(Q90354072)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31564962%20AND%20SRC:MED&resulttype=core&format=json

13 April 2020

review article

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title

Voltage gated sodium channels as therapeutic targets for chronic pain (English)

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13 April 2020

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5

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13 April 2020

Raihan Mohammed

7

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13 April 2020

author name string

Renee Siu Yu Ma

1

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13 April 2020

Kayani Kayani

2

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13 April 2020

Danniella Whyte-Oshodi

3

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13 April 2020

Aiyesha Whyte-Oshodi

4

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13 April 2020

Shaene Gnanarajah

6

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13 April 2020

publication date

9 September 2019

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13 April 2020

published in

Journal of Pain Research

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13 April 2020

volume

12

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13 April 2020

page(s)

2709-2722

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Creative Commons Attribution-NonCommercial 3.0 Unported

13 April 2020

copyright license

start time

1 September 2019

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April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

The Use of Oral Mexiletine for the Treatment of Pain after Peripheral Nerve Injury

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12 December 2020

Cellular and molecular biology of voltage-gated sodium channels

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12 December 2020

Na+ conductance and the threshold for repetitive neuronal firing

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12 December 2020

Painful neuropathy: altered central processing maintained dynamically by peripheral input

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12 December 2020

Systemic lidocaine silences ectopic neuroma and DRG discharge without blocking nerve conduction

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12 December 2020

Distribution of sodium channels in chronically demyelinated spinal cord axons: immuno-ultrastructural localization and electrophysiological observations

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12 December 2020

Ion channels in transit: voltage-gated Na and K channels in axoplasmic organelles of the squid Loligo pealei

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12 December 2020

The effect of intravenous lidocaine on nociceptive processing in diabetic neuropathy.

1 reference

12 December 2020

Axonal transport of the voltage-dependent Na+ channel protein identified by its tetrodotoxin binding site in rat sciatic nerves

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12 December 2020

Myelinated afferents signal the hyperalgesia associated with nerve injury.

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12 December 2020

Evidence for a central component of post-injury pain hypersensitivity

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12 December 2020

Anticonvulsant drugs for management of pain: a systematic review.

1 reference

12 December 2020

A single pulse of nerve growth factor triggers long-term neuronal excitability through sodium channel gene induction

1 reference

12 December 2020

Structure and functional expression of a new member of the tetrodotoxin-sensitive voltage-activated sodium channel family from human neuroendocrine cells

1 reference

12 December 2020

The microI skeletal muscle sodium channel: mutation E403Q eliminates sensitivity to tetrodotoxin but not to mu-conotoxins GIIIA and GIIIB.

1 reference

12 December 2020

Type III sodium channel mRNA is expressed in embryonic but not adult spinal sensory neurons, and is reexpressed following axotomy

1 reference

12 December 2020

Characterization of TTX-sensitive and TTX-resistant sodium currents in small cells from adult rat dorsal root ganglia.

1 reference

12 December 2020

A tetrodotoxin-resistant voltage-gated sodium channel expressed by sensory neurons

1 reference

12 December 2020

DAMGO inhibits prostaglandin E2-induced potentiation of a TTX-resistant Na+ current in rat sensory neurons in vitro

1 reference

12 December 2020

Downregulation of tetrodotoxin-resistant sodium currents and upregulation of a rapidly repriming tetrodotoxin-sensitive sodium current in small spinal sensory neurons after nerve injury.

1 reference

12 December 2020

A novel tetrodotoxin-sensitive, voltage-gated sodium channel expressed in rat and human dorsal root ganglia.

1 reference

12 December 2020

Inhibition of neuronal Na+ channels by antidepressant drugs

1 reference

12 December 2020

Rescue of alpha-SNS sodium channel expression in small dorsal root ganglion neurons after axotomy by nerve growth factor in vivo.

1 reference

12 December 2020

Slow closed-state inactivation: a novel mechanism underlying ramp currents in cells expressing the hNE/PN1 sodium channel.

1 reference

12 December 2020

Trans-splicing of a voltage-gated sodium channel is regulated by nerve growth factor

1 reference

12 December 2020

A comparison of the potential role of the tetrodotoxin-insensitive sodium channels, PN3/SNS and NaN/SNS2, in rat models of chronic pain

1 reference

12 December 2020

Tetrodotoxin-resistant Na+ currents and inflammatory hyperalgesia

1 reference

12 December 2020

Membrane potential oscillations in dorsal root ganglion neurons: role in normal electrogenesis and neuropathic pain.

1 reference

12 December 2020

Upregulation of a silent sodium channel after peripheral, but not central, nerve injury in DRG neurons.

