-3 interactions.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31514488

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The prioritization of cancer antigens: a national cancer institute pilot project for the acceleration of translational research

1 reference

https://pubmed.ncbi.nlm.nih.gov/31514488

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Case report of a serious adverse event following the administration of T cells transduced with a chimeric antigen receptor recognizing ERBB2

1 reference

https://pubmed.ncbi.nlm.nih.gov/31514488

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of cyclooxygenase-2 in cell proliferation and cell death in human malignancies.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31514488

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/31514488

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

B-cell depletion and remissions of malignancy along with cytokine-associated toxicity in a clinical trial of anti-CD19 chimeric-antigen-receptor-transduced T cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/31514488

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of immune responses by prostaglandin E2

1 reference

https://pubmed.ncbi.nlm.nih.gov/31514488

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MUC1 regulates PDGFA expression during pancreatic cancer progression

1 reference

https://pubmed.ncbi.nlm.nih.gov/31514488

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reversal of tumoral immune resistance by inhibition of tryptophan 2,3-dioxygenase

1 reference

https://pubmed.ncbi.nlm.nih.gov/31514488

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tim-3 is an inducible human natural killer cell receptor that enhances interferon gamma production in response to galectin-9

1 reference

https://pubmed.ncbi.nlm.nih.gov/31514488

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dual targeting of ErbB2 and MUC1 in breast cancer using chimeric antigen receptors engineered to provide complementary signaling.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31514488

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The use of a novel MUC1 antibody to identify cancer stem cells and circulating MUC1 in mice and patients with pancreatic cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/31514488

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Galectin-9 functionally impairs natural killer cells in humans and mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/31514488

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Galectin-9 in cancer therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/31514488

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Receptor affinity and extracellular domain modifications affect tumor recognition by ROR1-specific chimeric antigen receptor T cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/31514488

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IDO1 metabolites activate β-catenin signaling to promote cancer cell proliferation and colon tumorigenesis in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/31514488

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anti-PD-1 antibody therapy potently enhances the eradication of established tumors by gene-modified T cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/31514488

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kinetics of tumor destruction by chimeric antigen receptor-modified T cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/31514488

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mesothelin-specific chimeric antigen receptor mRNA-engineered T cells induce anti-tumor activity in solid malignancies.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31514488

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Addressing the challenges of pancreatic cancer: future directions for improving outcomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/31514488

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tryptophan-degrading enzymes in tumoral immune resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/31514488

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumor indoleamine 2,3-dioxygenase (IDO) inhibits CD19-CAR T cells and is downregulated by lymphodepleting drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/31514488

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Engineering CAR-T cells: Design concepts

1 reference

https://pubmed.ncbi.nlm.nih.gov/31514488

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel immune resistance mechanism of melanoma cells controlled by the ADAR1 enzyme

1 reference

https://pubmed.ncbi.nlm.nih.gov/31514488

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclooxygenase-Dependent Tumor Growth through Evasion of Immunity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31514488

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apoptosis of tumor infiltrating effector TIM-3+CD8+ T cells in colon cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/31514488

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel association of neuropilin-1 and MUC1 in pancreatic ductal adenocarcinoma: role in induction of VEGF signaling and angiogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/31514488

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pancreatic cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/31514488

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adaptive resistance to therapeutic PD-1 blockade is associated with upregulation of alternative immune checkpoints.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31514488

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase 1 clinical trial demonstrated that MUC1 positive metastatic seminal vesicle cancer can be effectively eradicated by modified Anti-MUC1 chimeric antigen receptor transduced T cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/31514488

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeting tumor tolerance: A new hope for pancreatic cancer therapy?

1 reference

https://pubmed.ncbi.nlm.nih.gov/31514488

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A Perspective of Immunotherapy for Prostate Cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/31514488

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pancreatic Cancer: A Review

1 reference

https://pubmed.ncbi.nlm.nih.gov/31514488

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antibody-Guided In Vivo Imaging for Early Detection of Mammary Gland Tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/31514488

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclooxygenase-2: A Role in Cancer Stem Cell Survival and Repopulation of Cancer Cells during Therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/31514488

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeting of Aberrant αvβ6 Integrin Expression in Solid Tumors Using Chimeric Antigen Receptor-Engineered T Cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/31514488

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mucin-1-Antibody-Conjugated Mesoporous Silica Nanoparticles for Selective Breast Cancer Detection in a Mucin-1 Transgenic Murine Mouse Model

1 reference

https://pubmed.ncbi.nlm.nih.gov/31514488

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Emerging immunotherapeutics in adenocarcinomas: A focus on CAR-T cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/31514488

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A tumor specific antibody to aid breast cancer screening in women with dense breast tissue

1 reference

https://pubmed.ncbi.nlm.nih.gov/31514488

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Tim-3-galectin-9 Secretory Pathway is Involved in the Immune Escape of Human Acute Myeloid Leukemia Cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31514488

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Treatment of pancreatic ductal adenocarcinoma with tumor antigen specific-targeted delivery of paclitaxel loaded PLGA nanoparticles.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31514488

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TIM-3, a promising target for cancer immunotherapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/31514488

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Loss of ADAR1 in tumours overcomes resistance to immune checkpoint blockade.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31514488

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pancreatic cancer chemo-resistance is driven by tumor phenotype rather than tumor genotype

1 reference

https://pubmed.ncbi.nlm.nih.gov/31514488

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CAR T Cells Targeting the Tumor MUC1 Glycoprotein Reduce Triple-Negative Breast Cancer Growth.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31514488

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.3390/CELLS8091070

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31514488%20AND%20SRC:MED&resulttype=core&format=json

11 April 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31514488%20AND%20SRC:MED&resulttype=core&format=json

11 April 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31514488%20AND%20SRC:MED&resulttype=core&format=json

11 April 2020

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