Wikidata

(Q905435)

English

FMRP translational regulator 1

mammalian protein found in Homo sapiens

  • Protein FMR-1
  • FMRP
  • fragile X mental retardation 1
  • truncated FMRP
  • FMR1
  • synaptic functional regulator FMR1
  • fragile X mental retardation protein 1
In more languages

Statements

molecular function
protein binding
determination method
IPI
16 references
retrieved
8 April 2019
stated in
82-FIP, a novel FMRP (fragile X mental retardation protein) interacting protein, shows a cell cycle-dependent intracellular localization
GOA
curator
UniProt
UniProt protein ID
Q06787
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06787
determination method
IPI
retrieved
8 April 2019
stated in
Evidence that fragile X mental retardation protein is a negative regulator of translation
GOA
curator
UniProt
UniProt protein ID
Q06787
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06787
determination method
IPI
retrieved
8 April 2019
stated in
Transport kinetics of FMRP containing the I304N mutation of severe fragile X syndrome in neurites of living rat PC12 cells
GOA
curator
UniProt
UniProt protein ID
Q06787
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06787
determination method
IPI
retrieved
8 April 2019
stated in
The C terminus of fragile X mental retardation protein interacts with the multi-domain Ran-binding protein in the microtubule-organising centre
GOA
curator
UniProt
UniProt protein ID
Q06787
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06787
determination method
IPI
retrieved
8 April 2019
stated in
The nuclear microspherule protein 58 is a novel RNA-binding protein that interacts with fragile X mental retardation protein in polyribosomal mRNPs from neurons
GOA
curator
UniProt
UniProt protein ID
Q06787
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06787
determination method
IPI
retrieved
8 April 2019
stated in
Fragile X mental retardation protein FMRP binds mRNAs in the nucleus
GOA
curator
UniProt
UniProt protein ID
Q06787
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06787
determination method
IPI
retrieved
8 April 2019
stated in
Fragile X mental retardation protein stimulates ribonucleoprotein assembly of influenza A virus
GOA
curator
UniProt
UniProt protein ID
Q06787
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06787
determination method
IPI
retrieved
8 April 2019
stated in
Subcellular fractionation and localization studies reveal a direct interaction of the fragile X mental retardation protein (FMRP) with nucleolin
GOA
curator
UniProt
UniProt protein ID
Q06787
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06787
determination method
IPI
retrieved
8 April 2019
stated in
Evidence for the association of the human regulatory protein Ki-1/57 with the translational machinery.
GOA
curator
UniProt
UniProt protein ID
Q06787
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06787
determination method
IPI
retrieved
8 April 2019
stated in
MOV10 and FMRP regulate AGO2 association with microRNA recognition elements
GOA
curator
UniProt
UniProt protein ID
Q06787
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06787
determination method
IPI
retrieved
8 April 2019
stated in
The fragile X mental retardation syndrome protein interacts with novel homologs FXR1 and FXR2
GOA
curator
UniProt
UniProt protein ID
Q06787
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06787
determination method
IPI
retrieved
8 April 2019
stated in
In vitro and in cellulo evidences for association of the survival of motor neuron complex with the fragile X mental retardation protein
GOA
curator
UniProt
UniProt protein ID
Q06787
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06787
determination method
IPI
retrieved
8 April 2019
stated in
A highly conserved protein family interacting with the fragile X mental retardation protein (FMRP) and displaying selective interactions with FMRP-related proteins FXR1P and FXR2P
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06787
determination method
IPI
retrieved
8 April 2019
stated in
The structure of the N-terminal domain of the fragile X mental retardation protein: a platform for protein-protein interaction
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06787
determination method
IPI
retrieved
8 April 2019
stated in
A novel RNA-binding nuclear protein that interacts with the fragile X mental retardation (FMR1) protein
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06787
determination method
IPI
retrieved
8 April 2019
stated in
Plakophilins 1 and 3 bind to FXR1 and thereby influence the mRNA stability of desmosomal proteins
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06787
determination method
IPI
RNA binding
determination method
IDA
IEA
IMP
TAS
8 references
retrieved
17 October 2017
stated in
Essential role for KH domains in RNA binding: impaired RNA binding by a mutation in the KH domain of FMR1 that causes fragile X syndrome
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q06787&geneProductId=UniProtKB:Q06787
determination method
TAS
retrieved
17 October 2017
stated in
Dissecting FMR1, the protein responsible for fragile X syndrome, in its structural and functional domains
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q06787&geneProductId=UniProtKB:Q06787
determination method
IMP
retrieved
17 October 2017
stated in
Plakophilins 1 and 3 bind to FXR1 and thereby influence the mRNA stability of desmosomal proteins
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q06787&geneProductId=UniProtKB:Q06787
determination method
IMP
retrieved
17 October 2017
stated in
GOA
curator
UniProt
UniProt protein ID
Q06787
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q06787&geneProductId=UniProtKB:Q06787
determination method
IEA
retrieved
17 October 2017
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q06787&geneProductId=UniProtKB:Q06787
determination method
IEA
retrieved