1 reference

12 December 2020

Plasticity of sodium channel expression in DRG neurons in the chronic constriction injury model of neuropathic pain.

1 reference

12 December 2020

SNS/PN3 and SNS2/NaN sodium channel-like immunoreactivity in human adult and neonate injured sensory nerves

1 reference

12 December 2020

Localization of the tetrodotoxin-resistant sodium channel NaN in nociceptors.

1 reference

12 December 2020

Encoding of burning pain from capsaicin-treated human skin in two categories of unmyelinated nerve fibres

1 reference

12 December 2020

Immunolocalization of SNS/PN3 and NaN/SNS2 sodium channels in human pain states

1 reference

12 December 2020

A possible role for nerve growth factor in the augmentation of sodium channels in models of chronic pain

1 reference

12 December 2020

From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels

1 reference

12 December 2020

Diversity of expression of the sensory neuron-specific TTX-resistant voltage-gated sodium ion channels SNS and SNS2.

1 reference

12 December 2020

Changes in expression of two tetrodotoxin-resistant sodium channels and their currents in dorsal root ganglion neurons after sciatic nerve injury but not rhizotomy.

1 reference

12 December 2020

Potent analgesic effects of GDNF in neuropathic pain states.

1 reference

12 December 2020

The primary erythermalgia-susceptibility gene is located on chromosome 2q31-32.

1 reference

12 December 2020

Early onset of spontaneous activity in uninjured C-fiber nociceptors after injury to neighboring nerve fibers

1 reference

12 December 2020

Contribution of Na(v)1.8 sodium channels to action potential electrogenesis in DRG neurons

1 reference

12 December 2020

Transcriptional channelopathies: an emerging class of disorders

1 reference

12 December 2020

A role for the TTX-resistant sodium channel Nav 1.8 in NGF-induced hyperalgesia, but not neuropathic pain

1 reference

12 December 2020

The involvement of the tetrodotoxin-resistant sodium channel Na(v)1.8 (PN3/SNS) in a rat model of visceral pain.

1 reference

12 December 2020

Neuropathic pain: what do we do with all these theories?

1 reference

12 December 2020

Molecular mechanisms of gating and drug block of sodium channels

1 reference

12 December 2020

Inhibition of neuropathic pain by decreased expression of the tetrodotoxin-resistant sodium channel, NaV1.8.

1 reference

12 December 2020

Burst discharge in primary sensory neurons: triggered by subthreshold oscillations, maintained by depolarizing afterpotentials.

1 reference

12 December 2020

The pattern of expression of the voltage-gated sodium channels Na(v)1.8 and Na(v)1.9 does not change in uninjured primary sensory neurons in experimental neuropathic pain models.

1 reference

12 December 2020

The presence and role of the tetrodotoxin-resistant sodium channel Na(v)1.9 (NaN) in nociceptive primary afferent neurons.

1 reference

12 December 2020

Prostaglandin E(2) modulates TTX-R I(Na) in rat colonic sensory neurons

1 reference

12 December 2020

Function and solution structure of huwentoxin-IV, a potent neuronal tetrodotoxin (TTX)-sensitive sodium channel antagonist from Chinese bird spider Selenocosmia huwena

1 reference

12 December 2020

Deficits in visceral pain and referred hyperalgesia in Nav1.8 (SNS/PN3)-null mice.

1 reference

12 December 2020

Changes of sodium channel expression in experimental painful diabetic neuropathy

1 reference

12 December 2020

Two tarantula peptides inhibit activation of multiple sodium channels

1 reference

12 December 2020

Redistribution of Na(V)1.8 in uninjured axons enables neuropathic pain.

1 reference

12 December 2020

Sensory and electrophysiological properties of guinea-pig sensory neurones expressing Nav 1.7 (PN1) Na+ channel alpha subunit protein

1 reference

12 December 2020

GTP-induced tetrodotoxin-resistant Na+ current regulates excitability in mouse and rat small diameter sensory neurones

1 reference

12 December 2020

Lamotrigine for HIV-associated painful sensory neuropathies: a placebo-controlled trial

1 reference

12 December 2020

The TTX-resistant sodium channel Nav1.8 (SNS/PN3): expression and correlation with membrane properties in rat nociceptive primary afferent neurons.

1 reference

12 December 2020

Reversal of visceral and cutaneous hyperalgesia by local rectal anesthesia in irritable bowel syndrome (IBS) patients.

