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TREM2 function impedes tau seeding in neuritic plaques
scientific article published on 24 June 2019
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instance of
scholarly article
1 reference
stated in
Europe PubMed Central
PMCID
6660358
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31235932%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 May 2020
title
TREM2 function impedes tau seeding in neuritic plaques
(English)
1 reference
stated in
Europe PubMed Central
PMCID
6660358
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31235932%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 May 2020
author
Cheryl E G Leyns
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMCID
6660358
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31235932%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 May 2020
Maud Gratuze
series ordinal
2
1 reference
stated in
Europe PubMed Central
PMCID
6660358
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31235932%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 May 2020
Melissa Manis
series ordinal
7
1 reference
stated in
Europe PubMed Central
PMCID
6660358
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31235932%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 May 2020
Jason D Ulrich
series ordinal
10
1 reference
stated in
Europe PubMed Central
PMCID
6660358
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31235932%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 May 2020
David M. Holtzman
series ordinal
11
1 reference
stated in
Europe PubMed Central
PMCID
6660358
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31235932%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 May 2020
Marco Colonna
series ordinal
8
object named as
Marco Colonna
1 reference
stated in
Europe PubMed Central
PMCID
6660358
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31235932%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 May 2020
author name string
Sneha Narasimhan
series ordinal
3
1 reference
stated in
Europe PubMed Central
PMCID
6660358
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31235932%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 May 2020
Nimansha Jain
series ordinal
4
1 reference
stated in
Europe PubMed Central
PMCID
6660358
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31235932%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 May 2020
Lauren J Koscal
series ordinal
5
1 reference
stated in
Europe PubMed Central
PMCID
6660358
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31235932%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 May 2020
Hong Jiang
series ordinal
6
1 reference
stated in
Europe PubMed Central
PMCID
6660358
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31235932%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 May 2020
Virginia M Y Lee
series ordinal
9
1 reference
stated in
Europe PubMed Central
PMCID
6660358
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31235932%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 May 2020
publication date
24 June 2019
1 reference
stated in
Europe PubMed Central
PMCID
6660358
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31235932%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 May 2020
published in
Nature Neuroscience
1 reference
stated in
Europe PubMed Central
PMCID
6660358
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31235932%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 May 2020
volume
22
1 reference
stated in
Europe PubMed Central
PMCID
6660358
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31235932%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 May 2020
issue
8
1 reference
stated in
Europe PubMed Central
PMCID
6660358
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31235932%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 May 2020
page(s)
1217-1222
1 reference
stated in
Europe PubMed Central
PMCID
6660358
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31235932%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 May 2020
describes a project that uses
ImageJ
1 reference
stated in
Europe PubMed Central
retrieved
11 June 2022
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/PMC6660358/fullTextXML
based on heuristic
inferred from PubMed Central ID database lookup
cites work
Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6660358
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11 February 2021
New insights into the role of TREM2 in Alzheimer's disease
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PubMed Central
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11 February 2021
Differential effects of partial and complete loss of TREM2 on microglial injury response and tauopathy
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6660358
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11 February 2021
The Trem2 R47H variant confers loss-of-function-like phenotypes in Alzheimer's disease.
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PubMed Central
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Assessment of the Genetic Architecture of Alzheimer's Disease Risk in Rate of Memory Decline.
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11 February 2021
Humanized TREM2 mice reveal microglia-intrinsic and -extrinsic effects of R47H polymorphism.
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11 February 2021
Amyloid-β plaques enhance Alzheimer's brain tau-seeded pathologies by facilitating neuritic plaque tau aggregation.
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11 February 2021
TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy
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11 February 2021
TREM2 deficiency exacerbates tau pathology through dysregulated kinase signaling in a mouse model of tauopathy
1 reference
stated in
PubMed Central
reference URL
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11 February 2021
Disease Progression-Dependent Effects of TREM2 Deficiency in a Mouse Model of Alzheimer's Disease.
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PubMed Central
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11 February 2021
Unique pathological tau conformers from Alzheimer's brains transmit tau pathology in nontransgenic mice
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PubMed Central
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11 February 2021
TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy
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11 February 2021
TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques
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Presynaptic dystrophic neurites surrounding amyloid plaques are sites of microtubule disruption, BACE1 elevation, and increased Aβ generation in Alzheimer's disease
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11 February 2021
TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer's disease mouse models.
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PubMed Central
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11 February 2021
TREM2 lipid sensing sustains the microglial response in an Alzheimer's disease model
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PubMed Central
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11 February 2021
Microglia constitute a barrier that prevents neurotoxic protofibrillar Aβ42 hotspots around plaques
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PubMed Central
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11 February 2021
Altered microglial response to Aβ plaques in APPPS1-21 mice heterozygous for TREM2.
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11 February 2021
Anti-tau antibodies that block tau aggregate seeding in vitro markedly decrease pathology and improve cognition in vivo.
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11 February 2021
Correlation of Alzheimer disease neuropathologic changes with cognitive status: a review of the literature
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11 February 2021
An update on the toxicity of Abeta in Alzheimer's disease
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PubMed Central
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11 February 2021
Cutting Edge: TREM-2 Attenuates Macrophage Activation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6660358
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11 February 2021
Abeta42-driven cerebral amyloidosis in transgenic mice reveals early and robust pathology
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11 February 2021
Identifiers
DOI
10.1038/S41593-019-0433-0
1 reference
stated in
Europe PubMed Central
PMCID
6660358
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31235932%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 May 2020
PMCID
6660358
1 reference
stated in
Europe PubMed Central
PMCID
6660358
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31235932%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 May 2020
PubMed ID
31235932
1 reference
stated in
Europe PubMed Central
PMCID
6660358
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31235932%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 May 2020
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