17 October 2017
stated in
The C terminus of fragile X mental retardation protein interacts with the multi-domain Ran-binding protein in the microtubule-organising centre
GOA
curator
UniProt
UniProt protein ID
Q06787
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q06787&geneProductId=UniProtKB:Q06787
determination method
IDA
retrieved
17 October 2017
stated in
Insights into RNA biology from an atlas of mammalian mRNA-binding proteins
GOA
curator
UniProt
UniProt protein ID
Q06787
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q06787&geneProductId=UniProtKB:Q06787
determination method
IDA
retrieved
17 October 2017
stated in
The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts
GOA
curator
UniProt
UniProt protein ID
Q06787
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q06787&geneProductId=UniProtKB:Q06787
determination method
IDA
RNA binding
determination method
HDA
IDA
IEA
IMP
TAS
8 references
retrieved
8 April 2019
stated in
Essential role for KH domains in RNA binding: impaired RNA binding by a mutation in the KH domain of FMR1 that causes fragile X syndrome
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06787
determination method
TAS
retrieved
8 April 2019
stated in
Dissecting FMR1, the protein responsible for fragile X syndrome, in its structural and functional domains
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06787
determination method
IMP
retrieved
8 April 2019
stated in
Plakophilins 1 and 3 bind to FXR1 and thereby influence the mRNA stability of desmosomal proteins
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06787
determination method
IMP
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q06787
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06787
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06787
determination method
IEA
retrieved
8 April 2019
stated in
The C terminus of fragile X mental retardation protein interacts with the multi-domain Ran-binding protein in the microtubule-organising centre
GOA
curator
UniProt
UniProt protein ID
Q06787
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06787
determination method
IDA
retrieved
8 April 2019
stated in
The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts
GOA
curator
UniProt
UniProt protein ID
Q06787
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06787
determination method
HDA
retrieved
8 April 2019
stated in
Insights into RNA biology from an atlas of mammalian mRNA-binding proteins
GOA
curator
UniProt
UniProt protein ID
Q06787
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06787
determination method
HDA
mRNA binding
determination method
IBA
IDA
IEA
TAS
6 references
retrieved
8 April 2019
stated in
FMR1 protein: conserved RNP family domains and selective RNA binding
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06787
determination method
TAS
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06787
determination method
IEA
retrieved
8 April 2019
stated in
Independent role for presynaptic FMRP revealed by an FMR1 missense mutation associated with intellectual disability and seizures
GOA
curator
UniProt
UniProt protein ID
Q06787
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06787
determination method
IDA
retrieved
8 April 2019
stated in
Evidence that fragile X mental retardation protein is a negative regulator of translation
GOA
curator
UniProt
UniProt protein ID
Q06787
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06787
determination method
IDA
retrieved
8 April 2019
stated in
Fragile X mental retardation protein FMRP binds mRNAs in the nucleus
GOA
curator
UniProt
UniProt protein ID
Q06787
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06787
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06787
determination method
IBA
cell component
cytoplasm
determination method
IDA
TAS
IEA
7 references
retrieved
17 October 2017
stated in
The structure of the N-terminal domain of the fragile X mental retardation protein: a platform for protein-protein interaction
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q06787&geneProductId=UniProtKB:Q06787
determination method
TAS
retrieved
17 October 2017
stated in
GOA
curator
UniProt
UniProt protein ID
Q06787
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q06787&geneProductId=UniProtKB:Q06787
determination method
IEA
retrieved
17 October 2017
stated in
The nuclear microspherule protein 58 is a novel RNA-binding protein that interacts with fragile X mental retardation protein in polyribosomal mRNPs from neurons
GOA
curator
UniProt
UniProt protein ID
Q06787
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q06787&geneProductId=UniProtKB:Q06787
determination method
IDA
retrieved
17 October 2017
stated in
The C terminus of fragile X mental retardation protein interacts with the multi-domain Ran-binding protein in the microtubule-organising centre
GOA
curator
UniProt
UniProt protein ID
Q06787
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q06787&geneProductId=UniProtKB:Q06787
determination method
IDA
retrieved
17 October 2017
stated in
Fragile X mental retardation protein FMRP binds mRNAs in the nucleus
GOA
curator
UniProt
UniProt protein ID
Q06787
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q06787&geneProductId=UniProtKB:Q06787
determination method
IDA
retrieved
17 October 2017
stated in
FMRP associates with polyribosomes as an mRNP, and the I304N mutation of severe fragile X syndrome abolishes this association
GOA
curator
UniProt
UniProt protein ID
Q06787
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q06787&geneProductId=UniProtKB:Q06787
determination method
IDA
retrieved
17 October 2017
stated in
Nuclear Fragile X Mental Retardation Protein is localized to Cajal bodies
GOA
curator
UniProt
UniProt protein ID
Q06787
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q06787&geneProductId=UniProtKB:Q06787
determination method
IDA
polysome
determination method
ISS
IDA