1 reference

12 December 2020

Upregulation of Sodium Channel Nav1.3 and Functional Involvement in Neuronal Hyperexcitability Associated with Central Neuropathic Pain after Spinal Cord Injury

1 reference

12 December 2020

Voltage-gated sodium channels and hyperalgesia

1 reference

12 December 2020

Changes in the expression of tetrodotoxin-sensitive sodium channels within dorsal root ganglia neurons in inflammatory pain

1 reference

12 December 2020

Gating and modulation of presumptive NaV1.9 channels in enteric and spinal sensory neurons.

1 reference

12 December 2020

Altered sodium channel expression in second-order spinal sensory neurons contributes to pain after peripheral nerve injury.

1 reference

12 December 2020

PGE2 increases the tetrodotoxin-resistant Nav1.9 sodium current in mouse DRG neurons via G-proteins

1 reference

12 December 2020

Decrease in inflammatory hyperalgesia by herpes vector-mediated knockdown of Nav1.7 sodium channels in primary afferents

1 reference

12 December 2020

Gain-of-function mutation in Nav1.7 in familial erythromelalgia induces bursting of sensory neurons

1 reference

12 December 2020

Contribution of the tetrodotoxin-resistant voltage-gated sodium channel NaV1.9 to sensory transmission and nociceptive behavior

1 reference

12 December 2020

Pharmacological properties of neuronal TTX-resistant sodium channels and the role of a critical serine pore residue

1 reference

12 December 2020

Relationship between sodium channel NaV1.3 expression and neuropathic pain behavior in rats

1 reference

12 December 2020

Neuropathic pain develops normally in mice lacking both Na(v)1.7 and Na(v)1.8.

1 reference

12 December 2020

Block of peripheral nerve sodium channels selectively inhibits features of neuropathic pain in rats.

1 reference

12 December 2020

International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels

1 reference

12 December 2020

Acute p38-mediated modulation of tetrodotoxin-resistant sodium channels in mouse sensory neurons by tumor necrosis factor-alpha.

1 reference

12 December 2020

New treatments for neuropathic pain

1 reference

12 December 2020

Involvement of the TTX-resistant sodium channel Nav 1.8 in inflammatory and neuropathic, but not post-operative, pain states.

1 reference

12 December 2020

Antinociceptive efficacy of lacosamide in a rat model for painful diabetic neuropathy

1 reference

12 December 2020

A single sodium channel mutation produces hyper- or hypoexcitability in different types of neurons

1 reference

12 December 2020

Consequences of neuropathic pain: quality-of-life issues and associated costs.

1 reference

12 December 2020

Sodium channel expression in the ventral posterolateral nucleus of the thalamus after peripheral nerve injury

1 reference

12 December 2020

Mechanisms of Disease: neuropathic pain—a clinical perspective

1 reference

12 December 2020

Nerve injury induces robust allodynia and ectopic discharges in Nav1.3 null mutant mice.

1 reference

12 December 2020

muO-conotoxin MrVIB selectively blocks Nav1.8 sensory neuron specific sodium channels and chronic pain behavior without motor deficits

1 reference

12 December 2020

Na(V)1.7 mutant A863P in erythromelalgia: effects of altered activation and steady-state inactivation on excitability of nociceptive dorsal root ganglion neurons.

1 reference

12 December 2020

SCN9A mutations in paroxysmal extreme pain disorder: allelic variants underlie distinct channel defects and phenotypes

1 reference

12 December 2020

The voltage-gated sodium channel Na(v)1.9 is an effector of peripheral inflammatory pain hypersensitivity.

1 reference

12 December 2020

Neurobiology: a channel sets the gain on pain

1 reference

12 December 2020

An SCN9A channelopathy causes congenital inability to experience pain

1 reference

12 December 2020

1 reference

12 December 2020

Molecular interactions of the gating modifier toxin ProTx-II with NaV 1.5: implied existence of a novel toxin binding site coupled to activation

1 reference

12 December 2020

A case of inherited erythromelalgia

1 reference

12 December 2020

A Nav1.7 channel mutation associated with hereditary erythromelalgia contributes to neuronal hyperexcitability and displays reduced lidocaine sensitivity

1 reference

12 December 2020

Lacosamide: a review of preclinical properties.

1 reference

12 December 2020

Loss-of-function mutations in the Nav1.7 gene underlie congenital indifference to pain in multiple human populations

1 reference

12 December 2020

A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat.

1 reference

12 December 2020

Discovery of a novel class of benzazepinone Nav1.7 blockers: Potential treatments for neuropathic pain

1 reference

12 December 2020

Prevalence of chronic pain with neuropathic characteristics in the general population.

1 reference

12 December 2020

Pharmacologic management of neuropathic pain: evidence-based recommendations

1 reference

12 December 2020

The investigational anticonvulsant lacosamide selectively enhances slow inactivation of voltage-gated sodium channels.