5 references
retrieved
17 October 2017
stated in
GOA
curator
UniProt
UniProt protein ID
Q06787
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q06787&geneProductId=UniProtKB:Q06787
determination method
ISS
retrieved
17 October 2017
stated in
FMRP associates with polyribosomes as an mRNP, and the I304N mutation of severe fragile X syndrome abolishes this association
GOA
curator
UniProt
UniProt protein ID
Q06787
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q06787&geneProductId=UniProtKB:Q06787
determination method
IDA
retrieved
17 October 2017
stated in
Independent role for presynaptic FMRP revealed by an FMR1 missense mutation associated with intellectual disability and seizures
GOA
curator
UniProt
UniProt protein ID
Q06787
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q06787&geneProductId=UniProtKB:Q06787
determination method
IDA
retrieved
17 October 2017
stated in
MOV10 and FMRP regulate AGO2 association with microRNA recognition elements
GOA
curator
UniProt
UniProt protein ID
Q06787
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q06787&geneProductId=UniProtKB:Q06787
determination method
IDA
retrieved
17 October 2017
stated in
Translational regulation of the human achaete-scute homologue-1 by fragile X mental retardation protein
GOA
curator
UniProt
UniProt protein ID
Q06787
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q06787&geneProductId=UniProtKB:Q06787
determination method
IDA
cytoplasm
determination method
IBA
IDA
IEA
TAS
7 references
retrieved
8 April 2019
stated in
The structure of the N-terminal domain of the fragile X mental retardation protein: a platform for protein-protein interaction
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06787
determination method
TAS
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q06787
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06787
determination method
IEA
retrieved
8 April 2019
stated in
FMRP associates with polyribosomes as an mRNP, and the I304N mutation of severe fragile X syndrome abolishes this association
GOA
curator
UniProt
UniProt protein ID
Q06787
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06787
determination method
IDA
retrieved
8 April 2019
stated in
The nuclear microspherule protein 58 is a novel RNA-binding protein that interacts with fragile X mental retardation protein in polyribosomal mRNPs from neurons
GOA
curator
UniProt
UniProt protein ID
Q06787
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06787
determination method
IDA
retrieved
8 April 2019
stated in
Fragile X mental retardation protein FMRP binds mRNAs in the nucleus
GOA
curator
UniProt
UniProt protein ID
Q06787
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06787
determination method
IDA
retrieved
8 April 2019
stated in
The C terminus of fragile X mental retardation protein interacts with the multi-domain Ran-binding protein in the microtubule-organising centre
GOA
curator
UniProt
UniProt protein ID
Q06787
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06787
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06787
determination method
IBA
polysome
determination method
IBA
IDA
ISS
6 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q06787
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06787
determination method
ISS
retrieved
8 April 2019
stated in
Translational regulation of the human achaete-scute homologue-1 by fragile X mental retardation protein
GOA
curator
UniProt
UniProt protein ID
Q06787
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06787
determination method
IDA
retrieved
8 April 2019
stated in
MOV10 and FMRP regulate AGO2 association with microRNA recognition elements
GOA
curator
UniProt
UniProt protein ID
Q06787
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06787
determination method
IDA
retrieved
8 April 2019
stated in
FMRP associates with polyribosomes as an mRNP, and the I304N mutation of severe fragile X syndrome abolishes this association
GOA
curator
UniProt
UniProt protein ID
Q06787
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06787
determination method
IDA
retrieved
8 April 2019
stated in
Independent role for presynaptic FMRP revealed by an FMR1 missense mutation associated with intellectual disability and seizures
GOA
curator
UniProt
UniProt protein ID
Q06787
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06787
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06787
determination method
IBA
cytoplasmic ribonucleoprotein granule
determination method
IBA
IDA
IEA
5 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q06787
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06787
determination method
IEA
retrieved
8 April 2019
stated in
Transport kinetics of FMRP containing the I304N mutation of severe fragile X syndrome in neurites of living rat PC12 cells
GOA
curator
UniProt
UniProt protein ID
Q06787
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06787
determination method
IDA
retrieved
8 April 2019
stated in
In vitro and in cellulo evidences for association of the survival of motor neuron complex with the fragile X mental retardation protein
GOA
curator
UniProt
UniProt protein ID
Q06787
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06787
determination method
IDA
retrieved
8 April 2019
stated in
The composition of Staufen-containing RNA granules from human cells indicates their role in the regulated transport and translation of messenger RNAs
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06787
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06787
determination method
IBA
biological process
Gene Atlas image
PBB GE FMR1 203689 s at fs.png
732 × 530; 12 KB
0 references
Commons category
Fragile X intellectual disability protein
0 references

Identifiers

Freebase ID
/m/021mm7_
0 references
Microsoft Academic ID
2779063550
0 references
2911175337
0 references
 
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