1 reference

12 December 2020

From genes to pain: Na v 1.7 and human pain disorders

1 reference

12 December 2020

Mutations in sodium-channel gene SCN9A cause a spectrum of human genetic pain disorders

1 reference

12 December 2020

A selective Nav1.8 sodium channel blocker, A-803467 [5-(4-chlorophenyl-N-(3,5-dimethoxyphenyl)furan-2-carboxamide], attenuates spinal neuronal activity in neuropathic rats

1 reference

12 December 2020

GTP up-regulated persistent Na+ current and enhanced nociceptor excitability require NaV1.9.

1 reference

12 December 2020

Subthreshold oscillations facilitate neuropathic spike discharge by overcoming membrane accommodation

1 reference

12 December 2020

Tarantula huwentoxin-IV inhibits neuronal sodium channels by binding to receptor site 4 and trapping the domain ii voltage sensor in the closed configuration

1 reference

12 December 2020

Voltage-gated Na+ channels: potential for beta subunits as therapeutic targets

1 reference

12 December 2020

Paroxysmal extreme pain disorder M1627K mutation in human Nav1.7 renders DRG neurons hyperexcitable

1 reference

12 December 2020

Sensory neuron voltage-gated sodium channels as analgesic drug targets

1 reference

12 December 2020

Multiple sodium channel isoforms and mitogen-activated protein kinases are present in painful human neuromas.

1 reference

12 December 2020

Nociceptors are interleukin-1beta sensors

1 reference

12 December 2020

Voltage-gated sodium channels in pain states: role in pathophysiology and targets for treatment

1 reference

12 December 2020

Animal models of pain: progress and challenges

1 reference

12 December 2020

Enhanced central pain processing of fibromyalgia patients is maintained by muscle afferent input: a randomized, double-blind, placebo-controlled study

1 reference

12 December 2020

Sodium channels in normal and pathological pain

1 reference

12 December 2020

Voltage-gated sodium channel organization in neurons: protein interactions and trafficking pathways.

1 reference

12 December 2020

Nociceptor sensitization in pain pathogenesis

1 reference

12 December 2020

Central mechanisms of pathological pain

1 reference

12 December 2020

Imbalance of ionic conductances contributes to diverse symptoms of demyelination

1 reference

12 December 2020

Gain-of-function Nav1.8 mutations in painful neuropathy.

1 reference

12 December 2020

Small-fiber neuropathy Nav1.8 mutation shifts activation to hyperpolarized potentials and increases excitability of dorsal root ganglion neurons.

1 reference

12 December 2020

The G1662S NaV1.8 mutation in small fibre neuropathy: impaired inactivation underlying DRG neuron hyperexcitability

1 reference

12 December 2020

Crystal Structure and Molecular Imaging of the Nav Channel 3 Subunit Indicates a Trimeric Assembly

1 reference

12 December 2020

Gain-of-function mutations in sodium channel Na(v)1.9 in painful neuropathy

1 reference

12 December 2020

Transgene regulation using the tetracycline-inducible TetR-KRAB system after AAV-mediated gene transfer in rodents and nonhuman primates

1 reference

12 December 2020

Inhibitors of voltage-gated sodium channel Nav1.7: patent applications since 2010.

1 reference

12 December 2020

Human Na(v)1.8: enhanced persistent and ramp currents contribute to distinct firing properties of human DRG neurons

1 reference

12 December 2020

Heterologous expression of NaV1.9 chimeras in various cell systems

1 reference

12 December 2020

Diversity of composition and function of sodium channels in peripheral sensory neurons.

1 reference

12 December 2020

The role of Nav1.9 channel in the development of neuropathic orofacial pain associated with trigeminal neuralgia.

1 reference

12 December 2020

Endogenous opioids contribute to insensitivity to pain in humans and mice lacking sodium channel Nav1.7

1 reference

12 December 2020

Nav1.7 and other voltage-gated sodium channels as drug targets for pain relief

1 reference

12 December 2020

The Selective Nav1.7 Inhibitor, PF-05089771, Interacts Equivalently with Fast and Slow Inactivated Nav1.7 Channels.

1 reference

12 December 2020

The complete structure of an activated open sodium channel

1 reference

12 December 2020

Tetrodotoxin for Moderate to Severe Cancer-Related Pain: A Multicentre, Randomized, Double-Blind, Placebo-Controlled, Parallel-Design Trial

1 reference

12 December 2020

Identifiers

DOI

10.2147/JPR.S207610

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31564962%20AND%20SRC:MED&resulttype=core&format=json

13 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31564962%20AND%20SRC:MED&resulttype=core&format=json

13 April 2020

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